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Review Article

Sesquiterpene lactones: Adverse health effects and toxicity mechanisms

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Pages 559-579 | Received 14 Dec 2012, Accepted 07 Jun 2013, Published online: 23 Jul 2013

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Miguel Peña-Espinoza, Angela H. Valente, Stig M. Thamsborg, Henrik T. Simonsen, Ulrik Boas, Heidi L. Enemark, Rodrigo López-Muñoz & Andrew R. Williams. (2018) Antiparasitic activity of chicory (Cichorium intybus) and its natural bioactive compounds in livestock: a review. Parasites & Vectors 11:1.
Crossref
Tushar R. Valkute, Eswar K. Aratikatla, Neha A. Gupta, S. Ganga, Manas K. Santra & Asish K. Bhattacharya. (2018) Synthesis and anticancer studies of Michael adducts and Heck arylation products of sesquiterpene lactones, zaluzanin D and zaluzanin C from Vernonia arborea . RSC Advances 8:67, pages 38289-38304.
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D. Staseviciene, A. Chomiciene, L. Malinauskiene & J. Grigaitiene. (2018) Allergic contact dermatitis caused by laurel fruit oil. Journal of the European Academy of Dermatology and Venereology 32:11.
Crossref
Evy Paulsen, Rime B. El-Houri, Klaus E. Andersen & Lars P. Christensen. (2018) Parthenolide in Danish biodynamic and organic milk: A new source of exposure to an allergenic sesquiterpene lactone. Contact Dermatitis 79:4, pages 208-212.
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Ghader babaei, Azadeh Aliarab, Sina Abroon, Yusof Rasmi & Shiva Gholizadeh- Ghaleh Aziz. (2018) Application of sesquiterpene lactone: A new promising way for cancer therapy based on anticancer activity. Biomedicine & Pharmacotherapy 106, pages 239-246.
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Crossref
Gerhard Prinsloo, Noluyolo Nogemane & Renee Street. (2018) The use of plants containing genotoxic carcinogens as foods and medicine. Food and Chemical Toxicology 116, pages 27-39.
Crossref
Margherita Barbero & Cristina Prandi. (2019) Pseudoguaianolides: Recent Advances in Synthesis and Applications. Natural Product Communications 13:3, pages 1934578X1801300.
Crossref
Yan Luo, Man-Ju Che, Cong Liu, Hua-Ge Liu, Xiang-Wei Fu & Yun-Peng Hou. (2018) Toxicity and related mechanisms of dihydroartemisinin on porcine oocyte maturation in vitro. Toxicology and Applied Pharmacology 341, pages 8-15.
Crossref
Jiang-Jiang Tang, Qiu-Rui He, Shuai Dong, Xin Guo, Yu-Gong Wang, Bei-Lei Lei, Jun-Mian Tian & Jin-Ming Gao. (2018) Diversity Modification and Structure-Activity Relationships of Two Natural Products 1β-hydroxy Alantolactone and Ivangustin as Potent Cytotoxic Agents. Scientific Reports 8:1.
Crossref
Valeria P. Sülsen & Virginia S. Martino. 2018. Sesquiterpene Lactones. Sesquiterpene Lactones 3 17 .
Li Tao, Yuzhu Cao, Zhonghong Wei, Qi Jia, Suyun Yu, Jinqiu Zhong, Ainyun Wang, James R. Woodgett & Yin Lu. (2017) Xanthatin triggers Chk1-mediated DNA damage response and destabilizes Cdc25C via lysosomal degradation in lung cancer cells. Toxicology and Applied Pharmacology 337, pages 85-94.
Crossref
Lin Chen, Jian-Ping Zhang, Xin Liu, Jiang-Jiang Tang, Ping Xiang & Xing-Ming Ma. (2017) Semisynthesis, an Anti-Inflammatory Effect of Derivatives of 1β-Hydroxy Alantolactone from Inula britannica. Molecules 22:11, pages 1835.
Crossref
Tivadar Kiss, Andrea Szabó, Gábor Oszlánczi, Anita Lukács, Zoltán Tímár, László Tiszlavicz & Dezső Csupor. (2017) Repeated-dose toxicity of common ragweed on rats. PLOS ONE 12:5, pages e0176818.
Crossref
Carlos Santos, Manuel Vilanova, Rui Medeiros & Rui M. Gil da Costa. (2017) HPV-transgenic mouse models: Tools for studying the cancer-associated immune response. Virus Research 235, pages 49-57.
Crossref
Mohamed Zaki, Mohamed Akssira & Sabine Berteina-Raboin. (2017) Modification of Natural Eudesmane Scaffolds via Mizoroki-Heck Reactions. Molecules 22:4, pages 652.
Crossref
Yu Chuan LiuSe Lim KimYoung Ran ParkSoo-Teik LeeSang Wook Kim. (2017) Parthenolide promotes apoptotic cell death and inhibits the migration and invasion of SW620 cells. Intestinal Research 15:2, pages 174.
Crossref
Evy Paulsen. (2017) Systemic allergic dermatitis caused by sesquiterpene lactones. Contact Dermatitis 76:1, pages 1-10.
Crossref
Ana M.L. Seca, Artur M.S. Silva & Diana C.G.A. Pinto. 2017. 337 372 .
Axel Mithöfer & Massimo E. Maffei. 2017. Plant Toxins. Plant Toxins 3 24 .
Ean-Jeong Seo & Thomas Efferth. 2017. Toxicology of Herbal Products. Toxicology of Herbal Products 217 235 .
Issakwisa B. Ngondya, Linus K. Munishi, Anna C. Treydte & Patrick A. Ndakidemi. (2016) A nature-based approach for managing the invasive weed species Gutenbergia cordifolia for sustainable rangeland management. SpringerPlus 5:1.
Crossref
Jared N. Balaich, Derrick K. Mathias, Baldwyn Torto, Bryan T. Jackson, Dingyin Tao, Babak Ebrahimi, Brian B. Tarimo, Xavier Cheseto, Woodbridge A. Foster & Rhoel R. Dinglasan. (2016) The Nonartemisinin Sesquiterpene Lactones Parthenin and Parthenolide Block Plasmodium falciparum Sexual Stage Transmission. Antimicrobial Agents and Chemotherapy 60:4, pages 2108-2117.
Crossref
Brett D. McKinnon, Vida Kocbek, Kostantinos Nirgianakis, Nick A. Bersinger & Michael D. Mueller. (2016) Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics. Human Reproduction Update 22:3, pages 382-403.
Crossref
Chim Chan, Gomathi Chan, Khalijah Awang & Habsah Abdul Kadir. (2016) Deoxyelephantopin from Elephantopus scaber Inhibits HCT116 Human Colorectal Carcinoma Cell Growth through Apoptosis and Cell Cycle Arrest. Molecules 21:3, pages 385.
Crossref
Ping Xiang, Xin Guo, Yang-Yang Han, Jin-Ming Gao & Jiang-Jiang Tang. (2019) Cytotoxic and Pro-apoptotic Activities of Sesquiterpene Lactones from Inula Britannica . Natural Product Communications 11:1, pages 1934578X1601100.
Crossref
Ying Peng, Siqi Wang, Mengyue Wang, Fang Wang, Jingyu Yang, Chunfu Wu & Xiaobo Li. (2016) Dual effects on constipation and diarrhea: protective potential of Radix Inulae lactones on irritable bowel syndrome. RSC Advances 6:97, pages 94486-94495.
Crossref
Vera P. Demertzidou & Alexandros L. Zografos. (2016) Platinum-catalyzed cycloisomerizations of a common enyne: a divergent entry to cyclopropane sesquiterpenoids. Formal synthesis of sarcandralactone A. Organic & Biomolecular Chemistry 14:29, pages 6942-6946.
Crossref
Christos I. Stathakis, Petros L. Gkizis & Alexandros L. Zografos. (2016) Metal-catalyzed cycloisomerization as a powerful tool in the synthesis of complex sesquiterpenoids. Natural Product Reports 33:9, pages 1093-1117.
Crossref
Yasutomo Shinohara, Makoto Kawatani, Yushi Futamura, Hiroyuki Osada & Yasuji Koyama. (2015) An overproduction of astellolides induced by genetic disruption of chromatin-remodeling factors in Aspergillus oryzae. The Journal of Antibiotics 69:1, pages 4-8.
Crossref
A. Calderón-Komáromy, N. Puente-Pablo, S. Córdoba & J. Borbujo. (2016) Allergic Contact Dermatitis Due to Dittrichia viscosa. Actas Dermo-Sifiliográficas (English Edition) 107:1, pages 76-78.
Crossref
A. Calderón-Komáromy, N. Puente-Pablo, S. Córdoba & J. Borbujo. (2016) Dermatitis alérgica de contacto por Dittrichia viscosa. Actas Dermo-Sifiliográficas 107:1, pages 76-78.
Crossref
Axel Mithöfer & Massimo E. Maffei. 2015. Plant Toxins. Plant Toxins 1 22 .
Juraj Harmatha, Karel Vokáč, Miloš Buděšínský, Zdeněk Zídek & Eva Kmoníčková. (2015) Immunobiological properties of sesquiterpene lactones obtained by chemically transformed structural modifications of trilobolide. Fitoterapia 107, pages 90-99.
Crossref
Aaron M. Kempema, John C. Widen, Joseph K. Hexum, Timothy E. Andrews, Dan Wang, Susan K. Rathe, Frederick A. Meece, Klara E. Noble, Zohar Sachs, David A. Largaespada & Daniel A. Harki. (2015) Synthesis and antileukemic activities of C1–C10-modified parthenolide analogues. Bioorganic & Medicinal Chemistry 23:15, pages 4737-4745.
Crossref
Michael Plöger, Jandirk Sendker, Klaus Langer & Thomas Schmidt. (2015) Covalent Modification of Human Serum Albumin by the Natural Sesquiterpene Lactone Parthenolide. Molecules 20:4, pages 6211-6223.
Crossref
Akram Ziaei, Jessica Hoppstädter, Alexandra K. Kiemer, Mohammad Ramezani, Zahra Amirghofran & Britta Diesel. (2015) Inhibitory effects of teuclatriol, a sesquiterpene from salvia mirzayanii, on nuclear factor-κB activation and expression of inflammatory mediators. Journal of Ethnopharmacology 160, pages 94-100.
Crossref
Bianca Ivanescu, Anca Miron & Andreia Corciova. (2015) Sesquiterpene Lactones from Artemisia Genus: Biological Activities and Methods of Analysis . Journal of Analytical Methods in Chemistry 2015, pages 1-21.
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Elissavet E. Anagnostaki, Vera P. Demertzidou & Alexandros L. Zografos. (2015) Divergent pathways to furosesquiterpenes: first total syntheses of (+)-zedoarol and (Rac)-gweicurculactone. Chemical Communications 51:12, pages 2364-2367.
Crossref
V. Jimenez, U. Kemmerling, R. Paredes, J.D. Maya, M.A. Sosa & N. Galanti. (2014) Natural sesquiterpene lactones induce programmed cell death in Trypanosoma cruzi: A new therapeutic target?. Phytomedicine 21:11, pages 1411-1418.
Crossref
Ana M.L. Seca, Alice Grigore, Diana C.G.A. Pinto & Artur M.S. Silva. (2014) The genus Inula and their metabolites: From ethnopharmacological to medicinal uses. Journal of Ethnopharmacology 154:2, pages 286-310.
Crossref
Natan de David, Mariana de Oliveira Mauro, Caroline Amélia Gonçalves, João Renato Pesarini, Regiane Lauriano Batista Strapasson, Cândida Aparecida Leite Kassuya, Maria Élida Alves Stefanello, Andréa Luiza Cunha-Laura, Antônio Carlos Duenhas Monreal & Rodrigo Juliano Oliveira. (2014) Gochnatia polymorpha ssp. floccosa: Bioprospecting of an anti-inflammatory phytotherapy for use during pregnancy. Journal of Ethnopharmacology 154:2, pages 370-379.
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