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Review Article

Formaldehyde exposure and leukemia: Critical review and reevaluation of the results from a study that is the focus for evidence of biological plausibility

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Pages 661-670 | Received 18 Mar 2013, Accepted 19 Jun 2013, Published online: 31 Jul 2013

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Laura H. Allen, Claire Hamaji, Hannah L. Allen, Gwendolyn H. Parker, Jzyk S. Ennis & Marisa L. Kreider. (2022) Assessment of formaldehyde exposures under contemporary embalming conditions in U.S. funeral homes. Journal of Occupational and Environmental Hygiene 19:7, pages 425-436.
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Letícia Bernardini, Eduardo Barbosa, Mariele Feiffer Charão & Natália Brucker. (2022) Formaldehyde toxicity reports from in vitro and in vivo studies: a review and updated data. Drug and Chemical Toxicology 45:3, pages 972-984.
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Robinan Gentry, Chad M. Thompson, Allison Franzen, Joshua Salley, Richard Albertini, Kun Lu & Tracy Greene. (2020) Using mechanistic information to support evidence integration and synthesis: a case study with inhaled formaldehyde and leukemia. Critical Reviews in Toxicology 50:10, pages 885-918.
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Kenneth A. Mundt, Alexa E. Gallagher, Linda D. Dell, Ethan A. Natelson, Paolo Boffetta & P. Robinan Gentry. (2018) Response to Dr. Bernard D. Goldstein’s Letter to the Editor. Critical Reviews in Toxicology 48:5, pages 341-343.
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Kenneth A. Mundt, Alexa E. Gallagher, Linda D. Dell, Ethan A. Natelson, Paolo Boffetta & P. Robinan Gentry. (2017) Does occupational exposure to formaldehyde cause hematotoxicity and leukemia-specific chromosome changes in cultured myeloid progenitor cells?. Critical Reviews in Toxicology 47:7, pages 598-608.
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Richard J. Albertini & Debra A. Kaden. (2017) Do chromosome changes in blood cells implicate formaldehyde as a leukemogen?. Critical Reviews in Toxicology 47:2, pages 145-184.
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Kenneth T. Bogen & Jacqueline M. Heilman. (2015) Reassessment of MTBE cancer potency considering modes of action for MTBE and its metabolites. Critical Reviews in Toxicology 45:sup1, pages 1-56.
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Articles from other publishers (19)

G. La Torre, T. Vitello, R.A. Cocchiara & C. Della Rocca. (2023) Relationship between formaldehyde exposure, respiratory irritant effects and cancers: a review of reviews. Public Health 218, pages 186-196.
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Doo Seok Kang, Hyun Soo Kim, Jong-Hyeon Jung, Cheol Min Lee, Yeon-Soon Ahn & Young Rok Seo. (2021) Formaldehyde exposure and leukemia risk: a comprehensive review and network-based toxicogenomic approach. Genes and Environment 43:1.
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Oriana Motta, Bruno Charlier, Francesco De Caro, Albino CoglianeseFederica Rosa, Giuseppina Moccia, Concetta Pironti, Mario Capunzo, Anna Borrelli, Amelia Filippelli & Viviana Izzo. (2022) Environmental and Biological Monitoring of Formaldehyde inside A Hospital Setting: A Combined Approach to Manage Chemical Risk in Workplaces. Journal of Public Health Research 10:1, pages jphr.2021.2012.
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George D. Leikauf. 2020. Environmental Toxicants. Environmental Toxicants 555 626 .
Alessandro Allegra, Giovanna Spatari, Stefano Mattioli, Stefania Curti, Vanessa Innao, Roberta Ettari, Andrea Gaetano Allegra, Concetto Giorgianni, Sebastiano Gangemi & Caterina Musolino. (2019) Formaldehyde Exposure and Acute Myeloid Leukemia: A Review of the Literature. Medicina 55:10, pages 638.
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N. V. Efimova, S. S. Khankharev, Vladimir R. Motorov & E. V. Madeeva. (2019) ASSESSMENT OF THE CARCINOGENIC RISK FOR THE POPULATION OF ULAN-UDE. Hygiene and sanitation 98:1, pages 90-93.
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Paul Scheepers, Martien Graumans, Gwendolyn Beckmann, Maurice van Dael, Rob Anzion, Maarten Melissen, Nicole Pinckaers, Luuk van Wel, Laurie de Werdt, Vera Gelsing & Albert van Linge. (2018) Changes in Work Practices for Safe Use of Formaldehyde in a University-Based Anatomy Teaching and Research Facility. International Journal of Environmental Research and Public Health 15:9, pages 2049.
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Kenneth A. Mundt, P. Robinan Gentry, Linda D. Dell, Joseph V. Rodricks & Paolo Boffetta. (2018) Six years after the NRC review of EPA's Draft IRIS Toxicological Review of Formaldehyde : Regulatory implications of new science in evaluating formaldehyde leukemogenicity. Regulatory Toxicology and Pharmacology 92, pages 472-490.
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J.R. Kuykendall & N.S. Kuykendall. 2018. Comprehensive Toxicology. Comprehensive Toxicology 352 388 .
Enrico Pira, Canzio Romano, Carlo La Vecchia & Paolo Boffetta. (2017) Hematologic and cytogenetic biomarkers of leukemia risk from formaldehyde exposure. Carcinogenesis 38:12, pages 1251-1252.
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Pieranna Chiarella, Giovanna Tranfo, Daniela Pigini & Damiano Carbonari. (2016) Is it possible to use biomonitoring for the quantitative assessment of formaldehyde occupational exposure?. Biomarkers in Medicine 10:12, pages 1287-1303.
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B. Athanassiadis, G. A. George, P. V. Abbott & L. J. Wash. (2015) A review of the effects of formaldehyde release from endodontic materials. International Endodontic Journal 48:9, pages 829-838.
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Suna Aydin, Murat Ogeturk, Tuncay Kuloglu, Ahmet Kavakli & Suleyman Aydin. (2015) Effect of carnosine supplementation on apoptosis and irisin, total oxidant and antioxidants levels in the serum, liver and lung tissues in rats exposed to formaldehyde inhalation. Peptides 64, pages 14-23.
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Q. Lan, M. T. Smith, X. Tang, W. Guo, R. Vermeulen, Z. Ji, W. Hu, A. E. Hubbard, M. Shen, C. M. McHale, C. Qiu, S. Liu, B. Reiss, L. Beane-Freeman, A. Blair, Y. Ge, J. Xiong, L. Li, S. M. Rappaport, H. Huang, N. Rothman & L. Zhang. (2014) Chromosome-wide aneuploidy study of cultured circulating myeloid progenitor cells from workers occupationally exposed to formaldehyde. Carcinogenesis 36:1, pages 160-167.
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Sloane K. Tilley & Rebecca C. Fry. 2015. Systems Biology in Toxicology and Environmental Health. Systems Biology in Toxicology and Environmental Health 117 169 .
Pil Kyun Jung, Inah Kim, Inhyo Park, Chinyon Kim, Eun-A Kim & Jaehoon Roh. (2014) A case of multiple myeloma in a poultry worker. Annals of Occupational and Environmental Medicine 26:1.
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Kaowen Zhou, Yanling Cheng, Hongwei Yang, Chunxiu Gu, Yu Xiao & Minghang Zhao. (2014) Simultaneous determination of benzene and formaldehyde in air by cross cataluminescence on nano-3TiO2–2BiVO4. Sensors and Actuators B: Chemical 202, pages 721-726.
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. (2014) Scientific Opinion on the safety and efficacy of formaldehyde for all animal species based on a dossier submitted by Adiveter S.L.. EFSA Journal 12:2.
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. (2014) Scientific Opinion on the safety and efficacy of formaldehyde for all animal species based on a dossier submitted by Regal BV. EFSA Journal 12:2.
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