Advanced search
Publication Cover
Critical Reviews in Toxicology Volume 44, 2014 - Issue 2
Submit an article Journal homepage
1,013
Views
62
CrossRef citations to date
0
Altmetric
Review Article

Human and ecological risk assessment of a crop protection chemical: a case study with the azole fungicide epoxiconazole

Janice E. ChambersCenter for Environmental Health Sciences, College of Veterinary Medicine, Mississippi State University Mississippi State, MSUSA
,
Helmut GreimInstitute of Toxicology and Environmental Hygiene, Technical University of Munich Hohenbachernstr, Freising-WeihenstephanGermany
,
Ronald J. KendallDepartment of Environmental Toxicology, and The Institute of Environmental and Human Health, Texas Tech University Lubbock, TXUSACorrespondence[email protected]
,
Helmut SegnerCentre for Fish and Wildlife Health, Vetsuisse Faculty, University of Bern BernSwitzerland
,
Richard M. SharpeMRC/University of Edinburgh Centre for Reproductive Health, The Queen's Medical Research Institute EdinburghUK
&
Glen Van Der KraakDepartment of Integrative Biology, University of Guelph Guelph, OntarioCanada
Pages 176-210 | Received 10 Jul 2013, Accepted 10 Oct 2013, Published online: 25 Nov 2013

Citations (62)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Jaime Alioscha Cuervo-Parra, Victor Hugo Pérez España, Ernesto Alejandro Zavala-González, Martin Peralta-Gil, José Esteban Aparicio Burgos & Teresa Romero-Cortes. (2022) Trichoderma Asperellum strains as potential biological control agents against Fusarium verticillioides and Ustilago maydis in maize. Biocontrol Science and Technology 32:5, pages 624-647.
Read now
Monika Drážovská, Katarína Šiviková, Beáta Holečková, Ján Dianovský, Martina Galdíková & Viera Schwarzbacherová. (2016) Evaluation of potential genotoxic/cytotoxic effects induced by epoxiconazole and fenpropimorph-based fungicide in bovine lymphocytes in vitro. Journal of Environmental Science and Health, Part B 51:11, pages 769-776.
Read now
Peter Matthiessen & Lennart Weltje. (2015) A review of the effects of azole compounds in fish and their possible involvement in masculinization of wild fish populations. Critical Reviews in Toxicology 45:5, pages 453-467.
Read now

Articles from other publishers (59)

Premila N. Achar, Quenton Kritzinger & Santosh Sharma. 2024. Anti‐Mycotoxin Strategies for Food and Feed. Anti‐Mycotoxin Strategies for Food and Feed 7 29 .
Seyedeh Faezeh Taghizadeh, Ramin Rezaee & Gholamreza Karimi. (2024) Occurrence and dietary exposure to metals and pesticides in Citrus fruits: A probabilistic assessment of risk to health of Iranian consumers. Journal of Food Composition and Analysis 125, pages 105805.
Crossref
Yangyang Zhang, Xinjie Gu, Xiuwen Li, Qiuyun Zhao, Xiaodong Hu, Rui Huang, Jixiong Xu, Zilong Yin, Qing Zhou, Aimin Li & Peng Shi. (2023) Occurrence and risk assessment of azole fungicides during the urban water cycle: A year-long study along the Yangtze River, China. Journal of Environmental Sciences.
Crossref
Loïse Serra, Anthony Estienne, Giovanni Caria, Christelle Ramé, Claudy Jolivet, Claire Froger, Abel Henriot, Laurence Amalric, Fabrice Guérif, Pascal Froment & Joëlle Dupont. (2023) In vitro exposure to triazoles used as fungicides impairs human granulosa cells steroidogenesis. Environmental Toxicology and Pharmacology 104, pages 104295.
Crossref
Carlotta Alias, Donatella Feretti, Gaia V.C. Viola, Ilaria Zerbini, Franco Bisceglie, Giorgio Pelosi, Claudia Zani, Annamaria Buschini, Mauro Carcelli, Dominga Rogolino, Francesco Maria Restivo & Francesca Degola. (2023) Allium cepa tests: A plant-based tool for the early evaluation of toxicity and genotoxicity of newly synthetized antifungal molecules. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 889, pages 503654.
Crossref
Priyanka Bokade, Vivek Kumar Gaur, Varsha Tripathi, Shishir Bobate, Natesan Manickam & Abhay Bajaj. (2023) Bacterial remediation of pesticide polluted soils: Exploring the feasibility of site restoration. Journal of Hazardous Materials 441, pages 129906.
Crossref
Yongchuang Zhu, Xingdong Lin, Lan Wen & Daohang He. (2022) Synthesis and Biological Evaluation of Dipeptide-Based Stilbene Derivatives Bearing a Biheterocyclic Moiety as Potential Fungicides. Molecules 27:24, pages 8755.
Crossref
Bozhen Wang, Li Li, Yuheng Lin, Danyu Shen, Xiaolong Shao, Caihong Zhong & Guoliang Qian. (2022) Targeted isolation of biocontrol agents from plants through phytopathogen co-culture and pathogen enrichment. Phytopathology Research 4:1.
Crossref
Linxuan Li, Tingting Zhu, Yun Song, Li Feng, Philip James Kear, Rooallah Saberi Riseh, Mahmoud Sitohy, Raju Datla & Maozhi Ren. (2022) Salicylic acid fights against Fusarium wilt by inhibiting target of rapamycin signaling pathway in Fusarium oxysporum. Journal of Advanced Research 39, pages 1-13.
Crossref
Shiqun Dai, Jiayao Zhang, Weidong Jia, Mingxiong Ou, Huitao Zhou, Xiang Dong, Hong Chen, Ming Wang, Yu Chen & Shuai Yang. (2022) Experimental Study on the Droplet Size and Charge-to-Mass Ratio of an Air-Assisted Electrostatic Nozzle. Agriculture 12:6, pages 889.
Crossref
Ying Zhang, Yong Zhou, Tingting Duan, Abdul Kaium & Xiaogang Li. (2021) Dissipation and dietary risk assessment of carbendazim and epoxiconazole in citrus fruits in China. Journal of the Science of Food and Agriculture 102:4, pages 1415-1421.
Crossref
Hiba Hamdi, Yosra Ben othmene, Aida Khlifi, Elhem Hallara, Zohra Houas, Mohamed Fadhel Najjar & Salwa Abid-Essefi. (2022) Subchronic exposure to Epoxiconazole induced-heart damage in male Wistar rats. Pesticide Biochemistry and Physiology 182, pages 105034.
Crossref
Hiba Hamdi, Karima Rjiba-Touati, Imen Ayed-Boussema, Assma M’nassri, Hanen Chaabani, Siwar Rich & Salwa Abid-Essefi. (2022) Epoxiconazole caused oxidative stress related DNA damage and apoptosis in PC12 rat Pheochromocytoma. NeuroToxicology 89, pages 184-190.
Crossref
James R. Wheeler, Lennart Weltje, Laurent Lagadic & Katherine Coady. (2022) Response to “A comprehensive review on environmental toxicity of azole compounds to fish”. Chemosphere 291, pages 133023.
Crossref
T. Goessens, S. De Baere, A. Deknock, N. De Troyer, R. Van Leeuwenberg, A. Martel, F. Pasmans, P. Goethals, L. Lens, P. Spanoghe, L. Vanhaecke & S. Croubels. (2022) Agricultural contaminants in amphibian breeding ponds: Occurrence, risk and correlation with agricultural land use. Science of The Total Environment 806, pages 150661.
Crossref
Hiba Hamdi, Imen Graiet, Salwa Abid-Essefi & Joel Eyer. (2022) Epoxiconazole profoundly alters rat brain and properties of neural stem cells. Chemosphere 288, pages 132640.
Crossref
Erqin Li, Aleksandra Krsmanovic, Max‐Bernhard Ballhausen & Matthias C. Rillig. (2021) Fungal response to abruptly or gradually delivered antifungal agent amphotericin B is growth stage dependent. Environmental Microbiology 23:12, pages 7701-7709.
Crossref
Zhi-Heng Lu, Dai-Zhu Lv, Dong-Dong Zhou, Zhong-Hua Yang, Ming-Yue Wang, Ibrahim Abdelhai Senosy, Xiao Liu, Min Chen & Lv-Yun Zhuang. (2021) Enhanced removal efficiency towards azole fungicides from environmental water using a metal organic framework functionalized magnetic lignosulfonate. Separation and Purification Technology 279, pages 119785.
Crossref
Karin Lauschke, Marlene Danner Dalgaard, Jenny Emnéus & Anne Marie Vinggaard. (2021) Transcriptomic changes upon epoxiconazole exposure in a human stem cell-based model of developmental toxicity. Chemosphere 284, pages 131225.
Crossref
Long Lin, Kangwen Xu, Danyu Shen, Shan‐Ho Chou, Mark Gomelsky & Guoliang Qian. (2021) Antifungal weapons of Lysobacter , a mighty biocontrol agent . Environmental Microbiology 23:10, pages 5704-5715.
Crossref
Shuchun Wu, Xiaofeng Ji, Jianmei Wang, Huizhen Wu, Jianzhong Han, Hu Zhang, Jie Xu & Mingrong Qian. (2021) Fungicide bromuconazole has the potential to induce hepatotoxicity at the physiological, metabolomic and transcriptomic levels in rats. Environmental Pollution 280, pages 116940.
Crossref
NR Shepelskaya & YaV Kolyanchuk. (2021) Reproductive toxicity of triazole fungicides cyproconazole and epoxiconazole when exposed to male and female wistar rats during gametogenesis. One Health and Nutrition Problems of Ukraine 54:1, pages 52-61.
Crossref
Holger Klink, Joseph-Alexander Verreet, Mario Hasler & Tim Birr. (2021) Will Triazoles Still Be of Importance in Disease Control of Zymoseptoria tritici in the Future?. Agronomy 11:5, pages 933.
Crossref
Nicola De Simone, Vittorio Capozzi, Maria Luisa Amodio, Giancarlo Colelli, Giuseppe Spano & Pasquale Russo. (2021) Microbial-based Biocontrol Solutions for Fruits and Vegetables: Recent Insight, Patents, and Innovative Trends. Recent Patents on Food, Nutrition & Agriculture 12:1, pages 3-18.
Crossref
Petr Heneberg, Jakub Svoboda & Pavel Pech. (2021) Claustral colony founding does not prevent sensitivity to the detrimental effects of azole fungicides on the fecundity of ants. Journal of Environmental Management 280, pages 111740.
Crossref
Hiba Hamdi, Salwa Abid-Essefi & Joel Eyer. (2021) Neuroprotective effects of Myricetin on Epoxiconazole-induced toxicity in F98 cells. Free Radical Biology and Medicine 164, pages 154-163.
Crossref
Mamta Behl, Cynthia J. Willson, Helen Cunny, Paul M.D. Foster, Barry McIntyre, Cynthia Shackelford, Keith R. Shockley, Sandra McBride, Katie Turner, Suramya Waidyanatha & Chad R. Blystone. (2020) Multigenerational reproductive assessment of 4-methylimidazole administered in the diet to Hsd:Sprague Dawley SD rats. Reproductive Toxicology 98, pages 13-28.
Crossref
Heriberto Fortino Ramírez-Cariño, Paula Cecilia Guadarrama-Mendoza, Vladimir Sánchez-López, Jaime Alioscha Cuervo-Parra, Thalía Ramírez-Reyes, Christopher A. Dunlap & Rogelio Valadez-Blanco. (2020) Biocontrol of Alternaria alternata and Fusarium oxysporum by Trichoderma asperelloides and Bacillus paralicheniformis in tomato plants. Antonie van Leeuwenhoek 113:9, pages 1247-1261.
Crossref
Diogo A.M. Alexandrino, Ana P. Mucha, C. Marisa R. Almeida & Maria F. Carvalho. (2020) Microbial degradation of two highly persistent fluorinated fungicides - epoxiconazole and fludioxonil. Journal of Hazardous Materials 394, pages 122545.
Crossref
V. Michalová, M. Galdíková, B. Holečková, S. Koleničová & V. Schwarzbacherová. (2020) Micronucleus Assay in Environmental Biomonitoring. Folia Veterinaria 64:2, pages 20-28.
Crossref
Nicolas Creusot, Carmen Casado-Martinez, Aurea Chiaia-Hernandez, Karin Kiefer, Benoit J.D. Ferrari, Qiuguo Fu, Nicole Munz, Christian Stamm, Ahmed Tlili & Juliane Hollender. (2020) Retrospective screening of high-resolution mass spectrometry archived digital samples can improve environmental risk assessment of emerging contaminants: A case study on antifungal azoles. Environment International 139, pages 105708.
Crossref
Muhammad Akram, Melanie Patt, Teresa Kaserer, Veronika Temml, Watcharee Waratchareeyakul, Denise V. Kratschmar, Joerg Haupenthal, Rolf W. Hartmann, Alex Odermatt & Daniela Schuster. (2019) Identification of the fungicide epoxiconazole by virtual screening and biological assessment as inhibitor of human 11β-hydroxylase and aldosterone synthase. The Journal of Steroid Biochemistry and Molecular Biology 192, pages 105358.
Crossref
Sheila A. Tesh, John M. Tesh, Ivana Fegert, Roland Buesen, Steffen Schneider, Tobias Mentzel, Bennard van Ravenzwaay & Stefan Stinchcombe. (2019) Innovative selection approach for a new antifungal agent mefentrifluconazole (Revysol®) and the impact upon its toxicity profile. Regulatory Toxicology and Pharmacology 106, pages 152-168.
Crossref
Bastien Durenne, Alodie Blondel, Philippe Druart & Marie-Laure Fauconnier. (2019) Epoxiconazole exposure affects terpenoid profiles of oilseed rape plantlets based on a targeted metabolomic approach. Environmental Science and Pollution Research 26:17, pages 17362-17372.
Crossref
Hiba Hamdi, Yosra Ben Othmène, Oumaima Ammar, Aida Klifi, Elhem Hallara, Faten Ben Ghali, Zohra Houas, Mohamec Fadhel Najjar & Salwa Abid-Essefi. (2019) Oxidative stress, genotoxicity, biochemical and histopathological modifications induced by epoxiconazole in liver and kidney of Wistar rats. Environmental Science and Pollution Research 26:17, pages 17535-17547.
Crossref
Simone Caetani Machado, Bruna Maciel Souza, Luiz Paulo de Aguiar Marciano, Ana Flávia Souza Pereira, Diailison Teixeira de Carvalho & Isarita Martins. (2019) A sensitive and accurate vortex-assisted liquid-liquid microextraction-gas chromatography-mass spectrometry method for urinary triazoles. Journal of Chromatography A 1586, pages 9-17.
Crossref
Jana Vašíčková, Martina Hvězdová, Petra Kosubová & Jakub Hofman. (2019) Ecological risk assessment of pesticide residues in arable soils of the Czech Republic. Chemosphere 216, pages 479-487.
Crossref
Elena Nilsen, Kelly L. Smalling, Lutz Ahrens, Meritxell Gros, Karina S.B. Miglioranza, Yolanda Picó & Heiko L. Schoenfuss. (2018) Critical review: Grand challenges in assessing the adverse effects of contaminants of emerging concern on aquatic food webs. Environmental Toxicology and Chemistry 38:1, pages 46-60.
Crossref
Ana Lopez-Antia, Manuel E. Ortiz-Santaliestra, François Mougeot, Pablo R. Camarero & Rafael Mateo. (2018) Brood size is reduced by half in birds feeding on flutriafol-treated seeds below the recommended application rate. Environmental Pollution 243, pages 418-426.
Crossref
B. Durenne, A. Blondel, N. Ducat, O. Pigeon, M.L. Fauconnier & P. Druart. (2018) Phenotyping of Brassica napus L. plantlets affected during in vitro growth by the presence of epoxiconazole . Acta Horticulturae:1202, pages 101-106.
Crossref
Nancy Baker, Alan Boobis, Lyle Burgoon, Edward Carney, Richard Currie, Ellen Fritsche, Thomas Knudsen, Madeleine Laffont, Aldert H. Piersma, Alan Poole, Steffen Schneider & George Daston. (2018) Building a developmental toxicity ontology. Birth Defects Research 110:6, pages 502-518.
Crossref
Martina Hvězdová, Petra Kosubová, Monika Košíková, Kerstin E. Scherr, Zdeněk Šimek, Lukáš Brodský, Marek Šudoma, Lucia Škulcová, Milan Sáňka, Markéta Svobodová, Lucia Krkošková, Jana Vašíčková, Natália Neuwirthová, Lucie Bielská & Jakub Hofman. (2018) Currently and recently used pesticides in Central European arable soils. Science of The Total Environment 613-614, pages 361-370.
Crossref
Katarína Šiviková, Beáta Holečková, Viera Schwarzbacherová, Martina Galdíková & Ján Dianovský. (2018) Potential chromosome damage, cell-cycle kinetics/and apoptosis induced by epoxiconazole in bovine peripheral lymphocytes in vitro. Chemosphere 193, pages 82-88.
Crossref
Brice Marolleau, Matthieu Gaucher, Christelle Heintz, Alexandre Degrave, Romain Warneys, Gilles Orain, Arnaud Lemarquand & Marie-Noëlle Brisset. (2017) When a Plant Resistance Inducer Leaves the Lab for the Field: Integrating ASM into Routine Apple Protection Practices. Frontiers in Plant Science 8.
Crossref
Yao Wang, Miaomiao Teng, Dezhen Wang, Jin Yan, Jiyan Miao, Zhiqiang Zhou & Wentao Zhu. (2017) Enantioselective bioaccumulation following exposure of adult zebrafish ( Danio rerio ) to epoxiconazole and its effects on metabolomic profile as well as genes expression. Environmental Pollution 229, pages 264-271.
Crossref
Viera Schwarzbacherová, Maciej Wnuk, Anna Lewinska, Leszek Potocki, Jacek Zebrowski, Marek Koziorowski, Beáta Holečková, Katarína Šiviková & Ján Dianovský. (2017) Evaluation of cytotoxic and genotoxic activity of fungicide formulation Tango® Super in bovine lymphocytes. Environmental Pollution 220, pages 255-263.
Crossref
Raquel Sabino. 2017. Exposure to Microbiological Agents in Indoor and Occupational Environments. Exposure to Microbiological Agents in Indoor and Occupational Environments 393 402 .
Gian Mario Tiboni & Adalisa Ponzano. (2016) Fetal safety profile of aromatase inhibitors: Animal data. Reproductive Toxicology 66, pages 84-92.
Crossref
Yunhui Li, Minhui Zhang, Shaojun Li, Rongrong Lv, Pan Chen, Ran Liu, Geyu Liang & Lihong Yin. (2016) The Use of the Nematode Caenorhabditis elegans to Evaluate the Adverse Effects of Epoxiconazole Exposure on Spermatogenesis. International Journal of Environmental Research and Public Health 13:10, pages 993.
Crossref
Manoj Kumar Patel, Hemant Kumar Sahoo, Manoj Kumar Nayak & C. Ghanshyam. (2016) Plausibility of variable coverage high range spraying: Experimental studies of an externally air-assisted electrostatic nozzle. Computers and Electronics in Agriculture 127, pages 641-651.
Crossref
Stephen Nesnow. 2016. Toxicogenomics in Predictive Carcinogenicity. Toxicogenomics in Predictive Carcinogenicity 280 351 .
Daniel R. Dietrich. (2016) EU safety regulations: Don't mar legislation with pseudoscience. Nature 535:7612, pages 355-355.
Crossref
. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 1 58 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 51 .
Maria-Manuel Azevedo, Isabel Faria-Ramos, Luísa Costa Cruz, Cidália Pina-Vaz & Acácio Gonçalves Rodrigues. (2015) Genesis of Azole Antifungal Resistance from Agriculture to Clinical Settings. Journal of Agricultural and Food Chemistry 63:34, pages 7463-7468.
Crossref
Renáta Konášová, Jana Jaklová Dytrtová & Václav Kašička. (2015) Determination of acid dissociation constants of triazole fungicides by pressure assisted capillary electrophoresis. Journal of Chromatography A 1408, pages 243-249.
Crossref
Johanna Gräns, Junko Johansson, Marie Michelová, Britt Wassmur, Elisabeth Norström, Margareta Wallin & Malin C. Celander. (2015) Mixture effects between different azoles and β-naphthoflavone on the CYP1A biomarker in a fish cell line. Aquatic Toxicology 164, pages 43-51.
Crossref
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 46 .
. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 1 12 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.