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Research Article

Biochemical Mechanisms in Chemical-Induced Lung Injury: Roles of Metabolic Activation

Michael R. Boyd Molecular Toxicology Section, Clinical Pharmacology Branch, Clinical Oncology Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
&
H. P. Witschi Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee
Pages 103-176 | Published online: 26 Sep 2008

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RossC. Beier, RobinC. Anderson, NathanA. Krueger, ThomasS. Edrington, ToddR. Callaway & DavidJ. Nisbet. (2009) Effect of nitroethane and nitroethanol on the production of indole and 3-methylindole (skatole) from bacteria in swine feces by gas chromatography. Journal of Environmental Science and Health, Part B 44:6, pages 613-620.
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Brian R. Baer & Allan E. Rettie. (2006) CYP4B1: An Enigmatic P450 at the Interface between Xenobiotic and Endobiotic Metabolism. Drug Metabolism Reviews 38:3, pages 451-476.
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A. Buckpitt, B. Boland, M. Isbell, D. Morin, M. Shultz, R. Baldwin, K. Chan, A. Karlsson, C. Lin, A. Taff, J. West, M. Fanucchi, L. Van Winkle & C. Plopper. (2002) NAPHTHALENE-INDUCED RESPIRATORY TRACT TOXICITY: METABOLIC MECHANISMS OF TOXICITY. Drug Metabolism Reviews 34:4, pages 791-820.
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Iftiquar A. Khan, B. Vijaybhasker Reddy, Mohd. Mahboob, Mohd. F. Rahman & Kaiser Jamil. (2001) EFFECTS OF PHOSPHOROTHIONATE ON THE REPRODUCTIVE SYSTEM OF MALE RATS. Journal of Environmental Science and Health, Part B 36:4, pages 445-456.
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Raymond F. Robledo Mark L. Witten. (1998) ACUTE PULMONARY RESPONSE TO INHALED JP-8 JET FUEL AEROSOL IN MICE. Inhalation Toxicology 10:5, pages 531-553.
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Jürgen Jacob, Makido Emura, Gernot Grimmer, Jan Wolfgang Knebel, Gottfried Raab & Ulrich Mohr. (1996) Requirement of Monooxygenase Induction in Cultured Lung Epithelial Cells for Metabolism of PAH. Polycyclic Aromatic Compounds 10:1-4, pages 123-128.
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M. Emura, J. Jacob, G. Grimmer, J.W. Knebel, G. Raab & U. Mohr. (1996) PAH Metabolism in Cultured Mammalian Lung Epithelial Cells. Polycyclic Aromatic Compounds 10:1-4, pages 35-42.
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Z. E. Suntres & P. N. Shek. (1995) Prevention of Phorbol Myristate Acetate-induced Acute Lung Injury by α-Tocopherol Liposomes. Journal of Drug Targeting 3:3, pages 201-208.
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Heidi Foth. (1995) Role of the Lung in Accumulation and Metabolism of Xenobiotic Compounds — Implications for Chemically Induced Toxicity. Critical Reviews in Toxicology 25:2, pages 165-205.
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Vijayalakshmi Ravindranath & Michael R. Boyd. (1995) Xenobiotic Metabolism in Brain. Drug Metabolism Reviews 27:3, pages 419-448.
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Jay Gandy, GlennC. Millner, HudsonK. Bates, DanielA. Casciano & RaymondD. Harbison. (1990) Effects of selected chemicals on the glutathione status in the male reproductive system of rats. Journal of Toxicology and Environmental Health 29:1, pages 45-57.
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James V. Bruckner, Barbara D. Davis & Jerry N. Blancato. (1989) Metabolism, Toxicity, and Carcinogenicity of Trichloroethylene. Critical Reviews in Toxicology 20:1, pages 31-50.
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Rune Becher, Jon E. Dahl, Kjell Aarstad, Odd C. Nilsen & Erik Dybing. (1989) Lung and Liver Damage in Mice After Bromobenzene Inhalation: Effects of Enzyme Inducers. Inhalation Toxicology 1:2, pages 181-196.
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R.J. Julian, JudithA. Frazier & M. Goryo. (1989) Right ventricular hypertrophy, right ventricular failure and ascites in broiler chickens caused by Amiodarone‐induced lung pathology. Avian Pathology 18:1, pages 161-173.
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Gregory L. Kedderis & Gerald T. Miwa. (1988) The metabolic activation of nitroheterocyclic therapeutic agents. Drug Metabolism Reviews 19:1, pages 33-62.
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James Gillette, Elizabeth K. Weisburger, Herman Kraybill & Morris Kelsey. (1985) Strategies for Determining the Mechanisms of Toxicity. Journal of Toxicology: Clinical Toxicology 23:1, pages 1-78.
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F. Peter Guengerich, Daniel C. Liebler & Donald L. Reed. (1985) Enzymatic activation of chemicals to toxic metabolites. CRC Critical Reviews in Toxicology 14:3, pages 259-307.
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Jawaharlal M. Patel & Edward R. Block. (1985) Cyclophosphamide-Induced Depression of the Antioxidant Defense Mechanisms of the Lung. Experimental Lung Research 8:2-3, pages 153-165.
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Glenn F. Rush, Jacqueline H. Smith, John F. Newton, Jerry B. Hook & William O. Berndt. (1984) Chemically Induced Nephrotoxicity: Role of Metabolic Activation. CRC Critical Reviews in Toxicology 13:2, pages 99-160.
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Michael R. Boyd & Charles N. Statham. (1983) The Effect of Hepatic Metabolism on the Production and Toxicity of Reactive Metabolites in Extrahepatic Organs. Drug Metabolism Reviews 14:1, pages 35-47.
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J. S. Bus & J. E. Gibson. (1982) Mechanisms of superoxide Radical-mediated toxicity. Journal of Toxicology: Clinical Toxicology 19:6-7, pages 689-697.
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