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Research Article

Saturable Metabolism and its Relationship to Toxicity

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Pages 105-150 | Published online: 26 Sep 2008

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Simone Esposito, Laura Orsatti & Vincenzo Pucci. (2022) Subcutaneous catabolism of peptide therapeutics: bioanalytical approaches and ADME considerations. Xenobiotica 52:8, pages 828-839.
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Ahmed A. El-Sherbeni & Ayman O. S. El-Kadi. (2017) Microsomal cytochrome P450 as a target for drug discovery and repurposing. Drug Metabolism Reviews 49:1, pages 1-17.
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Harvey J. Clewell, Justin Teeguarden, Tracy McDonald, Ramesh Sarangapani, Greg Lawrence, Tammie Covington, Robinan Gentry & Annette Shipp. (2002) Review and Evaluation of the Potential Impact of Age- and Gender-Specific Pharmacokinetic Differences on Tissue Dosimetry. Critical Reviews in Toxicology 32:5, pages 329-389.
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GloriaA. Skowronski & MohamedS. Abdel‐Rahman. (1997) Interspecies comparison of kinetic data of chlorinated chemicals of potential relevance to risk assessment. Human and Ecological Risk Assessment: An International Journal 3:4, pages 635-653.
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Melvin E. Andersen. (1995) What do we Mean by Dose. Inhalation Toxicology 7:6, pages 909-915.
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Hon‐Wing Leung. (1991) Development and utilization of physiologically based pharmacokinetic models for toxicological applications. Journal of Toxicology and Environmental Health 32:3, pages 247-267.
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Bruce Clark, Dennis A. Smith & John Caldwell. (1984) Pharmacokinetics and Toxicity Testing. CRC Critical Reviews in Toxicology 12:4, pages 343-385.
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Garth Powis. (1983) Dose-Dependent Metabolism, Therapeutic Effect, and Toxicity of Anticancer Drugs in Man. Drug Metabolism Reviews 14:6, pages 1145-1163.
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