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Research Article

Pharmacokinetics and Toxicity Testing

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Pages 343-385 | Published online: 26 Sep 2008

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Hugh A. Barton, Timothy P. Pastoor, Karl Baetcke, Janice E. Chambers, Janet Diliberto, Nancy G. Doerrer, Jeffrey H. Driver, Charles E. Hastings, Seshadri Iyengar, Robert Krieger, Bernhard Stahl & Charles Timchalk. (2006) The Acquisition and Application of Absorption, Distribution, Metabolism, and Excretion (ADME) Data in Agricultural Chemical Safety Assessments. Critical Reviews in Toxicology 36:1, pages 9-35.
Read now
D. A. SMITH. (1997) Pharmacokinetics and pharmacodynamics in toxicology. Xenobiotica 27:5, pages 513-525.
Read now
Li You, Cham E. Dallas & Srinivasa Muralidhara. (1994) The Pharmacokinetics of Inhaled 1,1,1-Trichloroethane Following high Milk Intake in Mice. Drug and Chemical Toxicology 17:4, pages 479-498.
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D. A. Smith, M. J. Humphrey & C. Charuel. (1990) Design of toxicokinetic studies. Xenobiotica 20:11, pages 1187-1199.
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C. T. Eason, P. Powles, G. Henry, A. J. Spencer, A. Pattison & F. W. Bonner. (1989) The comparative pharmacokinetics and gastric toxicity of bezafibrate and ciprofibrate in the rat. Xenobiotica 19:8, pages 913-925.
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Kenneth R. Butterworth, Beverley A. Mangham & Stuart R. Walker. (1987) The Application of Clinical Toxicology. CRC Critical Reviews in Toxicology 18:2, pages 81-128.
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L. R. Kao & L. S. Birnbaum. (1986) Disposition of o‐benzyl‐p‐chlorophenol in male rats. Journal of Toxicology and Environmental Health 18:3, pages 441-458.
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Articles from other publishers (45)

Wade J. Adams. 2019. Generics and Bloequivalence. Generics and Bloequivalence 139 178 .
John F. Reichard, M. Andrew Maier, Bruce D. Naumann, Alison M. Pecquet, Thomas Pfister, Reena Sandhu, Edward V. Sargent, Anthony J. Streeter & Patricia A. Weideman. (2016) Toxicokinetic and toxicodynamic considerations when deriving health-based exposure limits for pharmaceuticals. Regulatory Toxicology and Pharmacology 79, pages S67-S78.
Crossref
Esther F.A. Brandon, Petra C.E. van Kesteren, Jan C.H. van Eijkeren, Marc Tienstra, Patricia Lopez Sanchez, Elisa C.M. Tonk, Aldert H. Piersma & Peter M.J. Bos. (2015) Implementation of toxicokinetics in toxicity studies – Toxicokinetics of 4-methylanisole and its metabolites in juvenile and adult rats. Regulatory Toxicology and Pharmacology 73:1, pages 55-64.
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Grace B. Hatton, Vipul Yadav, Abdul W. Basit & Hamid A. Merchant. (2015) Animal Farm: Considerations in Animal Gastrointestinal Physiology and Relevance to Drug Delivery in Humans. Journal of Pharmaceutical Sciences 104:9, pages 2747-2776.
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Takuya Matsumoto, Aya Kiriake, Shoichiro Ishizaki, Shugo Watabe & Yuji Nagashima. (2015) Biliary excretion of tetrodotoxin in the cultured pufferfish Takifugu rubripes juvenile after intramuscular administration. Toxicon 93, pages 98-102.
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Peter JH Webborn. (2014) The role of pharmacokinetic studies in drug discovery: where are we now, how did we get here and where are we going?. Future Medicinal Chemistry 6:11, pages 1233-1235.
Crossref
Koon-Pong Wong, Xiaoli Zhang & Sung-Cheng Huang. (2013) Improved Derivation of Input Function in Dynamic Mouse [18F]FDG PET Using Bladder Radioactivity Kinetics. Molecular Imaging and Biology 15:4, pages 486-496.
Crossref
Michelle Anne Kutzler. 2013. Small Animal Toxicology. Small Animal Toxicology 203 214 .
Lixia Pei, Dongmei Dai, Yuanwu Bao, Feng Chen, Jin Zheng, Ji Li, Sheng Liu & Xiuping Chen. (2012) Determination of bakkenolide A in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study. Journal of Mass Spectrometry 47:8, pages 962-968.
Crossref
Jim E. RiviereMarilyn Martinez. 2011. Comparative Pharmacokinetics. Comparative Pharmacokinetics 315 346 .
Vijay Sharma & John H McNeill. (2009) To scale or not to scale: the principles of dose extrapolation. British Journal of Pharmacology 157:6, pages 907-921.
Crossref
Chris Logan. 2008. Drug Bioavailability. Drug Bioavailability 161 184 .
Karen Yokley, Hien T. Tran, Kaija Pekari, Stephen Rappaport, Vesa Riihimaki, Nat Rothman, Suramya Waidyanatha & Paul M. Schlosser. (2006) Physiologically-Based Pharmacokinetic Modeling of Benzene in Humans: A Bayesian Approach. Risk Analysis 26:4, pages 925-943.
Crossref
Michelle Anne Kutzler. 2006. Small Animal Toxicology. Small Animal Toxicology 178 190 .
Jiunn H. Lin, Drazen Ostovic & Joseph P. Vacca. 2002. Integration of Pharmaceutical Discovery and Development. Integration of Pharmaceutical Discovery and Development 233 255 .
. 2002. Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists. Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists 229 239 .
. 2002. Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists. Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists 175 188 .
Thor HilbergÅse RipelLars SlørdalAnders BjørneboeJørg Mørland. (1999) The Extent of Postmortem Drug Redistribution in a Rat Model. Journal of Forensic Sciences 44:5, pages 12023J.
Crossref
Yuan Hua Wen, Jacob Kalff & Robert Henry Peters. (1999) Pharmacokinetic modeling in toxicology: a critical perspective. Environmental Reviews 7:1, pages 1-18.
Crossref
D. BRUCE CAMPBELL. (1996) Extrapolation from Animals to Man.. Annals of the New York Academy of Sciences 801:1 Cellular and, pages 116-135.
Crossref
D. Bruce Campbell. (1995) The use of toxicokinetics for the safety assessment of drugs acting in the brain. Molecular Neurobiology 11:1-3, pages 193-216.
Crossref
Mitchell N. Cayen. (2016) Considerations in the Design of Toxicokinetic Programs. Toxicologic Pathology 23:2, pages 148-157.
Crossref
Li You, Srinivasa Muralidhara & Cham E. Dallas. (1994) Comparisons between operant response and 1,1,1-trichloroethane toxicokinetics in mouse blood and brain. Toxicology 93:2-3, pages 151-163.
Crossref
D. Gwyn Morgan, Alan S. Kelvin, Lewis B. Kinter, Colin J. Fish, William D. Kerns & Gerald Rhodes. (2016) The Application of Toxicokinetic Data to Dosage Selection in Toxicology Studies. Toxicologic Pathology 22:2, pages 112-123.
Crossref
Watze de Wolf, Bert Mast, Eddy S.E. Yedema, Willem Seinen & Joop L.M. Hermens. (1994) Kinetics of 4-chloroaniline in guppy, Poecilia reticulata. Aquatic Toxicology 28:1-2, pages 65-78.
Crossref
C. Parkinson & P. Grasso. (2016) The Use of the Dog in Toxicity Tests on Pharmaceutical Compounds. Human & Experimental Toxicology 12:2, pages 99-109.
Crossref
D. A. Smith. (1993) Integration of animal pharmacokinetic and pharmacodynamic data in drug safety assessment. European Journal of Drug Metabolism and Pharmacokinetics 18:1, pages 31-39.
Crossref
C. Charuel, P. Comby & A. M. Monro. (2006) Diurnal exposure profile in rats from dietary administration of a chemical (doxazosin) with a short half‐life: Interplay of age and diurnal feeding pattern. Journal of Applied Toxicology 12:1, pages 7-11.
Crossref
Alex D. Huffman, Sharon L. Bertelsen & Michael L. Gargas. (1992) An in vitro gas equilibration method for determination of chemical partition coefficients in fish. Comparative Biochemistry and Physiology Part A: Physiology 101:1, pages 47-51.
Crossref
Mace G. Barron, Guy R. Stehly & William L. Hayton. (1990) Pharmacokinetic modeling in aquatic animals I. Models and concepts. Aquatic Toxicology 18:2, pages 61-85.
Crossref
A.M. Monro. (1990) Interspecies comparisons in toxicology: The utility and futility of plasma concentrations of the test substance. Regulatory Toxicology and Pharmacology 12:2, pages 137-160.
Crossref
Mace G. Barron, Guy R. Stehly & William L. Hayton. (1990) Pharmacokinetic modeling in aquatic animals I. Models and concepts. Aquatic Toxicology 17:3, pages 187-212.
Crossref
Charles T. Eason, Frank W. Bonner & Dennis V. Parke. (1990) The importance of pharmacokinetic and receptor studies in drug safety evaluation. Regulatory Toxicology and Pharmacology 11:3, pages 288-307.
Crossref
Wade J. Adams. 1990. Early Phase Drug Evaluation in Man. Early Phase Drug Evaluation in Man 25 38 .
Kenneth Bachmann. (1989) Predicting toxicokinetic parameters in humans from toxicokinetic data acquired from three small mammalian species. Journal of Applied Toxicology 9:5, pages 331-338.
Crossref
Cham E. Dallas, Raghupathy Ramanathan, Srinivasa Muralidhara, James M. Gallo & James V. Bruckner. (1989) The uptake and elimination of 1,1,1-trichloroethane during and following inhalation exposures in rats. Toxicology and Applied Pharmacology 98:3, pages 385-397.
Crossref
Robert J. Scheuplein. 1989. Risk Assessment in Setting National Priorities. Risk Assessment in Setting National Priorities 279 285 .
F G Standaert. (1988) Absorption and distribution of xenobiotics.. Environmental Health Perspectives 77, pages 63-71.
Crossref
C. T. Eason, J. I. Usansky, G. P. Henry, P. Powles & F. W. Bonner. (1988) The relationship between the pharmacokinetics of amrinone in the marmoset and platelet effects. European Journal of Drug Metabolism and Pharmacokinetics 13:2, pages 129-133.
Crossref
William SlikkerJr.Jr.. (1987) The role of metabolism in the testing of developmental toxicants. Regulatory Toxicology and Pharmacology 7:4, pages 390-413.
Crossref
D.A. Smith. (1987) Aminopyrine N-demethylation in young, old and tumour bearing B6C3 F1 mice. Pharmacology & Therapeutics 33:1, pages 187-191.
Crossref
H Nau. (1986) Species differences in pharmacokinetics and drug teratogenesis.. Environmental Health Perspectives 70, pages 113-129.
Crossref
M.J. Angelo, A.B. Pritchard, D.R. Hawkins, A.R. Waller & A. Roberts. (1986) The pharmacokinetics of dichloromethane. I. Disposition in B6C3F1 mice following intravenous and oral administration. Food and Chemical Toxicology 24:9, pages 965-974.
Crossref
Per Sj�berg, Ulf Bondesson & Margareta Hammarlund. (1985) Non-linearities in the pharmacokinetics of di-(2-ethylhexyl) phthalate and metabolites in male rats. Archives of Toxicology 58:2, pages 72-77.
Crossref
W. Riess. 1986. Receptors and Other Targets for Toxic Substances. Receptors and Other Targets for Toxic Substances 205 207 .

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