187
Views
269
CrossRef citations to date
0
Altmetric
Research Article

Enzymatic activation of chemicals to toxic metabolites

, &
Pages 259-307 | Published online: 26 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (23)

Dominique Pessayre, Bernard Fromenty, Alain Berson, Marie-Anne Robin, Philippe Lettéron, Richard Moreau & Abdellah Mansouri. (2012) Central role of mitochondria in drug-induced liver injury. Drug Metabolism Reviews 44:1, pages 34-87.
Read now
Cheri M Turman, Jade M Hatley, Daniel J Ryder, Vijayalakshmi Ravindranath & Henry W Strobel. (2006) Alternative splicing within the human cytochrome P450 superfamily with an emphasis on the brain: the convolution continues. Expert Opinion on Drug Metabolism & Toxicology 2:3, pages 399-418.
Read now
Shufeng Zhou, Eli Chan, Wei Duan, Min Huang & Yu-Zong Chen. (2005) Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance. Drug Metabolism Reviews 37:1, pages 41-213.
Read now
Jack A. Hinson, Angela B. Reid, Sandra S. McCullough & Laura P. James. (2004) Acetaminophen‐Induced Hepatotoxicity: Role of Metabolic Activation, Reactive Oxygen/Nitrogen Species, and Mitochondrial Permeability Transition. Drug Metabolism Reviews 36:3-4, pages 805-822.
Read now
Reem H. Elbekai, Hesham M. Korashy, Kelly Wills, Negar Gharavi & Ayman O.S. El-Kadi. (2004) Benzo[a]Pyrene, 3-Methylcholanthrene and ß-Naphthoflavone Induce Oxidative Stress in Hepatoma Hepa 1c1c7 Cells by an AHR-dependent Pathway. Free Radical Research 38:11, pages 1191-1200.
Read now
Ruth Carlson, James Wilson, Robert Lochmiller, David Janz, Jackie Schroder & Nicholas Basta. (2003) Ecotoxicological Risks Associated with Land Treatment of Petrochemical Wastes. II. Effects on Hepatic Phase I and Phase II Detoxification Enzymes in Cotton Rats. Journal of Toxicology and Environmental Health, Part A 66:4, pages 327-343.
Read now
J. J. Whyte, R. E. Jung, C. J. Schmitt & D. E. Tillitt. (2000) Ethoxyresorufin-O-deethylase (EROD) Activity in Fish as a Biomarker of Chemical Exposure. Critical Reviews in Toxicology 30:4, pages 347-570.
Read now
JohnK. Pollak. (1998) A short review of the problems posed by xenobiotics in chemical mixtures and the role of mixed function oxidases. International Journal of Environmental Health Research 8:2, pages 157-163.
Read now
J. D. Adams$suffix/text()$suffix/text(), L. K. Klaidman & P. Ribeiro. (1997) Tyrosine hydroxylase: mechanisms of oxygen radical formation. Redox Report 3:5-6, pages 273-279.
Read now
Miranda Cornet & Vera Rogiers. (1997) Metabolism and Toxicity of 2-Methylpropene (Isobutene) — A Review. Critical Reviews in Toxicology 27:3, pages 223-232.
Read now
Wolfgang Dekant & Spiros Vamvakas. (1996) Biotransformation and Membrane Transport in Nephrotoxicity. Critical Reviews in Toxicology 26:3, pages 309-334.
Read now
Vijayalakshmi Ravindranath & Michael R. Boyd. (1995) Xenobiotic Metabolism in Brain. Drug Metabolism Reviews 27:3, pages 419-448.
Read now
F. Peter Guengerich. (1990) Enzymatic Oxidation of Xenobiotic Chemical. Critical Reviews in Biochemistry and Molecular Biology 25:2, pages 97-153.
Read now
Zigang Dong & Alan M. Jeffrey. (1990) Mechanisms of Organ Specificity in Chemical Carcinogenesis. Cancer Investigation 8:5, pages 523-533.
Read now
James V. Bruckner, Barbara D. Davis & Jerry N. Blancato. (1989) Metabolism, Toxicity, and Carcinogenicity of Trichloroethylene. Critical Reviews in Toxicology 20:1, pages 31-50.
Read now
James r. Halpert, John-Yan Jaw & Eric F. Johnson. (1989) Design of Specific Mechanism Based Inactivators of Hepatic and Adrenal Microsomal Cytochromes P-450 Responsible for Progesterone 21-Hydroxylation. Drug Metabolism Reviews 20:2-4, pages 645-655.
Read now
Dennis R. Koop, Carmen L. Laethem & Daniel J. Tierney. (1989) The Utility of p-Mtrophenol Hydroxylation in P450iie1 Analysis. Drug Metabolism Reviews 20:2-4, pages 541-551.
Read now
Kwang-Mu Yen, Cuneyt M. Serdar & Irwin C. Gunsalus. (1988) Genetics of Naphthalene Catabolism in Pseudomonads. CRC Critical Reviews in Microbiology 15:3, pages 247-268.
Read now
S. A. Horner, J. R. Fry, R. H. Clothier & M. Balls. (1987) The detection of cytotoxicity produced by short-lived reactive intermediates: a study with bromobenzene. Xenobiotica 17:6, pages 777-782.
Read now
F. P. Guengerich, D. R. Umbenhauer, P. F. Churchill, P. H. Beaune, R. Böcker, R. G. Knodell, M. V. Martin & R. S. Lloyd. (1987) Polymorphism of human cytochrome P-450. Xenobiotica 17:3, pages 311-316.
Read now

Articles from other publishers (246)

Matteo Rosellini, Alicia Schulze, Ejlal A. Omer, Nadeen T. Ali, Federico Marini, Jan-Heiner Küpper & Thomas Efferth. (2023) The Effect of Plastic-Related Compounds on Transcriptome-Wide Gene Expression on CYP2C19-Overexpressing HepG2 Cells. Molecules 28:16, pages 5952.
Crossref
Oluwadamilola Daramola & Amy A. Rand. (2021) Emerging investigator series: human CYP2A6 catalyzes the oxidation of 6:2 fluorotelomer alcohol. Environmental Science: Processes & Impacts 23:11, pages 1688-1695.
Crossref
David Kirkland, Michael Kovochich, Sharlee L. More, F. Jay Murray, Andrew D. Monnot, Julie V. Miller, Hartmut Jaeschke, David Jacobson-Kram, Milind Deore, Suresh Kumar Pitchaiyan, Kenneth Unice & Gary Eichenbaum. (2021) A comprehensive weight of evidence assessment of published acetaminophen genotoxicity data: Implications for its carcinogenic hazard potential. Regulatory Toxicology and Pharmacology 122, pages 104892.
Crossref
Yeowool Choi & Sang Don Kim. (2021) Identification and Toxicity Prediction of Biotransformation Molecules of Organophosphate Flame Retardants by Microbial Reactions in a Wastewater Treatment Plant. International Journal of Molecular Sciences 22:10, pages 5376.
Crossref
Hartmut Jaeschke, F. Jay Murray, Andrew D. Monnot, David Jacobson-Kram, Samuel M. Cohen, Jerry F. Hardisty, Evren Atillasoy, Anne Hermanowski-Vosatka, Edwin Kuffner, Daniele Wikoff, Grace A. Chappell, Suren B. Bandara, Milind Deore, Suresh Kumar Pitchaiyan & Gary Eichenbaum. (2021) Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its carcinogenic hazard potential. Regulatory Toxicology and Pharmacology 120, pages 104859.
Crossref
David J. Kirkland, Meredith L. Sheil, Michael A. Streicker & George E. Johnson. (2021) A weight of evidence assessment of the genotoxicity of 2,6-xylidine based on existing and new data, with relevance to safety of lidocaine exposure. Regulatory Toxicology and Pharmacology 119, pages 104838.
Crossref
Ann-Kathrin Loerracher & Thomas Braunbeck. (2020) Inducibility of cytochrome P450-mediated 7-methoxycoumarin-O-demethylase activity in zebrafish (Danio rerio) embryos. Aquatic Toxicology 225, pages 105540.
Crossref
John P Rooney, Keiyu Oshida, Ramiya Kumar, William S Baldwin & J Christopher Corton. (2019) Chemical Activation of the Constitutive Androstane Receptor Leads to Activation of Oxidant-Induced Nrf2. Toxicological Sciences 167:1, pages 172-189.
Crossref
Helmut Sies. 2019. Stress: Physiology, Biochemistry, and Pathology. Stress: Physiology, Biochemistry, and Pathology 153 163 .
Shyamal K. Goswami. 2019. Modulation of Oxidative Stress in Heart Disease. Modulation of Oxidative Stress in Heart Disease 403 418 .
Helmut Sies. (2018) On the history of oxidative stress: Concept and some aspects of current development. Current Opinion in Toxicology 7, pages 122-126.
Crossref
F.P. Guengerich. 2018. Comprehensive Toxicology. Comprehensive Toxicology 54 86 .
Michael G. Leeming, William A. Donald & Richard A. J. O’Hair. (2017) Nontargeted Identification of Reactive Metabolite Protein Adducts. Analytical Chemistry 89:11, pages 5748-5756.
Crossref
Paramahamsa MaturuYanhong Wei-LiangWeiwu JiangLihua WangKrithika LingappanRoberto Barrios, Yao LiangBhagavatula MoorthyXanthi I. Couroucli. (2017) Newborn Mice Lacking the Gene for Cyp1a1 Are More Susceptible to Oxygen-Mediated Lung Injury, and Are Rescued by Postnatal β-Naphthoflavone Administration: Implications for Bronchopulmonary Dysplasia in Premature Infants. Toxicological Sciences 157:1, pages 260-271.
Crossref
LeeAnne R Thayer & Heather J Hamlin. (2015) Investigating factors contributing to reduced embryo survival in farm‐raised Atlantic salmon, Salmo salar L. . Aquaculture Research 47:12, pages 3980-3989.
Crossref
Barbara Bonamassa, Donatella Canistro, Andrea Sapone, Fabio Vivarelli, Andrea Vornoli, Vincenzo Longo & Moreno Paolini. (2016) Harmful effects behind the daily supplementation of a fixed vegetarian blend in the rat model. Food and Chemical Toxicology 97, pages 367-374.
Crossref
Fahad A Al-Abbasi. (2015) In vitro activation of dibromoacetonitrile to cyanide by myeloperoxidase . Toxicology and Industrial Health 32:8, pages 1478-1485.
Crossref
Waranya Chatuphonprasert, Kanokwan Jarukamjorn & Waraporn Putalun. (2016) Regulation of cancer-related genes – Cyp1a1 , Cyp1b1 , Cyp19 , Nqo1 and Comt – expression in β-naphthoflavone-treated mice by miroestrol . Journal of Pharmacy and Pharmacology 68:4, pages 475-484.
Crossref
Jeffrey W. Short & Kathrine R. Springman. 2016. Standard Handbook Oil Spill Environmental Forensics. Standard Handbook Oil Spill Environmental Forensics 1039 1069 .
Ibrahim K. Ragab & Hala Z.E. Mohamed. (2015) The effect of chloroacetonitrile on the liver and kidney of adult male rats. The Egyptian Journal of Histology 38:4, pages 766-777.
Crossref
Sheng-Yao Hsu, Je-Wen Liou, Tsung-Lin Cheng, Shih-Yi Peng, Chi-Chen Lin, Yuan-Yuan Chu, Wei-Cheng Luo, Zheng-Kai Huang & Shinn-Jong Jiang. (2015) beta-Naphthoflavone protects from peritonitis by reducing TNF-alpha-induced endothelial cell activation. Pharmacological Research 102, pages 192-199.
Crossref
T. Eric Ballard, Upendra P. Dahal, Andrew J. Bessire, Richard P. Schneider, Kieran F. Geoghegan & Alfin D. N. Vaz. (2015) A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry. Rapid Communications in Mass Spectrometry 29:22, pages 2175-2183.
Crossref
Volker M. Arlt, Colin J. Henderson, C. Roland Wolf, Marie Stiborová & David H. Phillips. (2015) The Hepatic Reductase Null (HRN ™ ) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants . Toxicology Research 4:3, pages 548-562.
Crossref
Nanci C. de Lucas, Guilherme L.C. Santos, Caio S. Gaspar, Simon J. Garden & José Carlos Netto-Ferreira. (2014) Laser flash photolysis study of the reactivity of β-naphthoflavone triplet: Hydrogen abstraction and singlet oxygen generation. Journal of Photochemistry and Photobiology A: Chemistry 294, pages 121-129.
Crossref
Philip C. BurchamPhilip C. Burcham. 2014. An Introduction to Toxicology. An Introduction to Toxicology 91 125 .
Jack A. Hinson. 2013. Drug-Induced Liver Disease. Drug-Induced Liver Disease 305 329 .
F. Peter Guengerich. 2013. Drug-Induced Liver Disease. Drug-Induced Liver Disease 15 33 .
Yasuhiro Shinkai, Noriko Iwamoto, Takashi Miura, Takeshi Ishii, Arthur K. Cho & Yoshito Kumagai. (2012) Redox Cycling of 1,2-Naphthoquinone by Thioredoxin1 through Cys32 and Cys35 Causes Inhibition of Its Catalytic Activity and Activation of ASK1/p38 Signaling. Chemical Research in Toxicology 25:6, pages 1222-1230.
Crossref
Alexander V. LyubimovHayley M. Webb, Sophie Regan, Daniel J. Antoine, Nicola Lane, Rachel J. Walsh, Abhishek Srivastava, Philip Starkey‐Lewis, Craig Benson, Dominic P. Williams, Hugh Laverty, Christopher Goldring & B. Kevin Park. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 44 .
Miia J. Rainio, Mirella Kanerva, Niklas Wahlberg, Mikko Nikinmaa & Tapio Eeva. (2012) Variation of Basal EROD Activities in Ten Passerine Bird Species – Relationships with Diet and Migration Status. PLoS ONE 7:3, pages e33926.
Crossref
J. T. Samuelsen, J. A. Holme, M. Låg, P. E. Schwarze, J. E. Dahl & R. Becher. (2011) Biotransformation enzymes and lung cell response to 2‐hydroxyethyl‐methacrylate. Journal of Biomedical Materials Research Part A 100A:2, pages 462-469.
Crossref
Alexander V. LyubimovDeepak K. Dalvie. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 54 .
Andrea Sapone, Donatella Canistro, Simone Melega, Ramona Moles, Fabio Vivarelli & Moreno Paolini. (2012) On Enzyme-Based Anticancer Molecular Dietary Manipulations. Journal of Biomedicine and Biotechnology 2012, pages 1-7.
Crossref
Björn Meermann, Marc Bockx, Aline Laenen, Cis Van Looveren, Filip Cuyckens & Frank Vanhaecke. (2011) Speciation analysis of bromine-containing drug metabolites in feces samples from a human in vivo study by means of HPLC/ICP-MS combined with on-line isotope dilution. Analytical and Bioanalytical Chemistry 402:1, pages 439-448.
Crossref
Wolfgang Dekant & Spiridon Vamvakas. 2000. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry.
Miguel González-Doncel, Laura San Segundo, Salvador Sastre, José Vicente Tarazona & Carlos Fernández Torija. (2011) Dynamics of BNF-induced in vivo ethoxyresorufin-O-deethylase (EROD) activity during embryonic development of medaka (Oryzias latipes). Aquatic Toxicology 105:3-4, pages 421-427.
Crossref
Keisuke Shimamoto, Yasuaki Dewa, Sayaka Kemmochi, Eriko Taniai, Hitomi Hayashi, Masako Imaoka, Makoto Shibutani & Kunitoshi Mitsumori. (2011) Relationship between CYP1A induction by indole-3-carbinol or flutamide and liver tumor-promoting potential in rats. Archives of Toxicology 85:9, pages 1159-1166.
Crossref
Mohammad Monir Tawfeeq, Terumasa Suzuki, Keisuke Shimamoto, Hitomi Hayashi, Makoto Shibutani & Kunitoshi Mitsumori. (2010) Evaluation of in vivo genotoxic potential of fenofibrate in rats subjected to two-week repeated oral administration. Archives of Toxicology 85:8, pages 1003-1011.
Crossref
Nislanha Ana dos Anjos, Tobias Schulze, Werner Brack, Adalberto Luis Val, Kristin Schirmer & Stefan Scholz. (2011) Identification and evaluation of cyp1a transcript expression in fish as molecular biomarker for petroleum contamination in tropical fresh water ecosystems. Aquatic Toxicology 103:1-2, pages 46-52.
Crossref
Kazunori Kuwata, Makoto Shibutani, Hitomi Hayashi, Keisuke Shimamoto, Shim-Mo Hayashi, Kazuhiko Suzuki & Kunitoshi Mitsumori. (2011) Concomitant apoptosis and regeneration of liver cells as a mechanism of liver-tumor promotion by β-naphthoflavone involving TNFα-signaling due to oxidative cellular stress in rats. Toxicology 283:1, pages 8-17.
Crossref
J.-P. Lepoittevin. (2011) Les bases chimiques de l’allergie de contact. Revue Française d'Allergologie 51:3, pages 208-211.
Crossref
X Cahours, M Blanchet, M Dubois & C Haond. (2011) Development of a Rapid Cell-free Method for Cytotoxicity Assessment of Vapor Phase of Cigarette Smoke. Beiträge zur Tabakforschung International/Contributions to Tobacco Research 24:4, pages 157-165.
Crossref
Emile P. Chen, Liangfu Chen, Yan Ji, Guoying Tai, Yuan H. Wen & Harma Ellens. (2010) A Mechanism-Based Mathematical Model of Aryl Hydrocarbon Receptor-Mediated CYP1A Induction in Rats Using β-Naphthoflavone as a Tool Compound. Drug Metabolism and Disposition 38:12, pages 2278-2285.
Crossref
Eugene G. Hrycay & Stelvio M. Bandiera. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 70 .
Yuko Shimada, Yasuaki Dewa, Ryohei Ichimura, Terumasa Suzuki, Sayaka Mizukami, Shim-mo Hayashi, Makoto Shibutani & Kunitoshi Mitsumori. (2010) Antioxidant enzymatically modified isoquercitrin suppresses the development of liver preneoplastic lesions in rats induced by β-naphthoflavone. Toxicology 268:3, pages 213-218.
Crossref
Philip C. Burcham, Colin A. Thompson & Peter J. Henry. 2010. 1 36 .
F.P. Guengerich. 2010. Comprehensive Toxicology. Comprehensive Toxicology 41 76 .
Mirco Weil, Stefan Scholz, Michaela Zimmer, Frank Sacher & Karen Duis. (2010) Gene expression analysis in zebrafish embryos: A potential approach to predict effect concentrations in the fish early life stage test. Environmental Toxicology and Chemistry 28:9, pages 1970-1978.
Crossref
Yasuaki Dewa, Jihei Nishimura, Meilan Jin, Masaomi Kawai, Yukie Saegusa, Tomoaki Harada, Makoto Shibutani & Kunitoshi Mitsumori. (2009) Molecular Expression Analysis of β-Naphthoflavone-induced Hepatocellular Tumors in Rats. Toxicologic Pathology 37:4, pages 446-455.
Crossref
Katsuhiko Mizuno, Miki Katoh, Hirotoshi Okumura, Nao Nakagawa, Toru Negishi, Takanori Hashizume, Miki Nakajima & Tsuyoshi Yokoi. (2009) Metabolic Activation of Benzodiazepines by CYP3A4. Drug Metabolism and Disposition 37:2, pages 345-351.
Crossref
Wolfgang Dekant. 2009. Molecular, Clinical and Environmental Toxicology. Molecular, Clinical and Environmental Toxicology 57 86 .
Yousif Asiri, Abdlatif Al-Dhawailie, Saleh Alqasoumi, Mohammed Al-Yahya & Syed Rafatullah. (2008) Pharmacovigilance in Herbal Medicine: A Paradigm to Drug Toxicity Monitoring in Conventional Health Care. Hungarian Medical Journal 2:3, pages 351-363.
Crossref
Jian-Dong Duan, Alan M. Jeffrey & Gary M. Williams. (2008) Assessment of the Medicines Lidocaine, Prilocaine, and Their Metabolites, 2,6-Dimethylaniline and 2-Methylaniline, for DNA Adduct Formation in Rat Tissues. Drug Metabolism and Disposition 36:8, pages 1470-1475.
Crossref
Frank Gerberick, Maja Aleksic, David Basketter, Silvia Casati, Ann-Therese Karlberg, Petra Kern, Ian Kimber, Jean Pierre Lepoittevin, Andreas Natsch, Jean Marc Ovigne, Costanza Rovida, Hitoshi Sakaguchi & Terry Schultz. (2008) Chemical Reactivity Measurement and the Predictive Identification of Skin Sensitisers. Alternatives to Laboratory Animals 36:2, pages 215-242.
Crossref
Yasuaki Dewa, Jihei Nishimura, Masako Muguruma, Meilan Jin, Yukie Saegusa, Toshiya Okamura, Masako Tasaki, Takashi Umemura & Kunitoshi Mitsumori. (2008) β-Naphthoflavone enhances oxidative stress responses and the induction of preneoplastic lesions in a diethylnitrosamine-initiated hepatocarcinogenesis model in partially hepatectomized rats. Toxicology 244:2-3, pages 179-189.
Crossref
F. Peter Guengerich. (2007) Cytochrome P450 and Chemical Toxicology. Chemical Research in Toxicology 21:1, pages 70-83.
Crossref
Doris Voelker, Nicole Stetefeld, Kristin Schirmer & Stefan Scholz. (2008) The role of cyp1a and heme oxygenase 1 gene expression for the toxicity of 3,4-dichloroaniline in zebrafish (Danio rerio) embryos. Aquatic Toxicology 86:1, pages 112-120.
Crossref
Karen G. Burnett, Lisa J. Bain, William S. Baldwin, Gloria V. Callard, Sarah Cohen, Richard T. Di Giulio, David H. Evans, Marta Gómez-Chiarri, Mark E. Hahn, Cindi A. Hoover, Sibel I. Karchner, Fumi Katoh, Deborah L. MacLatchy, William S. Marshall, Joel N. Meyer, Diane E. Nacci, Marjorie F. Oleksiak, Bernard B. Rees, Thomas D. Singer, John J. Stegeman, David W. Towle, Peter A. Van Veld, Wolfgang K. Vogelbein, Andrew Whitehead, Richard N. Winn & Douglas L. Crawford. (2007) Fundulus as the premier teleost model in environmental biology: Opportunities for new insights using genomics. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 2:4, pages 257-286.
Crossref
Alexandra Druckova, Raymond L. Mernaugh, Amy-Joan L. Ham & Lawrence J. Marnett. (2007) Identification of the Protein Targets of the Reactive Metabolite of Teucrin A in Vivo in the Rat. Chemical Research in Toxicology 20:10, pages 1393-1408.
Crossref
Dong-Hak Kim & Young-Jin Chun. (2007) Human Cytochrome P450 Metabolic Activation in Chemical Toxicity. Toxicological Research 23:3, pages 189-196.
Crossref
F Guengerich. 2007. Drug-Induced Liver Disease, Second Edition. Drug-Induced Liver Disease, Second Edition 13 31 .
Dominique Pessayre & Dominique Larrey. 2007. Textbook of Hepatology. Textbook of Hepatology 1209 1268 .
F. Peter Guengerich & James S. MacDonald. (2007) Applying Mechanisms of Chemical Toxicity to Predict Drug Safety. Chemical Research in Toxicology 20:3, pages 344-369.
Crossref
Sandra Marini, Annalisa Nannelli, Daria Sodini, Stefania Dragoni, Massimo Valoti, Vincenzo Longo & Pier Giovanni Gervasi. (2007) Expression, microsomal and mitochondrial activities of cytochrome P450 enzymes in brain regions from control and phenobarbital-treated rabbits. Life Sciences 80:10, pages 910-917.
Crossref
Jeffrey W. Short & Kathrine R. Springman. 2007. Oil Spill Environmental Forensics. Oil Spill Environmental Forensics 381 403 .
. 2007. Exploring the Vertebrate Central Cholinergic Nervous System. Exploring the Vertebrate Central Cholinergic Nervous System 237 310 .
Kengo Watanabe & F. Peter Guengerich. (2006) Limited Reactivity of Formyl Chloride with Glutathione and Relevance to Metabolism and Toxicity of Dichloromethane. Chemical Research in Toxicology 19:8, pages 1091-1096.
Crossref
Mary Beth Genter, Corey D. Clay, Timothy P. Dalton, Hongbin Dong, Daniel W. Nebert & Howard G. Shertzer. (2006) Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment. Biochemical and Biophysical Research Communications 342:4, pages 1375-1381.
Crossref
Xiao-Xia Yang, Ze-Ping Hu, Sui Yung Chan & Shu-Feng Zhou. (2006) Monitoring drug–protein interaction. Clinica Chimica Acta 365:1-2, pages 9-29.
Crossref
Patrick M. Dansette, Gildas Bertho & Daniel Mansuy. (2005) First evidence that cytochrome P450 may catalyze both S-oxidation and epoxidation of thiophene derivatives. Biochemical and Biophysical Research Communications 338:1, pages 450-455.
Crossref
John F. Reichard, Timothy P. Dalton, Howard G. Shertzer & Alvaro Puga. (2005) Induction of Oxidative Stress Responses by Dioxin and other Ligands of the Aryl Hydrocarbon Receptor. Dose-Response 3:3, pages dose-response.0.
Crossref
F. Peter Guengerich. (2005) Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophiles by conjugation. Archives of Biochemistry and Biophysics 433:2, pages 369-378.
Crossref
F. Peter Guengerich. 2005. Cytochrome P450. Cytochrome P450 377 530 .
Wolfgang Dekant & Spiridon Vamvakas. 2000. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry.
ValÉRie Berl & Jean-Pierre Lepoittevin. 2004. Dermatotoxicology, Sixth Edition. Dermatotoxicology, Sixth Edition 265 283 .
Ashraf B. Abdel-Naim & Ahmed M. Mohamadin. (2004) Myeloperoxidase-catalyzed oxidation of chloroacetonitrile to cyanide. Toxicology Letters 146:3, pages 249-257.
Crossref
Sherifa A. Hamed & Moustafa M. Abdellah. (2004) Trace Elements and Electrolytes Homeostasis and Their Relation to Antioxidant Enzyme Activity in Brain Hyperexcitability of Epileptic Patients. Journal of Pharmacological Sciences 96:4, pages 349-359.
Crossref
Shufeng Zhou, Hwee-Ling Koh, Yihuai Gao, Zhi-yuan Gong & Edmund Jon Deoon Lee. (2004) Herbal bioactivation: The good, the bad and the ugly. Life Sciences 74:8, pages 935-968.
Crossref
Shufeng Zhou. (2003) Separation and detection methods for covalent drug–protein adducts. Journal of Chromatography B 797:1-2, pages 63-90.
Crossref
Pallavi B Limaye, Udayan M Apte, Kartik Shankar, Thomas J Bucci, Alan Warbritton & Harihara M Mehendale. (2003) Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants. Toxicology and Applied Pharmacology 191:3, pages 211-226.
Crossref
Moreno Paolini & Marion Nestle. (2003) Pitfalls of enzyme-based molecular anticancer dietary manipulations: food for thought. Mutation Research/Reviews in Mutation Research 543:3, pages 181-189.
Crossref
Ayman A. Farghaly. (2003) Mutagenic Evaluation of Paracetamol in Somatic and Germ Cells of Mice. CYTOLOGIA 68:2, pages 133-139.
Crossref
F Peter Guengerich. (2003) Cytochrome P450 oxidations in the generation of reactive electrophiles: epoxidation and related reactions. Archives of Biochemistry and Biophysics 409:1, pages 59-71.
Crossref
Albert P Senft, Timothy P Dalton, Daniel W Nebert, Mary Beth Genter, Alvaro Puga, Richard J Hutchinson, J.Kevin Kerzee, Shigeyuki Uno & Howard G Shertzer. (2002) Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor. Free Radical Biology and Medicine 33:9, pages 1268-1278.
Crossref
Timothy P Dalton, Alvaro Puga & Howard G Shertzer. (2002) Induction of cellular oxidative stress by aryl hydrocarbon receptor activation. Chemico-Biological Interactions 141:1-2, pages 77-95.
Crossref
Richard C Kolanczyk & Patricia K Schmieder. (2002) Rate and capacity of hepatic microsomal ring-hydroxylation of phenol to hydroquinone and catechol in rainbow trout (Oncorhynchus mykiss). Toxicology 176:1-2, pages 77-90.
Crossref
K.H Lu, K.L Lin, C.C Yang, T.C Hsia, Y.M Hsiao, M.C Chou, H.C Ho & J.G Chung. (2002) The effect of paclitaxel on gene expression and activity of arylamine N-acetyltransferase and DNA-2-aminofluorene adduct formation in human leukemia HL-60 cells. Food and Chemical Toxicology 40:5, pages 705-713.
Crossref
H V Pai, S C Upadhya, S J Chinta, S N Hegde & V Ravindranath. (2002) Differential metabolism of alprazolam by liver and brain cytochrome (P4503A) to pharmacologically active metabolite. The Pharmacogenomics Journal 2:4, pages 243-258.
Crossref
Daniel C Liebler. (2002) Proteomic approaches to characterize protein modifications: new tools to study the effects of environmental exposures.. Environmental Health Perspectives 110:suppl 1, pages 3-9.
Crossref
Mitsuo Miyazawa, Masaki Shindo & Tsutomu Shimada. (2001) Sex Differences in the Metabolism of (+)- and (−)-Limonene Enantiomers to Carveol and Perillyl Alcohol Derivatives by Cytochrome P450 Enzymes in Rat Liver Microsomes. Chemical Research in Toxicology 15:1, pages 15-20.
Crossref
Milan Jokanović. (2001) Biotransformation of organophosphorus compounds. Toxicology 166:3, pages 139-160.
Crossref
F.Peter Guengerich. (2001) Forging the links between metabolism and carcinogenesis. Mutation Research/Reviews in Mutation Research 488:3, pages 195-209.
Crossref
Yogeshwer Shukla, Annu Arora & Alka Singh. (2001) Tumourigenic studies on deltamethrin in Swiss albino mice. Toxicology 163:1, pages 1-9.
Crossref
Sonja Sieben, Michael Hertl, Tames Al Masaoudi, Hans F. Merk & Brunhilde Blömeke. (2001) Characterization of T Cell Responses to Fragrances. Toxicology and Applied Pharmacology 172:3, pages 172-178.
Crossref
Dieter Schwarz, Pyotr Kisselev, Wolf-Hagen Schunck, Alexey Chernogolov, Werner Boidol, Ingolf Cascorbi & Ivar Roots. (2000) Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity. Pharmacogenetics 10:6, pages 519-530.
Crossref
M Paolini, J Barillari, M Broccoli, L Pozzetti, P Perocco & G Cantelli-Forti. (1999) Effect of liquorice and glycyrrhizin on rat liver carcinogen metabolizing enzymes. Cancer Letters 145:1-2, pages 35-42.
Crossref
A.M. MOSTAFA, A.B. ABDEL-NAIM, O. ABO-SALEM, A.H. ABDEL-AZIZ & F.M.A. HAMADA. (1999) RENAL METABOLISM OF ACRYLONITRILE TO CYANIDE: IN VITRO STUDIES. Pharmacological Research 40:2, pages 195-200.
Crossref
Arungundrum S Prakash, Tamara N Pereira, Paul E.B Reilly & Alan A Seawright. (1999) Pyrrolizidine alkaloids in human diet. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 443:1-2, pages 53-67.
Crossref
Moreno Paolini, Gian Luigi Biagi & Giorgio Cantelli-Forti. (1999) The many consequences of chemical- and genetic-based modulation of drug metabolizing enzyme activities. Life Sciences 65:8, pages PL75-PL79.
Crossref
G. J. Dear, R. S. Plumb, B. C. Sweatman, I. M. Ismail & J. Ayrton. (1999) Tandem mass spectrometry linked fraction collection for the isolation of drug metabolites from biological matrices. Rapid Communications in Mass Spectrometry 13:10, pages 886-894.
Crossref
Timothy P. DaltonHoward G. ShertzerAlvaro Puga. (1999) REGULATION OF GENE EXPRESSION BY REACTIVE OXYGEN. Annual Review of Pharmacology and Toxicology 39:1, pages 67-101.
Crossref
Moreno Paolini. (1998) Brussels Sprouts: An Exceptionally Rich Source of Ambiguity for Anticancer Strategies. Toxicology and Applied Pharmacology 152:2, pages 293-294.
Crossref
Giorgio Cantelli-Forti, Patrizia Hrelia & Moreno Paolini. (1998) The pitfall of detoxifying enzymes. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 402:1-2, pages 179-183.
Crossref
P.D. Dwivedi, Mukul Das & S.K. Khanna. (1998) Role of Cytochrome P-450 in Quinalphos Toxicity: Effect on Hepatic and Brain Antioxidant Enzymes in RatsITRC Communication No. 1965.. Food and Chemical Toxicology 36:5, pages 437-444.
Crossref
Moreno Paolini, Laura Pozzetti, Paola Silingardi, Clara Della Croce, Giorgio Bronzetti & Giorgio Cantelli-Forti. (1998) Isolation of a novel metabolizing system enriched in phase-II enzymes for short-term genotoxicity bioassays. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 413:3, pages 205-217.
Crossref
Paolini, Mesirca, Pozzetti, Gialluca, Bauer, Biagi & Cantelli-Forti. (1998) Cancer Chemoprevention: Some Complications and Limitations. Cancer Detection <html_ent glyph="@amp;" ascii="&"/> Prevention 22:1, pages 68-74.
Crossref
Gennady Ilyin, Anne Corlu, Pascal Loyer & Christiane Guguen-Guillouzo. 1998. Animal Cell Culture Techniques. Animal Cell Culture Techniques 371 392 .
Hans F. Merk. 1998. Allergic Contact Dermatitis. Allergic Contact Dermatitis 68 80 .
L. Chastine Bell & F. Peter Guengerich. (1997) Oxidation Kinetics of Ethanol by Human Cytochrome P450 2E1. Journal of Biological Chemistry 272:47, pages 29643-29651.
Crossref
Moreno Paolini & Pasquale Chieco. (1997) Polymorphism in gene for microsomal epoxide hydrolase and lung disease. The Lancet 350:9090, pages 1554.
Crossref
M Paolini, G.L Biagi & G Cantelli-Forti. (1997) Cancer chemoprevention from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazol[4,5-b]pyridine: reconsideration of the evidence. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 381:2, pages 279-282.
Crossref
E.B. Brittebo & I. Brandt. (1997) Cell- and tissue-specific metabolic activation of chemicals as determined by autoradiography: in vitro—in vivo correlations. Toxicology in Vitro 11:5, pages 417-426.
Crossref
Moreno Paolini & Giorgio Cantelli-Forti. (1997) On the metabolizing systems for short-term genotoxicity assays: a review. Mutation Research/Reviews in Mutation Research 387:1, pages 17-34.
Crossref
M. Das, S. Ramchandani, R.K. Upreti & S.K. Khanna. (1997) Metanil yellow: a bifunctional inducer of hepatic phase I and phase II xenobiotic-metabolizing enzymes. Food and Chemical Toxicology 35:8, pages 835-838.
Crossref
Han Chu Lee, Yong Bum Yoon & Chung Yong Kim. (1997) Association Between Genetic Polymorphisms of the Cytochromes P-450 1A1, 2D6, and 2E1 and the Susceptibility to Pancreatic Cancer. The Korean Journal of Internal Medicine 12:2, pages 128-136.
Crossref
Ivonne M. C. M. Rietjens, Cathaline den Besten, Robert P. Hanzlik & Peter J. van Bladeren. (1997) Cytochrome P450-Catalyzed Oxidation of Halobenzene Derivatives. Chemical Research in Toxicology 10:6, pages 629-635.
Crossref
A.H. ABDEL-AZIZ, A.B. ABDEL-NAIM, F.M. HAMADA & A.E. AHMED. (1997) IN-VITROTESTICULAR BIOACTIVATION OF ACRYLONITRILE. Pharmacological Research 35:2, pages 129-134.
Crossref
Jørn A. Holme, Richard Wiger, Jan K. Hongslo, Erik J. Søderlund, Gunnar Brunborg & Erik Dybing. 1997. Mechanisms of Cell Toxicity. Mechanisms of Cell Toxicity 145 182 .
Odile de Silva, David A. Basketter, Martin D. Barratt, Emanuela Corsini, Mark T.D. Cronin, Pranab K. Das, Joachim Degwert, Alexander Enk, Jean Luc Garrigue, Conrad Hauser, Ian Kimber, Jean-Pierre Lepoittevin, Josette Peguet & Maria Ponec. (2020) Alternative Methods for Skin Sensitisation Testing. Alternatives to Laboratory Animals 24:5, pages 683-705.
Crossref
Moreno PaoliniLaura Pozzetti, Renata Mesirca, Andrea Sapone, Paola Silingardi, Sandro Grilli, Clara Dalla Croce, Giorgio Bronzetti & Giorgio Cantelli-Forti. (2020) Role of Phase II Enzymes in the Bioactivation of 1,4-Dichlorobenzene and 1,4-Dibromobenzene. Alternatives to Laboratory Animals 24:4, pages 603-608.
Crossref
N.G.M. Palmen & C.T.A. Evelo. (1996) Glutathione depletion in human erythrocytes and rat liver: a study on the interplay between bioactivation and inactivation functions of liver and blood. Toxicology in Vitro 10:3, pages 273-281.
Crossref
Andreas Baumann, Rasoul S. Kerdar, Peter Cramer, Werner Feser, Hartmut Blode, Andreas Salomon & Wilhelm Kuhnz. (2009) Use of Rat and Human Liver Slices for the Detection of Steroid Hormone‐Induced DNA‐Adducts in vitro by Means of the 32 P‐Postlabeling Technique . Pharmacology & Toxicology 78:4, pages 214-223.
Crossref
K. Bergman, L. Müller & S.Weberg Teigen. (1996) The genotoxicity and carcinogenicity of paracetamol: a regulatory (re) view. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 349:2, pages 263-288.
Crossref
C Nebbia, M Dacasto, L Ceppa & P Roncada. (1996) Changes in the activities of hepatic xenobiotic metabolising enzymes after the administration of clenbuterol to female broilers. Research in Veterinary Science 60:1, pages 33-36.
Crossref
J. S. Leeder & A. B. Okey. 1996. Drug-Induced Hepatotoxicity. Drug-Induced Hepatotoxicity 119 153 .
M. Pirmohamed & B. K. Park. 1996. Drug-Induced Hepatotoxicity. Drug-Induced Hepatotoxicity 411 440 .
M. Cornet, A. Callaerts, A. Vercruysse & V. Rogiers. (1995) In vitro biotransformation of 2-methylpropene (isobutene) in rat lung tissue in comparison with liver tissue. Archives of Toxicology 70:1, pages 64-67.
Crossref
S.V. Bhagwat, B.C. Leelavathi, S.K. Shankar, M.R. Boyd & V. Ravindranath. (1995) Cytochrome P450 and assocaited monooxygenase activities in the rat and human spinal cord: Induction, immunological characterization and immunocytochemical localization. Neuroscience 68:2, pages 593-601.
Crossref
Emanuela Taioli, Frances Crofts, Julie Trachman, Sine Bayo, Paolo Toniolo & Seymour J. Garte. (1995) Racial differences in CYP1A1 genotype and function. Toxicology Letters 77:1-3, pages 357-362.
Crossref
Anjali Singh & A.R. Rao. (1995) Modulatory influence of arecanut on antioxidant 2(3)-tert-butyl-4-hydroxy anisole-induced hepatic detoxification system and antioxidant defence mechanism in mice. Cancer Letters 91:1, pages 107-114.
Crossref
VJ Green, M Pirmohamed, NR Kitteringham, MJ Knapp & BK Park. (2012) Glutathione S‐transferase mu genotype (GSTM1*0) in Alzheimer's patients with tacrine transaminitis.. British Journal of Clinical Pharmacology 39:4, pages 411-415.
Crossref
U. Rannug, J.A. Holme, J.K. Hongslo & R. Srám. (1995) An evaluation of the genetic toxicity of paracetamol. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 327:1-2, pages 179-200.
Crossref
David Basketter, An Dooms‐Goossens, Ann‐Therese Karlberg & Jean‐Pierre Lepoittevin. (2006) The chemistry of contact allergy: why is a molecule allergenic?. Contact Dermatitis 32:2, pages 65-73.
Crossref
Anjali Singh & A. R. Rao. (2005) Evaluation of the modifying influence of arecanut on the garlic‐modulated hepatic detoxication system enzymes, sulfhydryl content, and lipid peroxidation in mice. Teratogenesis, Carcinogenesis, and Mutagenesis 15:3, pages 127-134.
Crossref
S. Ramchandani, M. Das & S.K. Khanna. (1994) Effect of metanil yellow, orange II and their blend on hepatic xenobiotic metabolizing enzymes in rats. Food and Chemical Toxicology 32:6, pages 559-563.
Crossref
Jeffrey I. Penny & F.Charles Campbell. (1994) Active transport of benzo[a]pyrene in apical membrane vesicles from normal human intestinal epithelium. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1226:2, pages 232-236.
Crossref
Mikhail Manjgaladze, Shu Chen, Lynn T. Frame, John E. Seng, Peter H. Duffy, Ritchie J. Feuers, Ronald W. Hart & Julian E.A. Leakey. (1993) Effects of caloric restriction on rodent drug and carcinogen metabolizing enzymes: implications for mutagenesis and cancer. Mutation Research/DNAging 295:4-6, pages 201-222.
Crossref
J. P. Uetrecht & S. P. Spielberg. (1993) Mechanisms of neutropenia: The role of Neutrophil-specific pathways of drug metabolism. Pharmacoepidemiology & Drug Safety 2:S7, pages S37-S42.
Crossref
Nicole G.M. Palmen & Chris T.A. Evelo. (1993) Glutathione depletion in human erythrocytes as an indicator for microsomal activation of cyclophosphamide and 3-hydroxyacetanilide. Toxicology 84:1-3, pages 157-170.
Crossref
Malcolm D. Tingle, Munir Pirmohamed, Elizabeth Templeton, Andrew S. Wilson, Stephen Madden, Neil R. Kitteringham & B.Kevin Park. (1993) An investigation of the formation of cytotoxic, genotoxic, protein-reactive and stable metabolites from naphthalene by human liver microsomes. Biochemical Pharmacology 46:9, pages 1529-1538.
Crossref
Robyn Fisher, Klaus Brendel & Robert P. Hanzlik. (1993) Correlation of metabolism, covalent binding and toxicity for a series of bromobenzene derivatives using rat liver slices in vitro. Chemico-Biological Interactions 88:2-3, pages 191-208.
Crossref
Anjali Singh & A.R. Rao. (1993) Effect of arecanut on the black mustard (Brassica niger, L.)-modulated detoxication enzymes and sulfhydryl content in the liver of mice. Cancer Letters 72:1-2, pages 45-51.
Crossref
A. Singh & A.R. Rao. (1993) Modulatory effect of areca nut on the action of mace (myristica fragrans, houtt) on the hepatic detoxification system in mice. Food and Chemical Toxicology 31:7, pages 517-521.
Crossref
Henrik E. Poulsen, Steffen Loft & Karsten Wassermann. (1993) Cancer Risk Related to Genetic Polymorphisms in Carcinogen Metabolism and DNA Repair. Pharmacology & Toxicology 72, pages 93-103.
Crossref
RYAN J. HUXTABLE. 1993. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells 213 237 .
RONALD B. FRANKLIN, CHARLES G. PLOPPER & ALAN R. BUCKPITT. 1993. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells 123 144 .
F. PETER GUENGERICH. 1993. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells 77 87 .
JEFFREY BARON & JEFFREY M. VOIGT. 1993. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells 41 75 .
F P GuengerichT ShimadaK D RaneyC H YunD J MeyerB KettererT M HarrisJ D GroopmanF F Kadlubar. (1992) Elucidation of catalytic specificities of human cytochrome P450 and glutathione S-transferase enzymes and relevance to molecular epidemiology.. Environmental Health Perspectives 98, pages 75-80.
Crossref
P.M. Dansette, Do Cao Thang & H. El Amri D. Mansuy. (1992) Evidence for thiophene-s-oxide as a primary reactive metabolite of thiophene in vivo: Formation of a dihydrothiophene sulfoxide mercapturic acid. Biochemical and Biophysical Research Communications 186:3, pages 1624-1630.
Crossref
David K. La & John R. Froines. (1992) 32P-postlabelling analysis of DNA adducts from Fischer-344 rats administered 2,4-diaminotoluene. Chemico-Biological Interactions 83:2, pages 121-134.
Crossref
R. J. Laib, M. Tucholski, J. G. Filser & G. A. Csanády. (1992) Pharmacokinetic interaction between 1,3-butadiene and styrene in Sprague-Dawley rats. Archives of Toxicology 66:5, pages 310-314.
Crossref
A.K. Giri, S. Sai Sivam & K.A. Khan. (1992) Sister-chromatid exchange and chromosome aberrations induced by paracetamol in vivo in bone-marrow cells of mice. Mutation Research/Genetic Toxicology 278:4, pages 253-258.
Crossref
Peter J. Harvison, Robert J. Griffin, Vonda J. Teets, Derek W. Nicoll, Patrick I. Brown & Gary O. Rankin. (1992) Nephrotoxic potential of N-(3,5-dichloro-4-hydroxyphenyl)succinimide and N-(3,5-dichloro-4-hydroxyphenyl)succinamic acid in Fischer-344 rats. Toxicology Letters 60:2, pages 221-226.
Crossref
Sylviane Lemaire-Gony & Philippe Lemaire. (1992) Interactive effects of cadmium and benzo(a)pyrene on cellular structure and biotransformation enzymes of the liver of the European eel Anguilla anguilla. Aquatic Toxicology 22:2, pages 145-159.
Crossref
Michael D. Corbett, Bernadette R. Corbett, Marie-Hélène Hannothiaux & Sergio J. Quintana. (1992) The covalent binding of acetaminophen to cellular nucleic acids as the result of the respiratory burst of neutrophils derived from the HL-60 cell line. Toxicology and Applied Pharmacology 113:1, pages 80-86.
Crossref
Philippe Lemaire, Jocelyne Berhaut, Sylviane Lemaire-Gony & Marc Lafaurie. (1992) Ultrastructural changes induced by benzo[a]pyrene in sea bass (Dicentrarchus labrax) liver and intestine: Importance of the intoxication route. Environmental Research 57:1, pages 59-72.
Crossref
Wolfgang Dekant & Spyridon Vamvakas. 1992. 297 337 .
Tsutomu Nakatsugawa. 1992. Organophosphates Chemistry, Fate, and Effects. Organophosphates Chemistry, Fate, and Effects 201 227 .
F. Peter Guengerich. (1992) Metabolic activation of carcinogens. Pharmacology & Therapeutics 54:1, pages 17-61.
Crossref
M. Pirmohamed, N.R. Kitteringham & B.K. Park. (1992) Idiosyncratic reactions to antidepressants: A review of the possible mechanisms and predisposing factors. Pharmacology & Therapeutics 53:1, pages 105-125.
Crossref
J.-P. Lepoittevin & C. Benezra. (1991) Chimie de l'allergie de contact. Revue Française d'Allergologie et d'Immunologie Clinique 31:4, pages 235-241.
Crossref
Moreno Paolini, Gian Luigi Biagi, Carlo Bauer & Giorgio Cantelli-Forti. (1991) Is clonal adaptation a product of evolution over the millennia?. Biochemical Pharmacology 42:3, pages 457-458.
Crossref
Matthias Schweizer, Martina A. Peter, Djordje Filipovic, Rahel Tinner, Hans Rudolf Bosshard & Maja Oertle. (1991) Mechanism of monoclonal antibody inhibition/ stimulation of reactions catalyzed by cytochrome P450IIB1. Archives of Biochemistry and Biophysics 288:1, pages 64-70.
Crossref
Urs A. Boelsterli & Christian Göldlin. (1991) Biomechanisms of cocaine-induced hepatocyte injury mediated by the formation of reactive metabolites. Archives of Toxicology 65:5, pages 351-360.
Crossref
Chandikumar S. Elangbam, Charles W. QuailsJr.Jr. & Robert L. Lochmiller. (1991) O-dealkylation of resorufin ethers as an indicator of hepatic cytochrome P-450 isoenzyme induction in the cotton rat (Sigmodon hispidus): A method for monitoring environmental contamination. Bulletin of Environmental Contamination and Toxicology 47:1, pages 23-28.
Crossref
Damrong Ratanasavanh, Philippe Beaune, Fabrice Morel, Jean-Pierre Flinois, F. Peter Guengerich & Andre Guillouzo. (1991) Intralobular distribution and quantitation of cytochrome P-450 enzymes in human liver as a function of age. Hepatology 13:6, pages 1142-1151.
Crossref
Silvia B.M. Barros, Kiyoko Simizu & Virginia B.C. Junqueira. (1991) Liver lipid peroxidation-related parameters after short-term administration of hexachlorocyclohexane isomers to rats. Toxicology Letters 56:1-2, pages 137-144.
Crossref
Eva B. Brittebo, Catarina Eriksson & Ingvar Brandt. (1991) Metabolic activation of halogenated hydrocarbons in the conjunctival epithelium and excretory ducts of the intraorbital lacrimal gland in mice. Experimental Eye Research 52:3, pages 245-252.
Crossref
Jens Huober, Barbara Bertram, Edgar Petru, Manfred Kaufmann & Dietrich Schmähl. (1991) Metabolism of debrisoquine and susceptibility to breast cancer. Breast Cancer Research and Treatment 18:1, pages 43-48.
Crossref
Judes Poirier, Sandra Kogan & Serge Gauthier. (2015) Environment, Genetics and Idiopathic Parkinson's Disease. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 18:1, pages 70-76.
Crossref
C M Giachelli, M W Majesky & S M Schwartz. (1991) Developmentally regulated cytochrome P-450IA1 expression in cultured rat vascular smooth muscle cells. Journal of Biological Chemistry 266:6, pages 3981-3986.
Crossref
G. A. Csanády, D. Freise, B. Denk, J. G. Filser, M. Cornet, V. Rogiers & R. J. Laib. (1991) Investigation of species differences in isobutene (2-methylpropene) metabolism between mice and rats. Archives of Toxicology 65:2, pages 100-105.
Crossref
Robert Massé, Honggang Bi, Christiane Ayotte, Ping Du, Huguette Gélinas & Robert Dugal. (1991) Studies on anabolic steroids. Journal of Chromatography B: Biomedical Sciences and Applications 562:1-2, pages 323-340.
Crossref
Michael Koob & Wolfgang Dekant. (1991) Bioactivation of xenobiotics by formation of toxic glutathione conjugates. Chemico-Biological Interactions 77:2, pages 107-136.
Crossref
H. F. Merk, D. Niederau, M. Hertl & F. Jugert. 1991. New Trends in Allergy III. New Trends in Allergy III 269 280 .
Spyridon Vamvakas & M. W. Anders. 1991. Biological Reactive Intermediates IV. Biological Reactive Intermediates IV 13 24 .

Displaying 200 of 269 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.