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Research Article

The Ah Locus: Genetic Differences in Toxicity, Cancer, Mutation, and Birth Defects

Pages 153-174 | Published online: 25 Sep 2008

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Ronald N. Hines, Sevasti B. Koukouritaki, Mark T. Poch & Michael C. Stephens. (2008) Regulatory Polymorphisms and their Contribution to Interindividual Differences in the Expression of Enzymes Influencing Drug and Toxicant Disposition. Drug Metabolism Reviews 40:2, pages 263-301.
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Yingmei Zhang, Carlo Gandini, Andrew Sabuneti, Mauro Fasola, Simonetta Lambiase & Aldo Grigolo. (2007) Differential retention of PCB congeners in cockroaches Blattella germanica . Journal of Environmental Science and Health, Part A 42:6, pages 721-727.
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KevinT. Connor & LesaL. Aylward. (2006) Human Response to Dioxin: Aryl Hydrocarbon Receptor (AhR) Molecular Structure, Function, and Dose-Response Data for Enzyme Induction Indicate an Impaired Human AhR. Journal of Toxicology and Environmental Health, Part B 9:2, pages 147-171.
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H. Chang, Ying-Jan Wang, LouisW. Chang & Pinpin Lin. (2005) A Histochemical and Pathological Study on the Interrelationship Between TCDD-induced AhR Expression, AhR Activation, and Hepatotoxicity in Mice. Journal of Toxicology and Environmental Health, Part A 68:17-18, pages 1567-1579.
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Kenneth S. Ramos & Bhagavatula Moorthy. (2005) Bioactivation of Polycyclic Aromatic Hydrocarbon Carcinogens within the vascular Wall: Implications for Human Atherogenesis. Drug Metabolism Reviews 37:4, pages 595-610.
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Sang-Kwang Lee, Yongmo Kim, Mie Young Kim, Young-Jin Chun & Sanghee Kim. (2004) POTENT INHIBITION OF RECOMBINANT HUMAN CYTOCHROME P-450 1A1 BY PENTAMETHOXYSTILBENE. Journal of Toxicology and Environmental Health, Part A 67:23-24, pages 1987-2000.
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J.-M. Pascussi, S. Gerbal-Chaloin, L. Drocourt, E. Assénat, D. Larrey, L. Pichard-Garcia, M.-J. Vilarem & P. Maurel. (2004) Cross-talk between xenobiotic detoxication and other signalling pathways: clinical and toxicological consequences. Xenobiotica 34:7, pages 633-664.
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F. Peter Guengerich. (2004) Cytochrome P450: What Have We Learned and What Are the Future Issues?. Drug Metabolism Reviews 36:2, pages 159-197.
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Sofia Pavanello. (2003) Metabolic and DNA Repair Variations in Susceptibility to Genotoxins. Polycyclic Aromatic Compounds 23:1, pages 49-107.
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M. Saint-denis, A. Pfohl-leszkowicz, J.F. Narbonne & D. Ribera. (2000) Dose-response and Kinetics of the Formation of DNA Adducts in the Earthworm Eisenia Fetida Andrei Exposed to B(A)P-contaminated Artificial Soil. Polycyclic Aromatic Compounds 18:2, pages 117-127.
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Satnam Singh, K. L. Khanduja & P. K. Mittal. (1998) Influence of 50-Hz Sinusoidal Electromagnetic Field on Hepatic and Pulmonary Phase I and II Drug-Metabolizing Enzymes in Mice. Electro- and Magnetobiology 17:3, pages 343-350.
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Mont R. Juchau, Hélène Boutelet-Bochan & Ying Huang. (1998) Cytochrome-P450-Dependent Biotransformation of Xenobiotics in Human and Rodent Embryonic Tissues. Drug Metabolism Reviews 30:3, pages 541-568.
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Lisa Dirocco, Timothy Dalton, Dong Liang, Daniel W. Nebert & Thomas N. Seyfried. (1998) Nonallelism for the Audiogenic Seizure Prone (ASP1) and the Aryl Hydrocarbon Receptor (AHR) Loci in Mice. Journal of Neurogenetics 12:4, pages 191-203.
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Jukka Hakkola, Olavi Pelkonen, Markku Pasanen & Hannu Raunio. (1998) Xenobiotic-Metabolizing Cytochrome P450 Enzymes in the Human Feto-Placental Unit: Role in Intrauterine Toxicity. Critical Reviews in Toxicology 28:1, pages 35-72.
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M. M. IBA, H. SCHOLL, J. FUNG, P. E. THOMAS & J. ALAM. (1998) Induction of pulmonary CYP1A1 by nicotine. Xenobiotica 28:9, pages 827-843.
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O. PELKONEN, J. MÄEENPÄEÄ, P. TAAVITSAINEN, A. RAUTIO & H. RAUNIO. (1998) Inhibition and induction of human cytochrome P450 (CYP) enzymes. Xenobiotica 28:12, pages 1203-1253.
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Eric J. De Waal, Henk-Jan Schuurman, Henk van Loveren & Joseph G. Vos. (1997) Differential Effects of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin,bis(Tri-N-Butyltin)Oxide and Cyclosporine on Thymus Histophysiology. Critical Reviews in Toxicology 27:4, pages 381-430.
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Alvaro Puga, Daniel W. Nebert, Ross A. McKinnon & Anil G. Menon. (1997) Genetic Polymorphisms in Human Drug-Metabolizing Enzymes: Potential Uses of Reverse Genetics to Identify Genes of Toxicological Relevance. Critical Reviews in Toxicology 27:2, pages 199-222.
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J. Craig Rowlands & Jan-Åke Gustafsson. (1997) Aryl Hydrocarbon Receptor-Mediated Signal Transduction. Critical Reviews in Toxicology 27:2, pages 109-134.
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Martin Reick, Richard W. Robertson, David S. Pasco & John B. Fagan. (1994) Down-Regulation of Nuclear Aryl Hydrocarbon Receptor DNA-Binding and Transactivation Functions: Requirement for a Labile or Inducible Factor. Molecular and Cellular Biology 14:9, pages 5653-5660.
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Markku Pasanen & Olavi Pelkonen. (1994) The Expression and Environmental Regulation of P450 Enzymes in Human Placenta. Critical Reviews in Toxicology 24:3, pages 211-229.
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Martin Van den Berg, Joost De Jongh, Hermann Poiger & James R. Olson. (1994) The Toxicokinetics and Metabolism of Polychlorinated Dibenzo-p-Dioxins (PCDDs) and Dibenzofurans (PCDFs) and Their Relevance for Toxicity. Critical Reviews in Toxicology 24:1, pages 1-74.
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C. Ioannides & D. V. Parke. (1993) Induction of Cytochrome P4501 as an Indicator of Potential Chemical Carcinogenesis. Drug Metabolism Reviews 25:4, pages 485-501.
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France Carrier, Roland A. Owens, Daniel W. Nebert & Alvaro Puga. (1992) Dioxin-Dependent Activation of Murine Cypla-1 Gene Transcription Requires Protein Kinase C-Dependent Phosphorylation. Molecular and Cellular Biology 12:4, pages 1856-1863.
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Mont R. Juchau, Qwihee P. Lee & Alan G. Fantel. (1992) Xenobiotic Biotransfor Mation/Bioactivation in Organogenesis-Stage Conceptal Tissues: Implications for Embryotoxicity and Teratogenesis. Drug Metabolism Reviews 24:2, pages 195-238.
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Stephen Safe. (1991) Polychlorinated dibenzo‐p‐dioxins and related compounds: Sources, environmental distribution and risk assessment. Journal of Environmental Science and Health, Part C 9:2, pages 261-302.
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