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Critical Reviews in Toxicology Volume 20, 1990 - Issue 4
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Research Article

Drug Metabolism by Leukocytes and Its Role in Drug-Induced Lupus and Other Idiosyncratic Drug Reactions

Jack Uetrecht University of Cincinnati, Cincinnati, Ohio; Cornell University, Ithaca, New York; The Ohio State University, Columbus; University of Toronto and Sun-nybrook Medical Centre, Toronto, Ontario, Canada
Pages 213-235 | Published online: 25 Sep 2008

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Shufeng Zhou, Eli Chan, Wei Duan, Min Huang & Yu-Zong Chen. (2005) Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance. Drug Metabolism Reviews 37:1, pages 41-213.
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Janine Ezendam, Joseph G. Vos & Raymond Pieters. (2005) Research Articles Mechanisms of Hexachlorobenzene-Induced Adverse Immune Effects in Brown Norway Rats. Journal of Immunotoxicology 1:3-4, pages 167-175.
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Geneviève Durand Ca Vagna, Pierre Delort, Lea R. Gordon, Chennekatup Peter & Robert L. Smith. (1995) Cross Sensitivity Reactions Among Carbonic Anhydrase Inhibitors in the Guinea Pig. Journal of Toxicology: Cutaneous and Ocular Toxicology 14:2, pages 63-73.
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Brigitte C. Scott, Okezie I. Aruoma, Patricia J. Evans, Charles O'neill, Albert Van Der Vliet, Carroll E. Cross, Hans Tritschler & Barry Halliwell. (1994) Lipoic and Dihydrolipoic Acids as Antioxidants. a Critical Evaluation. Free Radical Research 20:2, pages 119-133.
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J. P. Uetrecht. (1992) The Role of Leukocyte-Generated Reactive Metabolites in the Pathogenesis of Ideosyncratic Drug Reactions. Drug Metabolism Reviews 24:3, pages 299-366.
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Albert P. Li. 2021. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity 41 77 .
A. Mak & J. Uetrecht. 2018. Comprehensive Toxicology. Comprehensive Toxicology 681 716 .
Lauren A. Trepanier. (2013) Idiosyncratic Drug Toxicity Affecting the Liver, Skin, and Bone Marrow in Dogs and Cats. Veterinary Clinics of North America: Small Animal Practice 43:5, pages 1055-1066.
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Alexander V. LyubimovJack P. Uetrecht. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 51 .
Alexander V. LyubimovZbigniew W. Wojcinski & Jack P. Uetrecht. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 29 .
Alexander V. LyubimovMatthew J. Hutzler & Matthew A. Cerny. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 40 .
A-E. F. Nassar, I. King & J. Du. (2011) Characterization of Short-Lived Electrophilic Metabolites of the Anticancer Agent Laromustine (VNP40101M). Chemical Research in Toxicology 24:4, pages 568-578.
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Raymond Pieters, Joseph G. Vos, Jan Willem van der Laan & Henk van Loveren. 2011. Principles of Immunopharmacology. Principles of Immunopharmacology 623 654 .
Arno G. Siraki, JinJie Jiang & Ronald P. Mason. (2010) Investigating the Mechanisms of Aromatic Amine-Induced Protein Free Radical Formation by Quantitative Structure−Activity Relationships: Implications for Drug-Induced Agranulocytosis. Chemical Research in Toxicology 23:5, pages 880-887.
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Hao Chen, Scott Grover, Linning Yu, Gregory Walker & Abdul Mutlib. (2009) Bioactivation of Lamotrigine in Vivo in Rat and in Vitro in Human Liver Microsomes, Hepatocytes, and Epidermal Keratinocytes: Characterization of Thioether Conjugates by Liquid Chromatography/Mass Spectrometry and High Field Nuclear Magnetic Resonance Spectroscopy. Chemical Research in Toxicology 23:1, pages 159-170.
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Mona Ben m'rad, Stéphanie Leclerc-Mercier, Philippe Blanche, Nathalie Franck, Flore Rozenberg, Yvonne Fulla, Myriam Guesmi, Florence Rollot, Monique Dehoux, Loïc Guillevin & Laurence Moachon. (2009) Drug-Induced Hypersensitivity Syndrome. Medicine 88:3, pages 131-140.
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Jack Uetrecht. (2008) Immune-Mediated Adverse Drug Reactions. Chemical Research in Toxicology 22:1, pages 24-34.
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Tony Cox. 2009. Information Resources in Toxicology. Information Resources in Toxicology 447 450 .
SANFORD P. MARKEY. 2007. Principles of Clinical Pharmacology. Principles of Clinical Pharmacology 143 162 .
Piyush M. Vyas, Sanjoy Roychowdhury, Sevasti B. Koukouritaki, Ronald N. Hines, Sharon K. Krueger, David E. Williams, William M. Nauseef & Craig K. Svensson. (2006) Enzyme-Mediated Protein Haptenation of Dapsone and Sulfamethoxazole in Human Keratinocytes: II. Expression and Role of Flavin-Containing Monooxygenases and Peroxidases. Journal of Pharmacology and Experimental Therapeutics 319:1, pages 497-505.
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Piyush M. Vyas, Sanjoy Roychowdhury, Farah D. Khan, Thomas E. Prisinzano, Jatinder Lamba, Erin G. Schuetz, Joyce Blaisdell, Joyce A. Goldstein, Kimber L. Munson, Ronald N. Hines & Craig K. Svensson. (2006) Enzyme-Mediated Protein Haptenation of Dapsone and Sulfamethoxazole in Human Keratinocytes: I. Expression and Role of Cytochromes P450. Journal of Pharmacology and Experimental Therapeutics 319:1, pages 488-496.
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Xiao-Xia Yang, Ze-Ping Hu, Sui Yung Chan & Shu-Feng Zhou. (2006) Monitoring drug–protein interaction. Clinica Chimica Acta 365:1-2, pages 9-29.
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Jack P. Uetrecht. 2006. 139 183 .
Dan Roden. 2005. Pharmacogenomics, Second Edition. Pharmacogenomics, Second Edition 207 220 .
Jack Uetrecht. (2005) Current trends in drug-induced autoimmunity. Autoimmunity Reviews 4:5, pages 309-314.
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Shufeng Zhou. (2003) Separation and detection methods for covalent drug–protein adducts. Journal of Chromatography B 797:1-2, pages 63-90.
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Marie-Jeanne Haack, M.L.F.J. Bak, Rob Beurskens, Michael Maes, L.M.L Stolk & Philippe A.E.G. Delespaul. (2003) Toxic rise of clozapine plasma concentrations in relation to inflammation. European Neuropsychopharmacology 13:5, pages 381-385.
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Jack Uetrecht. 2003. Drug Metabolizing Enzymes. Drug Metabolizing Enzymes 87 145 .
Ludmiła Węglarz, Aneta Koceva-Chyła, Krzysztof Gwoździński, Zofia Dzierżewicz & Zofia Jóźwiak. (2003) Evaluation of hydralazine and procainamide effects on fibroblast membrane fluidity. Biochimie 85:5, pages 549-556.
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Sandra M ten Holder, Melanie S Joy & Ronald J Falk. (2016) Cutaneous and Systemic Manifestations of Drug-Induced Vasculitis. Annals of Pharmacotherapy 36:1, pages 130-147.
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Michael J. Rieder. (2001) Hypersensitivity adverse drug reactions in children: Pathophysiology and therapeutic implications. Current Therapeutic Research 62:12, pages 913-929.
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Sidney D. Nelson. (2001) Molecular mechanisms of adverse drug reactions. Current Therapeutic Research 62:12, pages 885-899.
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Cynthia Ju & Lance R. Pohl. (2001) Immunohistochemical Detection of Protein Adducts of 2,4-Dinitrochlorobenzene in Antigen Presenting Cells and Lymphocytes after Oral Administration to Mice:  Lack of a Role of Kupffer Cells in Oral Tolerance. Chemical Research in Toxicology 14:9, pages 1209-1217.
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L. Gail Darlington & Trevor W. Stone. (2007) Antioxidants and fatty acids in the amelioration of rheumatoid arthritis and related disorders. British Journal of Nutrition 85:3, pages 251-269.
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Sidney D. Nelson. 2001. Biological Reactive Intermediates VI. Biological Reactive Intermediates VI 33 43 .
Jack P. Uetrecht. (1999) New Concepts in Immunology Relevant to Idiosyncratic Drug Reactions:  The “Danger Hypothesis” and Innate Immune System. Chemical Research in Toxicology 12:5, pages 387-395.
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Nigel S.B. Rawson, Sheila Rutledge Harding, Edith Malcolm & Leah Lueck. (1998) Hospitalizations for Aplastic Anemia and Agranulocytosis in Saskatchewan. Journal of Clinical Epidemiology 51:12, pages 1343-1355.
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Jack P. Uetrecht. (2009) Reactive metabolites and agranulocytosis. European Journal of Haematology 57:S60, pages 83-88.
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Thomas Pollmacher, Dunja Hinze-Selch & Janet Mullington. (1996) Effects of Clozapine on Plasma Cytokine and Soluble Cytokine Receptor Levels. Journal of Clinical Psychopharmacology 16:5, pages 403-409.
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Edwin T. Parks. (1996) LESIONS ASSOCIATED WITH DRUG REACTIONS. Dermatologic Clinics 14:2, pages 327-337.
Crossref
Douglas C. Goodwin, Steven D. Aust & Thomas A. Grover. (1996) Free Radicals Produced during the Oxidation of Hydrazines by Hypochlorous Acid. Chemical Research in Toxicology 9:8, pages 1333-1339.
Crossref
Douglas C. Goodwin, Thomas A. Grover & Steven D. Aust. (1996) Redox Mediation in the Peroxidase-Catalyzed Oxidation of Aminopyrine:  Possible Implications for Drug−Drug Interactions. Chemical Research in Toxicology 9:2, pages 476-483.
Crossref
Thierry Vial, Rosine Tedone, Caroline Patriarca & Jacques Descotes. (1995) Effect of serotonin on the chemiluminescence response of rat peripheral blood leucocytes. International Journal of Immunopharmacology 17:10, pages 813-819.
Crossref
M P DaftarianL G FilionW CameronB ConwayR RoyF TropperF Diaz-Mitoma. (1995) Immune response to sulfamethoxazole in patients with AIDS. Clinical Diagnostic Laboratory Immunology 2:2, pages 199-204.
Crossref
M. HERTL, F. JUGERT & H.F. MERK. (2006) CD8+ dermal T cells from a sulphamethoxazole-induced bullous exanthem proliferate in response to drug-modified liver microsomes. British Journal of Dermatology 132:2, pages 215-220.
Crossref
B.Kevin Park, Munir Pirmohamed & Neil R. Kitteringham. (1995) The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity. Pharmacology & Therapeutics 68:3, pages 385-424.
Crossref
Patricia J. Evans, Dola Akanmu & Barry Halliwell. (1994) Promotion of oxidative damage to arachidonic acid and α1-antiproteinase by anti-inflammatory drugs in the presence of the haem proteins myoglobin and cytochrome C. Biochemical Pharmacology 48:12, pages 2173-2179.
Crossref
Michal Toborek, Krystyna Magner-Wróbel, Marian Drózdz, Alojzy Danch & Ewa Kopieczna-Grzebieniak. (1993) Modulation of procainamide toxicity by selenium-enriched yeast in rats. Archives of Toxicology 67:10, pages 691-695.
Crossref
Angela H. Hofstra & Jack P. Uetrecht. (1993) Myeloperoxidase-mediated activation of xenobiotics by human leukocytes. Toxicology 82:1-3, pages 221-242.
Crossref
George R. WoodburyJr.Jr., Walter Fried, James O. Ertle & Frederick D. Malkinson. (1993) Dapsone-associated agranulocytosis and severe anemia in a patient with leukocytoclastic vasculitis. Journal of the American Academy of Dermatology 28:5, pages 781-783.
Crossref
Márcia Gamberini & Luciana C.C. Leite. (1993) Carbon-centered free radical formation during the metabolism of hydrazine derivatives by neutrophils. Biochemical Pharmacology 45:9, pages 1913-1919.
Crossref
Michael J. Rieder. (2013) Immunopharmacology and Adverse Drug Reactions. The Journal of Clinical Pharmacology 33:4, pages 316-323.
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Jack P. Uetrecht. 1993. Oxygen Free Radicals in Tissue Damage. Oxygen Free Radicals in Tissue Damage 147 154 .
B Halliwell, P J Evans, H Kaur & S Chirico. (1992) Drug derived radicals: mediators of the side effects of anti-inflammatory drugs?. Annals of the Rheumatic Diseases 51:11, pages 1261-1263.
Crossref
BK Park, M. Pirmohamed & NR Kitteringham. (2012) Idiosyncratic drug reactions: a mechanistic evaluation of risk factors.. British Journal of Clinical Pharmacology 34:5, pages 377-395.
Crossref
Patricia J. Evans, Rubens Cecchini & Barry Halliwell. (1992) Oxidative damage to lipids and α1-antiproteinase by phenylbutazone in the presence of haem proteins: protection by ascorbic acid. Biochemical Pharmacology 44:5, pages 981-984.
Crossref
Robert Jaunkalns, NeilH. Shear, Bridget Sokoluk, David Gardner, Frans Claas & JackP. Uetrecht. (1992) Antimyeloperoxidase antibodies and adverse reactions to clozapine. The Lancet 339:8809, pages 1611-1612.
Crossref
M. Pirmohamed, N.R. Kitteringham & B.K. Park. (1992) Idiosyncratic reactions to antidepressants: A review of the possible mechanisms and predisposing factors. Pharmacology & Therapeutics 53:1, pages 105-125.
Crossref
Alfred D. Steinberg, Mark F. Gourley, Dennis M. Klinman, George C. Tsokos, Dorothy E. Scott & Arthur M. Krieg. (1991) Systemic Lupus Erythematosus. Annals of Internal Medicine 115:7, pages 548-559.
Crossref
Paul J. Benke & Patricia Belmar. (1991) Phytohemagglutinin-stimulated lymphocytes from patients with systemic lupus erythematosus demonstrate DNA damage. Metabolism 40:10, pages 1037-1042.
Crossref
A. L. Parke, C. Ioannides, D. F. V. Lewis & D. V. Parke. (1991) Molecular pathology of drug-disease interactions in chronic autoimmune inflammatory diseases. Inflammopharmacology 1:1, pages 3-36.
Crossref
S.L. Kelly & E. Sim. (2016) Expression of N-Acetyl Transferase in a Human Monocytic Cell-Line, U937. Human & Experimental Toxicology 10:1, pages 33-38.
Crossref
Mark A. Sanner & Terry J. Higgins. 1991. 181 190 .
Jack Uetrecht. 1991. Biological Reactive Intermediates IV. Biological Reactive Intermediates IV 121 132 .

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