112
Views
73
CrossRef citations to date
0
Altmetric
Research Article

The Isolated Perfused Porcine Skin Flap as anIn Vitro Model for Percutaneous Absorption and Cutaneous Toxicology

&
Pages 329-344 | Published online: 25 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Jim E. Riviere, Majid Jaberi-Douraki, James Lillich, Tahmineh Azizi, Hyun Joo, Kyoungju Choi, Ravi Thakkar & Nancy A. Monteiro-Riviere. (2018) Modeling gold nanoparticle biodistribution after arterial infusion into perfused tissue: effects of surface coating, size and protein corona. Nanotoxicology 12:10, pages 1093-1112.
Read now
Yuri G Anissimov. (2014) Mathematical models for skin toxicology. Expert Opinion on Drug Metabolism & Toxicology 10:4, pages 551-560.
Read now
Jim E. Riviere, James D. Brooks, James L. Yeatts & Elisha L. Koivisto. (2010) Surfactant Effects on Skin Absorption of Model Organic Chemicals: Implications for Dermal Risk Assessment Studies. Journal of Toxicology and Environmental Health, Part A 73:11, pages 725-737.
Read now
Nancy A. Monteiro-Riviere & Jim E. Riviere. (2009) Interaction of nanomaterials with skin: Aspects of absorption and biodistribution. Nanotoxicology 3:3, pages 188-193.
Read now
Jim Riviere, Ronald Baynes, James Brooks, James Yeatts & Nancy Monteiro-Riviere. (2003) Percutaneous Absorption of Topical N , N -Diethyl- m -Toluamide (Deet): Effects of Exposure Variables and Coadministered Toxicants. Journal of Toxicology and Environmental Health, Part A 66:2, pages 133-151.
Read now
Nancy A. Monteiro-Riviere & Alfred O. Inman. (2000) CHARACTERIZATION OF SULFUR MUSTARD–INDUCED TOXICITY BY ENZYME HISTOCHEMISTRY IN PORCINE SKIN. Toxicology Methods 10:2, pages 127-142.
Read now

Articles from other publishers (67)

Mark G. Papich & Roger J. Narayan. (2021) Naloxone and nalmefene absorption delivered by hollow microneedles compared to intramuscular injection. Drug Delivery and Translational Research 12:2, pages 376-383.
Crossref
Edward D. Clarkson & Richard K. Gordon. 2020. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 1233 1247 .
Patricia Perez Esteban, Juliette Pickles, Andrew D. Scott & Marianne J. Ellis. (2019) Hollow-fiber membrane technology: Characterization and proposed use as a potential mimic of skin vascularization towards the development of a novel skin absorption in vitro model. Biochemical Engineering Journal 145, pages 90-97.
Crossref
Jason T. Chittenden & Jim E. Riviere. 2017. Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin. Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin 95 117 .
Jason T. Chittenden & Jim E. Riviere. (2016) Assessment of penetrant and vehicle mixture properties on transdermal permeability using a mixed effect pharmacokinetic model of ex vivo porcine skin . Biopharmaceutics & Drug Disposition 37:7, pages 387-396.
Crossref
Howard Maibach. 2016. Drug Discovery and Evaluation: Pharmacological Assays. Drug Discovery and Evaluation: Pharmacological Assays 4013 4015 .
Edward D. Clarkson & Richard K. Gordon. 2015. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 1127 1139 .
Howard Maibach. 2014. Drug Discovery and Evaluation: Pharmacological Assays. Drug Discovery and Evaluation: Pharmacological Assays 1 3 .
Nancy Monteiro-Riviere & C TranJim Riviere. 2014. Nanotoxicology. Nanotoxicology 135 152 .
J.E. Riviere & N.A. Monteiro-Riviere. 2014. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Daniela Karadzovska, James D. Brooks, Nancy A. Monteiro-Riviere & Jim E. Riviere. (2013) Predicting skin permeability from complex vehicles. Advanced Drug Delivery Reviews 65:2, pages 265-277.
Crossref
Teresa L. Leavens, Nancy A. Monteiro‐Riviere, Alfred O. Inman, James D. Brooks, Steven J. Oldenburg & Jim E. Riviere. (2012) In vitro biodistribution of silver nanoparticles in isolated perfused porcine skin flaps . Journal of Applied Toxicology 32:11, pages 913-919.
Crossref
Jessica Stahl, Bettina Blume, Silvia Bienas & Manfred Kietzmann. (2012) The Comparability of In Vitro and Ex Vivo Studies on the Percutaneous Permeation of Topical Formulations Containing Ibuprofen . Alternatives to Laboratory Animals 40:2, pages 91-98.
Crossref
James B. Knaak, Curtis C. Dary, Xiaofei Zhang, Robert W. Gerlach, R. Tornero-Velez, Daniel T. Chang, Rocky Goldsmith & Jerry N. Blancato. 2012. Reviews of Environmental Contamination and Toxicology. Reviews of Environmental Contamination and Toxicology 1 114 .
Jim E. Riviere. 2011. Comparative Pharmacokinetics. Comparative Pharmacokinetics 39 71 .
Jim E. Riviere & James D. Brooks. (2011) Predicting Skin Permeability from Complex Chemical Mixtures: Dependency of Quantitative Structure Permeation Relationships on Biology of Skin Model Used. Toxicological Sciences 119:1, pages 224-232.
Crossref
Teresa L. Leavens, Xin Rui Xia, Hyun A. Lee, Nancy A. Monteiro-Riviere, James D. Brooks & Jim E. Riviere. (2010) Evaluation of perfused porcine skin as a model system to quantitate tissue distribution of fullerene nanoparticles. Toxicology Letters 197:1, pages 1-6.
Crossref
J.E. Riviere & N.A. Monteiro-Riviere. 2010. Comprehensive Toxicology. Comprehensive Toxicology 111 122 .
Jim E. Riviere & Nancy A. Monteiro‐Riviere. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Richard K. Gordon & Edward D. clarkson. 2009. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 1069 1081 .
Daniel Bacqueville & Alain Mavon. (2008) Caspase-3 Activation and DNA Damage in Pig Skin Organ Culture After Solar Irradiation. Photochemistry and Photobiology 84:5, pages 1164-1171.
Crossref
I. Boudry, O. Blanck, C. Cruz, M. Blanck, V. Vallet, A. Bazire, A. Capt, D. Josse & G. Lallement. (2008) Percutaneous penetration and absorption of parathion using human and pig skin models in vitro and human skin grafted onto nude mouse skin model in vivo . Journal of Applied Toxicology 28:5, pages 645-657.
Crossref
PJ Boogaard. (2008) Biomonitoring as a tool in the human health risk characterization of dermal exposure. Human & Experimental Toxicology 27:4, pages 297-305.
Crossref
Wilfried Meyer, Johannes Kacza, Nils-Holger Zschemisch, Szymon Godynicki & Johannes Seeger. (2007) Observations on the actual structural conditions in the stratum superficiale dermidis of porcine ear skin, with special reference to its use as model for human skin. Annals of Anatomy - Anatomischer Anzeiger 189:2, pages 143-156.
Crossref
Hans Gerhard Vogel. 2008. Drug Discovery and Evaluation. Drug Discovery and Evaluation 1941 2021 .
Scott Willens, Michael K. Stoskopf, Ronald E. Baynes, Gregory A. Lewbart, Sharon K. Taylor & Suzanne Kennedy-Stoskopf. (2006) Percutaneous malathion absorption by anuran skin in flow-through diffusion cells. Environmental Toxicology and Pharmacology 22:3, pages 255-262.
Crossref
P.C. Mills & S.E. Cross. (2006) Transdermal drug delivery: Basic principles for the veterinarian. The Veterinary Journal 172:2, pages 218-233.
Crossref
Anne C. O’Neill, Laurent Barbe, Mark A. Randolph & François Berthiaume. (2006) Isolated Perfusion of a Tubed Superficial Epigastric Flap in a Rodent Model. Journal of Surgical Research 135:1, pages 164-169.
Crossref
Günter Oberdörster, Andrew Maynard, Ken Donaldson, Vincent Castranova, Julie Fitzpatrick, Kevin Ausman, Janet Carter, Barbara Karn, Wolfgang Kreyling, David Lai, Stephen Olin, Nancy Monteiro-Riviere, David Warheit & Hong Yang. (2005) Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Particle and Fibre Toxicology 2:1.
Crossref
Jim Riviere. 2005. Dermal Absorption Models in Toxicology and Pharmacology. Dermal Absorption Models in Toxicology and Pharmacology 29 47 .
Jim Riviere. 2004. Dermatotoxicology, Sixth Edition. Dermatotoxicology, Sixth Edition 563 587 .
Alfred O Inman, Kenneth R Still, Warren W Jederberg, Robert L Carpenter, Jim E Riviere, James D Brooks & Nancy A Monteiro-Riviere. (2003) Percutaneous absorption of 2,6-di-tert-butyl-4-nitrophenol (DBNP) in isolated perfused porcine skin. Toxicology in Vitro 17:3, pages 289-292.
Crossref
Jim E Riviere, Nancy A Monteiro-Riviere & Ronald E Baynes. (2002) Gulf War related exposure factors influencing topical absorption of 14C-permethrin. Toxicology Letters 135:1-2, pages 61-71.
Crossref
Ronald E. Baynes, Nancy A. Monteiro-Riviere & Jim E. Riviere. (2002) Pyridostigmine Bromide Modulates the Dermal Disposition of [14C]Permethrin. Toxicology and Applied Pharmacology 181:3, pages 164-173.
Crossref
Patricia G. Johnson, Sek Wen Hui & Allan R. Oseroff. (2007) Electrically Enhanced Percutaneous Delivery Of δ-Aminolevulinic Acid Using Electric Pulses and a DC Potential¶. Photochemistry and Photobiology 75:5, pages 534-540.
Crossref
Patricia G. Johnson, Sek Wen Hui & Allan R. Oseroff. (2002) Electrically Enhanced Percutaneous Delivery Of δ-Aminolevulinic Acid Using Electric Pulses and a DC Potential¶. Photochemistry and Photobiology 75:5, pages 534.
Crossref
Russell 0. Potts, D. Bommannan, 1]Ooi Wong, Janet A. Tamada, Jim E. Riviere & Nancy A. Monteiro-Riviere. 2002. Protein Delivery. Protein Delivery 213 238 .
Jim E Riviere & Mark G Papich. (2001) Potential and problems of developing transdermal patches for veterinary applications. Advanced Drug Delivery Reviews 50:3, pages 175-203.
Crossref
. 2001. The Physiological Basis of Veterinary Clinical Pharmacology. The Physiological Basis of Veterinary Clinical Pharmacology 178 209 .
Jim E. Riviere, Charles E. Smith, Kamon Budsaba, James D. Brooks, Eugene J. Olajos, Harry Salem & Nancy A. Monteiro‐Riviere. (2001) Use of methyl salicylate as a simulant to predict the percutaneous absorption of sulfur mustard. Journal of Applied Toxicology 21:2, pages 91-99.
Crossref
Jim E. Riviere, James D. Brooks, Nancy A. Monteiro-Riviere, Kamon Budsaba & Charles E. Smith. (1999) Dermal Absorption and Distribution of Topically Dosed Jet Fuels Jet-A, JP-8, and JP-8(100). Toxicology and Applied Pharmacology 160:1, pages 60-75.
Crossref
Sek Wen Hui, Stephen A. Gallo, Patricia G. Johnson & Allan R. Oseroff. 1999. Electricity and Magnetism in Biology and Medicine. Electricity and Magnetism in Biology and Medicine 919 922 .
Patricia G. Johnson, Stephen A. Gallo, Sek Wen Hui & Allan R. Oseroff. (1998) A Pulsed Electric Field Enhances Cutaneous Delivery of Methylene Blue in Excised Full-Thickness Porcine Skin. Journal of Investigative Dermatology 111:3, pages 457-463.
Crossref
Ronald C. Wester, Joseph Melendres, Lena Sedik, Howard Maibach & Jim E. Riviere. (1998) Percutaneous Absorption of Salicylic Acid, Theophylline, 2,4-Dimethylamine, Diethyl Hexyl Phthalic Acid, andp-Aminobenzoic Acid in the Isolated Perfused Porcine Skin Flap Compared to Manin Vivo. Toxicology and Applied Pharmacology 151:1, pages 159-165.
Crossref
M.S. Thorniley, J.S. Sinclair, N.J. Barnett, C.B. Shurey & C.J. Green. (1998) The use of near-infrared spectroscopy for assessing flap viability during reconstructive surgery. British Journal of Plastic Surgery 51:3, pages 218-226.
Crossref
Ronald E Baynes, Nancy A Monteiro-Riviere, Gui L Qiao & Jim E Riviere. (1997) Cutaneous toxicity of the benzidine dye direct red 28 applied as mechanistically-defined chemical mixtures (MDCM) in perfused porcine skin. Toxicology Letters 93:2-3, pages 159-169.
Crossref
R.E Baynes, K.B Halling & J.E Riviere. (1997) The Influence of Diethyl-m-toluamide (DEET) on the Percutaneous Absorption of Permethrin and Carbaryl. Toxicology and Applied Pharmacology 144:2, pages 332-339.
Crossref
Nancy A. Monteiro-Riviere & Alfred O. Inman. (1997) Ultrastructural characterization of sulfur mustard-induced vesication in isolated perfused porcine skin. Microscopy Research and Technique 37:3, pages 229-241.
Crossref
Jim E. Riviere. 1996. Models for Assessing Drug Absorption and Metabolism. Models for Assessing Drug Absorption and Metabolism 387 407 .
Nancy A. Monteiro-Riviere & Jim Riviere. 1996. Advances in Swine in Biomedical Research. Advances in Swine in Biomedical Research 425 458 .
Jim E. Riviere, Nancy A. Monteiro-Riviere, Richard A. Rogers, D. Bommannan, Janet A. Tamada & Russell O. Potts. (1995) Pulsatile transdermal delivery of LHRH using electroporation: Drug delivery and skin toxicology. Journal of Controlled Release 36:3, pages 229-233.
Crossref
R. S. Chauhan, L. V. R. Murthy & S. C. Pant. (1995) Electron microscopic study of guinea pig skin exposed to sulphur mustard. Bulletin of Environmental Contamination and Toxicology 55:1, pages 50-57.
Crossref
Zili Zhang, Jim E Riviere & Nancy A Monteiro-Riviere. (1995) Evaluation of protective effects of sodium thiosulfate, cysteine, niacinamide and indomethacin on sulfur mustard-treated isolated perfused porcine skin. Chemico-Biological Interactions 96:3, pages 249-262.
Crossref
Nancy A. Monteiro-Riviere & Alfred O. Inman. (2016) Indirect Immunohistochemistry and Immunoelectron Microscopy Distribution of Eight Epidermal-Dermal Junction Epitopes in the Pig and in Isolated Perfused Skin Treated with Bis (2-Chloroethyl) Sulfide. Toxicologic Pathology 23:3, pages 313-325.
Crossref
Patrick L. Williams & Jim E. Riviere. (1995) A Biophysically Based Dermatopharmacokinetic Compartment Model for Quantifying Percutaneous Penetration and Absorption of Topically Applied Agents. I. Theory. Journal of Pharmaceutical Sciences 84:5, pages 599-608.
Crossref
Jerry W. Spoo, Nancy A. Monteiro-Riviere & Jim E. Riviere. (1995) Detection of sulfur mustard bis (2-chloroethyl) sulfide and metabolites after topical application in the isolated perfused porcine skin flap. Life Sciences 56:17, pages 1385-1394.
Crossref
Richard A. Rogers & Jim E. Riviere. (1994) Pharmacologic Modulation of the Cutaneous Vasculature in the Isolated Perfused Porcine Skin Flap. Journal of Pharmaceutical Sciences 83:12, pages 1682-1689.
Crossref
S.K. Chang, P.L. Williams, W.C. Dauterman & J.E. Riviere. (1994) Percutaneous absorption, dermatopharmacokinetics and related bio-transformation studies of carbaryl, lindane, malathion, and parathion in isolated perfused porcine skin. Toxicology 91:3, pages 269-280.
Crossref
P.L. Williams & J.E. Riviere. (1993) Model Describing Transdermal lontophoretic Delivery of Lidocaine Incorporating Consideration of Cutaneous Microvascular State. Journal of Pharmaceutical Sciences 82:11, pages 1080-1084.
Crossref
Mark C. Heit, Patrick L. Williams, Friederike L. Jayes, Shao K. Chang & Jim E. Riviere. (1993) Transdermal lontophoretic Peptide Delivery: In Vitro and In Vivo Studies with Luteinizing Hormone Releasing Hormone. Journal of Pharmaceutical Sciences 82:5, pages A240-A243.
Crossref
Mark C. Heit, Patrick L. Williams, Shao K. Chang, Jim E. Riviere & Friederike L. Jayes. (1993) Transdermal lontophoretic Peptide Delivery: In Vitro and In Vivo Studies with Luteinizing Hormone Releasing Hormone. Journal of Pharmaceutical Sciences 82:3, pages 240-243.
Crossref
J. Edmond Riviere & Nancy A. Monteiro-Riviere. 1993. In Vitro Biological Systems. In Vitro Biological Systems 515 524 .
J. Edmond Riviere. 1993. Topical Drug Bioavailability, Bioequivalence, and Penetration. Topical Drug Bioavailability, Bioequivalence, and Penetration 209 221 .
J.Randall King, Jim E. Riviere & Nancy A. Monteiro-Riviere. (1992) Characterization of lewisite toxicity in isolated perfused skin. Toxicology and Applied Pharmacology 116:2, pages 189-201.
Crossref
Vagdevi Srikrishna, J.Edmond Riviere & Nancy A. Monteiro-Riviere. (1992) Cutaneous toxicity and absorption of paraquat in porcine skin. Toxicology and Applied Pharmacology 115:1, pages 89-97.
Crossref
J.E. Riviere & P.L. Williams. (1992) Pharmacokinetic implications of changing blood flow in skin. Journal of Pharmaceutical Sciences 81:6, pages 601-602.
Crossref
J.E. Riviere, P.L. Williams, R.S. Hillman & L.M. Mishky. (1992) Quantitative Prediction of Transdermal Iontophoretic Delivery of Arbutamine in Humans with the in Vitro Isolated Perfused Porcine Skin Flap. Journal of Pharmaceutical Sciences 81:6, pages 504-507.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.