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Critical Reviews in Toxicology Volume 21, 1991 - Issue 3
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Research Article

New Developments in Therapeutic Chelating Agents as Antidotes for Metal Poisoning

Mark M. Jones Department of Chemistry and Center in Molecular Toxicology, Vanderbilt University, Nashville, TN, 37235
Pages 209-233 | Published online: 25 Sep 2008

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V. Volf, J. Rencová, M.M. Jones & P.K. Singh. (1995) Combined Chelation Treatment for Polonium after Simulated Wound Contamination in Rat. International Journal of Radiation Biology 68:4, pages 395-404.
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J. L. Domingo. (1994) Metal‐induced developmental toxicity in mammals: A review. Journal of Toxicology and Environmental Health 42:2, pages 123-141.
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J. Rencová, V. Volf, M.M. Jones & P.K. Singh. (1993) Relative Effectiveness of Dithiol and Dithiocarbamate Chelating Agents in Reducing Retention of Polonium-210 in Rats. International Journal of Radiation Biology 63:2, pages 223-232.
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Articles from other publishers (38)

Siyuan Zhou, Wangzi Li, Qi Zhao, Hongqiang Dong, Yueqi Wang, Feihong Lu, Jiahao Zhao, Shanshan Liu, Hong Chen, Lu Wang, Wei Liu, Mingchang Zhang & Shigui Chen. (2021) Detoxification of the Toxic Sulfur Mustard Simulant by a Supramolecular Antidote in Vitro and in Vivo. ACS Applied Materials & Interfaces 13:49, pages 58291-58300.
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Donatella Aiello, Federica Carnamucio, Massimiliano Cordaro, Claudia Foti, Anna Napoli & Ottavia Giuffrè. (2021) Ca2+ Complexation With Relevant Bioligands in Aqueous Solution: A Speciation Study With Implications for Biological Fluids. Frontiers in Chemistry 9.
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Denisse Calderón-Vallejo, María del Carmen Díaz-Galindo, Andrés Quintanar-Stephano, Carlos Olvera-Sandoval & J Luis Quintanar. (2020) Protective role of ascorbic acid on lead-induced damage to the thyroid gland in the rat. Toxicology Research 9:5, pages 632-635.
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Stephanie Hui Kit Yap, Yi-Hsin Chien, Kok Ken Chan, Chen-Hao Yeh, Gong Zhang, Jyh-Chiang Jiang, Swee Chuan Tjin & Ken-Tye Yong. (2020) A First Study of the Kinetics of Metal Ion Adsorption at Solid/Liquid Interface using Evanescent Wave-based Optical Microfiber. IEEE Sensors Journal, pages 1-1.
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Türker Acar, Egemen Kaya, Mustafa Deniz Yoruk, Neslihan Duzenli, Recep Selim Senturk, Cenk Can, Lokman Ozturk, Canberk Tomruk, Yigit Uyanikgil & Frank J. Rybicki. (2019) Changes in tissue gadolinium biodistribution measured in an animal model exposed to four chelating agents. Japanese Journal of Radiology 37:6, pages 458-465.
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Haewon Jeong, Yeji Kang, Jin Kim, Byung-Kwon Kim & Seungwoo Hong. (2019) Factors that determine thione(thiol)–disulfide interconversion in a bis(thiosemicarbazone) copper( ii ) complex . RSC Advances 9:16, pages 9049-9052.
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Julia Martín. (2018) An overview on ligands of therapeutically interest. Pharmacy & Pharmacology International Journal 6:3.
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Megha Mittal, Sreemoyee Chatterjee & S. J. S. Flora. (2018) Combination therapy with vitamin C and DMSA for arsenic–fluoride co-exposure in rats. Metallomics 10:9, pages 1291-1306.
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Swaran J.S. Flora & Shruti Agrawal. 2017. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 537 566 .
Ole Andersen. 2016. Chelation Therapy in the Treatment of Metal Intoxication. Chelation Therapy in the Treatment of Metal Intoxication 85 252 .
Carolina Mendoza, Susanna Jansat, Ramón Vilar & Miquel A. Pericàs. (2015) Clickable complexing agents: functional crown ethers for immobilisation onto polymers and magnetic nanoparticles. RSC Advances 5:106, pages 87352-87363.
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Lan-Chi Königsberger, Erich Königsberger, Glenn Hefter & Peter M. May. (2015) Formation constants of copper( i ) complexes with cysteine, penicillamine and glutathione: implications for copper speciation in the human eye . Dalton Transactions 44:47, pages 20413-20425.
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Masafumi Kumazaki, Hitoshi Ando, Masafumi Kakei, Kentarou Ushijima, Yosuke Taniguchi, Masashi Yoshida, Shiho Yamato, Satoshi Washino, Taka-aki Koshimizu & Akio Fujimura. (2013) α-Lipoic acid protects against arsenic trioxide-induced acute QT prolongation in anesthetized guinea pigs. European Journal of Pharmacology 705:1-3, pages 1-10.
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Gabriella Falcone, Claudia Foti & Silvio Sammartano. (2012) Binding Ability of Sodium Catechol Disulfonate ( Tiron ) toward Hg 2+ , CH 3 Hg + , (CH 3 ) 3 Sn + , and (CH 3 ) 2 Sn 2+ Cations . Journal of Chemical & Engineering Data 57:12, pages 3636-3643.
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Swaran J.S. Flora, Vidhu Pachauri & Geetu Saxena. 2011. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 415 438 .
Geetu Saxena & S J S Flora. (2006) Changes in brain biogenic amines and haem biosynthesis and their response to combined administration of succimers and Centella asiatica in lead poisoned rats . Journal of Pharmacy and Pharmacology 58:4, pages 547-559.
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A.M.M. Essa, N.J. Creamer, N.L. Brown & L.E. Macaskie. (2006) A new approach to the remediation of heavy metal liquid wastes via off-gases produced byKlebsiella pneumoniae M426. Biotechnology and Bioengineering 95:4, pages 574-583.
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Jin Sik Kim, Eun Wie Cho, Hai Won Chung & In Gyu Kim. (2006) Effects of Tiron, 4,5-dihydroxy-1,3-benzene disulfonic acid, on human promyelotic HL-60 leukemia cell differentiation and death. Toxicology 223:1-2, pages 36-45.
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Swaran J.S. Flora, Govinder Flora & Geetu Saxena. 2006. Lead. Lead 158 228 .
Geetu Saxena, Uma Pathak & S.J.S. Flora. (2005) Beneficial role of monoesters of meso-2,3-dimercaptosuccinic acid in the mobilization of lead and recovery of tissue oxidative injury in rats. Toxicology 214:1-2, pages 39-56.
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Alison L. Jones. (2004) Adverse drug reactions to poison antidotes. Adverse Drug Reaction Bulletin &NA;:229, pages 1-4.
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Ashish Mehta, G. M. Kannan, S. N. Dube, B. P. Pant, S. C. Pant & S. J. S. Flora. (2002) Haematological, hepatic and renal alterations after repeated oral or intraperitoneal administration of monoisoamyl DMSA. I. Changes in male rats. Journal of Applied Toxicology 22:6, pages 359-369.
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Alison Jones & Robert Flanagan. 2001. Antidotes. Antidotes 35 93 .
S K Tandon & S Prasad. (2016) Effect of thiamine on the cadmium–chelating capacity of thiol compounds. Human & Experimental Toxicology 19:9, pages 523-528.
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Maja Blanuša, Ljerka Prester, Veda M. Varnai, Draško Pavlović, Krista Kostial, Mark M. Jones & Pramod K. Singh. (2000) Chelation of aluminium by combining DFO and L1 in rats. Toxicology 147:3, pages 151-156.
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Ole Andersen. (1999) Principles and Recent Developments in Chelation Treatment of Metal Intoxication. Chemical Reviews 99:9, pages 2683-2710.
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Siegfried G. Schäfer, R.L.F. Dawes, Bernd Elsenhans, Wolfgang Forth & Klaus Schümann. 1999. Toxicology. Toxicology 755 804 .
Sushil K. Tandon, Surendra Singh, Satgur Prasad & Neeraj Mathur. (2007) MOBILIZATION OF LEAD BY CALCIUM VERSENATE AND DIMERCAPTOSUCCINATE IN THE RAT. Clinical and Experimental Pharmacology and Physiology 25:9, pages 686-692.
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Jose L. Domingo. (1998) Developmental toxicity of metal chelating agents. Reproductive Toxicology 12:5, pages 499-510.
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Sushil K Tandon, Satgur Prasad, Surendra Singh & Deepak K Agarwal. (1998) Efficacy of amphipathic dithiocarbamates in intracellular cadmium mobilization and in modulation of hepatic and renal metallothionein in cadmium pre-exposed rat. Chemico-Biological Interactions 114:3, pages 161-175.
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Kimberlie A GraemeMDMD & Charles V Pollack. (1998) Heavy Metal Toxicity, Part I: Arsenic and Mercury. The Journal of Emergency Medicine 16:1, pages 45-56.
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SK Tandon, S. Singh & S. Prasad. (2016) Chelation in metal intoxication LI: Efficacy of amphipathic dithiocarbamates in mobilization of lead in the rat. Human & Experimental Toxicology 16:10, pages 557-562.
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K. Kostial, M. Blanuša, M. Piasek, Lj. Prester, M. M. Jones & P. K. Singh. (2006) Monoisoamyl and mono‐ n ‐hexyl meso‐2,3‐dimercaptosuccinate in mobilizing 203 hg retention in relation to age of rats and route of administration . Journal of Applied Toxicology 15:3, pages 201-206.
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Jose L. Domingo. (1995) Prevention by chelating agents of metal-induced developmental toxicity. Reproductive Toxicology 9:2, pages 105-113.
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M. M. Jones. 1995. Toxicology of Metals. Toxicology of Metals 279 304 .
K KostialB KargacinM BlanusaM PiasekM M JonesP K Singh. (1994) Monoisoamyl meso-2,3-dimercaptosuccinate as a delayed treatment for mercury removal in rats.. Environmental Health Perspectives 102:suppl 3, pages 309-311.
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K. Kostial, M. Blanuša, M. Piasek, M. M. Jones & P. K. Singh. (1994) Effect of oral therapy with monoisoamyl meso-2,3-dimercaptosuccinate on 203Hg retention in rats. Bulletin of Environmental Contamination and Toxicology 52:4, pages 492-497.
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François Jasanada & Françoise Nepveu. (1992) Synthesis of amphiphilic chelating agents : Bis(hexadecylamide) and bis(octadecylamide) of diethylenetriaminepentaacetic Acid.. Tetrahedron Letters 33:39, pages 5745-5748.
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