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Review Article

Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase

&
Pages 185-198 | Received 27 Jan 2010, Accepted 12 Apr 2010, Published online: 20 May 2010

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Anke Loregger, Emma Claire Laura Cook, Jessica Kristin Nelson, Martina Moeton, Laura Jane Sharpe, Susanna Engberg, Madina Karimova, Gilles Lambert, Andrew John Brown & Noam Zelcer. (2016) A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes. Molecular and Cellular Biology 36:2, pages 285-294.
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Margaret A. WangelineNidhi VashisthaRandolph Y. Hampton. (2017) Proteostatic Tactics in the Strategy of Sterol Regulation. Annual Review of Cell and Developmental Biology 33:1, pages 467-489.
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Ignat Printsev, Daniel Curiel & Kermit L. CarrawayIIIIII. (2016) Membrane Protein Quantity Control at the Endoplasmic Reticulum. The Journal of Membrane Biology 250:4, pages 379-392.
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Anika V. Prabhu, Winnie Luu, Dianfan Li, Laura J. Sharpe & Andrew J. Brown. (2016) DHCR7: A vital enzyme switch between cholesterol and vitamin D production. Progress in Lipid Research 64, pages 138-151.
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Jun S. Min, Robert A. DeAngelis, Edimara S. Reis, Shakti Gupta, Mano R. Maurya, Charles Evans, Arun Das, Charles Burant, John D. Lambris & Shankar Subramaniam. (2016) Systems Analysis of the Complement-Induced Priming Phase of Liver Regeneration. The Journal of Immunology 197:6, pages 2500-2508.
Crossref
Yvonne Lange & Theodore L. Steck. (2016) Active membrane cholesterol as a physiological effector. Chemistry and Physics of Lipids 199, pages 74-93.
Crossref
Niroz Abu-Saleh, Michael Aviram & Tony Hayek. (2016) Aqueous or lipid components of atherosclerotic lesion increase macrophage oxidation and lipid accumulation. Life Sciences 154, pages 1-14.
Crossref
Y-W Chang, C-F Tseng, M-Y Wang, W-C Chang, C-C Lee, L-T Chen, M-C Hung & J-L Su. (2015) Deacetylation of HSPA5 by HDAC6 leads to GP78-mediated HSPA5 ubiquitination at K447 and suppresses metastasis of breast cancer. Oncogene 35:12, pages 1517-1528.
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Kunio Nakatsukasa & Takumi Kamura. (2016) Subcellular Fractionation Analysis of the Extraction of Ubiquitinated Polytopic Membrane Substrate during ER-Associated Degradation. PLOS ONE 11:2, pages e0148327.
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Hong Sun, Yang Yuan & Zilin Sun. (2016) Update on Mechanisms of Renal Tubule Injury Caused by Advanced Glycation End Products. BioMed Research International 2016, pages 1-9.
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Annalisa Marcuzzi, Elisa Piscianz, Claudia Loganes, Liza Vecchi Brumatti, Alessandra Knowles, Sabrine Bilel, Alberto Tommasini, Roberta Bortul & Marina Zweyer. (2015) Innovative Target Therapies Are Able to Block the Inflammation Associated with Dysfunction of the Cholesterol Biosynthesis Pathway. International Journal of Molecular Sciences 17:1, pages 47.
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Qi Wu & Qiang Liu. (2015) HBx truncation mutants differentially modulate SREBP-1a and -1c transcription and HBV replication. Virus Research 210, pages 46-53.
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Aurea K. Ramírez-Jiménez, Rosalía Reynoso-Camacho, M. Elizabeth Tejero, Fabiola León-Galván & Guadalupe Loarca-Piña. (2015) Potential role of bioactive compounds of Phaseolus vulgaris L. on lipid-lowering mechanisms. Food Research International 76, pages 92-104.
Crossref
Brian T. Kalish, Gillian L. Fell, Prathima Nandivada & Mark Puder. (2015) Clinically Relevant Mechanisms of Lipid Synthesis, Transport, and Storage. Journal of Parenteral and Enteral Nutrition 39:1_suppl, pages 8S-17S.
Crossref
Marie Ramsvik, Bodil Bjørndal, Inge Bruheim, Pavol Bohov & Rolf Berge. (2015) A Phospholipid-Protein Complex from Krill with Antioxidative and Immunomodulating Properties Reduced Plasma Triacylglycerol and Hepatic Lipogenesis in Rats. Marine Drugs 13:7, pages 4375-4397.
Crossref
R. Ren, X. Zhou, Y. He, M. Ke, J. Wu, X. Liu, C. Yan, Y. Wu, X. Gong, X. Lei, S. F. Yan, A. Radhakrishnan & N. Yan. (2015) Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels. Science 349:6244, pages 187-191.
Crossref
Emily Jane Gallagher & Derek LeRoith. (2015) Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality. Physiological Reviews 95:3, pages 727-748.
Crossref
Gene C. Ness. (2015) Physiological feedback regulation of cholesterol biosynthesis: Role of translational control of hepatic HMG-CoA reductase and possible involvement of oxylanosterols. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1851:5, pages 667-673.
Crossref
H. Corby Kistler & Karen Broz. (2015) Cellular compartmentalization of secondary metabolism. Frontiers in Microbiology 6.
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Wenchao Zheng, Natalia Mast, Aicha Saadane & Irina A. Pikuleva. (2015) Pathways of cholesterol homeostasis in mouse retina responsive to dietary and pharmacologic treatments. Journal of Lipid Research 56:1, pages 81-97.
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Lia R. Edmunds, Lokendra Sharma, Audry Kang, Jie Lu, Jerry Vockley, Shrabani Basu, Radha Uppala, Eric S. Goetzman, Megan E. Beck, Donald Scott & Edward V. Prochownik. (2014) c-Myc Programs Fatty Acid Metabolism and Dictates Acetyl-CoA Abundance and Fate. Journal of Biological Chemistry 289:36, pages 25382-25392.
Crossref
Kunio Nakatsukasa, Takumi Kamura & Jeffrey L Brodsky. (2014) Recent technical developments in the study of ER-associated degradation. Current Opinion in Cell Biology 29, pages 82-91.
Crossref
Kwangman Choi, Hyeongki Kim, Hyunju Kang, So-Young Lee, Sang Jun Lee, Sung Hoon Back, Seo Hyun Lee, M. Sun Kim, Jeong Eun Lee, Ju Young Park, Jiye Kim, Sunhong Kim, Jae-Hyung Song, Yura Choi, Suui Lee, Hyun-Jun Lee, Jong Heon Kim & Sungchan Cho. (2014) Regulation of diacylglycerol acyltransferase 2 protein stability by gp78-associated endoplasmic-reticulum-associated degradation. FEBS Journal 281:13, pages 3048-3060.
Crossref
Chris Williams. (2014) Going against the flow: A case for peroxisomal protein export. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843:7, pages 1386-1392.
Crossref
Ji Miao, Joel T. Haas, Praveen Manthena, Yanning Wang, Enpeng Zhao, Bhavapriya Vaitheesvaran, Irwin J. Kurland & Sudha B. Biddinger. (2014) Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins. Journal of Lipid Research 55:4, pages 659-667.
Crossref
Amélie Rodrigue‐Way, Véronique Caron, Stéphanie Bilodeau, Sarah Keil, Meryl Hassan, Emile Lévy, Grant A. Mitchell & André Tremblay. (2013) Scavenger receptor CD36 mediates inhibition of cholesterol synthesis via activation of the PPARγ/PGC‐1α pathway and Insig1/2 expression in hepatocytes . The FASEB Journal 28:4, pages 1910-1923.
Crossref
Phyllis L. Faust & Werner J. Kovacs. (2014) Cholesterol biosynthesis and ER stress in peroxisome deficiency. Biochimie 98, pages 75-85.
Crossref
Lee G.D. Fryer, Bethan Jones, Emma J. Duncan, Claire E. Hutchison, Tozen Ozkan, Paul A. Williams, Olivia Alder, Max Nieuwdorp, Anna K. Townley, Arjen R. Mensenkamp, David J. Stephens, Geesje M. Dallinga-Thie & Carol C. Shoulders. (2014) The Endoplasmic Reticulum Coat Protein II Transport Machinery Coordinates Cellular Lipid Secretion and Cholesterol Biosynthesis. Journal of Biological Chemistry 289:7, pages 4244-4261.
Crossref
Matthew R. McFarlane, Guosheng Liang & Luke J. Engelking. (2014) Insig Proteins Mediate Feedback Inhibition of Cholesterol Synthesis in the Intestine. Journal of Biological Chemistry 289:4, pages 2148-2156.
Crossref
Jacob Pollier, Tessa Moses, Miguel González-Guzmán, Nathan De Geyter, Saskia Lippens, Robin Vanden Bossche, Peter Marhavý, Anna Kremer, Kris Morreel, Christopher J. Guérin, Aldo Tava, Wieslaw Oleszek, Johan M. Thevelein, Narciso Campos, Sofie Goormachtig & Alain Goossens. (2013) The protein quality control system manages plant defence compound synthesis. Nature 504:7478, pages 148-152.
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Fu-Chia Yang, Ya-Huei Lin, Wei-Hao Chen, Jing-Yi Huang, Hsin-Yun Chang, Su-Hui Su, Hsiao-Ting Wang, Chun-Yi Chiang, Pang-Hung Hsu, Ming-Daw Tsai, Bertrand Chin-Ming Tan & Sheng-Chung Lee. (2013) Interaction between Salt-inducible Kinase 2 (SIK2) and p97/Valosin-containing Protein (VCP) Regulates Endoplasmic Reticulum (ER)-associated Protein Degradation in Mammalian Cells. Journal of Biological Chemistry 288:47, pages 33861-33872.
Crossref
Patrick G. Needham & Jeffrey L. Brodsky. (2013) How early studies on secreted and membrane protein quality control gave rise to the ER associated degradation (ERAD) pathway: The early history of ERAD. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1833:11, pages 2447-2457.
Crossref
Laura J. Sharpe & Andrew J. Brown. (2013) Controlling Cholesterol Synthesis beyond 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGCR). Journal of Biological Chemistry 288:26, pages 18707-18715.
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Chandra L. Theesfeld & Randolph Y. Hampton. (2013) Insulin-induced Gene Protein (INSIG)-dependent Sterol Regulation of Hmg2 Endoplasmic Reticulum-associated Degradation (ERAD) in Yeast. Journal of Biological Chemistry 288:12, pages 8519-8530.
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Youngah Jo, Isamu Z. Hartman & Russell A. DeBose-Boyd. (2013) Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet–associated endoplasmic reticulum membranes. Molecular Biology of the Cell 24:3, pages 169-183.
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Michael L. Nickerson, Allen D. Bosley, Jayne S. Weiss, Brittany N. Kostiha, Yoshihisa Hirota, Wolfgang Brandt, Dominic Esposito, Shigeru Kinoshita, Ludger Wessjohann, Scott G. Morham, Thorkell Andresson, Howard S. Kruth, Toshio Okano & Michael Dean. (2013) The UBIAD1 Prenyltransferase Links Menaquione-4 Synthesis to Cholesterol Metabolic Enzymes. Human Mutation 34:2, pages 317-329.
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Xu Xiao & Bao-Liang Song. (2013) SREBP: a novel therapeutic target. Acta Biochimica et Biophysica Sinica 45:1, pages 2-10.
Crossref
Roberto Bravo, Valentina Parra, Damián Gatica, Andrea E. Rodriguez, Natalia Torrealba, Felipe Paredes, Zhao V. Wang, Antonio Zorzano, Joseph A. Hill, Enrique Jaimovich, Andrew F.G. Quest & Sergio Lavandero. 2013. 215 290 .
P.J. Espenshade. 2013. Encyclopedia of Biological Chemistry. Encyclopedia of Biological Chemistry 516 520 .
Amitabha Das, Sook-Hee Lee, Tae Kyung Hyun, Seon-Won Kim & Jae-Yean Kim. (2012) Plant volatiles as method of communication. Plant Biotechnology Reports 7:1, pages 9-26.
Crossref
Yien Che Tsai, Gil S. Leichner, Margaret M. P. Pearce, Gaye Lynn Wilson, Richard J. H. Wojcikiewicz, Joseph Roitelman & Allan M. Weissman. (2012) Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system. Molecular Biology of the Cell 23:23, pages 4484-4494.
Crossref
Anna M. Taylor, Bing Liu, Yelenis Mari, Benny Liu & Joyce J. Repa. (2012) Cyclodextrin mediates rapid changes in lipid balance in Npc1 mice without carrying cholesterol through the bloodstream. Journal of Lipid Research 53:11, pages 2331-2342.
Crossref
Randolph Y Hampton & Thomas Sommer. (2012) Finding the will and the way of ERAD substrate retrotranslocation. Current Opinion in Cell Biology 24:4, pages 460-466.
Crossref
Sumana Raychaudhuri, Barry P Young, Peter J Espenshade & Christopher JR Loewen. (2012) Regulation of lipid metabolism: a tale of two yeasts. Current Opinion in Cell Biology 24:4, pages 502-508.
Crossref
Reem Smoum, Abraham Rubinstein, Valery M. Dembitsky & Morris Srebnik. (2012) Boron Containing Compounds as Protease Inhibitors. Chemical Reviews 112:7, pages 4156-4220.
Crossref
Luke J. Engelking, Matthew R. McFarlane, Christina K. Li & Guosheng Liang. (2012) Blockade of cholesterol absorption by ezetimibe reveals a complex homeostatic network in enterocytes. Journal of Lipid Research 53:7, pages 1359-1368.
Crossref
Andrew J. Brown. (2012) Cholesterol versus other sterols: How do they compare as physiological regulators of cholesterol homeostasis?. European Journal of Lipid Science and Technology 114:6, pages 617-623.
Crossref
Agata A. Bielska, Paul Schlesinger, Douglas F. Covey & Daniel S. Ory. (2012) Oxysterols as non-genomic regulators of cholesterol homeostasis. Trends in Endocrinology & Metabolism 23:3, pages 99-106.
Crossref
Mi-Jurng Kim & Wendy Jessup. (2012) Protein turnover regulated by cholesterol. Current Opinion in Lipidology 23:1, pages 76-77.
Crossref
Dennis M. Peffley & Patricia Hentosh. 2012. Natural compounds as inducers of cell death. Natural compounds as inducers of cell death 373 400 .
Hong Wang, Ghanashyam Sarikonda, Kia-Joo Puan, Yoshimasa Tanaka, Ju Feng, José-Luis Giner, Rong Cao, Jukka Mönkkönen, Eric Oldfield & Craig T. Morita. (2011) Indirect Stimulation of Human Vγ2Vδ2 T Cells through Alterations in Isoprenoid Metabolism. The Journal of Immunology 187:10, pages 5099-5113.
Crossref
John S. Burg & Peter J. Espenshade. (2011) Regulation of HMG-CoA reductase in mammals and yeast. Progress in Lipid Research 50:4, pages 403-410.
Crossref
Gil S. Leichner, Rachel Avner, Dror Harats & Joseph Roitelman. (2011) Metabolically Regulated Endoplasmic Reticulum-associated Degradation of 3-Hydroxy-3-methylglutaryl-CoA Reductase. Journal of Biological Chemistry 286:37, pages 32150-32161.
Crossref
John S. Burg & Peter J. Espenshade. (2011) Glucose Controls Phosphoregulation of Hydroxymethylglutaryl Coenzyme A Reductase through the Protein Phosphatase 2A-related Phosphatase Protein, Ppe1, and Insig in Fission Yeast. Journal of Biological Chemistry 286:31, pages 27139-27146.
Crossref
Chandra L. Theesfeld, Deeba Pourmand, Talib Davis, Renee M. Garza & Randolph Y. Hampton. (2011) The Sterol-sensing Domain (SSD) Directly Mediates Signal-regulated Endoplasmic Reticulum-associated Degradation (ERAD) of 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase Isozyme Hmg2. Journal of Biological Chemistry 286:30, pages 26298-26307.
Crossref
Poulomi Acharya, Mingxiang Liao, Juan C. Engel & Maria Almira Correia. (2011) Liver Cytochrome P450 3A Endoplasmic Reticulum-associated Degradation. Journal of Biological Chemistry 286:5, pages 3815-3828.
Crossref

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