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Review Article

The compartmentalization and translocation of the sphingosine kinases: Mechanisms and functions in cell signaling and sphingolipid metabolism

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Pages 365-375 | Received 11 Mar 2011, Accepted 07 Apr 2011, Published online: 25 Aug 2011

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Dharini van der Hoeven, Kwang-jin Cho, Yong Zhou, Xiaoping Ma, Wei Chen, Ali Naji, Dina Montufar-Solis, Yan Zuo, Sarah E. Kovar, Kandice R. Levental, Jeffrey A. Frost, Ransome van der Hoeven & John F. Hancock. (2018) Sphingomyelin Metabolism Is a Regulator of K-Ras Function. Molecular and Cellular Biology 38:3.
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M. S. Neiband, A. Mani-Varnosfaderani & A. Benvidi. (2017) Classification of sphingosine kinase inhibitors using counter propagation artificial neural networks: A systematic route for designing selective SphK inhibitors. SAR and QSAR in Environmental Research 28:2, pages 91-109.
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Hui Yan, Hu Zhao, Shao-wei Yi, Hang Zhuang, Dao-wen Wang, Jian-gang Jiang & Gui-fen Shen. (2022) Sphingosine-1-Phosphate Protects Against the Development of Cardiac Remodeling via Sphingosine Kinase 2 and the S1PR2/ERK Pathway. Current Medical Science 42:4, pages 702-710.
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Alhaji H. Janneh & Besim Ogretmen. (2022) Targeting Sphingolipid Metabolism as a Therapeutic Strategy in Cancer Treatment. Cancers 14:9, pages 2183.
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U. A. Gutner & M. A. Shupik. (2021) The Role of Sphingosine-1-Phosphate in Neurodegenerative Diseases. Russian Journal of Bioorganic Chemistry 47:6, pages 1155-1171.
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Saad A. Khan, Kayla F. Goliwas & Jessy S. Deshane. (2021) Sphingolipids in Lung Pathology in the Coronavirus Disease Era: A Review of Sphingolipid Involvement in the Pathogenesis of Lung Damage. Frontiers in Physiology 12.
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Olga A. Sukocheva, Dong Gui Hu, Robyn Meech & Anupam Bishayee. (2021) Divergence of Intracellular Trafficking of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Receptor 3 in MCF-7 Breast Cancer Cells and MCF-7-Derived Stem Cell-Enriched Mammospheres. International Journal of Molecular Sciences 22:9, pages 4314.
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Tiandi Ding, Ying Zhi, Weilin Xie, Qingqiang Yao & Bo Liu. (2021) Rational design of SphK inhibitors using crystal structures aided by computer. European Journal of Medicinal Chemistry 213, pages 113164.
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Fabiola N. Velazquez, Maria Hernandez-Corbacho, Magali Trayssac, Jeffrey L. Stith, Joseph Bonica, Bernandie Jean, Michael J. Pulkoski-Gross, Brittany L. Carroll, Mohamed F. Salama, Yusuf A. Hannun & Ashley J. Snider. (2021) Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid. Cellular Signalling 79, pages 109875.
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Kira Vanessa Blankenbach, Ralf Frederik Claas, Natalie Judith Aster, Anna Katharina Spohner, Sandra Trautmann, Nerea Ferreirós, Justin L. Black, John J. G. Tesmer, Stefan Offermanns, Thomas Wieland & Dagmar Meyer zu Heringdorf. (2020) Dissecting Gq/11-Mediated Plasma Membrane Translocation of Sphingosine Kinase-1. Cells 9:10, pages 2201.
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E. Jozefczuk, T.J. Guzik & M. Siedlinski. (2020) Significance of sphingosine-1-phosphate in cardiovascular physiology and pathology. Pharmacological Research 156, pages 104793.
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Jinmiao Zhang, Maoyu Zhang, Jinying Yu, Yanguo Shang, Kaixuan Jiang, Yihe Jia, Jinxin Wang & Kan Yang. (2020) Investigating the binding mechanism of sphingosine kinase 1/2 inhibitors: Insights into subtype selectivity by homology modeling, molecular dynamics simulation and free energy calculation studies. Journal of Molecular Structure 1208, pages 127900.
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Laura Riboni, Loubna Abdel Hadi, Stefania Elena Navone, Laura Guarnaccia, Rolando Campanella & Giovanni Marfia. (2020) Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer Hallmarks. Cells 9:2, pages 337.
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Kan Yang, Kaixuan Jiang, Zhengwen Xu, Yali Song & Jinxin Wang. (2019) Targeting sphingosine kinase 1 for the treatment of pulmonary arterial hypertension. Future Medicinal Chemistry 11:22, pages 2939-2953.
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Zijian Fang, Susan Pyne & Nigel J. Pyne. (2019) WITHDRAWN: Ceramide and Sphingosine 1-Phosphate in adipose dysfunction. Progress in Lipid Research, pages 100991.
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Zijian Fang, Susan Pyne & Nigel J. Pyne. (2019) Ceramide and sphingosine 1-phosphate in adipose dysfunction. Progress in Lipid Research 74, pages 145-159.
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Marcela Vettorazzi, Laura Vila, Santiago Lima, Lina Acosta, Felipe Yépes, Alirio Palma, Justo Cobo, Jan Tengler, Ivan Malik, Sergio Alvarez, Patrice Marqués, Nuria Cabedo, María J. Sanz, Josef Jampilek, Sarah Spiegel & Ricardo D. Enriz. (2019) Synthesis and biological evaluation of sphingosine kinase 2 inhibitors with anti-inflammatory activity. Archiv der Pharmazie 352:3, pages 1800298.
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Heidi A. Neubauer, Melinda N. Tea, Julia R. Zebol, Briony L. Gliddon, Cassandra Stefanidis, Paul A. B. Moretti, Melissa R. Pitman, Maurizio Costabile, Jasreen Kular, Brett W. Stringer, Bryan W. Day, Michael S. Samuel, Claudine S. Bonder, Jason A. Powell & Stuart M. Pitson. (2018) Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma. Oncogene 38:8, pages 1151-1165.
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Sungjin Kim & Derek Sieburth. (2018) Sphingosine Kinase Activates the Mitochondrial Unfolded Protein Response and Is Targeted to Mitochondria by Stress. Cell Reports 24:11, pages 2932-2945.e4.
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Kirsi Riento, Qifeng Zhang, Jonathan Clark, Farida Begum, Elaine Stephens, Michael J. Wakelam & Benjamin J. Nichols. (2018) Flotillin proteins recruit sphingosine to membranes and maintain cellular sphingosine-1-phosphate levels. PLOS ONE 13:5, pages e0197401.
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Burkhard Kleuser. (2018) Divergent Role of Sphingosine 1-Phosphate in Liver Health and Disease. International Journal of Molecular Sciences 19:3, pages 722.
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Clayton S. Lewis, Christina Voelkel-Johnson & Charles D. Smith. 2018. Sphingolipids in Cancer. Sphingolipids in Cancer 295 325 .
Diana Hatoum, Nahal Haddadi, Yiguang Lin, Najah T. Nassif & Eileen M. McGowan. (2017) Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget. Oncotarget 8:22, pages 36898-36929.
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Mei Li Ng, Carol Wadham & Olga A. Sukocheva. (2017) The role of sphingolipid signalling in diabetes-associated pathologies (Review). International Journal of Molecular Medicine 39:2, pages 243-252.
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Rafael Custódio, Christopher J. McLean, Andrew E. Scott, Jonathan Lowther, Amanda Kennedy, David J. Clarke, Dominic J. Campopiano, Mitali Sarkar‐Tyson & Alan R. Brown. (2016) Characterization of secreted sphingosine‐1‐phosphate lyases required for virulence and intracellular survival of Burkholderia pseudomallei . Molecular Microbiology 102:6, pages 1004-1019.
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Heidi A. Neubauer, Duyen H. Pham, Julia R. Zebol, Paul A.B. Moretti, Amanda L. Peterson, Tamara M. Leclercq, Huasheng Chan, Jason A. Powell, Melissa R. Pitman, Michael S. Samuel, Claudine S. Bonder, Darren J. Creek, Briony L. Gliddon & Stuart M. Pitson. (2016) An oncogenic role for sphingosine kinase 2. Oncotarget 7:40, pages 64886-64899.
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David R. Adams, Susan Pyne & Nigel J. Pyne. (2016) Sphingosine Kinases: Emerging Structure–Function Insights. Trends in Biochemical Sciences 41:5, pages 395-409.
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David P. Dimasi, Stuart M. Pitson & Claudine S. Bonder. (2016) Examining the Role of Sphingosine Kinase-2 in the Regulation of Endothelial Cell Barrier Integrity. Microcirculation 23:3, pages 248-265.
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H. Yu, C. Sun & K. M. Argraves. (2016) Periodontal inflammation and alveolar bone loss induced by Aggregatibacter actinomycetemcomitans is attenuated in sphingosine kinase 1-deficient mice . Journal of Periodontal Research 51:1, pages 38-49.
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Mohamad M. Adada, Daniel Canals, Nara Jeong, Ashwin D. Kelkar, Maria Hernandez‐Corbacho, Michael J. Pulkoski‐Gross, Jane C. Donaldson, Yusuf A. Hannun & Lina M. Obeid. (2015) Intracellular sphingosine kinase 2‐derived sphingosine‐1‐phosphate mediates epidermal growth factor‐induced ezrin‐radixin‐moesin phosphorylation and cancer cell invasion. The FASEB Journal 29:11, pages 4654-4669.
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Ilari Pulli, Tomas Blom, Christoffer Löf, Melissa Magnusson, Alessandro Rimessi, Paolo Pinton & Kid Törnquist. (2015) A novel chimeric aequorin fused with caveolin-1 reveals a sphingosine kinase 1-regulated Ca2+ microdomain in the caveolar compartment. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1853:9, pages 2173-2182.
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Jastrow Canlas, Phillip Holt, Alexander Carroll, Shane Rix, Paul Ryan, Lorena Davies, Dusan Matusica, Stuart M. Pitson, Claire F. Jessup, Ian L. Gibbins & Rainer V. Haberberger. (2015) Sphingosine kinase 2-deficiency mediated changes in spinal pain processing. Frontiers in Molecular Neuroscience 8.
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Mohamed F. Salama, Brittany Carroll, Mohamad Adada, Michael Pulkoski‐Gross, Yusuf A. Hannun & Lina M. Obeid. (2015) A novel role of sphingosine kinase‐1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma. The FASEB Journal 29:7, pages 2803-2813.
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Kazuyuki Kitatani, Makoto Taniguchi & Toshiro Okazaki. (2015) Role of Sphingolipids and Metabolizing Enzymes in Hematological Malignancies. Molecules and Cells 38:6, pages 482-495.
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Patrick MünzerEvi SchmidBritta WalkerAnna Fotinos, Madhumita Chatterjee, Dominik Rath, Sebastian Vogel, Sascha M. Hoffmann, Katja Metzger, Peter Seizer, Tobias Geisler, Meinrad Gawaz, Oliver Borst & Florian Lang. (2014) Sphingosine kinase 1 (Sphk1) negatively regulates platelet activation and thrombus formation. American Journal of Physiology-Cell Physiology 307:10, pages C920-C927.
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Shangang Zhao, Yves Mugabo, Jose Iglesias, Li Xie, Viviane Delghingaro-Augusto, Roxane Lussier, Marie-Line Peyot, Erik Joly, Bouchra Taïb, Matthew A. Davis, J. Mark Brown, Abdelkarim Abousalham, Herbert Gaisano, S.R. Murthy Madiraju & Marc Prentki. (2014) α/β-Hydrolase Domain-6-Accessible Monoacylglycerol Controls Glucose-Stimulated Insulin Secretion. Cell Metabolism 19:6, pages 993-1007.
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Heidi A. Neubauer & Stuart M. Pitson. (2013) Roles, regulation and inhibitors of sphingosine kinase 2. FEBS Journal 280:21, pages 5317-5336.
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Darin J. Gustin, Yihong Li, Matthew L. Brown, Xiaoshan Min, Mike J. Schmitt, Malgorzata Wanska, Xiaodong Wang, Richard Connors, Sheere Johnstone, Mario Cardozo, Alan C. Cheng, Shawn Jeffries, Brendon Franks, Shyun Li, Shanling Shen, Mariwil Wong, Holger Wesche, Guifen Xu, Timothy J. Carlson, Matthew Plant, Kurt Morgenstern, Karen Rex, Joanna Schmitt, Angela Coxon, Nigel Walker, Frank Kayser & Zhulun Wang. (2013) Structure guided design of a series of sphingosine kinase (SphK) inhibitors. Bioorganic & Medicinal Chemistry Letters 23:16, pages 4608-4616.
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Jillian M. Carr, Suresh Mahalingam, Claudine S. Bonder & Stuart M. Pitson. (2012) Sphingosine kinase 1 in viral infections. Reviews in Medical Virology 23:2, pages 73-84.
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Kai Liu, Tai L. Guo, Nitai C. Hait, Jeremy Allegood, Hardik I. Parikh, Wenfang Xu, Glen E. Kellogg, Steven Grant, Sarah Spiegel & Shijun Zhang. (2013) Biological Characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a Selective Sphingosine Kinase-2 Inhibitor and Anticancer Agent. PLoS ONE 8:2, pages e56471.
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K. Alexa Orr Gandy & Lina M. Obeid. (2013) Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: Review of sphingosine kinase inhibitors. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1831:1, pages 157-166.
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K. Alexa Orr Gandy & Lina M. Obeid. 2013. Sphingolipids in Disease. Sphingolipids in Disease 275 303 .

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