Advanced search
Publication Cover
Critical Reviews in Biochemistry and Molecular Biology Volume 51, 2016 - Issue 4
Submit an article Journal homepage
872
Views
18
CrossRef citations to date
0
Altmetric
Review Article

Drugging the undruggable: gabapentin, pregabalin and the calcium channel α2δ subunit

James OffordDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USACorrespondence[email protected]
&
Lori L. IsomDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA
Pages 246-256 | Received 30 Sep 2015, Accepted 29 Mar 2016, Published online: 25 Apr 2016

Citations (18)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Sarah B. Riley, Kelsie Garbutt, Chelsea Crow, T. Scott Isbell & Anthony J. Scalzo. (2021) Gabapentin prevalence: clinical and forensic experience in St. Louis, Missouri, USA. Forensic Sciences Research 6:3, pages 218-223.
Read now
Xi’an Dong, Yuantao Liu, Qianqian Yang, Zhaobin Liu & Zipu Zhang. (2021) Comparison of therapeutic effects of continuous epidural nerve block combined with drugs on postherpetic neuralgia. International Journal of Neuroscience 131:2, pages 191-195.
Read now

Articles from other publishers (16)

Xi-long Jin, Bao-hua Song, Xu-dong Zhao & Guang-biao Huang. (2022) Neonatal outcomes after gamma-aminobutyric acid analog use during pregnancy: a meta-analysis of cohort studies. European Journal of Clinical Pharmacology 78:11, pages 1739-1747.
Crossref
Inês Pinho, Cindy Santos, Inês Brito, João Coelho, Vítor Simões-Silva & António Marques. 2022. Digital Therapies in Psychosocial Rehabilitation and Mental Health. Digital Therapies in Psychosocial Rehabilitation and Mental Health 281 301 .
Minji Jeon, Kathleen M. Jagodnik, Eryk Kropiwnicki, Daniel J. Stein & Avi Ma’ayan. (2021) Prioritizing Pain-Associated Targets with Machine Learning. Biochemistry 60:18, pages 1430-1446.
Crossref
Soon‐Tae Lee, Byoung Joo Lee, Ji‐Yeon Bae, Young Sook Kim, Do‐Hyun Han, Hyun‐Sook Shin, Soyun Kim, Dong‐Kyu Park, Sang Won Seo, Kon Chu, Sang Kun Lee & Won‐Kyung Ho. (2021) Ca V α2δ Autoimmune Encephalitis: A Novel Antibody and its Characteristics . Annals of Neurology 89:4, pages 740-752.
Crossref
Hermann AM Mucke. (2020) Patent highlights April–May 2020. Pharmaceutical Patent Analyst 9:5, pages 139-146.
Crossref
Caroline E. Black, Eugene Zhou, Caitlin M. DeAngelo, Isaac Asante, Stan G. Louie, Nicos A. Petasis & Mark S. Humayun. (2020) Cyanine Nanocages Activated by Near-Infrared Light for the Targeted Treatment of Traumatic Brain Injury. Frontiers in Chemistry 8.
Crossref
Santanu Mallik & Pratap Chandra Acharya. 2020. Frontiers in Pharmacology of Neurotransmitters. Frontiers in Pharmacology of Neurotransmitters 683 721 .
Pieter S. Siebenga, Guido Amerongen, Pieter Okkerse, William S. Denney, Pinky Dua, Richard P. Butt, Justin L. Hay & Geert J. Groeneveld. (2019) Reproducibility of a battery of human evoked pain models to detect pharmacological effects of analgesic drugs. European Journal of Pain 23:6, pages 1129-1140.
Crossref
Fructuoso Ayala-Guerrero, Graciela Mexicano, Carlos A. Gutiérrez-Chávez, Legna Alejandra Lazo & Erik Leonardo Mateos. (2019) Effect of gabapentin on sleep patterns disturbed by epilepsy. Epilepsy & Behavior 92, pages 290-296.
Crossref
Tianhua Feng, Subha Kalyaanamoorthy & Khaled Barakat. 2018. Ion Channels in Health and Sickness. Ion Channels in Health and Sickness.
Martin Kotev, Rosalia Pascual, Carmen Almansa, Victor Guallar & Robert Soliva. (2018) Pushing the Limits of Computational Structure-Based Drug Design with a Cryo-EM Structure: The Ca 2+ Channel α2δ-1 Subunit as a Test Case . Journal of Chemical Information and Modeling 58:8, pages 1707-1715.
Crossref
Sascha R. A. Alles & Peter A. Smith. (2018) Etiology and Pharmacology of Neuropathic Pain. Pharmacological Reviews 70:2, pages 315-347.
Crossref
Nada M. Hamada, Rehab H. Ashour, Amany A. Shalaby & Hussien M. El-Beltagi. (2018) Calcitonin potentiates the anticonvulsant and antinociceptive effects of valproic acid and pregabalin in pentylenetetrazole-kindled mice. European Journal of Pharmacology 818, pages 351-355.
Crossref
Jorge Vidaurre, Satyanarayana Gedela & Shannon Yarosz. (2017) Antiepileptic Drugs and Liver Disease. Pediatric Neurology 77, pages 23-36.
Crossref
Beatriz Godínez-Chaparro, Geovanna Nallely Quiñonez-Bastidas, Isabel Rocío Rojas-Hernández, Amaya Montserrat Austrich-Olivares & Alfonso Mata-Bermudez. (2017) Synergistic Interaction of a Gabapentin- Mangiferin Combination in Formalin-Induced Secondary Mechanical Allodynia and Hyperalgesia in Rats Is Mediated by Activation of NO-Cyclic GMP-ATP-Sensitive K + Channel Pathway . Drug Development Research 78:8, pages 390-402.
Crossref
H.C. Stephen Chan, Dillon McCarthy, Jianing Li, Krzysztof Palczewski & Shuguang Yuan. (2017) Designing Safer Analgesics via μ-Opioid Receptor Pathways. Trends in Pharmacological Sciences 38:11, pages 1016-1037.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.