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Original Article

Activating Mutations of c-Kit at Codon 816 Confer Drug Resistance in Human Leukemia Cells

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Pages 513-522 | Received 08 Aug 2000, Published online: 01 Jul 2009

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Muneera Al-Hussaini & John F DiPersio. (2014) Small molecule inhibitors in acute myeloid leukemia: from the bench to the clinic. Expert Review of Hematology 7:4, pages 439-464.
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Kaja Rupar, Sausan A. Moharram, Julhash U. Kazi & Lars Rönnstrand. (2018) SRC-like adaptor protein 2 (SLAP2) is a negative regulator of KIT-D816V-mediated oncogenic transformation. Scientific Reports 8:1.
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Suzanne Dufresne, Amélie Rébillard, Paola Muti, Christine M. Friedenreich & Darren R. Brenner. (2018) A Review of Physical Activity and Circulating miRNA Expression: Implications in Cancer Risk and Progression. Cancer Epidemiology, Biomarkers & Prevention 27:1, pages 11-24.
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S Agarwal, J U Kazi, S Mohlin, S Påhlman & L Rönnstrand. (2014) The activation loop tyrosine 823 is essential for the transforming capacity of the c-Kit oncogenic mutant D816V. Oncogene 34:35, pages 4581-4590.
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Damian Szatkowski & Andrzej Hellmann. (2015) The Overexpression of <b><i>KIT</i></b> Proto-Oncogene in Acute Leukemic Cells Is Not Necessarily Caused by the Gene Mutation. Acta Haematologica 133:1, pages 116-123.
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J Sun, S Mohlin, A Lundby, J U Kazi, U Hellman, S Påhlman, J V Olsen & L Rönnstrand. (2013) The PI3-kinase isoform p110δ is essential for cell transformation induced by the D816V mutant of c-Kit in a lipid-kinase-independent manner. Oncogene 33:46, pages 5360-5369.
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Isaure Chauvot de Beauchêne, Ariane Allain, Nicolas Panel, Elodie Laine, Alain Trouvé, Patrice Dubreuil & Luba Tchertanov. (2014) Hotspot Mutations in KIT Receptor Differentially Modulate Its Allosterically Coupled Conformational Dynamics: Impact on Activation and Drug Sensitivity. PLoS Computational Biology 10:7, pages e1003749.
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Robert J. Arceci & Soheil Meshinchi. 2011. Childhood Leukemia. Childhood Leukemia 63 76 .
Robert J. Arceci & Donald Small. 2010. Molecularly Targeted Therapy for Childhood Cancer. Molecularly Targeted Therapy for Childhood Cancer 59 82 .
Óscar Fuster, Eva Barragán, Pascual Bolufer, José Cervera, Maria José Larráyoz, Antonio Jiménez-Velasco, Joaquín Martínez-López, Ana Valencia, Federico Moscardó & Miguel Ángel Sanz. (2009) Rapid Detection of KIT Mutations in Core-Binding Factor Acute Myeloid Leukemia Using High-Resolution Melting Analysis. The Journal of Molecular Diagnostics 11:5, pages 458-463.
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Jianmin Sun, Malin Pedersen & Lars Rönnstrand. (2009) The D816V Mutation of c-Kit Circumvents a Requirement for Src Family Kinases in c-Kit Signal Transduction. Journal of Biological Chemistry 284:17, pages 11039-11047.
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Sofia Pérez-Gutiérrez, Ricardo González-Cámpora, Joaquín Amérigo-Navarro, Antonio Beato-Moreno, Maria Sánchez-León, María Jesús Pareja Megía, Juan Antonio Virizuela-Echaburu & Antonio López-Beltrán. (2007) Expression of P-glycoprotein and metallothionein in gastrointestinal stromal tumor and leiomyosarcomas. Clinical implications. Pathology & Oncology Research 13:3, pages 203-208.
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Angela Tan, David Westerman, Grant A McArthur, Kevin Lynch, Paul Waring & Alexander Dobrovic. (2006) Sensitive Detection of KIT D816V in Patients with Mastocytosis. Clinical Chemistry 52:12, pages 2250-2257.
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Anjali S. Advani. (2006) Targeting the c-kit receptor in the treatment of acute myelogenous leukemia. Current Hematologic Malignancy Reports 1:2, pages 101-107.
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Jacques P. Zappulla, Patrice Dubreuil, Sabine Desbois, Sébastien Létard, Nadine Ben Hamouda, Marc Daëron, Georges Delsol, Michel Arock & Roland S. Liblau. (2005) Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation. The Journal of Experimental Medicine 202:12, pages 1635-1641.
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Trevor LucasBarbara PratscherDieter FinkMarkus WolschekPuchit SamorapoompichitChristian SchöferHubert PehambergerMarkus MüllerPoul SorensenBurkhard Jansen. (2005) The Human Orthologue of a Novel Apoptosis Response Gene Induced During Rat Myelomonocytic Stem Cell Apoptosis Maps to 20q13.12. Stem Cells and Development 14:5, pages 556-563.
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B F Goemans, Ch M Zwaan, M Miller, M Zimmermann, A Harlow, S Meshinchi, A H Loonen, K Hählen, D Reinhardt, U Creutzig, G J L Kaspers & M C Heinrich. (2005) Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia. Leukemia 19:9, pages 1536-1542.
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Tanya JelacicDiana Linnekin. (2005) PKCδ plays opposite roles in growth mediated by wild-type Kit and an oncogenic Kit mutant. Blood 105:5, pages 1923-1929.
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Rowan Foster, Renate Griffith, Petranel Ferrao & Leonie Ashman. (2004) Molecular basis of the constitutive activity and STI571 resistance of Asp816Val mutant KIT receptor tyrosine kinase. Journal of Molecular Graphics and Modelling 23:2, pages 139-152.
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Anette Duensing, Fabiola Medeiros, Bryna McConarty, Nora E Joseph, Dipak Panigrahy, Samuel Singer, Christopher DM Fletcher, George D Demetri & Jonathan A Fletcher. (2004) Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs). Oncogene 23:22, pages 3999-4006.
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David W. Sternberg & D. Gary Gilliland. (2004) The Role of Signal Transducer and Activator of Transcription Factors in Leukemogenesis. Journal of Clinical Oncology 22:2, pages 361-371.
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Seyed JALAL HOSSEINIMEHR, Osamu INANAMI, Taku HAMASU, Momoko TAKAHASHI, Ikuo KASHIWAKURA, Taketoshi ASANUMA & Mikinori KUWABARA. (2004) Activation of C-Kit by Stem Cell Factor Induces Radioresistance to Apoptosis through ERK-dependent Expression of Survivin in HL60 Cells. Journal of Radiation Research 45:4, pages 557-561.
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Kathleen Kemmer, Christopher L. Corless, Jonathan A. Fletcher, Laura McGreevey, Andrea Haley, Diana Griffith, Oscar W. Cummings, Cecily Wait, Ajia Town & Michael C. Heinrich. (2004) KIT Mutations Are Common in Testicular Seminomas. The American Journal of Pathology 164:1, pages 305-313.
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Soheil Meshinchi, Franklin O. Smith & Robert J. Arceci. (2003) Prognostic factors and risk-based therapy in pediatric acute myeloid leukemia. Current Oncology Reports 5:6, pages 489-497.
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F Lorenzo V, K Nishii, E Usui, N Katayama & H Shiku. (2003) Reply to SE Langabeer et al. Leukemia 17:9, pages 1915-1916.
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S E Langabeer, A Beghini & L Larizza. (2003) AML with t(8;21) and trisomy 4: possible involvement of c-kit?. Leukemia 17:9, pages 1915-1915.
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Soheil MeshinchiDerek L. StirewaltTodd A. AlonzoQuangeng ZhangDavid A. SweetserWilliam G. WoodsIrwin D. BernsteinRobert J. ArceciJerald P. Radich. (2003) Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia. Blood 102:4, pages 1474-1479.
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Petranel T Ferrao, Thomas J Gonda & Leonie K Ashman. (2003) Constitutively active mutant D816VKit induces megakayocyte and mast cell differentiation of early haemopoietic cells from murine foetal liver. Leukemia Research 27:6, pages 547-555.
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Yoshinori Nio, Hiroshi Omori, Tomoko Toga, Koji Hashimoto, Masayuki Itakura, Makoto Koike, Seiji Yano & Tetsuya Higami. (2003) Immunohistochemical expression of receptor-tyrosine kinase c-kit protein in invasive ductal carcinoma of the pancreas. Anti-Cancer Drugs 14:4, pages 313-319.
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Robert J. Arceci & Timothy P. Cripe. (2002) Emerging cancer-targeted therapies. Pediatric Clinics of North America 49:6, pages 1339-1368.
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Francis J. Giles. (2002) New drugs in acute myeloid leukemia. Current Oncology Reports 4:5, pages 369-374.
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Robert J. Arceci. (2002) Progress and controversies in the treatment of pediatric acute myelogenous leukemia. Current Opinion in Hematology 9:4, pages 353-360.
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Blanca Scheijen & James D Griffin. (2002) Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease. Oncogene 21:21, pages 3314-3333.
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Ronald P. Dematteo, Michael C. Heinrich, Wa'el M. El-Rifai & George Demetri. (2002) Clinical management of gastrointestinal stromal tumors: Before and after STI-571. Human Pathology 33:5, pages 466-477.
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