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Leukemia & Lymphoma Volume 42, 2001 - Issue 3
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Original Article

Telomere Dynamics in Myelodysplastic Syndromes and Acute Leukemic Transformation

Kazuma Ohyashiki First Department of Internal Medicine, Tokyo Medical University, Tokyo, 160-0023, Japan; Department of Virology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 160-0023, JapanCorrespondence[email protected]
,
Hiroshi Iwama First Department of Internal Medicine, Tokyo Medical University, Tokyo, 160-0023, Japan; Department of Virology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 160-0023, Japan
,
Naoyuki Yahata First Department of Internal Medicine, Tokyo Medical University, Tokyo, 160-0023, Japan; Department of Virology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 160-0023, Japan
,
Tetsuzou Tauchi First Department of Internal Medicine, Tokyo Medical University, Tokyo, 160-0023, Japan; Department of Virology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 160-0023, Japan
,
Ken Kawakubo First Department of Internal Medicine, Tokyo Medical University, Tokyo, 160-0023, Japan; Department of Virology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 160-0023, Japan
,
Takashi Shimamoto First Department of Internal Medicine, Tokyo Medical University, Tokyo, 160-0023, Japan; Department of Virology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 160-0023, Japan
&
Junko H. Ohyashiki First Department of Internal Medicine, Tokyo Medical University, Tokyo, 160-0023, Japan; Department of Virology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 160-0023, Japan
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Pages 291-299 | Received 15 Dec 2000, Published online: 01 Jul 2009

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Judith Neukirchen, Rainer Haas & Ulrich Germing. (2009) Prognostic molecular markers in myelodysplastic syndromes. Expert Review of Hematology 2:5, pages 563-575.
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Michael Pfeilstöcker, Heidrun Karlic, Thomas Nösslinger, Wolfgang Sperr, Reinhard Stauder, Otto Krieger & Peter Valent. (2007) Myelodysplastic syndromes, aging, and age: Correlations, common mechanisms, and clinical implications. Leukemia & Lymphoma 48:10, pages 1900-1909.
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Ron Ram, Orit Uziel & Meir Lahav. (2005) The importance of the telomere and telomerase system in hematological malignancies. Leukemia & Lymphoma 46:8, pages 1121-1135.
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K. Ohshima, K. Karube, K. Shimazaki, H. Kamma, J. Suzumiya, M. Hamasaki & M. Kikuchi. (2003) Imbalance Between Apoptosis and Telomerase Activity in Myelodysplastic Syndromes: Possible Role in Ineffective Hemopoiesis. Leukemia & Lymphoma 44:8, pages 1339-1346.
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Articles from other publishers (30)

Kleoniki Roka, Elena E. Solomou & Antonis Kattamis. (2023) Telomere biology: from disorders to hematological diseases. Frontiers in Oncology 13.
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Hee Sue Park, Jungeun Choi, Cha-Ja See, Jung-Ah Kim, Si Nae Park, Kyongok Im, Sung-Min Kim, Dong Soon Lee & Sang Mee Hwang. (2017) Dysregulation of Telomere Lengths and Telomerase Activity in Myelodysplastic Syndrome. Annals of Laboratory Medicine 37:3, pages 195-203.
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Sang Mee Hwang, Seon Young Kim, Jung Ah Kim, Hee-Sue Park, Si Nae Park, Kyongok Im, Kwantae Kim, Sung-Min Kim & Dong Soon Lee. (2016) Short telomere length and its correlation with gene mutations in myelodysplastic syndrome. Journal of Hematology & Oncology 9:1.
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Peng Wang, Huifang Liu, Ting Jiang & Julun Yang. (2015) Cigarette Smoking and the Risk of Adult Myeloid Disease: A Meta-Analysis. PLOS ONE 10:9, pages e0137300.
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Salah Aref, Mohamed Sabry El-Ghonemy, Tarek Elsayed Abouzeid, Amr Mohamed El-Sabbagh & Mohamed Ali El-Baiomy. (2014) Telomerase reverse transcriptase (TERT) A1062T mutation as a prognostic factor in Egyptian patients with acute myeloid leukemia (AML). Medical Oncology 31:9.
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Antonella Poloni, Federica Serrani, Eleonora Berardinelli, Giulia Maurizi, Marianna Mariani, Benedetta Costantini, Silvia Trappolini, Stefania Mancini, Attilio Olivieri & Pietro Leoni. (2013) Telomere length, c-myc and mad-1 expression could represent prognosis markers of myelodysplastic syndrome. Leukemia Research 37:11, pages 1538-1544.
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E. Kjeldsen & M. Kallenbach. (2013) Duplication of Isodicentric Chromosome 13, idic(13)(p11.2), Leading to Pentasomy 13q in Acute Myeloid Leukemia without Maturation. Cytogenetic and Genome Research 140:1, pages 21-28.
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Macoura Gadji, Julius Adebayo Awe, Prerana Rodrigues, Rajat Kumar, Donald S. Houston, Ludger Klewes, Tandakha Ndiaye Dièye, Eduardo Magalhães Rego, Roberto Falcão Passetto, Fábio Morato de Oliveira & Sabine Mai. (2012) Profiling Three-Dimensional Nuclear Telomeric Architecture of Myelodysplastic Syndromes and Acute Myeloid Leukemia Defines Patient Subgroups. Clinical Cancer Research 18:12, pages 3293-3304.
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Ceri H. Jones, Chris Pepper & Duncan M. Baird. (2012) Telomere dysfunction and its role in haematological cancer. British Journal of Haematology 156:5, pages 573-587.
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Shahinaz M. Gadalla & Sharon A. Savage. (2011) Telomere biology in hematopoiesis and stem cell transplantation. Blood Reviews 25:6, pages 261-269.
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Moshe Mittelman, Howard S. Oster, Michael Hoffman & Drorit Neumann. (2010) The lower risk MDS patient at risk of rapid progression. Leukemia Research 34:12, pages 1551-1555.
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Chris PepperDuncan M Baird. (2010) Shortened telomeres: a driving force behind leukemia?. Future Oncology 6:11, pages 1681-1686.
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A. Mario Marcondes, Steven Bair, Peter S. Rabinovitch, Ted Gooley, H. Joachim Deeg & Rosana Risques. (2008) No telomere shortening in marrow stroma from patients with MDS. Annals of Hematology 88:7, pages 623-628.
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Laure Deville, Josette Hillion & Evelyne Ségal-Bendirdjian. (2009) Telomerase regulation in hematological cancers: A matter of stemness?. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1792:4, pages 229-239.
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Sujata ChakrabortyCan-Lan SunLiton FranciscoMelanie SabadoLiang LiKaren L. ChangStephen FormanSmita BhatiaRavi Bhatia. (2009) Accelerated Telomere Shortening Precedes Development of Therapy-Related Myelodysplasia or Acute Myelogenous Leukemia After Autologous Transplantation for Lymphoma. Journal of Clinical Oncology 27:5, pages 791-798.
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Sumaiyah K. Rehman, Gustavo Baldassarre, George A. Calin & Milena S. Nicoloso. (2009) MicroRNAs: The Jack of All Trades. Clinical Leukemia 3:1, pages 20-32.
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H. Ohyashiki Junko & Ohyashiki Kazuma. 2009. Telomeres and Telomerase in Cancer. Telomeres and Telomerase in Cancer 211 224 .
Mark W. Drummond, Stefan Balabanov, Tessa L. Holyoake & Tim H. Brummendorf. (2007) Concise Review: Telomere Biology in Normal and Leukemic Hematopoietic Stem Cells. Stem Cells 25:8, pages 1853-1861.
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David P. Steensma. 2007. Acute Myelogenous Leukemia. Acute Myelogenous Leukemia 97 131 .
Marcia Bellon, Abhik Datta, Megan Brown, Jean‐Francois Pouliquen, Pierre Couppie, Mirdad Kazanji & Christophe Nicot. (2006) Increased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T‐cell leukemia. International Journal of Cancer 119:9, pages 2090-2097.
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T H Brümmendorf & S Balabanov. (2006) Telomere length dynamics in normal hematopoiesis and in disease states characterized by increased stem cell turnover. Leukemia 20:10, pages 1706-1716.
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Zhenyu Ju & Karl Lenhard Rudolph. (2006) Telomeres and telomerase in cancer stem cells. European Journal of Cancer 42:9, pages 1197-1203.
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Emel Gürkan, Kahraman Tanrıverdi & Fikri Başlamışlı. (2005) Telomerase activity in myelodysplastic syndromes. Leukemia Research 29:10, pages 1131-1139.
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Frederik W. van Delft, Tony Bellotti, Zhiyuan Luo, Louise K. Jones, Naina Patel, Olga Yiannikouris, Alex S. Hill, Mike Hubank, Helena Kempski, Danielle Fletcher, Tracy Chaplin, Nicola Foot, Bryan D. Young, Ian M. Hann, Alex Gammerman & Vaskar Saha. (2005) Prospective gene expression analysis accurately subtypes acute leukaemia in children and establishes a commonality between hyperdiploidy and t(12;21) in acute lymphoblastic leukaemia. British Journal of Haematology 130:1, pages 26-35.
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Gian Matteo Rigolin, Matteo Della Porta, Anna Maria Bugli, Barbara Castagnari, Endri Mauro, Letizia Zenone Bragotti, Maria Ciccone, Antonio Cuneo & Gianluigi Castoldi. (2004) Flow cytometric detection of accelerated telomere shortening in myelodysplastic syndromes: correlations with aetiological and clinical-biological findings*. European Journal of Haematology 73:5, pages 351-358.
Crossref
Zuzana Sieglová, Soňa Žilovcová, Jaroslav Čermák, Hana Řı́hová, Dagmar Březinová, Renáta Dvořáková, Markéta Marková, Jacqueline Maaloufová, Jana Sajdová, Jana Březinová, Zuzana Zemanová & Kyra Michalová. (2004) Dynamics of telomere erosion and its association with genome instability in myelodysplastic syndromes (MDS) and acute myelogenous leukemia arising from MDS: a marker of disease prognosis?. Leukemia Research 28:10, pages 1013-1021.
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Oliver Bock, Ebru Serinsöz, Jerome Schlué & Hans Kreipe. (2004) Different expression levels of the telomerase catalytic subunit hTERT in myeloproliferative and myelodysplastic diseases. Leukemia Research 28:5, pages 457-460.
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Ngaire J. Elwood. (2017) Telomere Biology of Human Hematopoietic Stem Cells. Cancer Control 11:2, pages 77-85.
Crossref
David P. SteensmaVip ViprakasitAlex HendrickDavid K. GoffJoanne LeachRichard J. GibbonsDouglas R. Higgs. (2004) Deletion of the α-globin gene cluster as a cause of acquired α-thalassemia in myelodysplastic syndrome. Blood 103:4, pages 1518-1520.
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K.-K. Wong & R. A. DePinho. (2003) Walking the Telomere Plank Into Cancer. JNCI Journal of the National Cancer Institute 95:16, pages 1184-1186.
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