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Leukemia & Lymphoma Volume 52, 2011 - Issue 4
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Original Articles: Clinical

Phase II study of the tetrahydropyranyl adriamycin–cyclophosphamide, vincristine, and prednisolone regimen combined with rituximab as first-line treatment for elderly patients with diffuse large B-cell lymphoma

Senji KasaharaFirst Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
,
Takeshi HaraFirst Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
,
Hisashi TsurumiFirst Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, JapanCorrespondence[email protected]
,
Naoe GotoFirst Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
,
Jun-Ichi KitagawaDepartment of Hematology, Gifu Red-Cross Hospital, Gifu, Japan
,
Nobuhiro KanemuraFirst Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
,
Takeshi YoshikawaFirst Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
,
Hideko GotoDepartment of Internal Medicine, Kisogawa Municipal Hospital, Kisogawa, Japan
,
Kenji FukunoDivision of Hematology, Gifu Municipal Hospital, Gifu, Japan
,
Toshiki YamadaFirst Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
,
Michio SawadaDepartment of Hematology, Gifu Red-Cross Hospital, Gifu, Japan
,
Takeshi TakahashiDivision of Hematology, Gifu Municipal Hospital, Gifu, Japan
,
Tsuyoshi TakamiDepartment of Immunopathology, Gifu University Graduate School of Medicine, Gifu, Japan
&
Hisataka MoriwakiFirst Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
 show all
Pages 629-634 | Received 13 Sep 2010, Accepted 06 Jan 2011, Published online: 25 Mar 2011

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Sara Beygi, Santhosh Sadashiv, James B Reilly, Cyrus Khan & John Lister. (2018) Frontline treatment of diffuse large B-cell lymphoma in elderly: a systematic review of clinical trials in post-rituximab era. Leukemia & Lymphoma 59:12, pages 2847-2861.
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Yaran Wu, Zhenhong Ni, Xiaojing Yan, Xufang Dai, Changjiang Hu, Yingru Zheng, Fengtian He & Jiqin Lian. (2016) Targeting the MIR34C-5p-ATG4B-autophagy axis enhances the sensitivity of cervical cancer cells to pirarubicin. Autophagy 12:7, pages 1105-1117.
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Pier Luigi Zinzani, Massimo Federico, Stefano Oliva, Antonello Pinto, Luigi Rigacci, Giorgina Specchia, Alessandra Tucci & Umberto Vitolo. (2015) The more patients you treat, the more you cure: managing cardiotoxicity in the treatment of aggressive non-Hodgkin lymphoma. Leukemia & Lymphoma 56:1, pages 12-25.
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Soranobu Ninomiya, Takeshi Hara, Hisashi Tsurumi, Naoe Goto, Kuniaki Saito, Mitsuru Seishima, Tsuyoshi Takami & Hisataka Moriwaki. (2012) Indoleamine 2,3-dioxygenase expression and serum kynurenine concentrations in patients with diffuse large B-cell lymphoma. Leukemia & Lymphoma 53:6, pages 1143-1145.
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Hisashi Tsurumi, Takeshi Hara, Naoe Goto, Jun-Ichi Kitagawa, Nobuhiro Kanemura, Takeshi Yoshikawa, Senji Kasahara, Hideko Goto, Kenji Fukuno, Toshiki Yamada, Michio Sawada, Masahito Shimizu, Takeshi Takahashi, Tsuyoshi Takami & Hisataka Moriwaki. (2012) A phase II study of rituximab combined with pirarubicin–cyclophosphamide, vincristine and prednisolone regimen as first-line therapy for patients with indolent B-cell lymphoma. Leukemia & Lymphoma 53:2, pages 247-253.
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Articles from other publishers (18)

Takayuki Hiroi, Hiroki Hosoi, Kodai Kuriyama, Shogo Murata, Masaya Morimoto, Toshiki Mushino, Akinori Nishikawa, Shinobu Tamura & Takashi Sonoki. (2023) An evaluation based on relative treatment intensity in older patients treated with reduced-dose R-THP-COP therapy for diffuse large B-cell lymphoma: A multicenter retrospective cohort study. Journal of Geriatric Oncology 14:1, pages 101396.
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Hiroshi Nakamura, Takeshi Hara, Ryoko Mabuchi, Takuro Matsumoto, Nobuhiko Nakamura, Soranobu Ninomiya, Junichi Kitagawa, Nobuhiro Kanemura, Yusuke Kito, Tsuyoshi Takami, Tatsuhiko Miyazaki, Tamotsu Takeuchi, Masahito Shimizu & Hisashi Tsurumi. (2021) Clinical significance of oxidative stress for untreated patients with diffuse large B‑cell lymphoma. Molecular and Clinical Oncology 16:1.
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Alda Tavares & Ilídia Moreira. (2021) Diffuse large B-cell lymphoma in very elderly patients: Towards best tailored treatment – A systematic review. Critical Reviews in Oncology/Hematology 160, pages 103294.
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Takeshi Hara, Takeshi Yoshikawa, Hideko Goto, Michio Sawada, Toshiki Yamada, Kenji Fukuno, Senji Kasahara, Yuhei Shibata, Takuro Matsumoto, Ryoko Mabuchi, Nobuhiko Nakamura, Hiroshi Nakamura, Soranobu Ninomiya, Junichi Kitagawa, Nobuhiro Kanemura, Yasuhito Nannya, Naoki Katsumura, Takeshi Takahashi, Yusuke Kito, Tsuyoshi Takami, Tatsuhiko Miyazaki, Tamotsu Takeuchi, Masahito Shimizu & Hisashi Tsurumi. (2018) R-THP-COP versus R-CHOP in patients younger than 70 years with untreated diffuse large B cell lymphoma: A randomized, open-label, noninferiority phase 3 trial. Hematological Oncology 36:4, pages 638-644.
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Shinji Hasebe, Keiko Tanaka, Yoshihiro Miyake, Hiroaki Asai, Kazuto Takeuchi, Tomomi Fujii, Hitoshi Kawazoe, Kazushi Tanimoto, Jun Yamanouchi, Taichi Azuma, Masaki Yasukawa & Yoshihiro Yakushijin. (2018) Analysis of Clinical Factors and Mortality in Diffuse Large B-cell Lymphoma Patients Over or Under 80 Years of Age. International Journal of Gerontology 12:2, pages 100-104.
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Yuhei Shibata, Takeshi Hara, Takuro Matsumoto, Nobuhiko Nakamura, Hiroshi Nakamura, Soranobu Ninomiya, Junichi Kitagawa, Naoe Goto, Yasuhito Nannya, Hiroyasu Ito, Yusuke Kito, Tatsuhiko Miyazaki, Tamotsu Takeuchi, Kuniaki Saito, Mitsuru Seishima, Tsuyoshi Takami, Hisataka Moriwaki, Masahito Shimizu & Hisashi Tsurumi. (2017) Serum concentrations of l -kynurenine predict clinical outcomes of patients with peripheral T-cell lymphoma, not otherwise specified . Hematological Oncology 35:4, pages 637-644.
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Yuhei Shibata, Takeshi Hara, Senji Kasahara, Toshiki Yamada, Michio Sawada, Ryoko Mabuchi, Takuro Matsumoto, Nobuhiko Nakamura, Hiroshi Nakamura, Soranobu Ninomiya, Junichi Kitagawa, Nobuhiro Kanemura, Yusuke Kito, Naoe Goto, Tatsuhiko Miyazaki, Tsuyoshi Takami, Tamotsu Takeuchi, Masahito Shimizu & Hisashi Tsurumi. (2017) CHOP or THP-COP regimens in the treatment of newly diagnosed peripheral T-cell lymphoma, not otherwise specified: a comparison of doxorubicin and pirarubicin. Hematological Oncology 35:2, pages 163-171.
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Rui Zhu, Dan Lu, Yu-Waye Chu, Akiko Chai, Michelle Green, Nancy Zhang & Jin Yan Jin. (2017) Assessment of Correlation Between Early and Late Efficacy Endpoints to Identify Potential Surrogacy Relationships in Non-Hodgkin Lymphoma: a Literature-Based Meta-analysis of 108 Phase II and Phase III Studies. The AAPS Journal 19:3, pages 669-681.
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Hiroko Hayashi, Akio Suzuki, Koichi Ohata, Masashi Ishihara, Yushi Kubota, Ryo Kobayashi, Yuhei Shibata, Hiroshi Nakamura, Nobuhiko Nakamura, Junichi Kitagawa, Hisashi Tsurumi, Masahito Shimizu & Yoshinori Itoh. (2017) Control of Constipation in Patients Receiving CHOP or CHOP-Like Chemotherapy Regimens for Non-Hodgkin’s Lymphoma. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 40:5, pages 698-702.
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Masakazu Higuchi, Shoichi Sasaki, Shin-ichiro Kawadoko, Hikaru Uchiyama, Takaharu Yasui, Takashi Kamihira, Ken-ichi Aoki, Takakazu Sasaguri, Ryuji Nakano, Akihiko Uchiyama, Tsuyoshi Muta & Koichi Ohshima. (2015) Epstein–Barr virus-positive diffuse large B-cell lymphoma following acute myeloid leukemia: a common clonal origin indicated by chromosomal translocation t(3;4)(p25;q21). International Journal of Hematology 102:4, pages 482-487.
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Satoshi Okayama, Yoko Dote, Yukiji Takeda, Shiro Uemura, Shinichi Fujimoto & Yoshihiko Saito. (2012) Primary Cardiac Lymphoma: Echocardiography and F ‐18‐Fluorodeoxyglucose Positron Emission Tomography in Selection of a Biopsy Site . Echocardiography 30:1.
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Shui-er Zheng, Sang Xiong, Feng Lin, Guang-lei Qiao, Tao Feng, Zan Shen, Da-liu Min, Chun-ling Zhang & Yang Yao. (2012) Pirarubicin inhibits multidrug-resistant osteosarcoma cell proliferation through induction of G2/M phase cell cycle arrest. Acta Pharmacologica Sinica 33:6, pages 832-838.
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Nobuyuki Toshikuni, Takeshi Maeda & Yasunori Ueda. (2012) Do Hepatitis C Virus Genotypes Influence Liver Dysfunction following Rituximab-Containing Regimens in Patients with Diffuse Large B Cell Lymphoma?. Acta Haematologica 127:3, pages 178-181.
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