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Induction by lenalidomide and dexamethasone combination increases regulatory cells of patients with previously untreated multiple myeloma

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Pages 1406-1408 | Received 25 Aug 2010, Accepted 17 Dec 2011, Published online: 31 Jan 2012

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Dimitrios C. Ziogas, Evangelos Terpos, Maria Gavriatopoulou, Magdalini Migkou, Despoina Fotiou, Maria Roussou, Nikolaos Kanellias, Ioanna Tatouli, Evangelos Eleutherakis-Papaiakovou, Ioannis Panagiotidis, Ioannis Ntanasis-Stathopoulos, Efstathios Kastritis & Meletios A. Dimopoulos. (2018) Coexistence of leishmaniasis and multiple myeloma in the era of monoclonal antibody (anti-CD38 or anti-SLAMF7) containing triplets: one shared story of two exceptional cases. Leukemia & Lymphoma 59:4, pages 983-987.
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Junya Kuroda, Tsutomu Kobayashi & Masafumi Taniwaki. (2015) Prognostic indicators of lenalidomide for multiple myeloma: consensus and controversy. Expert Review of Anticancer Therapy 15:7, pages 787-804.
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Emmanuel Clave, Corinne Douay, Tereza Coman, Marc Busson, Caroline Bompoint, Helene Moins-Teisserenc, Salomé Glauzy, Maryvonnick Carmagnat, Norbert Claude Gorin, Antoine Toubert & Laurent Garderet. (2014) Lenalidomide consolidation and maintenance therapy after autologous stem cell transplant for multiple myeloma induces persistent changes in T-cell homeostasis. Leukemia & Lymphoma 55:8, pages 1788-1795.
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James Favaloro, Ross Brown, Esther Aklilu, Shihong Yang, Hayley Suen, Derek Hart, Phillip Fromm, John Gibson, Liane Khoo, P. Joy Ho & Douglas Joshua. (2014) Myeloma skews regulatory T and pro-inflammatory T helper 17 cell balance in favor of a suppressive state. Leukemia & Lymphoma 55:5, pages 1090-1098.
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Chitta S. Kasyapa, Taimur Sher & Asher A. Chanan-Khan. (2012) Multiple myeloma and immunomodulation: regulating the regulatory cells. Leukemia & Lymphoma 53:7, pages 1253-1254.
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Articles from other publishers (21)

Zhaoyun Liu, Xianghong Zhao, Hongli Shen, Xiaohan Liu, Xintong Xu & Rong Fu. (2023) Cellular immunity in the era of modern multiple myeloma therapy. International Journal of Cancer 153:8, pages 1436-1447.
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Matthew Ho, Alexander Xiao, Dongni Yi, Saurabh Zanwar & Giada Bianchi. (2022) Treating Multiple Myeloma in the Context of the Bone Marrow Microenvironment. Current Oncology 29:11, pages 8975-9005.
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Yukie Tsubokura, Hideaki Yoshimura, Atsushi Satake, Yutaro Nasa, Ryohei Tsuji, Tomoki Ito & Shosaku Nomura. (2022) Early administration of lenalidomide after allogeneic hematopoietic stem cell transplantation suppresses graft‐versus‐host disease by inhibiting T‐cell migration to the gastrointestinal tract. Immunity, Inflammation and Disease 10:9.
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Murali Janakiram, Nivedita Arora, Veronika Bachanova & Jeffrey S. Miller. (2022) Novel Cell and Immune Engagers in Optimizing Tumor- Specific Immunity Post-Autologous Transplantation in Multiple Myeloma. Transplantation and Cellular Therapy 28:2, pages 61-69.
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Christina Hadjiaggelidou & Eirini Katodritou. (2021) Regulatory T-Cells and Multiple Myeloma: Implications in Tumor Immune Biology and Treatment. Journal of Clinical Medicine 10:19, pages 4588.
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Matthew Ho, Chia Yin Goh, Ashish Patel, Susannah Staunton, Ronan O’Connor, Marc Godeau & Giada Bianchi. (2020) Role of the Bone Marrow Milieu in Multiple Myeloma Progression and Therapeutic Resistance. Clinical Lymphoma Myeloma and Leukemia 20:10, pages e752-e768.
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Palumbo, Parrinello, Giallongo, D’Amico, Zanghì, Puglisi, Conticello, Chiarenza, Tibullo, Raimondo & Romano. (2019) Monocytic Myeloid Derived Suppressor Cells in Hematological Malignancies. International Journal of Molecular Sciences 20:21, pages 5459.
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Caterina Lapenta, Simona Donati, Francesca Spadaro, Laura Lattanzi, Francesca Urbani, Iole Macchia, Paola Sestili, Massimo Spada, Maria Christina Cox, Filippo Belardelli & Stefano M. Santini. (2019) Lenalidomide improves the therapeutic effect of an interferon-α-dendritic cell-based lymphoma vaccine. Cancer Immunology, Immunotherapy 68:11, pages 1791-1804.
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Christina Hadjiaggelidou, Evdokia Mandala, Evangelos Terpos, Efthalia Yiannaki, Dimitra Markala, Theodora Triantafyllou, Athanasios Papatheodorou, Vassiliki Gkastari, Evgenia Verrou, Asimina Papanikolaou, Pavlina Konstantinidou & Eirini Katodritou. (2019) Evaluation of regulatory T cells (Tregs) alterations in patients with multiple myeloma treated with bortezomib or lenalidomide plus dexamethasone: correlations with treatment outcome. Annals of Hematology 98:6, pages 1457-1466.
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Luigi Cari, Francesca De Rosa, Giuseppe Nocentini & Carlo Riccardi. (2019) Context-Dependent Effect of Glucocorticoids on the Proliferation, Differentiation, and Apoptosis of Regulatory T Cells: A Review of the Empirical Evidence and Clinical Applications. International Journal of Molecular Sciences 20:5, pages 1142.
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Laurens E. Franssen, Inger S. Nijhof, Chad C. Bjorklund, Hsiling Chiu, Ruud Doorn, Jeroen van Velzen, Maarten Emmelot, Berris van Kessel, Mark-David Levin, Gerard M.J. Bos, Annemiek Broijl, Saskia K. Klein, Harry R. Koene, Andries C. Bloem, Aart Beeker, Laura M. Faber, Ellen van der Spek, Reinier Raymakers, Pieter Sonneveld, Sonja Zweegman, Henk M. Lokhorst, Anjan Thakurta, Xiaozhong Qian, Tuna Mutis & Niels W.C.J. van de Donk. (2018) Lenalidomide combined with low-dose cyclophosphamide and prednisone modulates Ikaros and Aiolos in lymphocytes, resulting in immunostimulatory effects in lenalidomide-refractory multiple myeloma patients. Oncotarget 9:74, pages 34009-34021.
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Monika Anna Grygorowicz, Ilona Sara Borycka, Eliza Nowak, Ewa Paszkiewicz-Kozik, Grzegorz Rymkiewicz, Katarzyna Błachnio, Marzena Biernacka, Mateusz Bujko, Jan Walewski & Sergiusz Markowicz. (2016) Lenalidomide potentiates CD4+CD25+Treg-related suppression of lymphoma B-cell proliferation. Clinical and Experimental Medicine 17:2, pages 193-207.
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Bruno PaivaMaría Victoria MateosLuis Ignacio Sanchez-AbarcaNoemi PuigMaría-Belén VidrialesLucía López-CorralLuis A. CorcheteMiguel T. HernandezJoan BargayFelipe de ArribaJavier de la RubiaAna-Isabel TeruelPilar GiraldoLaura RosiñolFelipe ProsperAlbert OriolJosé HernándezGraça EstevesJuan José Lahuerta, Joan BladéJose Antonio Perez-Simon & Jesús F. San Miguel. (2016) Immune status of high-risk smoldering multiple myeloma patients and its therapeutic modulation under LenDex: a longitudinal analysis. Blood 127:9, pages 1151-1162.
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Eli Muchtar, Hila Magen, Gilad Itchaki, Amos Cohen, Ra’ama Rosenfeld, Tzippy Shochat, Ran Kornowski, Zaza Iakobishvili & Pia Raanani. (2016) Uninvolved immunoglobulins predicting hematological response in newly diagnosed AL amyloidosis. Leukemia Research 41, pages 56-61.
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Giovanni D’Arena, Giovanni Rossi, Luca Laurenti, Teodora Statuto, Fiorella D’Auria, Luciana Valvano, Vittorio Simeon, Aldo Giudice, Idanna Innocenti, Vincenzo De Feo, Rosanna Filosa & Pellegrino Musto. (2016) Circulating Regulatory T-Cells in Monoclonal Gammopathies of Uncertain Significance and Multiple Myeloma: In Search of a Role. Journal of Immunology Research 2016, pages 1-7.
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Michele Moschetta, Yawara Kawano & Klaus Podar. 2016. Plasma Cell Dyscrasias. Plasma Cell Dyscrasias 63 102 .
Karthick Raja Muthu Raja, Martin Plasil, Lucie Rihova, Jana Pelcova, Zdenek Adam & Roman Hajek. (2014) Flow cytometry-based enumeration and functional characterization of cd8 t regulatory cells in patients with multiple myeloma before and after lenalidomide plus dexamethasone treatment. Cytometry Part B: Clinical Cytometry 86:4, pages 220-228.
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Xiubao Chang, Yuanxiao Zhu, Changxin Shi & A. Keith Stewart. (2014) Mechanism of immunomodulatory drugs' action in the treatment of multiple myeloma. Acta Biochimica et Biophysica Sinica 46:3, pages 240-253.
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Alessandra Romano, Concetta Conticello, Maide Cavalli, Calogero Vetro, Alessia La Fauci, Nunziatina Laura Parrinello & Francesco Di Raimondo. (2014) Immunological Dysregulation in Multiple Myeloma Microenvironment. BioMed Research International 2014, pages 1-10.
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Maria Michael, Avichai Shimoni & Arnon Nagler. (2013) Regulatory T Cells in Allogeneic Stem Cell Transplantation. Clinical and Developmental Immunology 2013, pages 1-9.
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Lenka Sedlarikova, Lenka Kubiczkova, Sabina Sevcikova & Roman Hajek. (2012) Mechanism of immunomodulatory drugs in multiple myeloma. Leukemia Research 36:10, pages 1218-1224.
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