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Leukemia & Lymphoma Volume 53, 2012 - Issue 8
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Research Article

Vorinostat combined with bexarotene for treatment of cutaneous T-cell lymphoma: in vitro and phase I clinical evidence supporting augmentation of retinoic acid receptor/retinoid X receptor activation by histone deacetylase inhibition

Reinhard DummerUniversity Hospital Zürich, SwitzerlandCorrespondence[email protected]
,
Marc BeyerCharitè-Universitätsmedizin, Berlin, GermanyCorrespondence[email protected]
,
Kenneth HymesNew York University Clinical Cancer Center, NY, USA
,
Mirjam T. EppingThe Netherlands Cancer Institute, Amsterdam, The Netherlands
,
Rene BernardsThe Netherlands Cancer Institute, Amsterdam, The Netherlands
,
Matthias SteinhoffCharitè-Universitätsmedizin, Berlin, Germany
,
Wolfram SterryCharitè-Universitätsmedizin, Berlin, Germany
,
Helmut KerlMedical University of Graz, Austria
,
Karl HeathColumbia University, New York, NY, USA
,
Janet D. AhernColumbia University, New York, NY, USA
,
James S. HardwickColumbia University, New York, NY, USA
,
Jose Garcia-VargasColumbia University, New York, NY, USA
,
Katrin BaumannUniversity Hospital Zürich, Switzerland
,
Syed RizviColumbia University, New York, NY, USA
,
Stanley R. FrankelColumbia University, New York, NY, USA
,
Sean J. WhittakerKing's College London, UK
&
Chalid AssafCharitè-Universitätsmedizin, Berlin, Germany;Helios Klinikum, Krefeld, Germany
 show all
Pages 1501-1508 | Received 09 Aug 2011, Accepted 08 Jan 2012, Published online: 13 Feb 2012

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Han Liao, Shan Zhao, Huihui Wang, Yang Liu, Ying Zhang & Guangwei Sun. (2019) Self-Assembly Of Retinoid Nanoparticles For Melanoma Therapy. International Journal of Nanomedicine 14, pages 7963-7973.
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Danyang Shen, Xiaoming Yu, Yan Wu, Yuanlei Chen, Gonghui Li, Feng Cheng & Liqun Xia. (2018) Emerging roles of bexarotene in the prevention, treatment and anti-drug resistance of cancers. Expert Review of Anticancer Therapy 18:5, pages 487-499.
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Alison J. Moskowitz & Steven M. Horwitz. (2017) Targeting histone deacetylases in T-cell lymphoma. Leukemia & Lymphoma 58:6, pages 1306-1319.
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Pooja Virmani, Susan H. Hwang, Justin G. Hastings, Bradley M. Haverkos, Becca Kohnken, Alejandro A Gru, Anjali Mishra, Stephanie K. Fabbro, Steve M. Horwitz & Pierluigi Porcu. (2017) Systemic therapy for cutaneous T-cell lymphoma: who, when, what, and why?. Expert Review of Hematology 10:2, pages 111-121.
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Manisha R Panchal & Julia J Scarisbrick. (2015) The utility of bexarotene in mycosis fungoides and Sézary syndrome. OncoTargets and Therapy 8, pages 367-373.
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Brittany O’Neill Dulmage, Sara K. Story, Louis D. Falo$suffix/text()$suffix/text() & Larisa J. Geskin. (2015) Novel therapeutic combination demonstrates more than additive effects in cutaneous T-cell lymphoma. Leukemia & Lymphoma 56:7, pages 2225-2227.
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Ju-Hee Lee, Megan L. Choy & Paul A. Marks. 2012. Histone Deacetylase Inhibitors as Cancer Therapeutics. Histone Deacetylase Inhibitors as Cancer Therapeutics 39 86 .

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