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Leukemia & Lymphoma Volume 56, 2015 - Issue 6
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Original Article: Research

Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells

Yue YinDepartment of Hematology, PLA General Hospital, Beijing, P. R. China;Department of Hematology, Peking University First Hospital, Beijing, P. R. China
,
Huiyan SunDepartment of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing, P. R. China
,
Jun XuDepartment of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing, P. R. China
,
Fengjun XiaoDepartment of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing, P. R. China
,
Hua WangDepartment of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing, P. R. China
,
Yuefeng YangDepartment of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing, P. R. China
,
Hanyun RenDepartment of Hematology, Peking University First Hospital, Beijing, P. R. China
,
Chu-Tse WuDepartment of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing, P. R. China
,
Chunji GaoDepartment of Hematology, PLA General Hospital, Beijing, P. R. ChinaCorrespondence[email protected] [email protected]
&
Lisheng WangDepartment of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing, P. R. ChinaCorrespondence[email protected] [email protected]
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Pages 1813-1820 | Received 26 Mar 2014, Accepted 16 Aug 2014, Published online: 22 Sep 2014

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Chandrasekaran Balakumar, Muthusamy Ramesh, Chuin Lean Tham, Samukelisiwe Pretty Khathi, Frank Kozielski, Cherukupalli Srinivasulu, Girish A. Hampannavar, Nisar Sayyad, Mahmoud E. Soliman & Rajshekhar Karpoormath. (2018) Ligand- and structure-based in silico studies to identify kinesin spindle protein (KSP) inhibitors as potential anticancer agents. Journal of Biomolecular Structure and Dynamics 36:14, pages 3687-3704.
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Simon Kavanagh, Aisling Nee & Jeffrey H. Lipton. (2018) Emerging alternatives to tyrosine kinase inhibitors for treating chronic myeloid leukemia. Expert Opinion on Emerging Drugs 23:1, pages 51-62.
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Dany A. Curi, Elspeth M. Beauchamp & Leonidas C. Platanias. (2015) Overcoming treatment challenges in imatinib-resistant chronic myelogenous leukemia. Leukemia & Lymphoma 56:6, pages 1581-1582.
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Articles from other publishers (11)

Dongmei Tang, Shimei Zheng, Chang Liu, Na Zuo, Renchun Yan, Cheng Wu, Jun Ma, Chuanxi Wang, Bing Chen, Shaofeng Liu & Yingzi He. (2022) Kinesin spindle protein inhibitor exacerbates cisplatin-induced hair cell damage. Archives of Biochemistry and Biophysics 731, pages 109432.
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Md. Rabiul Islam & Hesham Fahmy. (2022) Thiazolopyrimidine Scaffold as a Promising Nucleus for Developing Anticancer Drugs: A Review Conducted in Last Decade. Anti-Cancer Agents in Medicinal Chemistry 22:17, pages 2942-2955.
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Yuanyuan Shi, Xiaowen Cui, Tianyi Jiang, Yufei Pan, Yunkai Lin, Xiaofan Feng, Zhiwen Ding, Chun Yang, Yexiong Tan, Hongyang Wang & Liwei Dong. (2022) The therapeutic effect of KSP inhibitors in preclinical models of cholangiocarcinoma. Cell Death & Disease 13:9.
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KC Remant, Bindu Thapa, Juliana Valencia‐Serna, Suraj S. Domun, Cailean Dimitroff, Xiaoyan Jiang & Hasan Uludağ. (2019) Cholesterol grafted cationic lipopolymers: Potential siRNA carriers for selective chronic myeloid leukemia therapy. Journal of Biomedical Materials Research Part A 108:3, pages 565-580.
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Huayao Li, Lijuan Liu, Jing Zhuang, Cun Liu, Chao Zhou, Jing Yang, Chundi Gao, Gongxi Liu & Changgang Sun. (2019) Deciphering the mechanism of Indirubin and its derivatives in the inhibition of Imatinib resistance using a “drug target prediction-gene microarray analysis-protein network construction” strategy. BMC Complementary and Alternative Medicine 19:1.
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Kayo Daigo, Atsushi Takano, Thang Manh, Yoshihiro Yoshitake, Masanori Shinohara, Iwau Tohnai, Yoshinori Murakami, Jiro Maegawa & Yataro Daigo. (2017) Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer. International Journal of Oncology.
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Meng Jiang, Huiru Zhuang, Rui Xia, Lei Gan, Yuantao Wu, Junzhe Ma, Yihui Sun & Zhixiang Zhuang. (2017) KIF11 is required for proliferation and self-renewal of docetaxel resistant triple negative breast cancer cells. Oncotarget 8:54, pages 92106-92118.
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Zheng Xu, Jian Sun, Qian Tong, Qian Lin, Lingbo Qian, Yongsoo Park & Yang Zheng. (2016) The Role of ERK1/2 in the Development of Diabetic Cardiomyopathy. International Journal of Molecular Sciences 17:12, pages 2001.
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Youguang Pu, Qiyi Yi, Fangfang Zhao, Haiyan Wang, Wenjing Cai & Shanbao Cai. (2016) MiR-20a-5p represses multi-drug resistance in osteosarcoma by targeting the KIF26B gene. Cancer Cell International 16:1.
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Li Zhu, Fengjun Xiao, Yue Yu, Hua Wang, Min Fang, Yuefeng Yang, Huiyan Sun, Lisheng Wang & Yuan Sheng. (2016) KSP inhibitor SB743921 inhibits growth and induces apoptosis of breast cancer cells by regulating p53, Bcl-2, and DTL. Anti-Cancer Drugs 27:9, pages 863-872.
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Bayalagmaa NyamaaHyoung Kyu KimYu Jeong JeongIn-Sung SongJin Han. (2014) Kinesin Spindle Protein Inhibition in Translational Research. Journal of Lipid and Atherosclerosis 3:2, pages 63.
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