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Leukemia & Lymphoma Volume 56, 2015 - Issue 10
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Original Articles: Clinical

Strong expression of EZH2 and accumulation of trimethylated H3K27 in diffuse large B-cell lymphoma independent of cell of origin and EZH2 codon 641 mutation

Zheng ZhouDivision of Hematology and Oncology, Department of Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
,
Juehua GaoDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
,
Relja PopovicDivision of Hematology and Oncology, Department of Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
,
Kristy WolniakDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
,
Vamsi ParimiDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
,
Jane N. WinterDivision of Hematology and Oncology, Department of Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
,
Jonathan D. LichtDivision of Hematology and Oncology, Department of Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
&
Yi-Hua ChenDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USACorrespondence[email protected]
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Pages 2895-2901 | Received 03 Sep 2014, Accepted 05 Jan 2015, Published online: 08 Mar 2015

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Virginia E. Duncan, Zheng Ping, Sooryanarayana Varambally & Deniz Peker. (2017) Loss of RUNX3 expression is an independent adverse prognostic factor in diffuse large B-cell lymphoma. Leukemia & Lymphoma 58:1, pages 179-184.
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Articles from other publishers (22)

Chenyun He, Wenbin Zhou, Xiaoxia Jin & Haining Zhou. (2023) Derepressing of STAT3 and USP7 contributes to resistance of DLBCL to EZH2 inhibition. Heliyon 9:10, pages e20650.
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Saumya Srivastava & Anjana Pandey. 2023. Oncology: Genomics, Precision Medicine and Therapeutic Targets. Oncology: Genomics, Precision Medicine and Therapeutic Targets 1 24 .
Ali Sakhdari, Caleb Class, Guillermo Montalban-Bravo, Koji Sasaki, Carlos E. Bueso-Ramos, Keyur P. Patel, Mark J. Routbort, Sanam Loghavi, Chi Young Ok, Andres Quesada, Joseph D. Khoury, Sergej N. Konoplev, Hagop P. Kantarjian, Guillermo Garcia-Manero, L. Jeffrey Medeiros & Rashmi Kanagal-Shamanna. (2022) Immunohistochemical loss of enhancer of Zeste Homolog 2 (EZH2) protein expression correlates with EZH2 alterations and portends a worse outcome in myelodysplastic syndromes. Modern Pathology 35:9, pages 1212-1219.
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Ammad Ahmad Farooqi, Sundas Fayyaz, Palmiro Poltronieri, George Calin & Massimo Mallardo. (2022) Epigenetic deregulation in cancer: Enzyme players and non-coding RNAs. Seminars in Cancer Biology 83, pages 197-207.
Crossref
Sean Harrop, Costas Kleanthes Yannakou, Carrie Van Der Weyden & Henry Miles Prince. (2022) Epigenetic Modifications in Lymphoma and Their Role in the Classification of Lymphomas. Hemato 3:1, pages 174-187.
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Sara Petronilho, José Pedro Sequeira, Sofia Paulino, Paula Lopes, Susana Lisboa, Sérgio Chacim, João Lobo, Manuel Teixeira, Carmen Jerónimo & Rui Henrique. (2021) Prognostic Value of Histone Modifying Enzyme EZH2 in RCHOP-Treated Diffuse Large B-Cell Lymphoma and High Grade B-Cell Lymphoma. Journal of Personalized Medicine 11:12, pages 1384.
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I. C. Barıs, S. Hacıoglu, N. S. Turk, G. O. Cetın, S. Zencır, G. Bagcı & V. Caner. (2020) Expression and DNA methylation profiles of EZH2-target genes in plasma exosomes and matched primary tumor tissues of the patients with diffuse large B-cell lymphoma. Clinical and Translational Oncology 23:6, pages 1152-1166.
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Eduardo Henrique Neves Filho, Carlos Gustavo Hirth, Igor Allen Frederico, Rommel Mario Burbano, Thiago Carneiro & Silvia Helena Rabenhorst. (2020) EZH2 expression is dependent on MYC and TP53 regulation in diffuse large B‐cell lymphoma. APMIS 128:4, pages 308-315.
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Mei Han, Lina Jia, Wencai Lv, Lihui Wang & Wei Cui. (2019) Epigenetic Enzyme Mutations: Role in Tumorigenesis and Molecular Inhibitors. Frontiers in Oncology 9.
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Rosemarie Tremblay-LeMay, Nasrin Rastgoo, Maryam Pourabdollah & Hong Chang. (2018) EZH2 as a therapeutic target for multiple myeloma and other haematological malignancies. Biomarker Research 6:1.
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Ambrus Gángó, Bence Bátai, Martin Varga, Dóra Kapczár, Gergő Papp, Márta Marschalkó, Enikő Kuroli, Tamás Schneider, Judit Csomor, András Matolcsy, Csaba Bödör & Ágota Szepesi. (2018) Concomitant 1p36 deletion and TNFRSF14 mutations in primary cutaneous follicle center lymphoma frequently expressing high levels of EZH2 protein. Virchows Archiv 473:4, pages 453-462.
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Kunshou Zhu, Yujie Deng, Guoxing Weng, Dan Hu, Cheng Huang, Keitaro Matsumoto, Takeshi Nagayasu, Takehiko Koji, Xiongwei Zheng, Wenhui Jiang, Gen Lin, Yibin Cai, Guibin Weng & Xiaohui Chen. (2018) Analysis of H3K27me3 expression and DNA methylation at CCGG sites in smoking and non-smoking patients with non-small cell lung cancer and their clinical significance. Oncology Letters.
Crossref
M. Winkle, J.L. Kluiver, A. Diepstra & A. van den Berg. (2017) Emerging roles for long noncoding RNAs in B-cell development and malignancy. Critical Reviews in Oncology/Hematology 120, pages 77-85.
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Juehua Gao, Amir Behdad, Peng Ji, Kristy L Wolniak, Olga Frankfurt & Yi-Hua Chen. (2017) EBV-negative aggressive NK-cell leukemia/lymphoma: a clinical and pathological study from a single institution. Modern Pathology 30:8, pages 1100-1115.
Crossref
Yang Liu, Kangjie Yu, Mingyang Li, Kaixuan Zeng, Jie Wei, Xia Li, Yixiong Liu, Danhui Zhao, Linni Fan, Zhou Yu, Yingmei Wang, Zengshan Li, Wei Zhang, Qingxian Bai, Qingguo Yan, Ying Guo, Zhe Wang & Shuangping Guo. (2017) EZH2 overexpression in primary gastrointestinal diffuse large B-cell lymphoma and its association with the clinicopathological features. Human Pathology 64, pages 213-221.
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Subhankar Biswas & C. Mallikarjuna Rao. (2017) Epigenetics in cancer: Fundamentals and Beyond. Pharmacology & Therapeutics 173, pages 118-134.
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S Huet, L Xerri, B Tesson, S Mareschal, S Taix, L Mescam-Mancini, E Sohier, M Carrère, J Lazarovici, O Casasnovas, L Tonon, S Boyault, S Hayette, C Haioun, B Fabiani, A Viari, F Jardin & G Salles. (2017) EZH2 alterations in follicular lymphoma: biological and clinical correlations. Blood Cancer Journal 7:4, pages e555-e555.
Crossref
C Pawlyn, M D Bright, A F Buros, C K Stein, Z Walters, L I Aronson, F Mirabella, J R Jones, M F Kaiser, B A Walker, G H Jackson, P A Clarke, P L Bergsagel, P Workman, M Chesi, G J Morgan & F E Davies. (2017) Overexpression of EZH2 in multiple myeloma is associated with poor prognosis and dysregulation of cell cycle control. Blood Cancer Journal 7:3, pages e549-e549.
Crossref
Thomas Cummin & Peter Johnson. (2016) Lymphoma: turning biology into cures. Clinical Medicine 16:Suppl 6, pages s125-s129.
Crossref
Shuangping Guo, Qingxian Bai, Joseph Rohr, Yingmei Wang, Yang Liu, Kaixuan Zeng, Kangjie Yu, Xiumin Zhang & Zhe Wang. (2016) Clinicopathological features of primary diffuse large B-cell lymphoma of the central nervous system - strong EZH2 expression implying diagnostic and therapeutic implication. APMIS 124:12, pages 1054-1062.
Crossref
Penelope Korkolopoulou, Theodoros Vassilakopoulos, Vassilios Milionis & Maria Ioannou. (2016) Recent Advances in Aggressive Large B-cell Lymphomas: A Comprehensive Review. Advances in Anatomic Pathology 23:4, pages 202-243.
Crossref
J.N. Nichol, D. Dupéré-Richer, T. Ezponda, J.D. Licht & W.H. MillerJr.Jr.. 2016. 59 95 .

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