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Leukemia & Lymphoma Volume 56, 2015 - Issue 10
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Original Articles: Clinical

Phase I dose escalation trial of the novel proteasome inhibitor carfilzomib in patients with relapsed chronic lymphocytic leukemia and small lymphocytic lymphoma

Farrukh T. AwanThe Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
,
Joseph M. FlynnThe Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
,
Jeffrey A. JonesThe Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
,
Leslie A. AndritsosThe Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
,
Kami J. MaddocksThe Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
,
Ellen J. SassThe Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
,
Margaret S. LucasThe Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
,
Weihong ChaseThe Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
,
Sharon WaymerThe Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
,
Yonghua LingThe Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
,
Yao JiangThe Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
,
Mitch A. PhelpsThe Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
,
John C. ByrdThe Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
,
David M. LucasThe Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
&
Jennifer A. WoyachThe Ohio State University Comprehensive Cancer Center, Columbus, OH, USACorrespondence[email protected]
 show all
Pages 2834-2840 | Received 12 Nov 2014, Accepted 25 Jan 2015, Published online: 11 Mar 2015

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Agata M. Bogusz & Adam Bagg. (2016) Genetic aberrations in small B-cell lymphomas and leukemias: molecular pathology, clinical relevance and therapeutic targets. Leukemia & Lymphoma 57:9, pages 1991-2013.
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Solomon A. Graf & Ajay K. Gopal. (2016) Idelalisib for the treatment of non-Hodgkin lymphoma. Expert Opinion on Pharmacotherapy 17:2, pages 265-274.
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Articles from other publishers (10)

Alice Barros Câmara & Igor Augusto Brandão. (2024) The Non-hodgkin Lymphoma Treatment and Side Effects: A Systematic Review and Meta-analysis. Recent Patents on Anti-Cancer Drug Discovery 19:1, pages 93-120.
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Noa Biran,Pooja Phull,andand & Andre Goy. 2023. Precision Cancer Therapies, Volume 1 ‐ Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies. Precision Cancer Therapies, Volume 1 ‐ Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies 331 360 .
Andrej Besse, Marianne Kraus, Max Mendez-Lopez, Elmer Maurits, Herman S. Overkleeft, Christoph Driessen & Lenka Besse. (2022) Immunoproteasome Activity in Chronic Lymphocytic Leukemia as a Target of the Immunoproteasome-Selective Inhibitors. Cells 11:5, pages 838.
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Hun J. Lee, Maria Badillo, Jorge Romaguera & Michael Wang. (2018) A phase II study of carfilzomib in the treatment of relapsed/refractory mantle cell lymphoma. British Journal of Haematology 184:3, pages 460-462.
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Jacqueline Cloos, Margot SF Roeten, Niels E Franke, Johan van Meerloo, Sonja Zweegman, Gertjan JL Kaspers & Gerrit Jansen. (2017) (Immuno)proteasomes as therapeutic target in acute leukemia. Cancer and Metastasis Reviews 36:4, pages 599-615.
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Adrian A Carballo-Zarate, L Jeffrey Medeiros, Lianghua Fang, Jatin J Shah, Donna M Weber, Sheeba K Thomas, Elisabet E Manasanch, Suyang Hao, Qi Shen, Robert Z Orlowski, Pei Lin & Xinyan Lu. (2017) Additional–structural–chromosomal aberrations are associated with inferior clinical outcome in patients with hyperdiploid multiple myeloma: a single-institution experience. Modern Pathology 30:6, pages 843-853.
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Vidal Jarauta, Paula Jaime, Oscar Gonzalo, Diego de Miguel, Ariel Ramírez-Labrada, Luis Martínez-Lostao, Alberto Anel, Julián Pardo, Isabel Marzo & Javier Naval. (2016) Inhibition of autophagy with chloroquine potentiates carfilzomib-induced apoptosis in myeloma cells in vitro and in vivo. Cancer Letters 382:1, pages 1-10.
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Betty Lamothe, William G. Wierda, Michael J. Keating & Varsha Gandhi. (2016) Carfilzomib Triggers Cell Death in Chronic Lymphocytic Leukemia by Inducing Proapoptotic and Endoplasmic Reticulum Stress Responses. Clinical Cancer Research 22:18, pages 4712-4726.
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Joseph Maly & James S. Blachly. (2016) Chronic Lymphocytic Leukemia: Exploiting Vulnerabilities with Targeted Agents. Current Hematologic Malignancy Reports 11:1, pages 52-60.
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Michael Mian & Annalisa Chiappella. (2015) Changing treatment paradigms in lymphoma: new targets and new drugs. memo - Magazine of European Medical Oncology 8:3, pages 184-188.
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