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Leukemia & Lymphoma Volume 57, 2016 - Issue 7
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Original Articles: Research

Whole-exome sequencing reveals potential molecular predictors of relapse after discontinuation of the targeted therapy in chronic myeloid leukemia patients

Svetlana A. SmirnikhinaFederal State Budgetary Institution “Research Centre for Medical Genetics”, Moscow, Russian Federation; Correspondence[email protected]
,
Alexander V. LavrovFederal State Budgetary Institution “Research Centre for Medical Genetics”, Moscow, Russian Federation; ;The Russian National Research Medical University Named after N.I. Pirogov, Moscow, Russian Federation;
,
Ekaterina Yu. ChelyshevaScientific and Advisory Department of Chemotherapy of Myeloproliferative Disorders, Federal State-Funded Institution “National Research Center for Hematology” of the Ministry of Healthcare of the Russian Federation, Moscow, Russian Federation
,
Elmira P. AdilgereevaFederal State Budgetary Institution “Research Centre for Medical Genetics”, Moscow, Russian Federation;
,
Oleg A. ShukhovScientific and Advisory Department of Chemotherapy of Myeloproliferative Disorders, Federal State-Funded Institution “National Research Center for Hematology” of the Ministry of Healthcare of the Russian Federation, Moscow, Russian Federation
,
Anna TurkinaScientific and Advisory Department of Chemotherapy of Myeloproliferative Disorders, Federal State-Funded Institution “National Research Center for Hematology” of the Ministry of Healthcare of the Russian Federation, Moscow, Russian Federation
&
Sergey I. KutsevFederal State Budgetary Institution “Research Centre for Medical Genetics”, Moscow, Russian Federation; ;The Russian National Research Medical University Named after N.I. Pirogov, Moscow, Russian Federation;
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Pages 1669-1676 | Received 08 Oct 2015, Accepted 12 Dec 2015, Published online: 12 Jan 2016

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Svetlana A. Smirnikhina, Ekaterina Yu. Chelysheva, Alexander V. Lavrov, Konstantin S. Kochergin-Nikitsky, Ivan V. Mozgovoy, Elmira P. Adilgereeva, Oleg A. Shukhov, Anna N. Petrova, Anastasia V. Bykova, Adhamjon O. Abdullaev, Anna G. Turkina & Sergey I. Kutsev. (2018) Genetic markers of stable molecular remission in chronic myeloid leukemia after targeted therapy discontinuation. Leukemia & Lymphoma 59:10, pages 2512-2515.
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Sameem Abedin & Leonidas C. Platanias. (2016) Whole-exome sequencing for relapse prediction in patients discontinuing TKI treatment in chronic myeloid leukemia. Leukemia & Lymphoma 57:7, pages 1503-1504.
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Erfan Zaker, Negar Nouri, Sepehr Sorkhizadeh, Hamidreza Ghasemirad, Amir Hossein Hajijafari & Fateme Zare. (2023) The importance of personalized medicine in chronic myeloid leukemia management: a narrative review. Egyptian Journal of Medical Human Genetics 24:1.
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Ruth Stuckey, Juan Francisco López Rodríguez & María Teresa Gómez-Casares. (2022) Discontinuation of Tyrosine Kinase Inhibitors in Patients with Chronic Myeloid Leukemia: a Review of the Biological Factors Associated with Treatment-Free Remission. Current Oncology Reports 24:4, pages 415-426.
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Huanhuan Sha, Yujie Gan, Renrui Zou, Jianzhong Wu & Jifeng Feng. (2021) Research Advances in the Role of the Poly ADP Ribose Polymerase Family in Cancer. Frontiers in Oncology 11.
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Yilin Chen, Jing Zou, Fanjun Cheng & Weiming Li. (2021) Treatment-Free Remission in Chronic Myeloid Leukemia and New Approaches by Targeting Leukemia Stem Cells. Frontiers in Oncology 11.
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David Vogrinc, Katja Goričar & Vita Dolžan. (2021) Genetic Variability in Molecular Pathways Implicated in Alzheimer's Disease: A Comprehensive Review. Frontiers in Aging Neuroscience 13.
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Lorena Vigón, Alejandro Luna, Miguel Galán, Sara Rodríguez-Mora, Daniel Fuertes, Elena Mateos, Miguel Piris-Villaespesa, Guiomar Bautista, Esther San José, José Rivera-Torres, Juan Luis Steegmann, Fernando de Ory, Mayte Pérez-Olmeda, José Alcamí, Vicente Planelles, María Rosa López-Huertas, Valentín García-Gutiérrez & Mayte Coiras. (2020) Identification of Immunological Parameters as Predictive Biomarkers of Relapse in Patients with Chronic Myeloid Leukemia on Treatment-Free Remission. Journal of Clinical Medicine 10:1, pages 42.
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Svetlana A. Smirnikhina, Ekaterina V. Kondrateva, Elmira P. Adilgereeva, Arina A. Anuchina, Milyausha I. Zaynitdinova, Yana S. Slesarenko, Angelina S. Ershova, Kirill D. Ustinov, Matvei I. Yasinovsky, Elena L. Amelina, Ekaterina S. Voronina, Valentina D. Yakushina, Vyacheslav Yu. Tabakov & Alexander V. Lavrov. (2020) P.F508del editing in cells from cystic fibrosis patients. PLOS ONE 15:11, pages e0242094.
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Stina Söderlund, Inger Persson, Mette Ilander, Joëlle Guilhot, Henrik Hjorth-Hansen, Perttu Koskenvesa, Johan Richter, Susanne Saussele, Satu Mustjoki & Ulla Olsson-Strömberg. (2020) Plasma proteomics of biomarkers for inflammation or cancer cannot predict relapse in chronic myeloid leukaemia patients stopping tyrosine kinase inhibitor therapy. Leukemia Research 90, pages 106310.
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Miguel Tábuas-Pereira, Isabel Santana, Rita Guerreiro & José Brás. (2020) Alzheimer’s Disease Genetics: Review of Novel Loci Associated with Disease. Current Genetic Medicine Reports 8:1, pages 1-16.
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Haijiao Zhang, Samantha Savage, Anna Reister Schultz, Daniel Bottomly, Libbey White, Erik Segerdell, Beth Wilmot, Shannon K. McWeeney, Christopher A. Eide, Tamilla Nechiporuk, Amy Carlos, Rachel Henson, Chenwei Lin, Robert Searles, Hoang Ho, Yee Ling Lam, Richard Sweat, Courtney Follit, Vinay Jain, Evan Lind, Gautam Borthakur, Guillermo Garcia-Manero, Farhad Ravandi, Hagop M. Kantarjian, Jorge Cortes, Robert Collins, Daelynn R. Buelow, Sharyn D. Baker, Brian J. Druker & Jeffrey W. Tyner. (2019) Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms. Nature Communications 10:1.
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Lanlan Zang, Shukkoor Muhammed Kondengaden, Fengyuan Che, Lijuan Wang & Xueyuan Heng. (2018) Potential Epigenetic-Based Therapeutic Targets for Glioma. Frontiers in Molecular Neuroscience 11.
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Alexander V. Lavrov, Oksana A. Ustaeva, Elmira P. Adilgereeva, Svetlana A. Smirnikhina, Ekaterina Y. Chelysheva, Oleg A. Shukhov, Yuriy V. Shatokhin, Sergey V. Mordanov, Anna G. Turkina & Sergey I. Kutsev. (2017) Copy number variation analysis in cytochromes and glutathione S-transferases may predict efficacy of tyrosine kinase inhibitors in chronic myeloid leukemia. PLOS ONE 12:9, pages e0182901.
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A. G. Turkina, E. Yu. Chelysheva, V. A. Shuvaev, G. A. Gusarova, A. V. Bykova, O. A. Shukhov, A. N. Petrova, M. V. Vakhrusheva, S. R. Goryacheva, L. Yu. Kolosova, P. S. Krasikova, M. S. Fominykh, I. S. Martynkevich, A. O. Abdullaev, A. B. Sudarikov & V. G. Savchenko. (2017) Results of following up patients with chronic myeloid leukemia and a deep molecular response without tyrosine kinase inhibitor therapy. Terapevticheskii arkhiv 89:12, pages 86.
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