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Leukemia & Lymphoma Volume 11, 1993 - Issue 5-6
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Original Article

Frequency of RAS and p53 Mutations in Acute Promyelocytic Leukemias

Letizia Longo Istituto Clinica Medica I, University of Perugia, Policlinico Monteluce, Perugia
,
Dino Trecca Laboratorio di Genetica Molecolare ed Ematologia Sperimentale, Servizio di Ematologia, Ospedale Maggiore I.R.C.C.S., Milano
,
Andrea Biondi Clinica Pediatrica, University of Milan, Ospedale S. Gerardo, Monza
,
Francesco Lo Coco Dipartimento di Biopatologia Divisione di Ematologia, I University of Rome, Rome, Italy
,
Fausto Grignani Istituto Clinica Medica I, University of Perugia, Policlinico Monteluce, Perugia
,
Anna Teresa Maiolo Laboratorio di Genetica Molecolare ed Ematologia Sperimentale, Servizio di Ematologia, Ospedale Maggiore I.R.C.C.S., Milano
,
Pier Giuseppe Pelicci Istituto Clinica Medica I, University of Perugia, Policlinico Monteluce, Perugia
&
Antonino Neri Laboratorio di Genetica Molecolare ed Ematologia Sperimentale, Servizio di Ematologia, Ospedale Maggiore I.R.C.C.S., Milano
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Pages 405-410 | Received 10 Feb 1993, Published online: 01 Jul 2009

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Zhao-Mei Mu, Xiao-Feng Le, Armand B. Glassman & Kun-Sang Chang. (1996) The Biologic Function of PML and its Role in Acute Promyelocytic Leukemia. Leukemia & Lymphoma 23:3-4, pages 277-285.
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Veronique Brunel, Marina Lafage-Pochitaloff, Myriam Alcalay, Pier-Giuseppe Pelicci & Francoise Birg. (1996) Variant and Masked Translocations in Acute Promyelocytic Leukemia. Leukemia & Lymphoma 22:3-4, pages 221-228.
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Zhao-Mei Mu, Khew-Voon Chin, Jin-Hwang Liu, Guillermina Lozano & Kun-Sang Chang. (1994) PML, a Growth Suppressor Disrupted in Acute Promyelocytic Leukemia. Molecular and Cellular Biology 14:10, pages 6858-6867.
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Articles from other publishers (21)

Julia Abramowitz, Tzahi Neuman, Riki Perlman & Dina Ben-Yehuda. (2017) Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia. BMC Medical Genomics 10:1.
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Antonio R. Lucena-AraujoHaesook T. KimCarolina ThoméRafael H. JacomoRaul A. MeloRosane BittencourtRicardo PasquiniKatia PagnanoAna Beatriz F. GlóriaMaria de Lourdes ChauffailleMelina AthaydeCarlos S. ChiattoneIngrid MitoRodrigo BendlinCarmino SouzaCristina BortolheiroJuan L. Coelho-SilvaStanley L. SchrierMartin S. TallmanDavid GrimwadeArnold GanserNancy BerlinerRaul C. RibeiroFrancesco Lo-CocoBob Löwenberg, Miguel A. Sanz & Eduardo M. Rego. (2015) High ΔNp73/TAp73 ratio is associated with poor prognosis in acute promyelocytic leukemia. Blood 126:20, pages 2302-2306.
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Ho Yin Ng, Thomas S Wan, Chi Chiu So & Chor Sang Chim. (2014) Epigenetic inactivation of DAPK1 , p14 ARF , mir-34a and -34b/c in acute promyelocytic leukaemia . Journal of Clinical Pathology 67:7, pages 626-631.
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Deepa Subramanyam, Cassandra D. Belair, Keegan Q. Barry-Holson, Haijiang Lin, Scott C. Kogan, Emmanuelle Passegué & Robert Blelloch. (2010) PML-RARα and Dnmt3a1 Cooperate in vivo to Promote Acute Promyelocytic Leukemia . Cancer Research 70:21, pages 8792-8801.
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Sue Haupt, Silvia di Agostino, Inbal Mizrahi, Osnat Alsheich-Bartok, Mathijs Voorhoeve, Alex Damalas, Giovanni Blandino & Ygal Haupt. (2009) Promyelocytic Leukemia Protein is Required for Gain of Function by Mutant p53. Cancer Research 69:11, pages 4818-4826.
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Christian BritschgiMartin F Fey. (2009) Tumor suppressor genes in myeloid differentiation and leukemogenesis. Future Oncology 5:2, pages 245-257.
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YeonSoo Joe, Jae-Hoon Jeong, Shutong Yang, Hyeog Kang, Noburu Motoyama, Pier Paolo Pandolfi, Jay H. Chung & Myung K. Kim. (2006) ATR, PML, and CHK2 Play a Role in Arsenic Trioxide-induced Apoptosis. Journal of Biological Chemistry 281:39, pages 28764-28771.
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Shutong Yang, Jae-Hoon Jeong, Alexandra L. Brown, Chang-Hun Lee, Pier Paolo Pandolfi, Jay H. Chung & Myung K. Kim. (2006) Promyelocytic Leukemia Activates Chk2 by Mediating Chk2 Autophosphorylation. Journal of Biological Chemistry 281:36, pages 26645-26654.
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C Callens, S Chevret, J-M Cayuela, B Cassinat, E Raffoux, S de Botton, X Thomas, A Guerci, N Fegueux, A Pigneux, A-M Stoppa, T Lamy, F Rigal-Huguet, A Vekhoff, S Meyer-Monard, A Ferrand, M Sanz, C Chomienne, P Fenaux & H Dombret. (2005) Prognostic implication of FLT3 and Ras gene mutations in patients with acute promyelocytic leukemia (APL): a retrospective study from the European APL Group. Leukemia 19:7, pages 1153-1160.
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M G Rizzo, E Giombini, D Diverio, M Vignetti, A Sacchi, U Testa, F Lo-Coco & G Blandino. (2004) Analysis of p73 expression pattern in acute myeloid leukemias: lack of ΔN-p73 expression is a frequent feature of acute promyelocytic leukemia. Leukemia 18:11, pages 1804-1809.
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Joseph M Scandura, Piernicola Boccuni, Jorg Cammenga & Stephen D Nimer. (2002) Transcription factor fusions in acute leukemia: variations on a theme. Oncogene 21:21, pages 3422-3444.
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Mark Pearson & Pier Giuseppe Pelicci. (2001) PML interaction with p53 and its role in apoptosis and replicative senescence. Oncogene 20:49, pages 7250-7256.
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Vanesa Gottifredi & Carol Prives. (2001) P53 and PML: new partners in tumor suppression. Trends in Cell Biology 11:5, pages 184-187.
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Ailan Guo, Paolo Salomoni, Jianyuan Luo, Alan Shih, Sue Zhong, Wei Gu & Pier Paolo Pandolfi. (2000) The function of PML in p53-dependent apoptosis. Nature Cell Biology 2:10, pages 730-736.
Crossref
T.E. Parry. (1997) The non-random distribution of point mutations in leukaemia and myelodysplasia—A possible pointer to their aetiology. Leukemia Research 21:6, pages 559-574.
Crossref
Patrik Andreasson, Bertil Johansson, Kristina Arheden, Rolf Billström, Felix Mitelman & Mattias Höglund. (1997) Deletions of CDKN1B and ETV6 in acute myeloid leukemia and myelodysplastic syndromes without cytogenetic evidence of 12p abnormalities. Genes, Chromosomes and Cancer 19:2, pages 77-83.
Crossref
D. Grimwade & E. Solomon. 1997. Chromosomal Translocations and Oncogenic Transcription Factors. Chromosomal Translocations and Oncogenic Transcription Factors 81 112 .
I. Panagopoulos, P. Åman, B. Johansson, C. Malm, S. Lenhoff, R. Billström & F. Mitelman. (2009) NRAS mutations are rare in acute myeloid leukaemias with t(8;21) or inv(16). European Journal of Haematology 56:1-2, pages 68-71.
Crossref
Francesco Grignani & Pier Giuseppe Pelicci. 1995. Hormones and Cancer. Hormones and Cancer 577 605 .
Dino Trecca, Letizia Longo, Andrea Biondi, Lilla Cro, Rossella Calori, Fausto Grignani, Anna Teresa Maiolo, Pier Giuseppe Pelicci & Antonino Neri. (1994) Analysis of p53 gene mutations in acute myeloid leukemia. American Journal of Hematology 46:4, pages 304-309.
Crossref
Francesco Grignani, Pier Francesco Ferrucci, Ugo Testa, Giampaolo Talamo, Marta Fagioli, Myriam Alcalay, Amedea Mencarelli, Fausto Grignani, Cesare Peschle, Ildo Nicoletti & Pier Giuseppe Pelicci. (1993) The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell 74:3, pages 423-431.
Crossref

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