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Leukemia & Lymphoma Volume 17, 1995 - Issue 1-2
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Original Article

Multiple Patterns of MDM-2 Deregulation in Human Leukemias: Implications in Leukemogenesis and Prognosis

Carlos E. Bueso-Ramos Hematopathology Program, Division of Laboratory Medicine, Houston, Texas
,
Taghi Manshouri Hematopathology Program, Division of Laboratory Medicine, Houston, Texas
,
Mohammad A. Haidar Hematopathology Program, Division of Laboratory Medicine, Houston, Texas
,
Yang O. Huh Laboratory Immunology, Division of Laboratory Medicine, Houston, Texas
,
Michael J. Keating The Department of Hematology, University of Texas M. D. Anderson Cancer Center, Houston, Texas
&
Maher Albitar Hematopathology Program, Division of Laboratory Medicine, Houston, Texas
Pages 13-18 | Received 21 May 1994, Published online: 01 Jul 2009

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Ismael J. Samudio, Seshagiri Duvvuri, Karen Clise-Dwyer, Julie C. Watt, Duncan Mak, Hagop Kantarjian, Dajun Yang, Vivian Ruvolo & Gautam Borthakur. (2010) Activation of p53 signaling by MI-63 induces apoptosis in acute myeloid leukemia cells. Leukemia & Lymphoma 51:5, pages 911-919.
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Britt Gustafsson, Olle Stål & Bertil Gustafsson. (1998) Overexpression of MDM2 in Acute Childhood Lymphoblastic Leukemia. Pediatric Hematology and Oncology 15:6, pages 519-526.
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Dale S. Haines. (1997) The mdm2 Proto-Oncogene. Leukemia & Lymphoma 26:3-4, pages 227-238.
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Ute M. Moll, Anne G. Ostermeyer, Robert Haladay, Blonka Winkfield, Mark Frazier & Gerard Zambetti. (1996) Cytoplasmic Sequestration of Wild-Type p53 Protein Impairs the G1 Checkpoint after DNA Damage. Molecular and Cellular Biology 16:3, pages 1126-1137.
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Julia Abramowitz, Tzahi Neuman, Riki Perlman & Dina Ben-Yehuda. (2017) Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia. BMC Medical Genomics 10:1.
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Ya-Huei Kuo, Jing Qi & Guerry J. Cook. (2016) Regain control of p53: Targeting leukemia stem cells by isoform-specific HDAC inhibition. Experimental Hematology 44:5, pages 315-321.
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Yu-Tien Chang. (2014) Verification of gene expression profiles for colorectal cancer using 12 internet public microarray datasets. World Journal of Gastroenterology 20:46, pages 17476.
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Yu-Tien Chang. (2014) Gene expression profile of peripheral blood in colorectal cancer. World Journal of Gastroenterology 20:39, pages 14463.
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H. Joachim Deeg, David T. Bowen, Steven D. Gore, Torsten Haferlach, Michelle M. Le Beau & Charlotte NiemeyerHarold J. Olney & Michelle M. Le Beau. 2013. Myelodysplastic Syndromes. Myelodysplastic Syndromes 41 72 .
Mustafa IsinMustafa YenerelMelih AktanNur BuyruNejat Dalay. (2012) Analysis of p53 Tumor Suppressor Pathway Genes in Chronic Lymphocytic Leukemia . DNA and Cell Biology 31:5, pages 777-782.
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LIN WANG, XIAO-YING ZHANG, LING XU, WEN-JUN LIU, JUAN ZHANG & JIAN-PING ZHANG. (2011) Expression and significance of p53 and mdm2 in atypical intestinal metaplasia and gastric carcinoma. Oncology Letters 2:4, pages 707-712.
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Nancy S Magnuson, Zeping Wang, Gang Ding & Raymond Reeves. (2010) Why target PIM1 for cancer diagnosis and treatment?. Future Oncology 6:9, pages 1461-1478.
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. 2010. Cancer Cytogenetics. Cancer Cytogenetics 141 178 .
Ismael Samudio, Marina Konopleva, Bing Carter & Michael Andreeff. 2010. Acute Myelogenous Leukemia. Acute Myelogenous Leukemia 197 217 .
M Dimitriadi, G Poulogiannis, L Liu, L M Bäcklund, D M Pearson, K Ichimura & V P Collins. (2008) p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours. British Journal of Cancer 99:7, pages 1144-1152.
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Paola Secchiero, Carlotta Zerbinati, Elisabetta Melloni, Daniela Milani, Diana Campioni, Roberto Fadda, Mario Tiribelli & Giorgio Zauli. (2007) The MDM-2 Antagonist Nutlin-3 Promotes the Maturation of Acute Myeloid Leukemic Blasts. Neoplasia 9:10, pages 853-861.
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H. J. Deeg, D. T. Bowen, S. D. Gore, T. Haferlach, M. M. Le Beau & C. NiemeyerHarold J. Olney & Michelle M. Le Beau. 2006. Hematologic Malignancies: Myelodysplastic Syndromes. Hematologic Malignancies: Myelodysplastic Syndromes 55 79 .
Harold J. Olney & Michelle M. Le Beau. 2009. Myelodysplastic Syndromes. Myelodysplastic Syndromes 95 128 .
Ming Dong. (2005) Clinicopathological significance of p53 and mdm2 protein expression in human pancreatic cancer. World Journal of Gastroenterology 11:14, pages 2162.
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Stanley R. Riddell & Philip D. Greenberg. 2003. Thomas' Hematopoietic Cell Transplantation. Thomas' Hematopoietic Cell Transplantation 380 404 .
Katrien Vermeulen, Dirk R. Van Bockstaele & Zwi N. Berneman. (2003) The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer. Cell Proliferation 36:3, pages 131-149.
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Michaela Herzig & Gerhard Christofori. (2002) Recent advances in cancer research: mouse models of tumorigenesis. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1602:2, pages 97-113.
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Andrew R. PettittPaul D. SherringtonGrant StewartJohn C. CawleyA. Malcolm R. TaylorTatjana Stankovic. (2001) p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative toTP53 mutation. Blood 98:3, pages 814-822.
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Stefan Faderl, Hagop M. Kantarjian, Elihu Estey, Taghi Manshouri, Ching-Yang Chan, Abdel Rahman Elsaied, Steven M. Kornblau, Jorge Cortes, Deborah A. Thomas, Sherry Pierce, Michael J. Keating, Zeev Estrov & Maher Albitar. (2000) The prognostic significance of p16 INK4a /p14 ARF locus deletion and MDM-2 protein expression in adult acute myelogenous leukemia . Cancer 89:9, pages 1976-1982.
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James W. Jacobberger, R. Michael Sramkoski, Desheng Zhang, Louis A. Zumstein, Lesah D. Doerksen, James A. Merritt, Susan A. Wright & Keith E. Shults. (1999) Bivariate analysis of the p53 pathway to evaluate Ad-p53 gene therapy efficacy. Cytometry 38:5, pages 201-213.
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M Alkhalaf, G Ganguli, N Messaddeq, M Le Meur & B Wasylyk. (1999) MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice. Oncogene 18:7, pages 1419-1434.
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Zhe Yu, Jian Chen, Barry N. Ford, Moyra E. Brackley & Barry W. Glickman. (1999) Human DNA repair systems: An overview. Environmental and Molecular Mutagenesis 33:1, pages 3-20.
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Gerrard TeohMitsuyoshi UrashimaAtsushi OgataDharminder ChauhanJames A. DeCaprioSteven P. TreonRobert L. SchlossmanKenneth C. Anderson. (1997) MDM2 Protein Overexpression Promotes Proliferation and Survival of Multiple Myeloma Cells. Blood 90:5, pages 1982-1992.
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PB Sugerman & EJ Shillitoe. (2008) The high risk human papillomaviruses and oral cancer: evidence for and against a causal relationship. Oral Diseases 3:3, pages 130-147.
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VASSILIS G. GORGOULIS, VASSILIS ZOUMPOURLIS, GEORGE Z. RASSIDAKIS, ANDREAS KARAMERIS, ANTONIS N. RASSIDAKIS, DEMETRIOS A. SPANDIDOS & CHRISTOS KITTAS. (1996) A MOLECULAR AND IMMUNOHISTOCHEMICAL STUDY OF THE MDM2 PROTEIN ISOFORMS ANDp53 GENE PRODUCT IN BRONCHOGENIC CARCINOMA. The Journal of Pathology 180:2, pages 129-137.
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Barbara Seliger, Stefan Papadileris, Detlef Vogel, Georg Hess, Cornelia Brendel, Stephen Störkel, Joachim örtel, Karin Kolbe, Christoph Huber, Dieter Huhn & Andreas Neubauer. (2009) Analysis of the p53 and MDM‐2 gene in acute myeloid leukemia . European Journal of Haematology 57:3, pages 230-240.
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C D Fegan & F E Davies. (1996) Karyotypic and molecular abnormalities in chronic lymphocytic leukaemia. Molecular Pathology 49:4, pages M185-M191.
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Carlos E. Bueso-Ramos, Taghi Manshouri, Mohammad A. Haidar, Yun Yang, Patrick McCown, Nelson Ordonez, Armand Glassman, Nour Sneige & Maher Albitar. (1996) Abnormal expression of MDM-2 in breast carcinomas. Breast Cancer Research and Treatment 37:2, pages 179-188.
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