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Original Article

TGF-β and Megakaryocytes in the Pathogenesis of Myelofibrosis in Myeloproliferative Disorders

Pages 39-44 | Received 03 Feb 1995, Published online: 01 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Li Xu, Juan Feng, Guangxun Gao & Hailong Tang. (2019) Momelotinib for the treatment of myelofibrosis. Expert Opinion on Pharmacotherapy 20:16, pages 1943-1951.
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Paolo Strati, William F. Glass, Maen Abdelrahim, Umut Selamet, Amanda Tchakarov, Biruh T. Workeneh, Srdan Verstovsek & Ala Abudayyeh. (2019) Renal complications of primary myelofibrosis. Leukemia & Lymphoma 60:2, pages 507-510.
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Seiichi Okabe, Keisuke Miyazawa, Tomotaka Iguchi, Masahiko Sumi, Tomoiku Takaku, Yoshikazu Ito, Yukihiko Kimura, Hiromi Serizawa, Kiyoshi Mukai & Kazuma Ohyashiki. (2005) Peripheral T-cell lymphoma together with myelofibrosis with elevated plasma transforming growth factor-β1. Leukemia & Lymphoma 46:4, pages 599-602.
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J. Thiele & H. M. Kvasnicka. (2001) Comparative Effects of Interferon and Hydroxyurea on Bone Marrow Fibrosis in Chronic Myelogenous Leukemia. Leukemia & Lymphoma 42:5, pages 855-862.
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Juergen Thiele, Hans Michael Kvasnicka, Annette Schmitt-Graeff, Thomas Karl Zirbes, Florian Birnbaum, Christian Kressmann, Manuel Melguizo-Grahmann, Holger Frackenpohl, Claudia Sprungmann, Lutz-Dietrich Leder, Volker Diehl, Rudolf Zankovich, Hans Eckart Schaefer, Norbert Niederle & Robert Fischer. (2000) Bone Marrow Features and Clinical Findings in Chronic Myeloid Leukemia - A Comparative, Multicenter, Immunohistological and Morphometric Study on 614 Patients. Leukemia & Lymphoma 36:3-4, pages 295-308.
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Niklas Zojer, Johannes Gobertus Meran, Michael Vesely, Helga Grüner, Jutta Ackermann, Christian Dellinger, Ilse Zimmer-Roth, Renate Heinz, Johannes Drach & Heinz Ludwig. (1999) Trisomy 13 is Associated with Poor Prognosis in Idiopathic Myelofibrosis with Myeloid Metaplasia. Leukemia & Lymphoma 35:3-4, pages 415-421.
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Juergen Thiele, Hans Michael Kvasnicka, Robert Fischer & Volker Diehl. (1997) Clinicopathological Impact of the Interaction Between Megakaryocytes and Myeloid Stroma in Chronic Myeloproliferative Disorders: A Concise Update. Leukemia & Lymphoma 24:5-6, pages 463-481.
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Articles from other publishers (52)

Hristo Popov, Tatiana Koleva, George S Stoyanov & Peter Ghenev. (2022) Myeloproliferative Neoplasm and Myelodysplastic Syndrome-Associated Renal Disease: A Histopathological Report of Two Cases. Cureus.
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Maria Zingariello, Paola Verachi, Francesca Gobbo, Fabrizio Martelli, Mario Falchi, Maria Mazzarini, Mauro Valeri, Giuseppe Sarli, Christian Marinaccio, Johanna Melo-Cardenas, John D. Crispino & Anna Rita Migliaccio. (2022) Resident Self-Tissue of Proinflammatory Cytokines Rather Than Their Systemic Levels Correlates with Development of Myelofibrosis in Gata1low Mice. Biomolecules 12:2, pages 234.
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Maike Büttner‐Herold, Carsten Sticht, Thorsten Wiech & Stefan Porubsky. (2020) Renal disease associated with myeloproliferative neoplasms and myelodysplastic syndrome/myeloproliferative neoplasms. Histopathology 78:5, pages 738-748.
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Paolo Strati, Maen Abdelrahim, Umut Selamet, Valda D. Page, Sherry A. Pierce, Srdan Verstovsek & Ala Abudayyeh. (2019) Ruxolitinib therapy is associated with improved renal function in patients with primary myelofibrosis. Annals of Hematology 98:7, pages 1611-1616.
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Seung-Woo Baek, Ji Young Moon, Hyewon Ryu, Yoon-Seok Choi, Ik-Chan Song, Hyo-Jin Lee, Hwan-Jung Yun, Samyoung Kim & Deog-Yeon Jo. (2018) Chronic kidney disease in the BCR-ABL1-negative myeloproliferative neoplasm: a single-center retrospective study. The Korean Journal of Internal Medicine 33:4, pages 790-797.
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Anthony D. Whetton, Norhaida Che Azmi, Stella Pearson, Ewa Jaworska, Liqun Zhang, Rognvald Blance, Alexandra C. Kendall, Anna Nicolaou, Samuel Taylor, Andrew J.K. Williamson & Andrew Pierce. (2016) MPL W515L expression induces TGFβ secretion and leads to an increase in chemokinesis via phosphorylation of THOC5 . Oncotarget 7:10, pages 10739-10755.
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Arun Rajasekaran, Thuy-Trang Ngo, Maen Abdelrahim, William Glass, Amber Podoll, Srdan Verstovsek & Ala Abudayyeh. (2015) Primary myelofibrosis associated glomerulopathy: significant improvement after therapy with ruxolitinib. BMC Nephrology 16:1.
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Glauco Akelinghton Freire Vitiello, Roberta Losi Guembarovski, Carlos Eduardo Coral de Oliveira, Marla Karine Amarante, Aparecida de Lourdes Perim & Maria Angelica Ehara Watanabe. (2015) Involvement of transforming growth factor beta-1 (TGFβ1) cytokine and FOXP3 transcription factor genetic polymorphisms in hematological malignancies. Brazilian Archives of Biology and Technology 58:4, pages 553-561.
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Christophe Desterke, Christophe Martinaud, Nadira Ruzehaji & Marie-Caroline Le Bousse-Kerdilès. (2015) Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis. Mediators of Inflammation 2015, pages 1-16.
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Paulo Vidal Campregher. (2014) Does angiogenesis matter in primary myelofibrosis?. Revista Brasileira de Hematologia e Hemoterapia 36:5, pages 311-312.
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Judit Bedekovics, Attila Kiss, Lívia Beke, Katalin Károlyi & Gábor Méhes. (2013) Platelet derived growth factor receptor-beta (PDGFRβ) expression is limited to activated stromal cells in the bone marrow and shows a strong correlation with the grade of myelofibrosis. Virchows Archiv 463:1, pages 57-65.
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R. Paule, M. Ponsoye, V. Gueutin, G. Deray & H. Izzedine. (2013) Glomérulopathies associées aux syndromes myéloprolifératifs. La Revue de Médecine Interne 34:6, pages 369-372.
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Effrosyni Apostolidou, Hagop Kantarjian, Deborah Thomas, Ian Burger, Gautam Borthakur & Srdan Verstovsek. (2010) Phase II Study of Sunitinib in Patients With Primary or Post–Polycythemia Vera/Essential Thrombocythemia Myelofibrosis. Clinical Lymphoma Myeloma and Leukemia 10:4, pages 281-284.
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Sara Galimberti, Martina Canestaro, Eugenio Ciancia, Rita Fazzi, Roberto Marasca & Mario Petrini. (2008) Bortezomib is able to reduce angiogenesis in half of patients affected by idiopathic myelofibrosis: An ex vivo study. Leukemia Research 32:8, pages 1324-1325.
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Kumiko Matsui, Mayumi Adachi, Takayuki Tominaga, Kenji Shinohara & Toshiaki Kamei. (2008) Angioimmunoblastic T Cell Lymphoma Associated with Reversible Myelofibrosis. Internal Medicine 47:21, pages 1921-1924.
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Verena Pihusch, Markus Pihusch, Marius Penovici, Hans J. Kolb, Erhard Hiller & Rudolf Pihusch. (2005) Transforming growth factor beta-1 released from platelets contributes to hypercoagulability in veno-occlusive disease following hematopoetic stem cell transplantation. Thrombosis Research 116:3, pages 233-240.
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Juergen Thiele, Hans Michael Kvasnicka, Dietrich Wilhelm Beelen, Guelken Cicek, Lutz-Dietrich Leder & Ulrich Wilhelm Schaefer. (2002) Dynamics of CD34 + Progenitor Cells Following Allogeneic Bone Marrow Transplantation in Ph 1+ CML—An Immunohistochemical Study on 113 Patients with Sequential Trephine Biopsies . Journal of Hematotherapy & Stem Cell Research 11:3, pages 565-574.
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