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Leukemia & Lymphoma Volume 17, 1995 - Issue 5-6
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Original Article

Intrinsic Expression of the Multidrug Transporter, P-Glycoprotein 170, in Multiple Myeloma: Implications for Treatment

Linda M. Pilarski Departments of Immunology and Oncology, University of Alberta, Edmonton, Alberta, Canada
&
Andrew R. Belch Departments of Immunology and Oncology, University of Alberta, Edmonton, Alberta, Canada
Pages 367-374 | Received 15 Jul 1994, Published online: 01 Jul 2009

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Divya Khaitan & B S Dwarakanath. (2006) Multicellular spheroids as an in vitro model in experimental oncology: applications in translational medicine. Expert Opinion on Drug Discovery 1:7, pages 663-675.
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Thomas Rasmussen. (2001) The Presence of Circulating Clonal CD19+ Cells in Multiple Myeloma. Leukemia & Lymphoma 42:6, pages 1359-1366.
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Thomas Rasmussen, Linda Jensen & Hans Erik Johnsen. (2000) The Clonal Hierachy in Multiple Myeloma. Acta Oncologica 39:7, pages 765-770.
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Linda M. Pilarski, Michael J. Mant & Andrew R. Belch. (1999) Drug Resistance in Multiple Myeloma: Novel Therapeutic Targets Within the Malignant Clone. Leukemia & Lymphoma 32:3-4, pages 199-210.
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Linda M. Pilarski, Anna Masellis-Smith, Agnieszka Szczepek, Michael J. Mant & Andrew R. Belch. (1996) Circulating Clonotypic B Cells in the Biology of Multiple Myeloma: Speculations on the Origin of Myeloma. Leukemia & Lymphoma 22:5-6, pages 375-383.
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Articles from other publishers (27)

S. Rajeev Krishnan & M. Bebawy. (2023) Circulating biosignatures in multiple myeloma and their role in multidrug resistance. Molecular Cancer 22:1.
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Chung-Pu Wu, Cheng-Yu Hung, Megumi Murakami, Yu-Shan Wu, Chun-Ling Lin, Yang-Hui Huang, Tai-Ho Hung, Jau-Song Yu & Suresh Ambudkar. (2022) P-glycoprotein Mediates Resistance to the Anaplastic Lymphoma Kinase Inhibitor Ensartinib in Cancer Cells. Cancers 14:9, pages 2341.
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Chung-Pu Wu, Cheng-Yu Hung, Sabrina Lusvarghi, Yen-Fu Chang, Sung-Han Hsiao, Yang-Hui Huang, Tai-Ho Hung, Jau-Song Yu & Suresh. V. Ambudkar. (2021) Overexpression of Human ABCB1 and ABCG2 Reduces the Susceptibility of Cancer Cells to the Histone Deacetylase 6-Specific Inhibitor Citarinostat. International Journal of Molecular Sciences 22:5, pages 2592.
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Sabna Rajeev Krishnan, Gabriele De Rubis, Hayley Suen, Douglas Joshua, Yiu Lam Kwan & Mary Bebawy. (2020) A liquid biopsy to detect multidrug resistance and disease burden in multiple myeloma. Blood Cancer Journal 10:3.
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Chung-Pu Wu, Sabrina Lusvarghi, Jyun-Cheng Wang, Sung-Han Hsiao, Yang-Hui Huang, Tai-Ho Hung & Suresh V. Ambudkar. (2019) The Selective Class IIa Histone Deacetylase Inhibitor TMP195 Resensitizes ABCB1- and ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Cytotoxic Anticancer Drugs. International Journal of Molecular Sciences 21:1, pages 238.
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Chung-Pu Wu, Sabrina Lusvarghi, Jyun-Cheng Wang, Sung-Han Hsiao, Yang-Hui Huang, Tai-Ho Hung & Suresh V. Ambudkar. (2019) Avapritinib: A Selective Inhibitor of KIT and PDGFRα that Reverses ABCB1 and ABCG2-Mediated Multidrug Resistance in Cancer Cell Lines. Molecular Pharmaceutics 16:7, pages 3040-3052.
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Sung-Han Hsiao, Sabrina Lusvarghi, Yang-Hui Huang, Suresh V. Ambudkar, Sheng-Chieh Hsu & Chung-Pu Wu. (2019) The FLT3 inhibitor midostaurin selectively resensitizes ABCB1-overexpressing multidrug-resistant cancer cells to conventional chemotherapeutic agents. Cancer Letters 445, pages 34-44.
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Sung-Han Hsiao, Megumi Murakami, Ni Yeh, Yan-Qing Li, Tai-Ho Hung, Yu-Shan Wu, Suresh V. Ambudkar & Chung-Pu Wu. (2018) The positive inotropic agent DPI-201106 selectively reverses ABCB1-mediated multidrug resistance in cancer cell lines. Cancer Letters 434, pages 81-90.
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Chung-Pu Wu, Megumi Murakami, Sung-Han Hsiao, Te-Chun Liu, Ni Yeh, Yan-Qing Li, Tai-Ho Hung, Yu-Shan Wu & Suresh. V. Ambudkar. (2018) SIS3, a specific inhibitor of Smad3 reverses ABCB1- and ABCG2-mediated multidrug resistance in cancer cell lines. Cancer Letters 433, pages 259-272.
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Chung-Pu Wu, Ya-Ju Hsieh, Megumi Murakami, Shahrooz Vahedi, Sung-Han Hsiao, Ni Yeh, An-Wei Chou, Yan-Qing Li, Yu-Shan Wu, Jau-Song Yu & Suresh V. Ambudkar. (2018) Human ATP-binding cassette transporters ABCB1 and ABCG2 confer resistance to histone deacetylase 6 inhibitor ricolinostat (ACY-1215) in cancer cell lines. Biochemical Pharmacology 155, pages 316-325.
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A Besse, S C Stolze, L Rasche, N Weinhold, G J Morgan, M Kraus, J Bader, H S Overkleeft, L Besse & C Driessen. (2017) Carfilzomib resistance due to ABCB1/MDR1 overexpression is overcome by nelfinavir and lopinavir in multiple myeloma. Leukemia 32:2, pages 391-401.
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SABNA RAJEEV KRISHNAN, RITU JAISWAL, ROSS D. BROWN, FREDERICK LUK & MARY BEBAWY. (2016) Multiple myeloma and persistence of drug resistance in the age of novel drugs (Review). International Journal of Oncology 49:1, pages 33-50.
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Emeline Valton, Christian Amblard, François Desmolles, Bruno Combourieu, Frédérique Penault-Llorca & Mahchid Bamdad. (2015) Mini-P-gp and P-gp Co-Expression in Brown Trout Erythrocytes: A Prospective Blood Biomarker of Aquatic Pollution. Diagnostics 5:1, pages 10-26.
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E. Joseph ConwayJianguo WenYongdong FengAlbert MoWan-Ting HuangCarolyn A. Keever-TaylorParameswaran HariDavid H. VesoleChung-Che Chang. (2009) Phenotyping Studies of Clonotypic B Lymphocytes From Patients With Multiple Myeloma by Flow Cytometry. Archives of Pathology & Laboratory Medicine 133:10, pages 1594-1599.
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Linda M. Pilarski, Jana Lauzon, Erin Strachan, Sophia Adamia, Alexey Atrazhev, Andrew R. Belch & Christopher J. Backhouse. (2005) Sensitive detection using microfluidics technology of single cell PCR products from high and low abundance IgH VDJ templates in multiple myeloma. Journal of Immunological Methods 305:1, pages 94-105.
Crossref
Linda M. Pilarski, Tony Reiman, Patrick M. Pilarski, F. William Orr & Andrew R. Belch. 2004. Bone Metastasis and Molecular Mechanisms. Bone Metastasis and Molecular Mechanisms 109 138 .
P. Sapra & T.M. Allen. (2003) Ligand-targeted liposomal anticancer drugs. Progress in Lipid Research 42:5, pages 439-462.
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Anouk B. Schroeijers, Anneke W. Reurs, George L. Scheffer, Anita G. M. Stam, Mariska C. de Jong, Thomas Rustemeyer, Erik A. C. Wiemer, Tanja D. de Gruijl & Rik J. Scheper. (2002) Up-Regulation of Drug Resistance-Related Vaults During Dendritic Cell Development. The Journal of Immunology 168:4, pages 1572-1578.
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Chung-Che Chang, Bernard C Schur, Bal Kampalath, Paul Lindholm, Carl G Becker & David H Vesole. (2001) A Novel Multiparametric Approach for Analysis of Cytoplasmic Immunoglobulin Light Chains by Flow Cytometry. Modern Pathology 14:10, pages 1015-1021.
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Mothanje Barbara Lucia, Sergio Rutella, Giuseppe Leone, Stefano Vella & Roberto Cauda. (2001) HIV-Protease Inhibitors Contribute to P-Glycoprotein Efflux Function Defect in Peripheral Blood Lymphocytes From HIV-Positive Patients Receiving HAART. JAIDS Journal of Acquired Immune Deficiency Syndromes 27:4, pages 321-330.
Crossref
Mothanje Barbara Lucia, Sergio Rutella, Giuseppe Leone, Stefano Vella & Roberto Cauda. (2001) HIV-Protease Inhibitors Contribute to P-Glycoprotein Efflux Function Defect in Peripheral Blood Lymphocytes From HIV-Positive Patients Receiving HAART. Journal of Acquired Immune Deficiency Syndromes 27:4, pages 321-330.
Crossref
Maria Wartenberg, Frederike C. Ling, Maurice Schallenberg, Anselm T. Bäumer, Kerstin Petrat, Jürgen Hescheler & Heinrich Sauer. (2001) Down-regulation of Intrinsic P-glycoprotein Expression in Multicellular Prostate Tumor Spheroids by Reactive Oxygen Species. Journal of Biological Chemistry 276:20, pages 17420-17428.
Crossref
Daniel E. Lopes de Menezes, Linda M. Pilarski, Andrew R. Belch & Theresa M. Allen. (2000) Selective targeting of immunoliposomal doxorubicin against human multiple myeloma in vitro and ex vivo. Biochimica et Biophysica Acta (BBA) - Biomembranes 1466:1-2, pages 205-220.
Crossref
Mary CrainieAndrew R. BelchMichael J. MantLinda M. Pilarski. (1999) Overexpression of the Receptor for Hyaluronan-Mediated Motility (RHAMM) Characterizes the Malignant Clone in Multiple Myeloma: Identification of Three Distinct RHAMM Variants. Blood 93:5, pages 1684-1696.
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Agnieszka J. SzczepekKaren SeebergerJuanita WizniakMichael J. MantAndrew R. BelchLinda M. Pilarski. (1998) A High Frequency of Circulating B Cells Share Clonotypic Ig Heavy-Chain VDJ Rearrangements With Autologous Bone Marrow Plasma Cells in Multiple Myeloma, as Measured by Single-Cell and In Situ Reverse Transcriptase-Polymerase Chain Reaction. Blood 92:8, pages 2844-2855.
Crossref
Linda M. PilarskiAgnieszka J. SzczepekAndrew R. Belch. (1997) Deficient Drug Transporter Function of Bone Marrow–Localized and Leukemic Plasma Cells in Multiple Myeloma. Blood 90:9, pages 3751-3759.
Crossref
Agnieszka J. SzczepekP.L. BergsagelLinus AxelssonChristopher B. BrownAndrew R. BelchLinda M. Pilarski. (1997) CD34+ Cells in the Blood of Patients With Multiple Myeloma Express CD19 and IgH mRNA and Have Patient-Specific IgH VDJ Gene Rearrangements. Blood 89:5, pages 1824-1833.
Crossref

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