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Leukemia & Lymphoma Volume 22, 1996 - Issue 5-6
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Original Article

Treatment of Three Patients with Systemic Mastocytosis with Interferon Alpha-2b

Alexandra S. Worobec Laboratory of Allergic Diseases, Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
,
Arnold S. Kirshenbaum Laboratory of Allergic Diseases, Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
,
Lawrence B. Schwartz Department of Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA
&
Dean D. Metcalfe Laboratory of Allergic Diseases, Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
Pages 501-508 | Received 10 Dec 1995, Published online: 01 Jul 2009

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Wolfgang R. Sperr, Hans P. Horny, Klaus Lechner & Peter Valent. (2000) Clinical and Biologic Diversity of Leukemias Occurring in Patients with Mastocytosis. Leukemia & Lymphoma 37:5-6, pages 473-486.
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Se Munn. (1998) Treatment of mastocytosis. Journal of Dermatological Treatment 9:2, pages 119-123.
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Articles from other publishers (64)

Animesh Pardanani, Kaaren Reichard & Ayalew Tefferi. (2023) Advanced systemic mastocytosis—Revised classification, new drugs and how we treat. British Journal of Haematology.
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Animesh Pardanani. (2023) Systemic mastocytosis in adults: 2023 update on diagnosis, risk stratification and management. American Journal of Hematology 98:7, pages 1097-1116.
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Maura Nicolosi, Andrea Patriarca, Annalisa Andorno, Abdurraouf Mokhtar Mahmoud, Alessandra Gennari, Renzo Boldorini, Gianluca Gaidano & Elena Crisà. (2021) Precision Medicine in Systemic Mastocytosis. Medicina 57:11, pages 1135.
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Animesh Pardanani. (2021) Systemic mastocytosis in adults: 2021 Update on diagnosis, risk stratification and management. American Journal of Hematology 96:4, pages 508-525.
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Laura Polivka & Christine Bodemer. 2019. Harper's Textbook of Pediatric Dermatology. Harper's Textbook of Pediatric Dermatology 1097 1109 .
Alexander Coltoff & John Mascarenhas. (2019) Relevant updates in systemic mastocytosis. Leukemia Research 81, pages 10-18.
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Justin Budnik & Michael T. Milano. (2019) A registry-based analysis of survival outcomes in mast cell leukemia. Leukemia Research 78, pages 24-28.
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Peter Valent, Cem Akin, Karin Hartmann, Gunnar Nilsson, Andreas Reiter, Olivier Hermine, Karl Sotlar, Wolfgang R. Sperr, Luis Escribano, Tracy I. George, Hanneke C. Kluin-Nelemans, Celalettin Ustun, Massimo Triggiani, Knut Brockow, Jason Gotlib, Alberto Orfao, Lawrence B. Schwartz, Sigurd Broesby-Olsen, Carsten Bindslev-Jensen, Petri T. Kovanen, Stephen J. Galli, K. Frank Austen, Daniel A. Arber, Hans-Peter Horny, Michel Arock & Dean D. Metcalfe. (2017) Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future. Cancer Research 77:6, pages 1261-1270.
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Animesh Pardanani. (2016) Systemic mastocytosis in adults: 2017 update on diagnosis, risk stratification and management. American Journal of Hematology 91:11, pages 1146-1159.
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Gerhard J. Molderings, Britta Haenisch, Stefan Brettner, Jürgen Homann, Markus Menzen, Franz Ludwig Dumoulin, Jens Panse, Joseph Butterfield & Lawrence B. Afrin. (2016) Pharmacological treatment options for mast cell activation disease. Naunyn-Schmiedeberg's Archives of Pharmacology 389:7, pages 671-694.
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Animesh Pardanani. (2015) Systemic mastocytosis in adults: 2015 update on diagnosis, risk stratification, and management. American Journal of Hematology 90:3, pages 250-262.
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Animesh Pardanani. (2013) Systemic mastocytosis in adults: 2013 update on diagnosis, risk stratification, and management. American Journal of Hematology 88:7, pages 612-624.
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Bérengère Gruson, Olivier Lortholary, Danielle Canioni, Olivia Chandesris, Fanny Lanternier, Julie Bruneau, Bernard Grosbois, Cristina Livideanu, Claire Larroche, Isabelle Durieu, Stéphane Barete, Henri Sevestre, Momar Diouf, Guillaume Chaby, Jean‐Pierre Marolleau, Patrice Dubreuil, Olivier Hermine & Gandhi Damaj. (2013) Thalidomide in systemic mastocytosis: results from an open‐label, multicentre, phase II study . British Journal of Haematology 161:3, pages 434-442.
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Jason GotlibAnimesh PardananiCem AkinAndreas ReiterTracy GeorgeOlivier HermineHanneke Kluin-NelemansKarin HartmannWolfgang R. SperrKnut BrockowLawrence B. SchwartzAlberto OrfaoDaniel J. DeAngeloMichel ArockKarl SotlarHans-Peter HornyDean D. MetcalfeLuis EscribanoSrdan Verstovsek, Ayalew TefferiPeter Valent. (2013) International Working Group-Myeloproliferative Neoplasms Research and Treatment (IWG-MRT) & European Competence Network on Mastocytosis (ECNM) consensus response criteria in advanced systemic mastocytosis. Blood 121:13, pages 2393-2401.
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Sophie Georgin-LavialleLudovic LhermittePatrice DubreuilMarie-Olivia ChandesrisOlivier Hermine & Gandhi Damaj. (2013) Mast cell leukemia. Blood 121:8, pages 1285-1295.
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Animesh Pardanani. (2012) Systemic Mastocytosis. Hematology/Oncology Clinics of North America 26:5, pages 1117-1128.
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Jason Gotlib & Cem Akin. (2012) Mast Cells and Eosinophils in Mastocytosis, Chronic Eosinophilic Leukemia, and Non-clonal Disorders. Seminars in Hematology 49:2, pages 128-137.
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Magalie Joris, Sophie Georgin-Lavialle, Marie-Olivia Chandesris, Ludovic Lhermitte, Jean-François Claisse, Danielle Canioni, Katia Hanssens, Gandhi Damaj, Olivier Hermine & Mohammed Hamidou. (2012) Mast Cell Leukaemia: c-KIT Mutations Are Not Always Positive. Case Reports in Hematology 2012, pages 1-6.
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Didem Ozdemir, Selcuk Dagdelen & Tomris Erbas. (2011) Systemic Mastocytosis. The American Journal of the Medical Sciences 342:5, pages 409-415.
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Animesh Pardanani. (2011) Systemic mastocytosis in adults: 2011 update on diagnosis, risk stratification, and management. American Journal of Hematology 86:4, pages 362-371.
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Peter Valent. 2009. Clinical Applications of Immunomics. Clinical Applications of Immunomics 107 125 .
Martin Metz, Knut Brockow, Dean D. Metcalfe & Stephen J. Galli. 2008. Clinical Immunology. Clinical Immunology 345 360 .
Peter Valent, Cem Akin, Hans-Peter Horny & Dean Metcalfe. 2007. Myeloproliferative Disorders. Myeloproliferative Disorders 161 184 .
Susan I. Hungness & Cem Akin. (2007) Mastocytosis: Advances in diagnosis and treatment. Current Allergy and Asthma Reports 7:4, pages 248-254.
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Karl J. AichbergerMatthias MayerhoferKaroline V. GleixnerMaria-Theresa KrauthAlexander GruzeWinfried F. PicklVolker WacheckEdgar SelzerLeonhard Müllauer, Hermine AgisChristian SillaberPeter Valent. (2006) Identification of MCL1 as a novel target in neoplastic mast cells in systemic mastocytosis: inhibition of mast cell survival by MCL1 antisense oligonucleotides and synergism with PKC412. Blood 109:7, pages 3031-3041.
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Lawrence B. Schwartz. (2006) Diagnostic Value of Tryptase in Anaphylaxis and Mastocytosis. Immunology and Allergy Clinics of North America 26:3, pages 451-463.
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Todd M. Wilson, Dean D. Metcalfe & Jamie Robyn. (2006) Treatment of Systemic Mastocytosis. Immunology and Allergy Clinics of North America 26:3, pages 549-573.
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Peter Valent. (2006) Diagnostic Evaluation and Classification of Mastocytosis. Immunology and Allergy Clinics of North America 26:3, pages 515-534.
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Jamie Robyn & Dean D. Metcalfe. 2006. 169 243 .
Joseph H. Butterfield, Ayalew Tefferi & Gerald F. Kozuh. (2005) Successful treatment of systemic mastocytosis with high-dose interferon-alfa: long-term follow-up of a case. Leukemia Research 29:2, pages 131-134.
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A. Pardanani. (2005) Systemic Mastocytosis: Bone Marrow Pathology, Classification, and Current Therapies. Acta Haematologica 114:1, pages 41-51.
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J.H. Butterfield. (2005) Interferon Treatment for Hypereosinophilic Syndromes and Systemic Mastocytosis. Acta Haematologica 114:1, pages 26-40.
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Bryan Hennessy, Francis Giles, Jorge Cortes, Susan O'Brien, Alessandra Ferrajoli, Gladys Ossa, Guillermo Garcia‐Manero, Stefan Faderl, Hagop Kantarjian & Srdan Verstovsek. (2004) Management of patients with systemic mastocytosis: Review of M. D. Anderson Cancer Center experience. American Journal of Hematology 77:3, pages 209-214.
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P. Valent, M. Ghannadan, C. Akin, M.-T. Krauth, E. Selzer, M. Mayerhofer, W. R. Sperr, M. Arock, P. Samorapoompichit, H.-P. Horny & D. D. Metcalfe. (2004) On the way to targeted therapy of mast cell neoplasms: identification of molecular targets in neoplastic mast cells and evaluation of arising treatment concepts. European Journal of Clinical Investigation 34:s2, pages 41-52.
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Peter Valent, Wolfgang R Sperr, Lawrence B Schwartz & Hans-Peter Horny. (2004) Diagnosis and classification of mast cell proliferative disorders: delineation from immunologic diseases and non–mast cell hematopoietic neoplasms. Journal of Allergy and Clinical Immunology 114:1, pages 3-11.
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J Simon, O Lortholary, N Caillat-Vigneron, M Raphaël, A Martin, J Brière, S Barète, O Hermine & Ph Casassus. (2004) Interest of interferon alpha in systemic mastocytosis. The French experience and review of the literature. Pathologie Biologie 52:5, pages 294-299.
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Knut Brockow. (2004) Urticaria pigmentosa. Immunology and Allergy Clinics of North America 24:2, pages 287-316.
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Ayalew Tefferi. (2004) Treatment of systemic mast cell disease: beyond interferon. Leukemia Research 28:3, pages 223-224.
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Alexander W Hauswirth, Ingrid Simonitsch-Klupp, Martin Uffmann, Elisabeth Koller, Wolfgang R Sperr, Klaus Lechner & Peter Valent. (2004) Response to therapy with interferon alpha-2b and prednisolone in aggressive systemic mastocytosis: report of five cases and review of the literature. Leukemia Research 28:3, pages 249-257.
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Cem AkinDean D. Metcalfe. (2004) Systemic Mastocytosis. Annual Review of Medicine 55:1, pages 419-432.
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A Pardanani, A.V Hoffbrand, J.H Butterfield & A Tefferi. (2004) Treatment of systemic mast cell disease with 2-chlorodeoxyadenosine. Leukemia Research 28:2, pages 127-131.
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Frédéric Féger, Olivier Hermine, Jean-Jacques Guillosson & Michel Arock. 2004. Molecular Basis of Chronic Myeloproliferative Disorders. Molecular Basis of Chronic Myeloproliferative Disorders 169 179 .
Huseyin Caksen, Dursun Odabas, Ahmet Faik Oner, Yasar Cesur, Şukru Arslan, Sinan Akbayram, Sevil Ari Yuca & Mehmet Erol. (2003) Use of interferon alpha-2b and prednisolone in the treatment of severe intractable diarrhea in a child with systemic mastocytosis. Pediatrics International 45:6, pages 751-754.
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Peter Valent, Cem Akin, Wolfgang R. Sperr, Hans-P. Horny, Michel Arock, Klaus Lechner, John M. Bennett & Dean D. Metcalfe. (2003) Diagnosis and treatment of systemic mastocytosis: state of the art. British Journal of Haematology 122:5, pages 695-717.
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F Marrache, N Mémain, I Bonté, S Barete, P Casassus, C de Gennes, O Fain, O Hermine & O Lortholary. (2003) Traitement des mastocytoses systémiques. La Revue de Médecine Interne 24:9, pages 594-601.
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Philippe Casassus, Nadine Caillat‐Vigneron, Antoine Martin, Jeanne Simon, Valérie Gallais, Patrice Beaudry, Virginie Eclache, Liliane Laroche, Pierre Lortholary, Martine Raphaël, Loïc Guillevin & Olivier Lortholary. (2002) Treatment of adult systemic mastocytosis with interferon‐α: results of a multicentre phase II trial on 20 patients. British Journal of Haematology 119:4, pages 1090-1097.
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Animesh Pardanani, Jin-Young Baek, Chin-Yang Li, Joseph H. Butterfield & Ayalew Tefferi. (2002) Systemic Mast Cell Disease Without Associated Hematologic Disorder: A Combined Retrospective and Prospective Study. Mayo Clinic Proceedings 77:11, pages 1169-1175.
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Albert T. LiaoMay B. ChienNarmada ShenoyDirk B. MendelGerald McMahonJulie M. CherringtonCheryl A. London. (2002) Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors. Blood 100:2, pages 585-593.
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Karin Hartmann, Stefanie B. Bruns & Beate M. Henz. (2001) Mastocytosis: Review of Clinical and Experimental Aspects. Journal of Investigative Dermatology Symposium Proceedings 6:2, pages 143-147.
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Michael D. Tharp & B. Jack LongleyJrJr. (2001) MASTOCYTOSIS. Dermatologic Clinics 19:4, pages 679-696.
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Gianni Marone, Giuseppe Spadaro, Francescopaolo Granata & Massimo Triggiani. (2001) Treatment of mastocytosis: pharmacologic basis and current concepts. Leukemia Research 25:7, pages 583-594.
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Peter Valent, Hans-P Horny, Luis Escribano, B.Jack Longley, Chin Y Li, Lawrence B Schwartz, Gianni Marone, Rosa Nuñez, Cem Akin, Karl Sotlar, Wolfgang R Sperr, Klaus Wolff, Richard D Brunning, Reza M Parwaresch, K.Frank Austen, Karl Lennert, Dean D Metcalfe, James W Vardiman & John M Bennett. (2001) Diagnostic criteria and classification of mastocytosis: a consensus proposal. Leukemia Research 25:7, pages 603-625.
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Lawrence B. Schwartz. (2001) Clinical utility of tryptase levels in systemic mastocytosis and associated hematologic disorders. Leukemia Research 25:7, pages 553-562.
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K. Hartmann & B.M. Henz. (2001) Mastocytosis: recent advances in defining the disease. British Journal of Dermatology 144:4, pages 682-695.
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Lawrence B. Schwartz & Anne-Marie A. Irani. (2000) SERUM TRYPTASE AND THE LABORATORY DIAGNOSIS OF SYSTEMIC MASTOCYTOSIS. Hematology/Oncology Clinics of North America 14:3, pages 641-657.
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Robert T. Jensen. (2000) GASTROINTESTINAL ABNORMALITIES AND INVOLVEMENT IN SYSTEMIC MASTOCYTOSIS. Hematology/Oncology Clinics of North America 14:3, pages 579-623.
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Robert I. Parker. (2000) HEMATOLOGIC ASPECTS OF SYSTEMIC MASTOCYTOSIS. Hematology/Oncology Clinics of North America 14:3, pages 557-568.
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Stephan C. Bischoff. 2000. Mast Cells and Basophils. Mast Cells and Basophils 541 565 .
Barbara J. Bain. (2004) SYSTEMIC MASTOCYTOSIS AND OTHER MAST CELL NEOPLASMS. British Journal of Haematology 106:1, pages 9-17.
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Alexandra S. Worobec, Tekli Semere, Hiroshi Nagata & Dean D. Metcalfe. (1998) Clinical correlates of the presence of the asp816Val c-kit mutation in the peripheral blood mononuclear cells of patients with mastocytosis. Cancer 83:10, pages 2120-2129.
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Granerus LÖnnqvist Nystrand Roupe. (2002) Serum tryptase measured with B12 and G5 antibody‐based immunoassays in mastocytosis patients and its relation to histamine turnover. British Journal of Dermatology 139:5, pages 858-861.
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Butterfield. (1998) Response of severe systemic mastocytosis to interferon alpha. British Journal of Dermatology 138:3, pages 489-495.
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N. Haas & B. M. Henz. 1998. Urticaria. Urticaria 125 138 .
Angela Duff Hogan & Lawrence B. Schwartz. (1997) Markers of Mast Cell Degranulation. Methods 13:1, pages 43-52.
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