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Original Article

The Human Immunodeficiency Virus Type-1 (HIV-1) Tat Protein and Bcl-2 Gene Expression

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Pages 551-560 | Received 16 Mar 1996, Published online: 01 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Manish K Johri, Ritu Mishra, Chintan Chhatbar, Salini K Unni & Sunit K Singh. (2011) Tits and bits of HIV Tat protein. Expert Opinion on Biological Therapy 11:3, pages 269-283.
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Articles from other publishers (30)

Yiqun Li, Mingyang Xue, Yanlin Dai, Yixing Xie, Ying Wei, Cheng Wang, Mingzhu Tian, Yuding Fan, Nan Jiang, Chen Xu, Wenzhi Liu, Yan Meng & Yong Zhou. (2023) Chinese giant salamander Bcl-w: An inhibitory role in iridovirus-induced mitochondrial apoptosis and virus replication. Virus Research 335, pages 199196.
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Aswath P. Chandrasekar, Nathan W. Cummins & Andrew D. Badley. (2019) The Role of the BCL-2 Family of Proteins in HIV-1 Pathogenesis and Persistence. Clinical Microbiology Reviews 33:1.
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Cassandra Spector, Anthony R. Mele, Brian Wigdahl & Michael R. Nonnemacher. (2019) Genetic variation and function of the HIV-1 Tat protein. Medical Microbiology and Immunology 208:2, pages 131-169.
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Sang Eun Kim, Eun Ok Lee, Ji Hye Yang, Ji Hee Lee Kang, Yoo‐Hun Suh & Young Hae Chong. (2012) 15‐deoxy‐Δ 12,14 ‐prostaglandin J 2 inhibits human immunodeficiency virus‐1 tat‐induced monocyte chemoattractant protein‐1/CCL2 production by blocking the extracellular signal‐regulated kinase‐1/2 signaling pathway independently of peroxisome proliferator‐activated receptor‐γ and heme oxygenase‐1 in rat hippocampal slices . Journal of Neuroscience Research 90:9, pages 1732-1742.
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Davide Gibellini, Anna Miserocchi, Pier Luigi Tazzari, Francesca Ricci, Alberto Clò, Silvia Morini, Cristina Ponti, Gianandrea Pasquinelli, Isabella Bon, Pasqualepaolo Pagliaro, Marco Borderi & Maria Carla Re. (2012) Analysis of the effects of HIV‐1 Tat on the survival and differentiation of vessel wall‐derived mesenchymal stem cells. Journal of Cellular Biochemistry 113:4, pages 1132-1141.
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Eun Ok Lee, Sang Eun Kim, Hae Kyung Park, JiHee Lee Kang & Young Hae Chong. (2011) Extracellular HIV-1 Tat upregulates TNF-α dependent MCP-1/CCL2 production via activation of ERK1/2 pathway in rat hippocampal slice cultures: Inhibition by resveratrol, a polyphenolic phytostilbene. Experimental Neurology 229:2, pages 399-408.
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N W Cummins & A D Badley. (2010) Mechanisms of HIV-associated lymphocyte apoptosis: 2010. Cell Death & Disease 1:11, pages e99-e99.
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M. R. Lopez-Huertas, S. Callejas, D. Abia, E. Mateos, A. Dopazo, J. Alcami & M. Coiras. (2010) Modifications in host cell cytoskeleton structure and function mediated by intracellular HIV-1 Tat protein are greatly dependent on the second coding exon. Nucleic Acids Research 38:10, pages 3287-3307.
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Seth W. Perry & Harris A. Gelbard. 2008. The Spectrum of Neuro-AIDS Disorders. The Spectrum of Neuro-AIDS Disorders 137 149 .
Lin Zheng, Yida Yang, Lu Guocai, C. David Pauza & Maria S. Salvato. (2007) HIV Tat Protein Increases Bcl-2 Expression in Monocytes Which Inhibits Monocyte Apoptosis Induced by Tumor Necrosis Factor-Alpha-Related Apoptosis-Induced Ligand. Intervirology 50:3, pages 224-228.
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Martyn K. White, Timothy S. Gorrill & Kamel Khalili. (2006) Reciprocal transactivation between HIV-1 and other human viruses. Virology 352:1, pages 1-13.
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Michele Carbone & Giuseppe Barbanti-Brodano. 2006. Oncology. Oncology 214 232 .
Tracy J. Ruckwardt, Ilia Tikhonov, Shannon Berg, Glen S. Hatfield, Angelika Chandra, Prakash Chandra, Bruce Gilliam, Robert R. Redfield, Robert C. Gallo & C. David Pauza. (2004) Sequence Variation within the Dominant Amino Terminus Epitope Affects Antibody Binding and Neutralization of Human Immunodeficiency Virus Type 1 Tat Protein. Journal of Virology 78:23, pages 13190-13196.
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Gunnar P.H. Dietz & Mathias Bähr. (2004) Delivery of bioactive molecules into the cell: the Trojan horse approach. Molecular and Cellular Neuroscience 27:2, pages 85-131.
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D GIBELLINI, M C RE, F VITONE, N RIZZO, C MALDINI, M LA PLACA & G ZAULI. (2003) Selective up-regulation of functional CXCR4 expression in erythroid cells by HIV-1 Tat protein. Clinical and Experimental Immunology 131:3, pages 428-435.
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Davide Gibellini, Maria Carla Re, Michele La Placa & Giorgio Zauli. (2002) Differentially expressed genes in HIV-1 tat-expressing CD4+ T-cell line. Virus Research 90:1-2, pages 337-345.
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Alfredo Corallini, Riccardo Sampaolesi, Laura Possati, Michela Merlin, Patrizia Bagnarelli, Catia Piola, Marina Fabris, Maria Agnese Menegatti, Simona Talevi, Davide Gibellini, Romina Rocchetti, Antonella Caputo & Giuseppe Barbanti-Brodano. (2002) Inhibition of HIV-1 Tat Activity Correlates with Down-Regulation of bcl-2 and Results in Reduction of Angiogenesis and Oncogenicity. Virology 299:1, pages 1-7.
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Mingjie Zhang, Xingxiang Li, Xiaowu Pang, Linna Ding, Owen Wood, Kathleen A. Clouse, Indira Hewlett & Andrew I. Dayton. (2002) Bcl-2 upregulation by HIV-1 tat during infection of primary human macrophages in culture. Journal of Biomedical Science 9:2, pages 133-139.
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Monica Betti, Rebecca Voltan, Marco Marchisio, Irene Mantovani, Chiara Boarini, Filomena Nappi, Barbara Ensoli & Antonella Caputo. (2001) Characterization of HIV-1 Tat proteins mutated in the transactivation domain for prophylactic and therapeutic application. Vaccine 19:25-26, pages 3408-3419.
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Mingjie Zhang, Xingxiang Li, Xiaowu Pang, Linna Ding, Owen Wood, Kathlene Clouse, Indira Hewlett & Andrew I. Dayton. (2001) Identification of a potential HIV-induced source of bystander-mediated apoptosis in T cells: Upregulation of TRAIL in primary human macrophages by HIV-1 tat. Journal of Biomedical Science 8:3, pages 290-296.
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Davide Gibellini, Maria Carla Re, Cristina Ponti, Claudio Celeghini, Elisabetta Melloni, Michele La Placa & Giorgio Zauli. (2001) Extracellular Tat activates c‐fos promoter in low serum‐starved CD4 + T cells . British Journal of Haematology 112:3, pages 663-670.
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Davide Gibellini, Maria Carla Re, Cristina Ponti, Claudia Maldini, Claudio Celeghini, Alessandra Cappellini, Michele La Placa & Giorgio Zauli. (2001) HIV-1 Tat Protects CD4+ Jurkat T Lymphoblastoid Cells from Apoptosis Mediated by TNF-Related Apoptosis-Inducing Ligand. Cellular Immunology 207:2, pages 89-99.
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Robert L. Caldwell, Brian S. Egan & Virginia L. Shepherd. (2000) HIV-1 Tat Represses Transcription from the Mannose Receptor Promoter. The Journal of Immunology 165:12, pages 7035-7041.
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Mingdong Zhang, Carl Q.-Y. Zeng, Andrew P. Morris & Mary K. Estes. (2000) A Functional NSP4 Enterotoxin Peptide Secreted from Rotavirus-Infected Cells. Journal of Virology 74:24, pages 11663-11670.
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Paola Secchiero, Davide Zella, Silvano Capitani, Robert C. Gallo & Giorgio Zauli. (1999) Extracellular HIV-1 Tat Protein Up-Regulates the Expression of Surface CXC-Chemokine Receptor 4 in Resting CD4+ T Cells. The Journal of Immunology 162:4, pages 2427-2431.
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Urban J. Scheuring, Helen Sabzevari, Jacques Corbeil & Argyrios N. Theofilopoulos. (1999) Differential expression profiles of apoptosis-affecting genes in HIV-infected cell lines and patient T cells. AIDS 13:2, pages 167-175.
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Anthony Jaworowski & Suzanne M Crowe. (1999) Does HIV cause depletion of CD4+ T cells in vivo by the induction of apoptosis? . Immunology and Cell Biology 77:1, pages 90-98.
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ALFREDO CORALLINI, MONICA BETTI, MARCO RUSNATI, DIANA CAMPIONI, MARINA CIOMEI, FRANCESCO SOLA, NILLA CALZA, GIORGIO ZAULI, MARCO PRESTA, GIUSEPPE BARBANTI-BRODANO & ANTONELLA CAPUTO. (1998) Characterization of the Effects of Two Polysulfonated Distamycin A Derivatives, PNU145156E and PNU153429, on HIV Type 1 Tat Protein. AIDS Research and Human Retroviruses 14:17, pages 1561-1571.
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Christopher M. Carthy, David J. Granville, Kathleen A. Watson, Daniel R. Anderson, Janet E. Wilson, Decheng Yang, David W. C. Hunt & Bruce M. McManus. (1998) Caspase Activation and Specific Cleavage of Substrates after Coxsackievirus B3-Induced Cytopathic Effect in HeLa Cells. Journal of Virology 72:9, pages 7669-7675.
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Carmela DeLuca, Hakju Kwon, Nadine Pelletier, Mark A. Wainberg & John Hiscott. (1998) NF-κB Protects HIV-1-Infected Myeloid Cells from Apoptosis. Virology 244:1, pages 27-38.
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