109
Views
20
CrossRef citations to date
0
Altmetric
Original Article

Methotrexate Pharmacology and Resistance in Childhood Acute Lymphoblastic Leukemia

&
Pages 359-368 | Received 18 Aug 1995, Published online: 01 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Larry H. Matherly & Jeffrey W. Taub. (1999) Molecular and Cellular Correlates of Methotrexate Response in Childhood Acute Lymphoblastic Leukemia. Leukemia & Lymphoma 35:1-2, pages 1-20.
Read now

Articles from other publishers (19)

Shu‐Mei Wang, Xiao‐Yan Kong, Miao Li, Lu‐Lu Sun & Dan Yan. (2020) Association of GGH Promoter Methylation Levels with Methotrexate Concentrations in Chinese Children with Acute Lymphoblastic Leukemia . Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 40:7, pages 614-622.
Crossref
Ittai B. MullerMarry LinEduard A. StruysPaniz HeydariRenske C. F. HebingMike T. Nurmohamed, Conny van der Laken, Willem F. Lems, Jacqueline CloosGerrit Jansen & Robert de Jonge. (2019) Development and Validation of a Sensitive UHPLC-MS/MS–Based Method for the Analysis of Folylpolyglutamate Synthetase Enzymatic Activity in Peripheral Blood Mononuclear Cells: Application in Rheumatoid Arthritis and Leukemia Patients. Therapeutic Drug Monitoring 41:5, pages 598-606.
Crossref
Fei Hao, Robert Lee, Chunmiao Yang, Lihuang Zhong, Yating Sun, Shiyan Dong, Ziyuan Cheng, Lirong Teng, Qingfan Meng, Jiahui Lu, Jing Xie & Lesheng Teng. (2019) Targeted Co-Delivery of siRNA and Methotrexate for Tumor Therapy via Mixed Micelles. Pharmaceutics 11:2, pages 92.
Crossref
Naama Kanarek, Heather R. Keys, Jason R. Cantor, Caroline A. Lewis, Sze Ham Chan, Tenzin Kunchok, Monther Abu-Remaileh, Elizaveta Freinkman, Lawrence D. Schweitzer & David M. Sabatini. (2018) Histidine catabolism is a major determinant of methotrexate sensitivity. Nature 559:7715, pages 632-636.
Crossref
Laurenţiu Lucaci, Ștefana Maria Moisă, Marin Burlea & Lucian Miron. (2014) Mathematical model to predict methotrexate elimination in children with acute lymphoblastic leukemia. Romanian Review of Laboratory Medicine 22:1.
Crossref
I. Ganmore, G. Smooha & S. Izraeli. (2009) Constitutional aneuploidy and cancer predisposition. Human Molecular Genetics 18:R1, pages R84-R93.
Crossref
Sébastien Malinge, Shai Izraeli & John D. Crispino. (2009) Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome. Blood 113:12, pages 2619-2628.
Crossref
L'Aurelle A. Johnson & Julie A. Ross. (2008) Host factors and consequence of chemotherapy in pediatric cancer patients. Pediatric Blood & Cancer 51:3, pages 320-326.
Crossref
W. Thomas Purcell & David S. Ettinger. (2003) Novel antifolate drugs. Current Oncology Reports 5:2, pages 114-125.
Crossref
Johnathan R. Whetstine, Teah L. Witt & Larry H. Matherly. (2002) The Human Reduced Folate Carrier Gene Is Regulated by the AP2 and Sp1 Transcription Factor Families and a Functional 61-Base Pair Polymorphism. Journal of Biological Chemistry 277:46, pages 43873-43880.
Crossref
Marina Cetkovic-CvrljeBertram A. RoersBarbara WaurzyniakXing-Ping LiuFatih M. Uckun. (2001) Targeting Janus kinase 3 to attenuate the severity of acute graft-versus-host disease across the major histocompatibility barrier in mice. Blood 98:5, pages 1607-1613.
Crossref
Sanjay J. Shah, Jeffrey W. Taub, Teah L. Witt, Brad H. Pollock, Bee Ching Ding, Daniel S. Moore, Michael Amylon, Jeanette Pullen, Yaddanapudi Ravindranath & Larry H. Matherly. (2001) Relationship of p15 and p16 gene alterations to elevated dihydrofolate reductase in childhood acute lymphoblastic leukaemia. British Journal of Haematology 113:3, pages 746-756.
Crossref
Jeffrey W. Taub. (2001) Relationship of Chromosome 21 and Acute Leukemia in Children With Down Syndrome. Journal of Pediatric Hematology/Oncology 23:3, pages 175-178.
Crossref
M.L McWilliams, J.T Blankemeyer & Mendel Friedman. (2000) The folic acid analogue methotrexate protects frog embryo cell membranes against damage by the potato glycoalkaloid α-chaconine. Food and Chemical Toxicology 38:10, pages 853-859.
Crossref
AM Wall, A Gajjar, A Link, H Mahmoud, C-H Pui & MV Relling. (2000) Individualized methotrexate dosing in children with relapsed acute lymphoblastic leukemia. Leukemia 14:2, pages 221-225.
Crossref
Batia Stark, Rivka Sharon, Gideon Rechavi, Dina Attias, Ami Ballin, Gabriel Cividalli, Yoav Burstein, Dalia Sthoeger, Ayala Abramov & Rina Zaizov. (2000) Effective preventive central nervous system therapy with extended triple intrathecal therapy and the modified ALL-BFM 86 chemotherapy program in an enlarged non-high risk group of children and adolescents with non-B-cell acute lymphoblastic leukemia. Cancer 88:1, pages 205-216.
Crossref
Long Zhang, So C Wong & Larry H Matherly. (1998) Structure and organization of the human reduced folate carrier gene. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1442:2-3, pages 389-393.
Crossref
Larry H. MatherlyJeffrey W. TaubSo C. WongPippa M. SimpsonRachenii EkizianSteve BuckMichael WilliamsonMichael AmylonJeannette PullenBruce CamittaY. Ravindranath. (1997) Increased Frequency of Expression of Elevated Dihydrofolate Reductase in T-Cell Versus B-Precursor Acute Lymphoblastic Leukemia in Children. Blood 90:2, pages 578-589.
Crossref
Larry H. MatherlyJeffrey W. TaubSo C. WongPippa M. SimpsonRachenii EkizianSteve BuckMichael WilliamsonMichael AmylonJeannette PullenBruce CamittaY. Ravindranath. (1997) Increased Frequency of Expression of Elevated Dihydrofolate Reductase in T-Cell Versus B-Precursor Acute Lymphoblastic Leukemia in Children. Blood 90:2, pages 578-589.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.