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Original Article

The Lysosomotropic Amines, Chloroquine and Hydroxychloroquine: A Potentially Novel Therapy for Graft-Versus-Host Disease

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Pages 201-210 | Received 12 May 1996, Published online: 01 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Axel Hage, Mathis de Vries, Andreas Leffler & Carsten Stoetzer. (2022) Local Anesthetic Like Inhibition of the Cardiac Na+ Channel Nav1.5 by Chloroquine and Hydroxychloroquine. Journal of Experimental Pharmacology 14, pages 353-365.
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Hassan Ih El-Sayyad & Yousef Ka Abdalhafid. (2020) COVID-19;-The origin, genetics,and management of the infection of mothers and babies. Egyptian Journal of Basic and Applied Sciences 7:1, pages 371-388.
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Yang Wang, Kairong Shi, Li Zhang, Guanlian Hu, Jingyu Wan, Jiajing Tang, Sheng Yin, Jiandong Duan, Ming Qin, Neng Wang, Dandan Xie, Xinle Gao, Huile Gao, Zhirong Zhang & Qin He. (2016) Significantly enhanced tumor cellular and lysosomal hydroxychloroquine delivery by smart liposomes for optimal autophagy inhibition and improved antitumor efficiency with liposomal doxorubicin. Autophagy 12:6, pages 949-962.
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Subhash D. Katewa & Surendra S. Katyare. (2005) Antimalarials Inhibit Human Erythrocyte Membrane Acetylcholinesterase. Drug and Chemical Toxicology 28:4, pages 467-482.
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G.J. Mahon, H.R. Anderson, T.A. Gardiner, S. McFarlane, D.B. Archer & A.W. Stitt. (2004) Chloroquine causes lysosomal dysfunction in neural retina and RPE: Implications for retinopathy. Current Eye Research 28:4, pages 277-284.
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Djavid Gaziev & Guido Lucarelli. (2001) Novel approaches to the treatment of chronic graft-versus-host disease. Expert Opinion on Investigational Drugs 10:5, pages 909-923.
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Mirko Paulikat, Daniele Vitone, Florian K. Schackert, Nils Schuth, Alessandra Barbanente, GiovanniMaria Piccini, Emiliano Ippoliti, Giulia Rossetti, Adam H. Clark, Maarten Nachtegaal, Michael Haumann, Holger Dau, Paolo Carloni, Silvano Geremia, Rita De Zorzi, Liliana Quintanar & Fabio Arnesano. (2022) Molecular Dynamics and Structural Studies of Zinc Chloroquine Complexes. Journal of Chemical Information and Modeling 63:1, pages 161-172.
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Suchetana Mukherjee & Dwaipayan Sinha. 2022. Coronavirus Drug Discovery. Coronavirus Drug Discovery 101 135 .
Vibha Sinha, Saurabh Saxena, Sanjay Kumar Pandey, Sudhakar Dwivedi, Suresh Thakur, Alexzander Asea, Ashwini Kumar Dixit, Vineeta Dixit, Naveen Kumar Vishvakarma & Dhananjay Shukla. 2021. Coronavirus Therapeutics – Volume II. Coronavirus Therapeutics – Volume II 131 149 .
Immacolata Faraone, Fabiana Labanca, Maria Ponticelli, Nunziatina De Tommasi & Luigi Milella. (2020) Recent Clinical and Preclinical Studies of Hydroxychloroquine on RNA Viruses and Chronic Diseases: A Systematic Review. Molecules 25:22, pages 5318.
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Cheng Cui, Siqi Tu, Valerie Sia Jie En, Xiaobei Li, Xueting Yao, Haiyan Li & Dongyang Liu. (2020) Review on the Clinical Pharmacology of Hydroxychloroquine Sulfate for the Treatment of COVID-19. Current Drug Metabolism 21:6, pages 427-435.
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Zhe Jin, Jing-Yi Liu, Rang Feng, Lu Ji, Zi-Li Jin & Hai-Bo Li. (2020) Drug treatment of coronavirus disease 2019 (COVID-19) in China.. European Journal of Pharmacology 883, pages 173326.
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Jin Wang, Mengmeng Jiang, Xin Chen & Luis J Montaner. (2020) Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts. Journal of Leukocyte Biology 108:1, pages 17-41.
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Renyi Wu, Lujing Wang, Hsiao-Chen Dina Kuo, Ahmad Shannar, Rebecca Peter, Pochung Jordan Chou, Shanyi Li, Rasika Hudlikar, Xia Liu, Zhigang Liu, George J. Poiani, Louis Amorosa, Luigi Brunetti & Ah-Ng Kong. (2020) An Update on Current Therapeutic Drugs Treating COVID-19. Current Pharmacology Reports 6:3, pages 56-70.
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Zhongwei Xue, Siyu Wang, Jian Li, Xin Chen, Jiahuai Han & Shoufa Han. (2018) Bifunctional Super-resolution Imaging Probe with Acidity-Independent Lysosome-Retention Mechanism. Analytical Chemistry 90:19, pages 11393-11400.
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Zhongwei Xue, Enkang Zhang, Jian Liu, Jiahuai Han & Shoufa Han. (2018) Bioorthogonal Conjugation Directed by a Sugar-Sorting Pathway for Continual Tracking of Stressed Organelles. Angewandte Chemie International Edition 57:32, pages 10096-10101.
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Zhongwei Xue, Enkang Zhang, Jian Liu, Jiahuai Han & Shoufa Han. (2018) Bioorthogonal Conjugation Directed by a Sugar-Sorting Pathway for Continual Tracking of Stressed Organelles. Angewandte Chemie 130:32, pages 10253-10258.
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Nadia Hamid & Jeffrey P. Krise. 2016. Lysosomes: Biology, Diseases, and Therapeutics. Lysosomes: Biology, Diseases, and Therapeutics 423 444 .
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Lucie Leveque, Laetitia Le Texier, Katie E Lineburg, Geoffrey R Hill & Kelli PA MacDonald. (2014) Autophagy and haematopoietic stem cell transplantation. Immunology & Cell Biology 93:1, pages 43-50.
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David J. BrowningDavid J. Browning. 2014. Hydroxychloroquine and Chloroquine Retinopathy. Hydroxychloroquine and Chloroquine Retinopathy 65 83 .
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Ilan Ben-Zvi, Shaye Kivity, Pnina Langevitz & Yehuda Shoenfeld. (2011) Hydroxychloroquine: From Malaria to Autoimmunity. Clinical Reviews in Allergy & Immunology 42:2, pages 145-153.
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Makoto Saka, Takayuki Amano, Koji Kajiwara, Koichi Yoshikawa, Makoto Ideguchi, Sadahiro Nomura, Hirosuke Fujisawa, Shoichi Kato, Masami Fujii, Koji Ueno, Yuji Hinoda & Michiyasu Suzuki. (2010) Vaccine therapy with dendritic cells transfected with Il13ra2 mRNA for glioma in mice. Journal of Neurosurgery 113:2, pages 270-279.
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Bettina Ramser, Agatha Kokot, Dieter Metze, Nina Weiß, Thomas A. Luger & Markus Böhm. (2009) Hydroxychloroquine Modulates Metabolic Activity and Proliferation and Induces Autophagic Cell Death of Human Dermal Fibroblasts. Journal of Investigative Dermatology 129:10, pages 2419-2426.
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Mesha Austin Taylor, Michael Bennett, Vinay Kumar & John D. Schatzle. (2000) Functional Defects of NK Cells Treated with Chloroquine Mimic the Lytic Defects Observed in Perforin-Deficient Mice. The Journal of Immunology 165:9, pages 5048-5053.
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