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Leukemia & Lymphoma Volume 31, 1998 - Issue 5-6
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Original Article

Accumulation of Methotrexate Polyglutamates, Ploidy and Trisomies of Both Chromosomes 4 and 10 in Lymphoblasts from Children with B-Progenitor Cell Acute Lymphoblastic Leukemia: a Pediatric Oncology Group Study

V. M. Whitehead The Penny Cole Hematology Research Laboratory, McGill University—Montreal Children's Hospital Research Institute, Montreal, Quebec; Department of Pediatrics, McGill University, Montreal, PQ
,
M. J. Vuchich The Penny Cole Hematology Research Laboratory, McGill University—Montreal Children's Hospital Research Institute, Montreal, Quebec
,
L. D. Cooley Department of Pathology, University of Texas Medical School, Houston, TX
,
S. J. Lauer Department of Pediatrics, Midwest Children's Cancer Center and Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI
,
D. H. Mahoney Department of Pediatrics, Baylor College of Medicine, Houston, TX
,
J. J. Shuster Department of Statistics and the Pediatric Oncology Group Statistical Office, University of Florida, Gainesville, FL
,
C. Payment The Penny Cole Hematology Research Laboratory, McGill University—Montreal Children's Hospital Research Institute, Montreal, Quebec
,
P. A. Koch Department of Pediatrics, McGill University, Montreal, PQ
,
J. J. Akabutu Department of Pediatrics, University of Alberta, Edmonton, Alberta
,
T. Bowen Department of Pediatrics, Alberta Children's Hospital, University of Alberta, Calgary, Alberta
,
B. A. Kamen Department of Pediatrics, University of Texas, Southwestern Medical Center, Dallas, TX
,
Y. Ravindranath Department of Pediatrics, Wayne State University, Detroit, Ml
,
A. Emami Department of Pediatrics, University of Kansas, Kansas City, KS
,
A. T. Look Department of Experimental Oncology, St. Jude Children's Research Hospital and Department of Pediatrics, University of Tennessee College of Medicine, Memphis, TN
,
G. P. Beardsley Department of Pediatrics, Yale University, New Haven, CT
,
D. J. Pullen Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS
&
B. Camitta Department of Pediatrics, Midwest Children's Cancer Center and Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI
 show all
Pages 507-519 | Received 04 Jan 1998, Published online: 01 Jul 2009

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David R. Betts, Mirjam Riesch, Michael A. Grotzer & Felix K. Niggli. (2001) The Investigation of Karyotypic Instability in the High-Hyperdiploidy Subgroup of Acute Lymphoblastic Leukemia. Leukemia & Lymphoma 42:1-2, pages 187-193.
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Spero R. Cataland, Christopher K. Daugherty, Elizabeth C. Weseman & Richard A. Larson. (2001) Preliminary Experience with a New Chemotherapy Regimen for Adults with Acute Lymphoblastic Leukemia. Leukemia & Lymphoma 41:3-4, pages 297-307.
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Articles from other publishers (23)

Kinga Panuciak, Emilia Nowicka, Angelika Mastalerczyk, Joanna Zawitkowska, Maciej Niedźwiecki & Monika Lejman. (2023) Overview on Aneuploidy in Childhood B-Cell Acute Lymphoblastic Leukemia. International Journal of Molecular Sciences 24:10, pages 8764.
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Magdalena Pierzyna-Świtała, Łukasz Sędek & Bogdan Mazur. (2022) Genetic and immunophenotypic diversity of acute leukemias in children. Postępy Higieny i Medycyny Doświadczalnej 76:1, pages 369-379.
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Markus Joerger, Christoph Ritter & Susen Burock. 2020. Kompendium Internistische Onkologie. Kompendium Internistische Onkologie 1 8 .
Jennifer L. Pauley, John C. Panetta, Kristine R. Crews, Deqing Pei, Cheng Cheng, John McCormick, Scott C. Howard, John T. Sandlund, Sima Jeha, Raul Ribeiro, Jeffrey Rubnitz, Ching-Hon Pui, William E. Evans & Mary V. Relling. (2013) Between-course targeting of methotrexate exposure using pharmacokinetically guided dosage adjustments. Cancer Chemotherapy and Pharmacology 72:2, pages 369-378.
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Anthony V. Moorman. (2012) The clinical relevance of chromosomal and genomic abnormalities in B-cell precursor acute lymphoblastic leukaemia. Blood Reviews 26:3, pages 123-135.
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Zeba N. Singh & Margaret L. Gulley. 2012. Pediatric Neoplasia. Pediatric Neoplasia 21 51 .
Sanjay R. MohanAnjali S. Advani. (2011) Treatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults. Journal of Adolescent and Young Adult Oncology 1:1, pages 19-24.
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Guy J. Leclerc, Christopher Sanderson, Stephen Hunger, Meenakshi Devidas & Julio C. Barredo. (2010) Folylpolyglutamate Synthetase Gene Transcription is Regulated by a Multiprotein Complex that Binds the TEL-AML1 Fusion in Acute Lymphoblastic Leukemia. Leukemia Research 34:12, pages 1601-1609.
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Manabu Shimoyama, Katsuya Yamamoto, Shinichiro Nishikawa, Kentaro Minagawa, Yoshio Katayama & Toshimitsu Matsui. (2009) Duplication of isodicentric chromosome 21, idic(21)(p11.2), leading to pentasomy 21q in acute myeloid leukemia with multilineage dysplasia. Cancer Genetics and Cytogenetics 194:1, pages 38-43.
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Kajsa Paulsson & Bertil Johansson. (2009) High hyperdiploid childhood acute lymphoblastic leukemia. Genes, Chromosomes and Cancer 48:8, pages 637-660.
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Deborah French, Wenjian Yang, Cheng Cheng, Susana C. Raimondi, Charles G. MullighanJames R. DowningWilliam E. Evans, Ching-Hon Pui & Mary V. Relling. (2009) Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia. Blood 113:19, pages 4512-4520.
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Catarina Lundin, Jesper Heldrup, Tomas Ahlgren, Tor Olofsson & Bertil Johansson. (2009) B-cell precursor t(8;14)(q11;q32)-positive acute lymphoblastic leukemia in children is strongly associated with Down syndrome or with a concomitant Philadelphia chromosome. European Journal of Haematology 82:1, pages 46-53.
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T V Ch Skärby, H Anderson, J Heldrup, J A Kanerva, H Seidel & K Schmiegelow. (2006) High leucovorin doses during high-dose methotrexate treatment may reduce the cure rate in childhood acute lymphoblastic leukemia. Leukemia 20:11, pages 1955-1962.
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Mignon L. LohMeredith A. GoldwasserLewis B. SilvermanWing-Man PoonShashaank VattikutiAngelo CardosoDonna S. NeubergKevin M. ShannonStephen E. SallanD. Gary Gilliland. (2006) Prospective analysis of TEL/AML1-positive patients treated on Dana-Farber Cancer Institute Consortium Protocol 95-01. Blood 107:11, pages 4508-4513.
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John J. McGuire, William H. Haile & Chen-Chen Yeh. (2006) 5-Amino-4-Imidazolecarboxamide Riboside Potentiates Both Transport of Reduced Folates and Antifolates by the Human Reduced Folate Carrier and Their Subsequent Metabolism. Cancer Research 66:7, pages 3836-3844.
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V M Whitehead, J J Shuster, M J Vuchich, D H MahoneyJrJr, S J Lauer, C Payment, P A Koch, L D Cooley, A T Look, D J Pullen & B Camitta. (2005) Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts and treatment outcome in children with B-progenitor-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study. Leukemia 19:4, pages 533-536.
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Leo Kager, Meyling Cheok, Wenjian Yang, Gianluigi Zaza, Qing Cheng, John C. Panetta, Ching-Hon Pui, James R. Downing, Mary V. Relling & William E. Evans. (2005) Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics. Journal of Clinical Investigation 115:1, pages 110-117.
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Rongbao Zhao & I David Goldman. (2003) Resistance to antifolates. Oncogene 22:47, pages 7431-7457.
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Harald Rieder & Michael Kneba. 2003. Molekularmedizinische Grundlagen von hämatologischen Neoplasien. Molekularmedizinische Grundlagen von hämatologischen Neoplasien 370 389 .
VM Whitehead, C Payment, L Cooley, SJ Lauer, DH Mahoney, JJ Shuster, M-J Vuchich, ML Bernstein, AT Look, DJ Pullen & B Camitta. (2001) The association of the TEL-AML1 chromosomal translocation with the accumulation of methotrexate polyglutamates in lymphoblasts and with ploidy in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study. Leukemia 15:7, pages 1081-1088.
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Ann Nordgren, Filip Farnebo, Bertil Johansson, Gösta Holmgren, Erik Forestier, Catharina Larsson, Stefan Söderhäll, Magnus Nordenskjöld & Elisabeth Blennow. (2001) Identification of numerical and structural chromosome aberrations in 15 high hyperdiploid childhood acute lymphoblastic leukemias using spectral karyotyping. European Journal of Haematology 66:5, pages 297-304.
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Stefan Faderl & Maher Albitar. (2000) INSIGHTS INTO THE BIOLOGIC AND MOLECULAR ABNORMALITIES IN ADULT ACUTE LYMPHOCYTIC LEUKEMIA. Hematology/Oncology Clinics of North America 14:6, pages 1267-1288.
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Niall G. Howlett & Robert H. Schiestl. (2000) Simultaneous measurement of the frequencies of intrachromosomal recombination and chromosome gain using the yeast DEL assay. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 454:1-2, pages 53-62.
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