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Original Article

The Expression of T Cell Related Costimulatory Molecules in Multiple Myeloma

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Pages 379-384 | Received 12 Dec 1997, Published online: 01 Jul 2009

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Mohammad Sadeghi, Atefeh Khodakarami, Armin Ahmadi, Mehrdad Fathi, Jamshid Gholizadeh Navashenaq, Hamed Mohammadi, Mehdi Yousefi, Mohammad Hojjat-Farsangi, Ali Akbar Movasaghpour Akbari & Farhad Jadidi-Niaragh. (2022) The prognostic and therapeutic potentials of CTLA-4 in hematological malignancies. Expert Opinion on Therapeutic Targets 26:12, pages 1057-1071.
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Bing Zhai, Chunmei Hou, Ruonan Xu, Ying Fang, He Xiao, Guojiang Chen, Xiaoqian Wang, Ning Ma, Gencheng Han & Renxi Wang. (2019) Loc108167440 suppressed myeloma cell growth by P53-mediated apoptosis. Leukemia & Lymphoma 60:10, pages 2541-2548.
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CJ Turtle, RD Brown, DE Joshua & DNJ Hart. (2004) DC in multiple myeloma immunotherapy. Cytotherapy 6:2, pages 128-137.
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Mahya Aghaee, Urszula Ledzewicz, Michael Robbins, Natalie Bezman, Hearn Jay Cho & Helen Moore. (2023) Determining optimal combination regimens for patients with multiple myeloma. European Journal of Pharmaceutical Sciences 187, pages 106492.
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Cinnie Yentia Soekojo & Wee Joo Chng. (2022) The evolution of immune dysfunction in multiple myeloma. European Journal of Haematology 109:5, pages 415-424.
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Olayinka O. Adebayo, Eric B. Dammer, Courtney D. Dill, Adeyinka O. Adebayo, Saheed O. Oseni, Ti’ara L. Griffen, Adaugo Q. Ohandjo, Fengxia Yan, Sanjay Jain, Benjamin G. Barwick, Rajesh Singh, Lawrence H. Boise & James W. Lillard, Jr.. (2022) Multivariant Transcriptome Analysis Identifies Modules and Hub Genes Associated with Poor Outcomes in Newly Diagnosed Multiple Myeloma Patients. Cancers 14:9, pages 2228.
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Ksenia Bezverbnaya, Duane Moogk, Derek Cummings, Christopher L. Baker, Craig Aarts, Galina Denisova, Michael Sun, Jamie D. McNicol, Rebecca C. Turner, Anthony F. Rullo, S. Ronan Foley & Jonathan L. Bramson. (2021) Development of a B-cell maturation antigen-specific T-cell antigen coupler receptor for multiple myeloma. Cytotherapy 23:9, pages 820-832.
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Jessica J. Liegel & David E. Avigan. 2020. Cancer Immunology. Cancer Immunology 75 102 .
Haimeng Yan, Gaofeng Zheng, Jianwei Qu, Yang Liu, Xi Huang, Enfan Zhang & Zhen Cai. (2019) Identification of key candidate genes and pathways in multiple myeloma by integrated bioinformatics analysis. Journal of Cellular Physiology 234:12, pages 23785-23797.
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Manisha Bhutani, David Foureau, Qing Zhang, Myra Robinson, Adina S. Wynn, Nury M. Steuerwald, Lawrence J. Druhan, Fei Guo, Katherine Rigby, Mitchell Turner, Daniel Slaughter, Reed Friend, Shebli Atrash, James T. Symanowski, Belinda R. Avalos, Edward A. Copelan, Peter M. Voorhees & Saad Z. Usmani. (2019) Peripheral Immunotype Correlates with Minimal Residual Disease Status and Is Modulated by Immunomodulatory Drugs in Multiple Myeloma. Biology of Blood and Marrow Transplantation 25:3, pages 459-465.
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Myo Htut. (2019) Immunotherapeutic Approaches for Multiple Myeloma: Where Are We Now?. Current Hematologic Malignancy Reports 14:1, pages 1-10.
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Jacalyn Rosenblatt & David Avigan. (2019) Cellular Immunotherapy for Multiple Myeloma. The Cancer Journal 25:1, pages 38-44.
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Xiao-Ying Qin, Jin Lu, Guo-Xuan Li, Lei Wen, Yang Liu, Lan-Ping Xu, Ying-Jun Chang, Kai-Yan Liu, Zheng-Fan Jiang & Xiao-Jun Huang. (2017) CTLA-4 polymorphisms are associated with treatment outcomes of patients with multiple myeloma receiving bortezomib-based regimens. Annals of Hematology 97:3, pages 485-495.
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Inger S. Nijhof, Niels W. C. J. van de Donk, Sonja Zweegman & Henk M. Lokhorst. (2017) Current and New Therapeutic Strategies for Relapsed and Refractory Multiple Myeloma: An Update. Drugs 78:1, pages 19-37.
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Don M. BensonJrJr. (2016) Checkpoint inhibition in myeloma. Hematology 2016:1, pages 528-533.
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Claudia Zelle-Rieser, Shanmugapriya Thangavadivel, Rainer Biedermann, Andrea Brunner, Patrizia Stoitzner, Ella Willenbacher, Richard Greil & Karin Jöhrer. (2016) T cells in multiple myeloma display features of exhaustion and senescence at the tumor site. Journal of Hematology & Oncology 9:1.
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Bruno PaivaMaría Victoria MateosLuis Ignacio Sanchez-AbarcaNoemi PuigMaría-Belén VidrialesLucía López-CorralLuis A. CorcheteMiguel T. HernandezJoan BargayFelipe de ArribaJavier de la RubiaAna-Isabel TeruelPilar GiraldoLaura RosiñolFelipe ProsperAlbert OriolJosé HernándezGraça EstevesJuan José Lahuerta, Joan BladéJose Antonio Perez-Simon & Jesús F. San Miguel. (2016) Immune status of high-risk smoldering multiple myeloma patients and its therapeutic modulation under LenDex: a longitudinal analysis. Blood 127:9, pages 1151-1162.
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Frederick L Locke, Meghan Menges, Anandharaman Veerapathran, Domenico Coppola, Dmitry Gabrilovich & Claudio Anasetti. (2015) Survivin-specific CD4+ T cells are decreased in patients with survivin-positive myeloma. Journal for Immunotherapy of Cancer 3:1.
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T Dosani, M Carlsten, I Maric & O Landgren. (2015) The cellular immune system in myelomagenesis: NK cells and T cells in the development of MM and their uses in immunotherapies. Blood Cancer Journal 5:4, pages e306-e306.
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Wieger J. Norde, Willemijn Hobo & Harry Dolstra. 2015. Resistance of Cancer Cells to CTL-Mediated Immunotherapy. Resistance of Cancer Cells to CTL-Mediated Immunotherapy 31 58 .
Frederick L Locke, Taiga Nishihori, Melissa Alsina & Mohamed A Kharfan-Dabaja. (2013) Immunotherapy strategies for multiple myeloma: the present and the future. Immunotherapy 5:9, pages 1005-1020.
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Alan G. Ramsay. (2013) Immune checkpoint blockade immunotherapy to activate anti-tumour T-cell immunity. British Journal of Haematology 162:3, pages 313-325.
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Wieger J. Norde, Willemijn Hobo, Robbert van der Voort & Harry Dolstra. (2012) Coinhibitory molecules in hematologic malignancies: targets for therapeutic intervention. Blood 120:4, pages 728-736.
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Megan E. Prosser, Christine E. Brown, Andrew F. Shami, Stephen J. Forman & Michael C. Jensen. (2012) Tumor PD-L1 co-stimulates primary human CD8+ cytotoxic T cells modified to express a PD1:CD28 chimeric receptor. Molecular Immunology 51:3-4, pages 263-272.
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Amir Sharabi & Nechama Haran-Ghera. (2011) Immune Recovery after Cyclophosphamide Treatment in Multiple Myeloma: Implication for Maintenance Immunotherapy. Bone Marrow Research 2011, pages 1-7.
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Guy Pratt, Oliver Goodyear & Paul Moss. (2007) Immunodeficiency and immunotherapy in multiple myeloma. British Journal of Haematology 138:5, pages 563-579.
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Sara Prutchi-Sagiv, Natalia Golishevsky, Howard S. Oster, Odelia Katz, Amos Cohen, Elizabeth Naparstek, Drorit Neumann & Moshe Mittelman. (2006) Erythropoietin treatment in advanced multiple myeloma is associated with improved immunological functions: could it be beneficial in early disease?. British Journal of Haematology 135:5, pages 660-672.
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Claudia M. Kowolik, Max S. Topp, Sergio Gonzalez, Timothy Pfeiffer, Simon Olivares, Nancy Gonzalez, David D. Smith, Stephen J. Forman, Michael C. Jensen & Laurence J.N. Cooper. (2006) CD28 Costimulation Provided through a CD19-Specific Chimeric Antigen Receptor Enhances In vivo Persistence and Antitumor Efficacy of Adoptively Transferred T Cells . Cancer Research 66:22, pages 10995-11004.
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Kristen J. Radford, Frank Vari & Derek N.J. Hart. (2005) Vaccine strategies to treat lymphoproliferative disorders. Pathology 37:6, pages 534-550.
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Brian G.M. Durie. (2005) New Approaches to Treatment for Multiple Myeloma: Durable Remission and Quality of Life as Primary Goals. Clinical Lymphoma and Myeloma 6:3, pages 181-190.
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Yu-hua Qiu, Zhong-wen Sun, Qin Shi, Cheng-hai Su, Yong-jing Chen, Yun-jie Shi, Ran Tao, Yan Ge & Xue-guang Zhang. (2005) Apoptosis of multiple myeloma cells induced by agonist monoclonal antibody against human CD28. Cellular Immunology 236:1-2, pages 154-160.
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M Pérez-Andrés, J Almeida, M Martín-Ayuso, M J Moro, G Martín-Nuñez, J Galende, D Borrego, M J Rodríguez, F Ortega, J Hernandez, I Moreno, M Domínguez, G Mateo, J F San Miguel & A Orfao. (2005) Clonal plasma cells from monoclonal gammopathy of undetermined significance, multiple myeloma and plasma cell leukemia show different expression profiles of molecules involved in the interaction with the immunological bone marrow microenvironment. Leukemia 19:3, pages 449-455.
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Brian G.M. DurieJoth JacobsonBart BarlogieJohn Crowley. (2004) Magnitude of Response With Myeloma Frontline Therapy Does Not Predict Outcome: Importance of Time to Progression in Southwest Oncology Group Chemotherapy Trials. Journal of Clinical Oncology 22:10, pages 1857-1863.
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Fariba Mozaffari, Lotta Hansson, Shahryar Kiaii, Xiuli Ju, Eva D. Rossmann, Hodjattallah Rabbani, Håkan Mellstedt & Anders Österborg. (2004) Signalling molecules and cytokine production in T cells of multiple myeloma-increased abnormalities with advancing stage. British Journal of Haematology 124:3, pages 315-324.
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Asad Bashey, Mark J. Cantwell & Thomas J. Kipps. (2002) Adenovirus transduction to effect CD40 signalling improves the immune stimulatory activity of myeloma cells. British Journal of Haematology 118:2, pages 506-513.
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Ross D. BrownBelinda PopeAllan MurrayWarren EsdaleDaniel M. SzeJohn GibsonP. Joy HoDerek HartDoug Joshua. (2001) Dendritic cells from patients with myeloma are numerically normal but functionally defective as they fail to up-regulate CD80 (B7-1) expression after huCD40LT stimulation because of inhibition by transforming growth factor-β1 and interleukin-10. Blood 98:10, pages 2992-2998.
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Belinda PopeRoss D. BrownJohn GibsonEdna YuenDoug Joshua. (2000) B7-2–positive myeloma: incidence, clinical characteristics, prognostic significance, and implications for tumor immunotherapy. Blood 96:4, pages 1274-1279.
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