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Original Article

Extramedullary Disease in Acute Promyelocytic Leukemia

&
Pages 219-229 | Accepted 02 Jul 1998, Published online: 01 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Vinay Gupta, Wilson Gonsalves, Mrinal Patnaik & Naseema Gangat. (2013) Central nervous system relapse in acute promyelocytic leukemia: a single institution experience. Leukemia & Lymphoma 54:12, pages 2728-2730.
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Heng-Xiang Wang, Lian-Ning Duan, Shu-Quan Ji & Zi-Kuan Guo. (2006) Arsenic trioxide-responsive leukemia cutis in a patient with acute promyelocytic leukemia after ATRA treatment. Leukemia & Lymphoma 47:7, pages 1438-1440.
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Jane L. Liesveld, Karen E. Rosell, Chaohui Lu, Jeremy Bechelli, Gordon Phillips II, Jeffrey E. Lancet & Camille N. Abboud. (2005) Acute myelogenous leukemia—microenvironment interactions: Role of endothelial cells and proteasome inhibition. Hematology 10:6, pages 483-494.
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Simrit Parmar & Martin S Tallman. (2003) Acute promyelocytic leukaemia:a review. Expert Opinion on Pharmacotherapy 4:8, pages 1379-1392.
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Yesid Alvarado, Hagop M. Kantarjian, Jorge E. Cortes, Efrosynl Apostolidou, Carol Bivins & Francis J. Giles. (2002) Troxacitabine Activity in Extramedullary Myeloid Leukemia. Hematology 7:3, pages 179-185.
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Articles from other publishers (54)

Aditi Sharma, Jay Yang & Vijendra Singh. (2023) Epidemiology and early mortality patterns of acute promyelocytic leukemia in the United States. Annals of Hematology 102:5, pages 1053-1062.
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Khalid Alodan & Oussama Abla. 2023. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Matteo Molica, Carla Mazzone, Tiziana Ottone, Pasquale Niscola, Elisabetta Abruzzese, Stefano Fratoni, Maria Teresa Voso & Paolo de Fabritiis. (2021) Case Report: Very Late, Atypical Extra-Medullary Relapse in a Patient With Acute Promyelocytic Leukemia (APL) Rescued With a Transplant-Free Approach. Frontiers in Oncology 11.
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Richard Bakst, Ann Powers & Joachim Yahalom. (2020) Diagnostic and Therapeutic Considerations for Extramedullary Leukemia. Current Oncology Reports 22:7.
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Masami KAMBARA, Hirotaka NODA, Kazuyoshi MASUDA & Chikao YUTANI. (2019) A case of acute promyelocytic leukemia tumor cells in cerebrospinal flud脳脊髄液中に急性前骨髄球性白血病の腫瘍細胞を認めた 1 例. The Journal of the Japanese Society of Clinical Cytology 58:2, pages 87-91.
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Iveta Oravcova, Eva Mikuskova, Michaela Leitnerova, Jan Gyarfas, Andrea Mlcakova, Peter Szepe, Lukas Plank, Ludmila Demitrovicova, Vanda Mikudova, Silvia Cingelova, Michal Mego & Lubos Drgona. (2018) A unique clinical presentation of de novo acute promyelocytic leukemia as a myeloid sarcoma of the breast. International Journal of Hematology 108:5, pages 550-553.
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Sameer Sawhney, Noa G. Holtzman, Derik L. Davis, Hannah Kaizer, Victoria Giffi, Ashkan Emadi & Rima Koka. (2017) Promyelocytic sarcoma of the right humerus: an unusual clinical presentation with unique diagnostic and treatment considerations. Clinical Case Reports 5:11, pages 1874-1877.
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Chin-Hin Ng & Wee-Joo Chng. (2017) Recent advances in acute promyelocytic leukaemia. F1000Research 6, pages 1273.
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Mohammad Faizan Zahid, Nadia Khan, Shahrukh K. Hashmi, Sani Haider Kizilbash & Stefan K. Barta. (2016) Central nervous system prophylaxis in diffuse large B-cell lymphoma. European Journal of Haematology 97:2, pages 108-120.
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Mike Leach, Mark Drummond, Allyson Doig, Pam McKay, Bob Jackson & Barbara J. Bain. 2015. Practical Flow Cytometry in Haematology Diagnosis. Practical Flow Cytometry in Haematology Diagnosis 166 167 .
J. Mishra & M. Gupta. (2015) Cerebrospinal fluid involvement in acute promyelocytic leukaemia at presentation. Case Reports 2015:mar09 1, pages bcr2014208418-bcr2014208418.
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Chezi Ganzel & Dan Douer. (2014) Extramedullary disease in APL: A real phenomenon to contend with or not?. Best Practice & Research Clinical Haematology 27:1, pages 63-68.
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Karen A. Breen, David Grimwade & Beverley J. Hunt. (2012) The pathogenesis and management of the coagulopathy of acute promyelocytic leukaemia. British Journal of Haematology 156:1, pages 24-36.
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Richard L. Bakst, Martin S. Tallman, Dan Douer & Joachim Yahalom. (2011) How I treat extramedullary acute myeloid leukemia. Blood 118:14, pages 3785-3793.
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Jae Park, Joseph G. Jurcic, Todd Rosenblat & Martin S. Tallman. (2011) Emerging new approaches for the treatment of acute promyelocytic leukemia. Therapeutic Advances in Hematology 2:5, pages 335-352.
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Misuk JiHyun-Sook ChiSeongsoo JangChan-Jeoung ParkJung-Hee LeeJong Jin Seo. (2011) Acute Promyelocytic Leukemia Presenting with Central Nervous System Involvement: A Report of 2 Cases. The Korean Journal of Laboratory Medicine 31:1, pages 9.
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Rachel C. Ochs, Rachel H. Gormley, Selina Luger & Adam Bagg. (2010) Isolated Bowel Relapse in Acute Promyelocytic Leukemia: An Unusual Site of Extramedullary Recurrence. Journal of Clinical Oncology 28:29, pages e550-e553.
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Bijender Kumar, Vineeta Sharma, Anita Chopra, Manoranjan Mahapatra, Ravi Kumar, Sandeep Mathur, Sudha Sazawal, Sunil Kumar & Renu Saxena. (2010) Central nervous system involvement at second relapse in acute promyelocytic leukemia treated with ATRA and chemotherapy. Leukemia Research 34:10, pages e264-e265.
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Nikolay D. Dimov, L. Jeffrey Medeiros, Farhad Ravandi & Carlos E. Bueso-Ramos. (2010) Acute Promyelocytic Leukemia at Time of Relapse Commonly Demonstrates Cytogenetic Evidence of Clonal Evolution and Variability in Blast Immunophenotypic Features. American Journal of Clinical Pathology 133:3, pages 484-490.
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David Grimwade, Jelena V. Jovanovic, Robert K. Hills, Ellen Solomon, Francesco Lo-Coco, Keith Wheatley & Alan K. Burnett. (2010) Reply to S. Nagai et al. Journal of Clinical Oncology 28:4, pages e63-e64.
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Leonardo Pacilli, Francesco Lo Coco, Safaa Mahmoud Ramadan, Laura Giannì, Alberto Pingi, Daniele Remotti & Ignazio Majolino. (2010) Promyelocytic Sarcoma of the Spine: A Case Report and Review of the Literature. Advances in Hematology 2010, pages 1-7.
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James Feusner & Jessica Chow. (2009) Isolated central nervous system relapse in acute promyelocytic leukemia (APL)-response. Pediatric Blood & Cancer 53:2, pages 237-237.
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Gertjan Kaspers, Brenda Gibson, David Grimwade, Andrea Pession, Owen Smith & Anna Maria Testi. (2009) Central nervous system involvement in relapsed acute promyelocytic leukemia. Pediatric Blood & Cancer 53:2, pages 235-236.
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Arturo Vega-Ruiz, Stefan Faderl, Zeev Estrov, Sherry Pierce, Jorge Cortes, Hagop Kantarjian & Farhad Ravandi. (2009) Incidence of extramedullary disease in patients with acute promyelocytic leukemia: a single-institution experience. International Journal of Hematology 89:4, pages 489-496.
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Miguel A. SanzDavid GrimwadeMartin S. TallmanBob LowenbergPierre FenauxElihu H. EsteyTomoki NaoeEva LengfelderThomas BüchnerHartmut DöhnerAlan K. Burnett & Francesco Lo-Coco. (2009) Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood 113:9, pages 1875-1891.
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Michael B. Tomblyn, Kathryn E. Dusenbery & Marcie R. Tomblyn. (2009) Central Nervous System Relapse in Acute Promyelocytic Leukemia: Two Cases and a Systematic Review. Clinical Leukemia 3:1, pages 58-64.
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Jennifer J. Clark, Jason N. Berman & A. Thomas Look. 2009. Oncology of Infancy and Childhood. Oncology of Infancy and Childhood 331 402 .
Jessica Chow & James Feusner. (2008) Isolated central nervous system recurrence of acute promyelocytic leukemia in children. Pediatric Blood & Cancer 52:1, pages 11-13.
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Melissa W. Ko, Madhura A. Tamhankar, Nicholas J. Volpe, David Porter, Cindy McGrath & Steven L. Galetta. (2008) Acute promyelocytic leukemic involvement of the optic nerves following mitoxantrone treatment for multiple sclerosis. Journal of the Neurological Sciences 273:1-2, pages 144-147.
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Katrin Scheinemann, Sheila Weitzman, Johann Hitzler, John Doyle & Oussama Abla. (2008) Isolated Central Nervous System Relapse in Childhood Acute Promyelocytic Leukemia. Journal of Pediatric Hematology/Oncology 30:2, pages 160-162.
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P. Raanani, O. Shpilberg & I. Ben-Bassat. (2007) Extramedullary disease and targeted therapies for hematological malignancies—is the association real?. Annals of Oncology 18:1, pages 7-12.
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Tatsuyuki Kai, Hideo Kimura, Yutaka Shiga, Kazuei Ogawa, Hisashi Sato & Yukio Maruyama. (2006) Recurrent Extramedullary Relapse of Acute Promyelocytic Leukemia after Allogeneic Stem Cell Transplantation: Successful Treatment by Arsenic Trioxide in Combination with Local Radiotherapy. International Journal of Hematology 83:4, pages 337-340.
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S de Botton, M A Sanz, S Chevret, H Dombret, G Martin, X Thomas, J D Mediavilla, C Recher, L Ades, B Quesnel, P Brault, M Fey, H Wandt, D Machover, A Guerci, F Maloisel, A M Stoppa, C Rayon, J M Ribera, C Chomienne, L Degos & P Fenaux. (2005) Extramedullary relapse in acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy. Leukemia 20:1, pages 35-41.
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Marisa Battistella, Lisa D Burry & Jack T Seki. (2016) Retinoic acid syndrome after one dose of all-transretinoic acid. Journal of Oncology Pharmacy Practice 10:3, pages 149-154.
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Martin S Tallman & Jacob M Rowe. (2003) Long-term follow-up and potential for cure in acute promyelocytic leukaemia. Best Practice & Research Clinical Haematology 16:3, pages 535-543.
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Lisa D Burry & Jack T Seki. (2016) CNS Relapses of Acute Promyelocytic Leukemia after All- Trans Retinoic Acid . Annals of Pharmacotherapy 36:12, pages 1900-1906.
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Pierre Fenaux, Christine Chomienne & Laurent Degos. (2001) Treatment of acute promyelocytic leukaemia. Best Practice & Research Clinical Haematology 14:1, pages 153-174.
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