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Original Article

Is Flow Cytometric DNA Content Hypodiploidy Prognostic in Multiple Myeloma?

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Pages 83-89 | Received 16 Jun 1998, Accepted 22 Jan 1999, Published online: 01 Jul 2009

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Avril López-Otero, Guillermo J. Ruiz-Delgado, Ana Hernández-Arizpe, Alejandro Ruiz-Argüelles & Guillermo J. Ruiz-Argüelles. (2010) The flow-cytometric DNA content of the plasma cells of patients with multiple myeloma is a prognostic factor: a single institution experience. Hematology 15:6, pages 378-381.
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A Keith Stewart & Rafael Fonseca. (2007) Review of molecular diagnostics in multiple myeloma. Expert Review of Molecular Diagnostics 7:4, pages 453-459.
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Athanasios B-T Fassas & Guido Tricot. (2004) Chromosome 13 Deletion/Hypodiploidy and Prognosis in Multiple Myeloma Patients. Leukemia & Lymphoma 45:6, pages 1083-1091.
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Athanasios B.-T. Fassas, Frits Van Rhee & Guido Tricot. (2003) Predicting Long-term Survival in Multiple Myeloma Patients Following Autotransplants. Leukemia & Lymphoma 44:5, pages 749-758.
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Articles from other publishers (27)

Pandurangan SathyaSmita KayalBheemanathi Hanuman SrinivasAbdoul HamideRakhee Kar. (2022) Study of DNA ploidy in newly diagnosed multiple myeloma by flow cytometry and its correlation with disease prognosis and outcome. Journal of Hematology and Allied Sciences 2, pages 78-84.
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Surbhi Sidana, Dragan Jevremovic, Rhett P. Ketterling, Nidhi Tandon, Angela Dispenzieri, Morie A. Gertz, Patricia T Greipp, Linda B. Baughn, Francis K. Buadi, Martha Q. Lacy, William Morice, Curtis Hanson, Michael Timm, David Dingli, Suzanne R. Hayman, Wilson I. Gonsalves, Prashant Kapoor, Robert A. Kyle, Nelson Leung, Ronald S. Go, John A. Lust, S. Vincent Rajkumar & Shaji K. Kumar. (2019) Rapid assessment of hyperdiploidy in plasma cell disorders using a novel multi‐parametric flow cytometry method. American Journal of Hematology 94:4, pages 424-430.
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Prashant Tembhare, Yajamanam Badrinath, Sitaram Ghogale, Nikhil Patkar, Nilesh Dhole, Pooja Dalavi, Nikesh Kunder, Ashok Kumar, Sumeet Gujral & P.G. Subramanian. (2016) A novel and easy FxCycle™ violet based flow cytometric method for simultaneous assessment of DNA ploidy and six-color immunophenotyping. Cytometry Part A 89:3, pages 281-291.
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X Papanikolaou, D Alapat, A Rosenthal, C Stein, J Epstein, R Owens, S Yaccoby, S Johnson, C Bailey, C Heuck, E Tian, A Joiner, F van Rhee, R Khan, M Zangari, Y Jethava, S Waheed, F Davies, G Morgan & B Barlogie. (2015) The flow cytometry-defined light chain cytoplasmic immunoglobulin index and an associated 12-gene expression signature are independent prognostic factors in multiple myeloma. Leukemia 29:8, pages 1713-1720.
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Nobutaka Kiyokawa, Kazutoshi Iijima, Osamu Tomita, Masashi Miharu, Daisuke Hasegawa, Kenichiro Kobayashi, Hajime Okita, Michiko Kajiwara, Hiroyuki Shimada, Takeshi Inukai, Atsushi Makimoto, Takashi Fukushima, Toru Nanmoku, Katsuyoshi Koh, Atsushi Manabe, Akira Kikuchi, Kanji Sugita, Junichiro Fujimoto, Yasuhide Hayashi & Akira Ohara. (2014) Significance of CD66c expression in childhood acute lymphoblastic leukemia. Leukemia Research 38:1, pages 42-48.
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Jesus San-Miguel, M Victoria Mateos & Norma C. Gutierrez. (2009) Risk Stratification in the Era of Novel Therapies. The Cancer Journal 15:6, pages 457-464.
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W J Chng, N Gonzalez-Paz, T Price-Troska, S Jacobus, S V Rajkumar, M M Oken, R A Kyle, K J Henderson, S Van Wier, P Greipp, B Van Ness & R Fonseca. (2008) Clinical and biological significance of RAS mutations in multiple myeloma. Leukemia 22:12, pages 2280-2284.
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Rafael Fonseca & P. Leif Bergsagel. 2009. Treatment of Multiple Myeloma and Related Disorders. Treatment of Multiple Myeloma and Related Disorders 1 17 .
Rafael Fonseca & Jesus San Miguel. (2007) Prognostic Factors and Staging in Multiple Myeloma. Hematology/Oncology Clinics of North America 21:6, pages 1115-1140.
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Zahid Kaleem. (2006) Flow Cytometric Analysis of Lymphomas: Current Status and Usefulness. Archives of Pathology & Laboratory Medicine 130:12, pages 1850-1858.
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Pierfrancesco Tassone, Pierosandro Tagliaferri, Marco Rossi, Marco Gaspari, Rosa Terracciano & Salvatore Venuta. (2006) Genetics and molecular profiling of multiple myeloma: Novel tools for clinical management?. European Journal of Cancer 42:11, pages 1530-1538.
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Wee J. ChngGreg J. AhmannKim HendersonRafael Santana-DavilaPhilip R. GreippMorie A. GertzMartha Q. LacyAngela DispenzieriShaji KumarS. Vincent RajkumarJohn A. LustRobert A. KyleSteven R. ZeldenrustSuzanne R. HaymanRafael Fonseca. (2006) Clinical implication of centrosome amplification in plasma cell neoplasm. Blood 107:9, pages 3669-3675.
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W J Chng, R Santana-Dávila, S A Van Wier, G J Ahmann, S M Jalal, P L Bergsagel, M Chesi, M C Trendle, S Jacobus, E Blood, M M Oken, K Henderson, R A Kyle, M A Gertz, M Q Lacy, A Dispenzieri, P R Greipp & R Fonseca. (2006) Prognostic factors for hyperdiploid-myeloma: effects of chromosome 13 deletions and IgH translocations. Leukemia 20:5, pages 807-813.
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W.J. Chng, J.M. Winkler, P.R. Greipp, S.M. Jalal, P.L. Bergsagel, M. Chesi, M.C. Trendle, G.J. Ahmann, K. Henderson, E. Blood, M.M. Oken, A. Hulbert, S.A. Van Wier, R. Santana-Dávila, R.A. Kyle, M.A. Gertz, M.Q. Lacy, A. Dispenzieri & R. Fonseca. (2006) Ploidy status rarely changes in myeloma patients at disease progression. Leukemia Research 30:3, pages 266-271.
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Michaela J. Higgins & Rafael Fonseca. (2005) Genetics of multiple myeloma. Best Practice & Research Clinical Haematology 18:4, pages 525-536.
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Friedrich W. Cremer, Jelena Bila, Isabelle Buck, Mutlu Kartal, Dirk Hose, Carina Ittrich, Axel Benner, Marc S. Raab, Ann‐Cathrin Theil, Marion Moos, Hartmut Goldschmidt, Claus R. Bartram & Anna Jauch. (2005) Delineation of distinct subgroups of multiple myeloma and a model for clonal evolution based on interphase cytogenetics. Genes, Chromosomes and Cancer 44:2, pages 194-203.
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Wee J Chng & Rafael Fonseca. (2005) Genomics in multiple myeloma: biology and clinical implications. Pharmacogenomics 6:6, pages 563-573.
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Joëlle Tchinda, Sarah Volpert, Martin Kropff, Wolfgang E. Berdel, Joachim Kienast, Friedhelm Meinhardt & Jürgen Horst. (2004) Frequent Gains of the Short Arm of Chromosome 9 in Multiple Myeloma With Normal G-Banded Karyotype Detected by Comparative Genomic Hybridization. American Journal of Clinical Pathology 122:6, pages 875-882.
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M A Gertz, E Blood, D H Vesole, R Abonour, H M Lazarus & P R Greipp. (2004) A multicenter phase 2 trial of stem cell transplantation for immunoglobulin light-chain amyloidosis (E4A97): an Eastern Cooperative Oncology Group Study. Bone Marrow Transplantation 34:2, pages 149-154.
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Rafael Fonseca, Bart Barlogie, Regis Bataille, Christian Bastard, P. Leif Bergsagel, Marta Chesi, Faith E. Davies, Johannes Drach, Philip R. Greipp, Ilan R. Kirsch, W. Michael Kuehl, Jesus M. Hernandez, Stephane Minvielle, Linda M. Pilarski, John D. ShaughnessyJr.Jr., A. Keith Stewart & Herve Avet-Loiseau. (2004) Genetics and Cytogenetics of Multiple Myeloma. Cancer Research 64:4, pages 1546-1558.
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Rafael FonsecaCarina S. Debes-MarunElisa B. PickenGordon W. DewaldSandra C. BryantJerry M. WinklerEmily BloodMartin M. OkenRafael Santana-DávilaNatalia González-PazRobert A. KyleMorie A. GertzAngela DispenzieriMartha Q. LacyPhilip R. Greipp. (2003) The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myeloma. Blood 102:7, pages 2562-2567.
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Didier Clerc, Jean-Paul Fermand & Xavier Mariette. (2003) Treatment of multiple myeloma. Joint Bone Spine 70:3, pages 175-186.
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Didier Clerc, Jean-Paul Fermand & Xavier Mariette. (2003) Traitement du myélome multiple. Revue du Rhumatisme 70:5, pages 379-391.
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C S Debes-Marun, G W Dewald, S Bryant, E Picken, R Santana-Dávila, N González-Paz, J M Winkler, R A Kyle, M A Gertz, T E Witzig, A Dispenzieri, M Q Lacy, S V Rajkumar, J A Lust, P R Greipp & R Fonseca. (2003) Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myeloma. Leukemia 17:2, pages 427-436.
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Athanasios B.-T. Fassas, Tray Spencer, Jeffrey Sawyer, Maurizio Zangari, Choon-Kee Lee, Elias Anaissie, Firas Muwalla, Christopher Morris, Bart Barlogie & Guido Tricot. (2002) Both hypodiploidy and deletion of chromosome 13 independently confer poor prognosis in multiple myeloma. British Journal of Haematology 118:4, pages 1041-1047.
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Rafael FonsecaEmily A. BloodMartin M. OkenRobert A. KyleGordon W. DewaldRichard J. BaileyScott A. Van WierKimberly J. HendersonJames D. HoyerDavid HarringtonNeil E. KayBrian Van NessPhilip R. Greipp. (2002) Myeloma and the t(11;14)(q13;q32); evidence for a biologically defined unique subset of patients. Blood 99:10, pages 3735-3741.
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Margarida Lima, Maria dos Anjos Teixeira, Sónia Fonseca, Cristina Gonçalves, Marisol Guerra, Maria Luı́s Queirós, Ana Helena Santos, António Coutinho, Luciana Pinho, Lucı́lia Marques, Manuel Cunha, Pinto Ribeiro, Luciana Xavier, Hermı́nia Vieira, Pureza Pinto & Benvindo Justiça. (2000) Immunophenotypic Aberrations, DNA Content, and Cell Cycle Analysis of Plasma Cells in Patients with Myeloma and Monoclonal Gammopathies. Blood Cells, Molecules, and Diseases 26:6, pages 634-645.
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