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Original Article

Inhibition of Myeloma Cell Growth by All-Trans Retinoic Acid is Associated with Upregulatidn of p21 and Dephosphorylation of the Retinoblastoma Protein

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Pages 261-268 | Received 20 Jan 1999, Published online: 01 Jul 2009

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Takemi Otsuki, Haruko Sakaguchi, Tamayo Hatayama, Ping Wu, Akiko Takata & Fuminori Hyodoh. (2003) Effects of All-trans Retinoic Acid (ATRA) on Human Myeloma Cells. Leukemia & Lymphoma 44:10, pages 1651-1656.
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Articles from other publishers (8)

Magda Babina, Metin Artuc, Sven Guhl & Torsten Zuberbier. (2017) Retinoic Acid Negatively Impacts Proliferation and MCTC Specific Attributes of Human Skin Derived Mast Cells, but Reinforces Allergic Stimulability. International Journal of Molecular Sciences 18:3, pages 525.
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Martin F. Kaiser, David C. JohnsonPing WuBrian A. WalkerAnnamaria Brioli, Fabio MirabellaChristopher P. WardellLorenzo MelchorFaith E. DaviesGareth J. Morgan. (2013) Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma. Blood 122:2, pages 219-226.
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Alaa Al-Tahan, Omar Sarkis, Mohamad Harajly, Omar Kebbe Baghdadi, Kazem Zibara, Fouad Boulos, Dipti Dighe, Steven Kregel, Ali Bazarbachi, Marwan El-Sabban, Stephen X. Skapek & Raya Saab. (2012) Retinoic acid fails to induce cell cycle arrest with myogenic differentiation in rhabdomyosarcoma. Pediatric Blood & Cancer 58:6, pages 877-884.
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Fuzhi Lian, Donald E. Smith, Hansgeorg Ernst, Robert M. Russell & Xiang-Dong Wang. (2007) Apo-10′-lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo. Carcinogenesis 28:7, pages 1567-1574.
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Kai Liu. (2005) Tissue microarray for high-throughput analysis of gene expression profiles in hepatocellular carcinoma. World Journal of Gastroenterology 11:9, pages 1369.
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A Arlt, J Minkenberg, B Kocs, M Großmann, M-L Kruse, U R Fölsch & H Schäfer. (2004) The expression of immediate early gene X-1 (IEX-1) is differentially induced by retinoic acids in NB4 and KG1 cells: possible implication in the distinct phenotype of retinoic acid-responsive and -resistant leukemic cells. Leukemia 18:10, pages 1646-1655.
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Takemi Otsuki, Kenichiro Yata, Haruko Sakaguchi, Junichi Kurebayashi, Yoshinobu Matsuo, Masako Uno, Tomohiro Fujii, Sakura Eda, Yumika Isozaki, Yoshihito Yawata, Osamu Yamada, Hideho Wada, Takashi Sugihara & Ayako Ueki. (2002) Interleukin 10 abolishes the growth inhibitory effects of all‐ trans retinoic acid on human myeloma cells . British Journal of Haematology 116:4, pages 787-795.
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Donald Lavelle, Yi‐Hsiang Chen, Maria Hankewych & Joseph DeSimone. (2001) Histone deacetylase inhibitors increase p21 WAF1 and induce apoptosis of human myeloma cell lines independent of decreased IL‐6 receptor expression . American Journal of Hematology 68:3, pages 170-178.
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