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Original Article

In Vitro and In Vivo Activities of Acylated Derivatives of Isoniazid Against Mycobacterium Tuberculosis

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Pages 103-108 | Published online: 04 Dec 2011

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Michael J. Hearn, Catherine D. Pugh & Michael H. Cynamon. (2023) Synthesis of functionalized sulfonamides as antitubercular agents. Phosphorus, Sulfur, and Silicon and the Related Elements 198:9, pages 733-751.
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Stephanie Thee, A. Anne Detjen, Ulrich Wahn & Klaus Magdorf. (2010) Isoniazid pharmacokinetic studies of the 1960s: considering a higher isoniazid dose in childhood tuberculosis. Scandinavian Journal of Infectious Diseases 42:4, pages 294-298.
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MichaelJ. Hearn, MichaelineF. Chen, MichaelH. Cynamon, Ruth Wang’ondu & EleanorR. Webster. (2006) Preparation and properties of new antitubercular thioureas and thiosemicarbazides. Journal of Sulfur Chemistry 27:2, pages 149-164.
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Articles from other publishers (16)

Mazen M. Almehmadi, Ahad Amer Alsaiari & Mohammad Asif. (2023) Synthesis and In-Vitro Antimycobacterial Evaluation of 4-Arylidene-2-Phenyl-6-(Aryl)-4,5-Dihydropyridazin-3(2H)-One Derivatives. Pharmaceutical Chemistry Journal 57:2, pages 265-273.
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S. Alghamdi & M. Asif. (2022) Pyrazinamide Analogs Designed for Rational Drug Designing Strategies against Resistant Tuberculosis. Russian Journal of Bioorganic Chemistry 48:3, pages 491-512.
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Richa Mardianingrum, Sri Rezeki Nur Endah, Eddy Suhardiana, Ruswanto Ruswanto & Siswandono Siswandono. (2021) Docking and molecular dynamic study of isoniazid derivatives as anti-tuberculosis drug candidate. Chemical Data Collections 32, pages 100647.
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Haiyan Liang, Bin Hu, Lei Chen, Shuaiqun Wang & Aorigele. (2020) Recognizing novel chemicals/drugs for anatomical therapeutic chemical classes with a heat diffusion algorithm. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866:11, pages 165910.
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Irina Zarafu, Lilia Matei, Coralia Bleotu, Petre Ionita, Arnaud Tatibouët, Anca Păun, Ioana Nicolau, Anamaria Hanganu, Carmen Limban, Diana Camelia Nuta, Roxana Maria Nemeș, Carmen Cristina Diaconu & Cristiana Radulescu. (2020) Synthesis, Characterization, and Biologic Activity of New Acyl Hydrazides and 1,3,4-Oxadiazole Derivatives. Molecules 25:14, pages 3308.
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Abdel Naser Dakkah, Yazan Bataineh, Bilal A Al Jaidi, Mohammad F. Bayan & Nabil A. Nimer. 2020. Integrative Nanomedicine for New Therapies. Integrative Nanomedicine for New Therapies 357 404 .
Ameeruddin Nusrath Unissa, Selvakumar Subbian, Luke Elizabeth Hanna & Nagamiah Selvakumar. (2016) Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis. Infection, Genetics and Evolution 45, pages 474-492.
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Ana Costa, Marina Pinheiro, Joana Magalhães, Ricardo Ribeiro, Vitor Seabra, Salette Reis & Bruno Sarmento. (2016) The formulation of nanomedicines for treating tuberculosis. Advanced Drug Delivery Reviews 102, pages 102-115.
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Ameeruddin Nusrath Unissa, Luke Elizabeth Hanna & Soumya Swaminathan. (2016) A Note on Derivatives of Isoniazid, Rifampicin, and Pyrazinamide Showing Activity Against Resistant Mycobacterium tuberculosis . Chemical Biology & Drug Design 87:4, pages 537-550.
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Lilia Matei, Coralia Bleotu, Ion Baciu, Carmen Cristina Diaconu, Anamaria Hanganu, Otilia Banu, Petre Ionita, Anca Paun, Arnaud Tatibou?t & Irina Zarafu. (2015) Synthesis and biological activities of some new isonicotinic acid 2-(2-hydroxy-8-substituted-tricyclo[7.3.1.02.7]tridec-13-ylidene)-hydrazides. Bioorganic & Medicinal Chemistry 23:3, pages 401-410.
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H. S. Naveen Kumar, Thaigarajan Parumasivam, Pazilah Ibrahim, Mohd. Zaini Asmawi & Amirin Sadikun. (2013) Synthesis of hydrophobic N-acylated isonicotinic acid hydrazide derivatives as potential enoyl–acyl carrier protein reductase (InhA) inhibitors. Medicinal Chemistry Research 23:3, pages 1267-1277.
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Lilia Matei, Coralia Bleotu, Ion Baciu, Constantin Draghici, Petre Ionita, Anca Paun, Mariana Carmen Chifiriuc, Adriana Sbarcea & Irina Zarafu. (2013) Synthesis and bioevaluation of some new isoniazid derivatives. Bioorganic & Medicinal Chemistry 21:17, pages 5355-5361.
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Mashooq A. Bhat & Mohamed A. Al-Omar. (2013) Synthesis, characterization, and in vitro anti-Mycobacterium tuberculosis activity of terpene Schiff bases. Medicinal Chemistry Research 22:9, pages 4522-4528.
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Vikramjeet Judge, Balasubramanian Narasimhan & Munish Ahuja. (2012) Isoniazid: the magic molecule. Medicinal Chemistry Research 21:12, pages 3940-3957.
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Michael D Adjei, Thomas M Heinze, Joanna Deck, James P Freeman, Anna J Williams & John B Sutherland. (2007) Acetylation and nitrosation of ciprofloxacin by environmental strains of mycobacteria. Canadian Journal of Microbiology 53:1, pages 144-147.
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Michael J. Hearn, Eleanor R. Webster & Michael H. Cynamon. (2005) Preparation and properties of antitubercular 1-piperidino-3-arylthioureas. Journal of Heterocyclic Chemistry 42:6, pages 1225-1229.
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