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Clinical Research and Regulatory Affairs Volume 11, 1994 - Issue 2
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Research Article

Influence of Inter-Animal Variability on the Estimation of Population Pharmacokinetic Parameters in Preclinical Studies

E. I. Ette University of Glasgow, Dept. of Medicine & Therapeutics, Western Infirmary, Gardiner Institute, Scotland; Division of Biopharmaceutics, HFD-426, Rm 13 B 06, CDER, FDA, 5600 Fishers Lane, Rockville, MD, 20857
,
A. W. Kelman University of Glasgow, Dept. of Medicine & Therapeutics, Western Infirmary, Gardiner Institute, Scotland
,
C. A. Howie University of Glasgow, Dept. of Medicine & Therapeutics, Western Infirmary, Gardiner Institute, Scotland
&
B. Whiting University of Glasgow, Dept. of Medicine & Therapeutics, Western Infirmary, Gardiner Institute, Scotland
Pages 121-139 | Published online: 28 Sep 2008

Citations (11)

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Read on this site (2)

Kimberley A. Jackson & Sara E. Rosenbaum. (1998) The Application of Population Pharmacokinetics to the Drug Development Process. Drug Development and Industrial Pharmacy 24:12, pages 1155-1162.
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C. D. Jones, H. Sun & E. I. Ette. (1996) Designing Cross-Sectional Population Pharmacokinetic Studies: Implications for Pediatric and Animal Studies. Clinical Research and Regulatory Affairs 13:3-4, pages 133-165.
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Articles from other publishers (9)

Michael S. Valic, Michael Halim, Pamela Schimmer & Gang Zheng. (2020) Guidelines for the experimental design of pharmacokinetic studies with nanomaterials in preclinical animal models. Journal of Controlled Release 323, pages 83-101.
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Mehdi Boroujerdi. 2015. Pharmacokinetics and Toxicokinetics. Pharmacokinetics and Toxicokinetics 479 488 .
Peter L. BonatePeter L. Bonate. 2011. Pharmacokinetic-Pharmacodynamic Modeling and Simulation. Pharmacokinetic-Pharmacodynamic Modeling and Simulation 303 358 .
Ene I Ette & Paul J Williams. (2004) Population Pharmacokinetics II: Estimation Methods. Annals of Pharmacotherapy 38:11, pages 1907-1915.
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Paul Williams, Ene Ette, Stephan Ogenstad & Christopher Godfrey. 2002. Simulation for Designing Clinical Trials. Simulation for Designing Clinical Trials.
Michael Mayersohn. (2000) Measurement of Disposition Half‐Life, Clearance, and Residence Times. Current Protocols in Toxicology 4:1.
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Gregory Hardee & J BaggotMarilyn Martinez & Melanie Berson. 1998. Development and Formulation of Veterinary Dosage Forms, Second Edition. Development and Formulation of Veterinary Dosage Forms, Second Edition 429 467 .
Peter A. Gething & Peter T. Daley-Yates. (1997) A Sparse Sampling, Mixed Effects Approach to Toxicokinetic Analyses. Drug Information Journal 31:2, pages 521-527.
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He Sun, Ene I. Ette & Thomas M. Ludden. (1997) On the recording of sample times and parameter estimation from repeated measures pharmacokinetic data. Journal of Pharmacokinetics and Biopharmaceutics 24:6, pages 637-650.
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