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Receptors and Channels Volume 10, 2004 - Issue 3-4
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Original Article

BacMam Recombinant Baculoviruses in G Protein–Coupled Receptor Drug Discovery

Robert S. Ames Gene Expression & Protein Biochemisty, Discovery Research Biology, GlaxoSmithKline, King of Prussia, PA, USA
,
James A. Fornwald Gene Expression & Protein Biochemisty, Discovery Research Biology, GlaxoSmithKline, King of Prussia, PA, USA
,
Parvathi Nuthulaganti Gene Expression & Protein Biochemisty, Discovery Research Biology, GlaxoSmithKline, King of Prussia, PA, USA
,
John J. Trill Gene Expression & Protein Biochemisty, Discovery Research Biology, GlaxoSmithKline, King of Prussia, PA, USA
,
James J. Foley Respiratory and Inflammation Center of Excellence for Drug Discovery, GlaxoSmithKline, King of Prussia, PA, USA
,
Peter T. Buckley Respiratory and Inflammation Center of Excellence for Drug Discovery, GlaxoSmithKline, King of Prussia, PA, USA
,
Thomas A. Kost Gene Expression & Protein Biochemisty, Discovery Research Biology, GlaxoSmithKline, Research Triangle Park, NC, USA
,
Zining Wu Assay Development & Compound Profiling, Discovery Research Biology, GlaxoSmithKline, Collegeville, PA, USA
&
Michael A. Romanos Gene Expression & Protein Biochemisty, Discovery Research Biology, GlaxoSmithKline, Stevenage, UK
 show all
Pages 99-107 | Received 14 Jul 2004, Accepted 30 Aug 2004, Published online: 04 Dec 2011

Citations (15)

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Read on this site (2)

Robert S Ames & Quinn Lu. (2009) Viral-mediated gene delivery for cell-based assays in drug discovery. Expert Opinion on Drug Discovery 4:3, pages 243-256.
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Robert S Ames, Thomas A Kost & J Patrick Condreay. (2007) BacMam technology and its application to drug discovery. Expert Opinion on Drug Discovery 2:12, pages 1669-1681.
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Articles from other publishers (13)

Ronald W. MathenyJr.Jr., Alyssa V. Geddis, Mary N. Abdalla & Luis A. Leandry. (2016) Phosphatidylinositol 3-kinase p110α mediates phosphorylation of AMP-activated protein kinase in myoblasts. Biochemical and Biophysical Research Communications 469:4, pages 1117-1122.
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Neil M. J. O’FlynnAvnish PatelJan Kadlec & Ian M. Jones. (2012) Improving promiscuous mammalian cell entry by the baculovirus Autographa californica multiple nuclear polyhedrosis virus . Bioscience Reports 33:1.
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Simon Trowitzsch, Martin Klumpp, Ralf Thoma, Jean‐Philippe Carralot & Imre Berger. (2011) Light it up: Highly efficient multigene delivery in mammalian cells. BioEssays 33:12, pages 946-955.
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Chris Kemp & David Kuninger. 2011. Primary and Stem Cells. Primary and Stem Cells 85 102 .
James C. Errey & Fiona H. Marshall. 2010. GPCR Molecular Pharmacology and Drug Targeting. GPCR Molecular Pharmacology and Drug Targeting 324 384 .
Michael C. FlickingerRobert D. Possee, Richard B. Hitchman & Linda A. King. 2009. Encyclopedia of Industrial Biotechnology. Encyclopedia of Industrial Biotechnology 1 40 .
Michael C. FlickingerDavid L. Hacker, Lucia Baldi, Myriam Adam & Florian M. Wurm. 2009. Encyclopedia of Industrial Biotechnology. Encyclopedia of Industrial Biotechnology 1 8 .
Jeffrey J. Clare. 2008. Protein Science Encyclopedia. Protein Science Encyclopedia 79 109 .
E Fonfria, W C Clay, D S Levy, J A Goodwin, S Roman, G D Smith, J P Condreay & A D Michel. (2008) Cloning and pharmacological characterization of the guinea pig P2X 7 receptor orthologue . British Journal of Pharmacology 153:3, pages 544-556.
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Charles R. Midgett & Dean R. Madden. (2007) Breaking the bottleneck: Eukaryotic membrane protein expression for high-resolution structural studies. Journal of Structural Biology 160:3, pages 265-274.
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David J Behm, Gerald Stankus, Christopher P A Doe, Robert N Willette, Henry M Sarau, James J Foley, Dulcie B Schmidt, Parvathi Nuthulaganti, James A Fornwald, Robert S Ames, David G Lambert, Girolamo Calo'Valeria Camarda, Nambi V Aiyar & Stephen A Douglas. (2006) The peptidic urotensin-II receptor ligand GSK248451 possesses less intrinsic activity than the low-efficacy partial agonists SB-710411 and urantide in native mammalian tissues and recombinant cell systems. British Journal of Pharmacology 148:2, pages 173-190.
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Wayne R. Leifert, Amanda L. Aloia, Olgatina Bucco, Richard V. Glatz & Edward J. McMurchie. (2005) G-Protein-Coupled Receptors in Drug Discovery: Nanosizing Using Cell-Free Technologies and Molecular Biology Approaches. SLAS Discovery 10:8, pages 765-779.
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Thomas A Kost, J Patrick Condreay & Donald L Jarvis. (2005) Baculovirus as versatile vectors for protein expression in insect and mammalian cells. Nature Biotechnology 23:5, pages 567-575.
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