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Receptors and Channels Volume 10, 2004 - Issue 3-4
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Original Article

Heterologous Expression of G Protein–Coupled Receptors in U-2 OS Osteosarcoma Cells

Robert S. Ames Gene Expression & Protein Biochemistry, Discovery Research Biology, GlaxoSmithKline, King of Prussia, Pennsylvania, USA
,
Parvathi Nuthulaganti Gene Expression & Protein Biochemistry, Discovery Research Biology, GlaxoSmithKline, King of Prussia, Pennsylvania, USA
,
Jim A. Fornwald Gene Expression & Protein Biochemistry, Discovery Research Biology, GlaxoSmithKline, King of Prussia, Pennsylvania, USA
,
Usman Shabon Gene Cloning & Proteomics, GlaxoSmithKline, Collegeville, Pennsylvania, USA
,
Harjeet K. van-der-Keyl Gene Cloning & Proteomics, GlaxoSmithKline, Collegeville, Pennsylvania, USA
&
Nabil A. Elshourbagy Gene Cloning & Proteomics, GlaxoSmithKline, Collegeville, Pennsylvania, USA
Pages 117-124 | Received 14 Jul 2004, Accepted 30 Aug 2004, Published online: 04 Dec 2011

Citations (10)

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Chang-Jun Zheng, Li-Li Yang, Jun Liu & Lei Zhong. (2018) JTC-801 exerts anti-proliferative effects in human osteosarcoma cells by inducing apoptosis. Journal of Receptors and Signal Transduction 38:2, pages 133-140.
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Robert S Ames & Quinn Lu. (2009) Viral-mediated gene delivery for cell-based assays in drug discovery. Expert Opinion on Drug Discovery 4:3, pages 243-256.
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Robert S Ames, Thomas A Kost & J Patrick Condreay. (2007) BacMam technology and its application to drug discovery. Expert Opinion on Drug Discovery 2:12, pages 1669-1681.
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Articles from other publishers (7)

David R. Thomas, Adeshola Dada, Gareth A. Jones, Rudolf A. Deisz, Sylvain Gigout, Christopher J. Langmead, Tim D. Werry, Nicola Hendry, Jim J. Hagan, Ceri H. Davies & Jeannette M. Watson. (2010) N-desmethylclozapine (NDMC) is an antagonist at the human native muscarinic M1 receptor. Neuropharmacology 58:8, pages 1206-1214.
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E Fonfria, W C Clay, D S Levy, J A Goodwin, S Roman, G D Smith, J P Condreay & A D Michel. (2008) Cloning and pharmacological characterization of the guinea pig P2X 7 receptor orthologue . British Journal of Pharmacology 153:3, pages 544-556.
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A D Michel, L J Chambers, W C Clay, J P Condreay, D S Walter & I P Chessell. (2007) Direct labelling of the human P2X 7 receptor and identification of positive and negative cooperativity of binding . British Journal of Pharmacology 151:1, pages 84-95.
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Celia P Briscoe, Andrew J Peat, Stephen C McKeown, David F Corbett, Aaron S Goetz, Thomas R Littleton, David C McCoy, Terry P Kenakin, John L Andrews, Carina Ammala, James A Fornwald, Diane M Ignar & Stephen Jenkinson. (2006) Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. British Journal of Pharmacology 148:5, pages 619-628.
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David J Behm, Gerald Stankus, Christopher P A Doe, Robert N Willette, Henry M Sarau, James J Foley, Dulcie B Schmidt, Parvathi Nuthulaganti, James A Fornwald, Robert S Ames, David G Lambert, Girolamo Calo'Valeria Camarda, Nambi V Aiyar & Stephen A Douglas. (2006) The peptidic urotensin-II receptor ligand GSK248451 possesses less intrinsic activity than the low-efficacy partial agonists SB-710411 and urantide in native mammalian tissues and recombinant cell systems. British Journal of Pharmacology 148:2, pages 173-190.
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Wayne R. Leifert, Amanda L. Aloia, Olgatina Bucco, Richard V. Glatz & Edward J. McMurchie. (2005) G-Protein-Coupled Receptors in Drug Discovery: Nanosizing Using Cell-Free Technologies and Molecular Biology Approaches. SLAS Discovery 10:8, pages 765-779.
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Thomas A Kost, J Patrick Condreay & Donald L Jarvis. (2005) Baculovirus as versatile vectors for protein expression in insect and mammalian cells. Nature Biotechnology 23:5, pages 567-575.
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