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Review Article

Biopharmaceutical drug targeting to the brain

Pages 157-167 | Received 23 Sep 2009, Accepted 08 Dec 2009, Published online: 12 Jan 2010

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Bapi Gorain, Hira Choudhury, Manisha Pandey, Mohd Cairul Iqbal Mohd Amin, Bhupinder Singh, Umesh Gupta & Prashant Kesharwani. 2018. Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors. Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors 267 305 .
Aikaterini Lalatsa & Arthur M. Butt. 2018. Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors. Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors 49 74 .
John J. Jamieson, Peter C. Searson & Sharon Gerecht. (2017) Engineering the human blood-brain barrier in vitro. Journal of Biological Engineering 11:1.
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Karl Sydow, Heike Nikolenko, Dorothea Lorenz, Rainer H. Müller & Margitta Dathe. (2016) Lipopeptide-based micellar and liposomal carriers: Influence of surface charge and particle size on cellular uptake into blood brain barrier cells. European Journal of Pharmaceutics and Biopharmaceutics 109, pages 130-139.
Crossref
XiuLing Xu, JingJing Li, ShunPing Han, ChengHao Tao, Luo Fang, Yue Sun, JiaZhen Zhu, ZeHua Liang & FanZhu Li. (2016) A novel doxorubicin loaded folic acid conjugated PAMAM modified with borneol, a nature dual-functional product of reducing PAMAM toxicity and boosting BBB penetration. European Journal of Pharmaceutical Sciences 88, pages 178-190.
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Ngoc H. On, Vinith Yathindranath, Zhizhi Sun & Donald W. Miller. 2016. Drug Delivery. Drug Delivery 353 382 .
Jennifer A. MacDiarmid, Veronika Langova, Dale Bailey, Scott T. Pattison, Stacey L. Pattison, Neil Christensen, Luke R. Armstrong, Vatsala N. Brahmbhatt, Katarzyna Smolarczyk, Matthew T. Harrison, Marylia Costa, Nancy B. Mugridge, Ilya Sedliarou, Nicholas A. Grimes, Debra L. Kiss, Bruce Stillman, Christine L. Hann, Gary L. Gallia, Robert M. Graham & Himanshu Brahmbhatt. (2016) Targeted Doxorubicin Delivery to Brain Tumors via Minicells: Proof of Principle Using Dogs with Spontaneously Occurring Tumors as a Model. PLOS ONE 11:4, pages e0151832.
Crossref
Ailing Hui, Shijing Zhu, Huayang Yin, Li Yang, Zheng Zhang, An Zhou, Jian Pan & Wencheng Zhang. (2016) Novel ginkgolide B derivative attenuated the function and expression of P-glycoprotein at the blood–brain barrier, presenting brain-targeting ability. RSC Advances 6:37, pages 31101-31106.
Crossref
Md. Tozammel Hoque, Arpit Shah, Vijay More, David S. Miller & Reina Bendayan. (2015) In vivo and ex vivo regulation of breast cancer resistant protein (Bcrp) by peroxisome proliferator-activated receptor alpha (Pparα) at the blood-brain barrier . Journal of Neurochemistry 135:6, pages 1113-1122.
Crossref
Sai-Wang Seto, Hosen Kiat, Simon M.Y. Lee, Alan Bensoussan, Yu-Ting Sun, Maggie P.M. Hoi & Dennis Chang. (2015) Zebrafish models of cardiovascular diseases and their applications in herbal medicine research. European Journal of Pharmacology 768, pages 77-86.
Crossref
Amir Zarebkohan, Farhood Najafi, Hamid Reza Moghimi, Mohammad Hemmati, Mohammad Reza Deevband & Bahram Kazemi. (2015) Synthesis and characterization of a PAMAM dendrimer nanocarrier functionalized by SRL peptide for targeted gene delivery to the brain. European Journal of Pharmaceutical Sciences 78, pages 19-30.
Crossref
CHAO LI, YAN LI, HAINING LV, SHAOWU LI, KE TANG, WANQI ZHOU, SHISHAN YU & XIAOGUANG CHEN. (2015) The novel anti-neuroblastoma agent PF403, inhibits proliferation and invasion in vitro and in brain xenografts. International Journal of Oncology 47:1, pages 179-187.
Crossref
Melvin M. Evers, Lodewijk J.A. Toonen & Willeke M.C. van Roon-Mom. (2015) Antisense oligonucleotides in therapy for neurodegenerative disorders. Advanced Drug Delivery Reviews 87, pages 90-103.
Crossref
Benjamin Shapiro, Sandip Kulkarni, Aleksander Nacev, Silvia Muro, Pavel Y. Stepanov & Irving N. Weinberg. (2014) Open challenges in magnetic drug targeting. WIREs Nanomedicine and Nanobiotechnology 7:3, pages 446-457.
Crossref
K. K. Pulicherla & Mahendra Kumar Verma. (2015) Targeting Therapeutics Across the Blood Brain Barrier (BBB), Prerequisite Towards Thrombolytic Therapy for Cerebrovascular Disorders—an Overview and Advancements. AAPS PharmSciTech 16:2, pages 223-233.
Crossref
Zhikun Xu, María Virtudes Céspedes, Ugutz Unzueta, Patricia Álamo, Mireia Pesarrodona, Ramón Mangues, Esther Vázquez, Antonio Villaverde & Neus Ferrer-Miralles. (2015) Targeting low-density lipoprotein receptors with protein-only nanoparticles. Journal of Nanoparticle Research 17:3.
Crossref
Daniel Rycroft, Jane Sosabowski, Edward Coulstock, Marie Davies, John Morrey, Sarah Friel, Fiona Kelly, Robert Hamatake, Milan Ovečka, Rob Prince, Laura Goodall, Armin Sepp & Adam Walker. (2015) Pharmacokinetic Characteristics, Pharmacodynamic Effect and In Vivo Antiviral Efficacy of Liver-Targeted Interferon Alpha. PLOS ONE 10:2, pages e0117847.
Crossref
Jean-Pierre Valentin, Annie Delaunois, Pierre Lainée, Matthew Skinner & Hugo M. Vargas. 2015. The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment. The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment 417 435 .
Bhushan S. Pattni & Vladimir P. Torchilin. 2015. Targeted Drug Delivery : Concepts and Design. Targeted Drug Delivery : Concepts and Design 3 38 .
Julia Georgieva, Dick Hoekstra & Inge Zuhorn. (2014) Smuggling Drugs into the Brain: An Overview of Ligands Targeting Transcytosis for Drug Delivery across the Blood–Brain Barrier. Pharmaceutics 6:4, pages 557-583.
Crossref
Philipp D. Kaiser, Julia Maier, Bjoern Traenkle, Felix Emele & Ulrich Rothbauer. (2014) Recent progress in generating intracellular functional antibody fragments to target and trace cellular components in living cells. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1844:11, pages 1933-1942.
Crossref
J. S. Klein, S. Jiang, R. P. Galimidi, J. R. Keeffe & P. J. Bjorkman. (2014) Design and characterization of structured protein linkers with differing flexibilities. Protein Engineering Design and Selection 27:10, pages 325-330.
Crossref
Xiang Yi, Devika S. Manickam, Anna Brynskikh & Alexander V. Kabanov. (2014) Agile delivery of protein therapeutics to CNS. Journal of Controlled Release 190, pages 637-663.
Crossref
Janet Hsu, Jeff Rappaport & Silvia Muro. (2014) Specific Binding, Uptake, and Transport of ICAM-1-Targeted Nanocarriers Across Endothelial and Subendothelial Cell Components of the Blood–Brain Barrier. Pharmaceutical Research 31:7, pages 1855-1866.
Crossref
Carmen Wängler, Shafinaz Chowdhury, Georg Höfner, Petia Djurova, Enrico O. Purisima, Peter Bartenstein, Björn Wängler, Gert Fricker, Klaus T. Wanner & Ralf Schirrmacher. (2014) Shuttle–Cargo Fusion Molecules of Transport Peptides and the hD 2/3 Receptor Antagonist Fallypride: A Feasible Approach To Preserve Ligand–Receptor Binding? . Journal of Medicinal Chemistry 57:10, pages 4368-4381.
Crossref
Douglas M McCarty & Haiyan Fu. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences.
Michel Demeule, Nicolas Beaudet, Anthony Régina, Élie Besserer-Offroy, Alexandre Murza, Pascal Tétreault, Karine Belleville, Christian Ché, Alain Larocque, Carine Thiot, Richard Béliveau, Jean-Michel Longpré, Éric Marsault, Richard Leduc, Jean E. Lachowicz, Steven L. Gonias, Jean-Paul Castaigne & Philippe Sarret. (2014) Conjugation of a brain-penetrant peptide with neurotensin provides antinociceptive properties. Journal of Clinical Investigation 124:3, pages 1199-1213.
Crossref
Hong Ding, Vidya Sagar, Marisela Agudelo, Sudheesh Pilakka-Kanthikeel, Venkata Subba Rao Atluri, Andrea Raymond, Thangavel Samikkannu & Madhavan P Nair. (2014) Enhanced blood?brain barrier transmigration using a novel transferrin embedded fluorescent magneto-liposome nanoformulation. Nanotechnology 25:5, pages 055101.
Crossref
Jens Frigell, Isabel García, Vanessa Gómez-Vallejo, Jordi Llop & Soledad Penadés. (2013) 68 Ga-Labeled Gold Glyconanoparticles for Exploring Blood–Brain Barrier Permeability: Preparation, Biodistribution Studies, and Improved Brain Uptake via Neuropeptide Conjugation . Journal of the American Chemical Society 136:1, pages 449-457.
Crossref
Mohammad Zaki Ahmad, Sohail Akhter, Ziyaur Rahman, Javed Ahmad, Iqbal Ahmad & Farhan Jalees Ahmad. 2014. Drug Design and Discovery in Alzheimer's Disease. Drug Design and Discovery in Alzheimer's Disease 716 739 .
Seung Rim Hwang & Kwangmeyung Kim. (2013) Nano-enabled delivery systems across the blood–brain barrier. Archives of Pharmacal Research 37:1, pages 24-30.
Crossref
Reinhard Gabathuler. 2014. Drug Delivery to the Brain. Drug Delivery to the Brain 455 484 .
F. Anthony Willyerd, Philip E. Empey, Patrick M. Kochanek & Robert S. B. Clark. 2014. Vascular Mechanisms in CNS Trauma. Vascular Mechanisms in CNS Trauma 125 140 .
Maria Ansar, Daniel Serrano, Iason Papademetriou, Tridib Kumar Bhowmick & Silvia Muro. (2013) Biological Functionalization of Drug Delivery Carriers To Bypass Size Restrictions of Receptor-Mediated Endocytosis Independently from Receptor Targeting. ACS Nano 7:12, pages 10597-10611.
Crossref
Ngoc H On, Sanjot Savant, Myron Toews & Donald W Miller. (2013) Rapid and Reversible Enhancement of Blood–Brain Barrier Permeability Using Lysophosphatidic Acid. Journal of Cerebral Blood Flow & Metabolism 33:12, pages 1944-1954.
Crossref
Hong Ding, Fang Wu & Madhavan P. Nair. (2013) Image-guided drug delivery to the brain using nanotechnology. Drug Discovery Today 18:21-22, pages 1074-1080.
Crossref
Luba Kozlovskaya & David Stepensky. (2013) Quantitative analysis of the brain-targeted delivery of drugs and model compounds using nano-delivery systems. Journal of Controlled Release 171:1, pages 17-23.
Crossref
Xiaoying Chen, Jennica L. Zaro & Wei-Chiang Shen. (2013) Fusion protein linkers: Property, design and functionality. Advanced Drug Delivery Reviews 65:10, pages 1357-1369.
Crossref
Sibel Bozdağ Pehlivan. (2013) Nanotechnology-Based Drug Delivery Systems for Targeting, Imaging and Diagnosis of Neurodegenerative Diseases. Pharmaceutical Research 30:10, pages 2499-2511.
Crossref
Ailing Fu, Zizhen Zhao, Feiyan Gao & Miaomiao Zhang. (2013) Cellular Uptake Mechanism and Therapeutic Utility of a Novel Peptide in Targeted-Delivery of Proteins into Neuronal Cells. Pharmaceutical Research 30:8, pages 2108-2117.
Crossref
Ernst Martin & Beat Werner. (2013) Focused Ultrasound Surgery of the Brain. Current Radiology Reports 1:2, pages 126-135.
Crossref
Mikhail I. Papisov, Vasily V. Belov & Kimberley S. Gannon. (2013) Physiology of the Intrathecal Bolus: The Leptomeningeal Route for Macromolecule and Particle Delivery to CNS. Molecular Pharmaceutics 10:5, pages 1522-1532.
Crossref
Jason Papademetriou, Carmen Garnacho, Daniel Serrano, Tridib Bhowmick, Edward H. Schuchman & Silvia Muro. (2012) Comparative binding, endocytosis, and biodistribution of antibodies and antibody-coated carriers for targeted delivery of lysosomal enzymes to ICAM-1 versus transferrin receptor. Journal of Inherited Metabolic Disease 36:3, pages 467-477.
Crossref
Roscoe O. Brady, Chunzhang Yang & Zhengping Zhuang. (2012) An innovative approach to the treatment of Gaucher disease and possibly other metabolic disorders of the brain. Journal of Inherited Metabolic Disease 36:3, pages 451-454.
Crossref
Dolores Remedios Serrano Lopez & Aikaterini Lalatsa. (2013) Peptide pills for brain diseases? Reality and future perspectives. Therapeutic Delivery 4:4, pages 479-501.
Crossref
Xiaoying Chen, Jennica Zaro & Wei‐Chiang Shen. 2013. Fusion Protein Technologies for Biopharmaceuticals. Fusion Protein Technologies for Biopharmaceuticals 57 73 .
Julia Lemmen, Iasson E.P. Tozakidis, Prachee Bele & Hans-Joachim Galla. (2013) Constitutive androstane receptor upregulates Abcb1 and Abcg2 at the blood–brain barrier after CITCO activation. Brain Research 1501, pages 68-80.
Crossref
Edward Coulstock, Jane Sosabowski, Milan Ove?ka, Rob Prince, Laura Goodall, Clare Mudd, Armin Sepp, Marie Davies, Julie Foster, Jerome Burnet, Gr?inne Dunlevy & Adam Walker. (2013) Liver-Targeting of Interferon-Alpha with Tissue-Specific Domain Antibodies. PLoS ONE 8:2, pages e57263.
Crossref
Claire Géral, Angelina Angelova & Sylviane Lesieur. (2013) From Molecular to Nanotechnology Strategies for Delivery of Neurotrophins: Emphasis on Brain-Derived Neurotrophic Factor (BDNF). Pharmaceutics 5:4, pages 127-167.
Crossref
Congsheng Cheng, Yong Hong Chen, Kim A Lennox, Mark A Behlke & Beverly L Davidson. (2013) In vivo SELEX for Identification of Brain-penetrating Aptamers. Molecular Therapy - Nucleic Acids 2, pages e67.
Crossref
Julia Lemmen, Iasson E.P. Tozakidis & Hans-Joachim Galla. (2013) Pregnane X receptor upregulates ABC-transporter Abcg2 and Abcb1 at the blood-brain barrier. Brain Research 1491, pages 1-13.
Crossref
T Lundqvist & S Bredenberg. 2013. Drug Discovery and Development. Drug Discovery and Development 227 238 .
Wendy Halpern & David Hutto. 2013. Haschek and Rousseaux's Handbook of Toxicologic Pathology. Haschek and Rousseaux's Handbook of Toxicologic Pathology 751 782 .
Charles W. RichardIIIIII. 2013. Introduction to Biological and Small Molecule Drug Research and Development. Introduction to Biological and Small Molecule Drug Research and Development 327 341 .
Shiran Ferber, Galia Tiram & Ronit Satchi-Fainaro. 2013. Cancer Targeted Drug Delivery. Cancer Targeted Drug Delivery 509 542 .
Christine Vauthier, Patrick Couvreur & Elias Fattal. 2013. Nanomaterials: A Danger or a Promise?. Nanomaterials: A Danger or a Promise? 131 151 .
Itzik Cooper, Keren Sasson, Vivian I. Teichberg, Michal Schnaider-Beeri, Mati Fridkin & Yoram Shechter. (2012) Peptide Derived from HIV-1 TAT Protein Destabilizes a Monolayer of Endothelial Cells in an in Vitro Model of the Blood-Brain Barrier and Allows Permeation of High Molecular Weight Proteins. Journal of Biological Chemistry 287:53, pages 44676-44683.
Crossref
Patrick T. Reilly & Tak W. Mak. (2012) Molecular Pathways: Tumor Cells Co-opt the Brain-Specific Metabolism Gene CPT1C to Promote Survival . Clinical Cancer Research 18:21, pages 5850-5855.
Crossref
William M Pardridge. (2012) Drug Transport across the Blood–Brain Barrier. Journal of Cerebral Blood Flow & Metabolism 32:11, pages 1959-1972.
Crossref
Mathew W. Smith, Ghaith Al-Jayyoussi & Mark Gumbleton. (2012) Peptide sequences mediating tropism to intact blood–brain barrier: An in vivo biodistribution study using phage display. Peptides 38:1, pages 172-180.
Crossref
Eun-Joo Park, Yong-Zhi Zhang, Natalia Vykhodtseva & Nathan McDannold. (2012) Ultrasound-mediated blood‐brain/blood-tumor barrier disruption improves outcomes with trastuzumab in a breast cancer brain metastasis model. Journal of Controlled Release 163:3, pages 277-284.
Crossref
Aikaterini Lalatsa, Andreas G. Schätzlein & Ijeoma F. Uchegbu*. 2012. Nanostructured Biomaterials for Overcoming Biological Barriers. Nanostructured Biomaterials for Overcoming Biological Barriers 329 363 .
Muthu Ramakrishnan, Fernando Alves De Melo, Berma M. Kinsey, John E. Ladbury, Thomas R. Kosten & Frank M. Orson. (2012) Probing Cocaine-Antibody Interactions in Buffer and Human Serum. PLoS ONE 7:7, pages e40518.
Crossref
Andrea Orthmann, Reiner Zeisig, Regine Süss, Dorothea Lorenz, Margit Lemm & Iduna Fichtner. (2012) Treatment of Experimental Brain Metastasis with MTO-Liposomes: Impact of Fluidity and LRP-Targeting on the Therapeutic Result. Pharmaceutical Research 29:7, pages 1949-1959.
Crossref
David Hymel & Blake R. Peterson. (2012) Synthetic cell surface receptors for delivery of therapeutics and probes. Advanced Drug Delivery Reviews 64:9, pages 797-810.
Crossref
Silvia Muro. (2012) Strategies for delivery of therapeutics into the central nervous system for treatment of lysosomal storage disorders. Drug Delivery and Translational Research 2:3, pages 169-186.
Crossref
Ailing Fu, Yilin Wang, Liping Zhan & Rumei Zhou. (2012) Targeted Delivery of Proteins into the Central Nervous System Mediated by Rabies Virus Glycoprotein-Derived Peptide. Pharmaceutical Research 29:6, pages 1562-1569.
Crossref
Eduard Urich, Stanley E. Lazic, Juliette Molnos, Isabelle Wells & Per-Ola Freskgård. (2012) Transcriptional Profiling of Human Brain Endothelial Cells Reveals Key Properties Crucial for Predictive In Vitro Blood-Brain Barrier Models. PLoS ONE 7:5, pages e38149.
Crossref
Chengyuan Ma, Yang Li, Zhixin Li, Haiyan Huang, Kan Xu, Haiyang Xu, Jieying Bai, Xiao Li & Gang Zhao. (2012) Synthesis and purification of a toxin-linked conjugate targeting epidermal growth factor receptor in Escherichia coli. Protein Expression and Purification 83:1, pages 1-7.
Crossref
Ho Lun Wong, Xiao Yu Wu & Reina Bendayan. (2012) Nanotechnological advances for the delivery of CNS therapeutics. Advanced Drug Delivery Reviews 64:7, pages 686-700.
Crossref
Md. Tozammel Hoque, Kevin R. Robillard & Reina Bendayan. (2012) Regulation of Breast Cancer Resistant Protein by Peroxisome Proliferator-Activated Receptor α in Human Brain Microvessel Endothelial Cells. Molecular Pharmacology 81:4, pages 598-609.
Crossref
Luca Costantino & Diana Boraschi. (2012) Is there a clinical future for polymeric nanoparticles as brain-targeting drug delivery agents?. Drug Discovery Today 17:7-8, pages 367-378.
Crossref
Ming-Jun Tsai, Pao-Chu Wu, Yaw-Bin Huang, Jui-Sheng Chang, Chin-Lin Lin, Yi-Hung Tsai & Jia-You Fang. (2012) Baicalein loaded in tocol nanostructured lipid carriers (tocol NLCs) for enhanced stability and brain targeting. International Journal of Pharmaceutics 423:2, pages 461-470.
Crossref
. 2012. Therapeutic Antibody Engineering. Therapeutic Antibody Engineering 225 595 .
Reinhard Gabathuler. (2012) Développement de nouveaux vecteurs protéiniques pour le transport physiologique d’agents thérapeutiques vers le système nerveux central. Biologie Aujourd'hui 206:3, pages 191-203.
Crossref
. 2012. Therapeutic Antibody Engineering. Therapeutic Antibody Engineering 459 595 .
William M. Pardridge & Ruben J. Boado. 2012. Protein Engineering for Therapeutics, Part B. Protein Engineering for Therapeutics, Part B 269 292 .
Hyun Bae Chun, Michael Scott, Sherry Niessen, Heather Hoover, Andrew Baird, John YatesIIIIII, Bruce E Torbett & Brian P Eliceiri. (2011) The Proteome of Mouse Brain Microvessel Membranes and Basal Lamina. Journal of Cerebral Blood Flow & Metabolism 31:12, pages 2267-2281.
Crossref
Chih-Jen Wen, Tzu-Chen Yen, Saleh A Al-Suwayeh, Hui-Wen Chang & Jia-You Fang. (2011) In vivo real-time fluorescence visualization and brain-targeting mechanisms of lipid nanocarriers with different fatty ester:oil ratios . Nanomedicine 6:9, pages 1545-1559.
Crossref
Qing-Hui Zhou, Rachita Sumbria, Eric Ka-Wai Hui, Jeff Zhiqiang Lu, Ruben J. Boado & William M. Pardridge. (2011) Neuroprotection with a Brain-Penetrating Biologic Tumor Necrosis Factor Inhibitor. Journal of Pharmacology and Experimental Therapeutics 339:2, pages 618-623.
Crossref
Gary N. Y. Chan, Md. Tozammel Hoque, Carolyn L. Cummins & Reina Bendayan. (2011) Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells. Journal of Neurochemistry 118:2, pages 163-175.
Crossref
Steven M. Paul. (2011) Therapeutic Antibodies for Brain Disorders. Science Translational Medicine 3:84.
Crossref
W. J. Bowers, X. O. Breakefield & M. Sena-Esteves. (2011) Genetic therapy for the nervous system. Human Molecular Genetics 20:R1, pages R28-R41.
Crossref
Annika Armulik, Maarja Mäe & Christer Betsholtz. (2011) Pericytes and the blood–brain barrier: recent advances and implications for the delivery of CNS therapy. Therapeutic Delivery 2:4, pages 419-422.
Crossref
Donatella Paolino, Donato Cosco, Roberto Molinaro, Christian Celia & Massimo Fresta. (2011) Supramolecular devices to improve the treatment of brain diseases. Drug Discovery Today 16:7-8, pages 311-324.
Crossref
Ian G Tucker. (2011) Drug delivery to the brain via the blood–brain barrier: a review of the literature and some recent patent disclosures. Therapeutic Delivery 2:3, pages 311-327.
Crossref
Edward A. Neuwelt, Björn Bauer, Christoph Fahlke, Gert Fricker, Constantino Iadecola, Damir Janigro, Luc Leybaert, Zoltán Molnár, Martha E. O'Donnell, John T. Povlishock, Norman R. Saunders, Frank Sharp, Danica Stanimirovic, Ryan J. Watts & Lester R. Drewes. (2011) Engaging neuroscience to advance translational research in brain barrier biology. Nature Reviews Neuroscience 12:3, pages 169-182.
Crossref
Qing-Hui Zhou, Ruben J. Boado, Eric Ka-Wai Hui, Jeff Zhiqiang Lu & William M. Pardridge. (2011) Brain-Penetrating Tumor Necrosis Factor Decoy Receptor in the Mouse. Drug Metabolism and Disposition 39:1, pages 71-76.
Crossref
Joan Domingo-Espín, Ugutz Unzueta, Paolo Saccardo, Escarlata Rodríguez-Carmona, José Luís Corchero, Esther Vázquez & Neus Ferrer-Miralles. 2011. Nanoparticles in Translational Science and Medicine. Nanoparticles in Translational Science and Medicine 247 298 .
Gillian Barratt. 2011. Intracellular Delivery. Intracellular Delivery 73 95 .
Ruben J. Boado, Eric Ka-Wai Hui, Jeff Zhiqiang Lu & William M. Pardridge. (2011) CHO cell expression, long-term stability, and primate pharmacokinetics and brain uptake of an IgG-paroxonase-1 fusion protein. Biotechnology and Bioengineering 108:1, pages 186-196.
Crossref
Yao-Sheng Tung, Fotios Vlachos, James J Choi, Thomas Deffieux, Kirsten Selert & Elisa E Konofagou. (2010) In vivo transcranial cavitation threshold detection during ultrasound-induced blood–brain barrier opening in mice . Physics in Medicine and Biology 55:20, pages 6141-6155.
Crossref
V Mangas-Sanjuan, M González-Alvarez, I Gonzalez-Alvarez & M Bermejo. (2010) Drug penetration across the blood–brain barrier: an overview. Therapeutic Delivery 1:4, pages 535-562.
Crossref
Reinhard Gabathuler. (2010) Development of new peptide vectors for the transport of therapeutic across the blood–brain barrier. Therapeutic Delivery 1:4, pages 571-586.
Crossref
Ailing Fu, Qing-Hui Zhou, Eric Ka-Wai Hui, Jeff Zhiqiang Lu, Ruben J. Boado & William M. Pardridge. (2010) Intravenous treatment of experimental Parkinson's disease in the mouse with an IgG-GDNF fusion protein that penetrates the blood–brain barrier. Brain Research 1352, pages 208-213.
Crossref

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