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Journal of Drug Targeting Volume 2, 1994 - Issue 1
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Research Article

Stability Study of Drug-loaded Proteinoid Microsphere Formulations during Freeze-drying

Xinghang Ma Pharmaceutical Sciences Laboratory, Emisphere Technologies, Inc., 15 Skyline Drive, Hawthorne, NY, 10532
,
Noemi Santiago Pharmaceutical Sciences Laboratory, Emisphere Technologies, Inc., 15 Skyline Drive, Hawthorne, NY, 10532
,
Yu-Shiaw Chen Collaborative Laboratories, 3 Technology Drive, East Setauket, NY, 11733
,
Kiran Chaudhary Pharmaceutical Sciences Laboratory, Emisphere Technologies, Inc., 15 Skyline Drive, Hawthorne, NY, 10532
,
Sam J. Milstein Pharmaceutical Sciences Laboratory, Emisphere Technologies, Inc., 15 Skyline Drive, Hawthorne, NY, 10532
&
Robert A. Baughman Pharmaceutical Sciences Laboratory, Emisphere Technologies, Inc., 15 Skyline Drive, Hawthorne, NY, 10532
Pages 9-21 | Received 11 Mar 1993, Accepted 01 Sep 1993, Published online: 28 Sep 2008

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Michal Kolitz-Domb, Enav Corem-Salkmon, Igor Grinberg & Shlomo Margel. (2014) Synthesis and characterization of bioactive conjugated near-infrared fluorescent proteinoid-poly(L-lactic acid) hollow nanoparticles for optical detection of colon cancer. International Journal of Nanomedicine 9, pages 5041-5053.
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Fanny De Jaeghere, Eric Allémann, Jan Feijen, Thomas Kissel, Eric Doelker & Robert Gurny. (2000) Freeze-Drying and Lyopreservation of Diblock and Triblock Poly(Lactic Acid)–Poly(Ethylene Oxide) (PLA–PEO) Copolymer Nanoparticles. Pharmaceutical Development and Technology 5:4, pages 473-483.
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H. Heiati, R. Tawashi & N. C. Phillips. (1998) Drug retention and stability of solid lipid nanoparticles containing azidothymidine palmitate after autoclaving, storage and lyophilization. Journal of Microencapsulation 15:2, pages 173-184.
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. (1995) Literature Alerts. Journal of Microencapsulation 12:2, pages 212-226.
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Articles from other publishers (21)

Sanchit Arora, Sanat Kumar Dash, Dimple Dhawan, Prabhat Kumar Sahoo, Anil Jindal & Dalapathi Gugulothu. (2023) Freeze-drying revolution: unleashing the potential of lyophilization in advancing drug delivery systems. Drug Delivery and Translational Research.
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Maria Chiara Cristiano, Nicola d’Avanzo, Antonia Mancuso, Martine Tarsitano, Antonella Barone, Daniele Torella, Donatella Paolino & Massimo Fresta. (2022) Ammonium Glycyrrhizinate and Bergamot Essential Oil Co-Loaded Ultradeformable Nanocarriers: An Effective Natural Nanomedicine for In Vivo Anti-Inflammatory Topical Therapies. Biomedicines 10:5, pages 1039.
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Gurunath S. DhaddeHanmant S. MaliIndrayani D. RautManoj M. NitalikarMangesh A. Bhutkar. (2021) A Review on Microspheres: Types, Method of Preparation, Characterization and Application. Asian Journal of Pharmacy and Technology, pages 149-155.
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Liroy Lugasi, Igor Grinberg, Rivka Sabag, Ravit Madar, Haim Einat & Shlomo Margel. (2020) Proteinoid Nanocapsules as Drug Delivery System for Improving Antipsychotic Activity of Risperidone. Molecules 25:17, pages 4013.
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Ling Liu, Wing M. R. Lam, Zheng Yang, Ming Wang, Xiafei Ren, Tao Hu, Jun Li, James Cho‐Hong Goh & Hee‐Kit Wong. (2020) Improving the handling properties and long‐term stability of polyelectrolyte complex by freeze‐drying technique for low‐dose bone morphogenetic protein 2 delivery. Journal of Biomedical Materials Research Part B: Applied Biomaterials 108:6, pages 2450-2460.
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Elisheva Sasson, Ruth Van Oss Pinhasi, Shlomo Margel & Liron Klipcan. (2020) Engineering and use of proteinoid polymers and nanocapsules containing agrochemicals. Scientific Reports 10:1.
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Michal Kolitz‐Domb & Shlomo Margel. (2018) Recent Advances of Novel Proteinoids and Proteinoid Nanoparticles and Their Applications in Biomedicine and Industrial Uses. Israel Journal of Chemistry 58:12, pages 1277-1285.
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Qing Shang, Aixin Zhang, Zhaoying Wu, Sijin Huang & Ruiqiong Tian. (2018) In vitro evaluation of sustained release of risperidone-loaded microspheres fabricated from different viscosity of PLGA polymers. Polymers for Advanced Technologies 29:1, pages 384-393.
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Marcus T. Cicerone, Michael J. Pikal & Ken K. Qian. (2015) Stabilization of proteins in solid form. Advanced Drug Delivery Reviews 93, pages 14-24.
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Michal Kolitz-Domb, Igor Grinberg, Enav Corem-Salkmon & Shlomo Margel. (2014) Engineering of near infrared fluorescent proteinoid-poly(L-lactic acid) particles for in vivo colon cancer detection. Journal of Nanobiotechnology 12:1.
Crossref
. 2014. Handbook of Industrial Drying. Handbook of Industrial Drying 877 890 .
Hee Jin Seo & Jin-Chul Kim. (2012) Self-assembly of coumarin-conjugated acidic proteinoids. Polymer Science Series A 54:5, pages 358-363.
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Zhi Min Wu, Liying Zhou, Xin Dong Guo, Wei Jiang, Li Ling, Yu Qian, Kathy Qian Luo & Li Juan Zhang. (2012) HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin. International Journal of Pharmaceutics 425:1-2, pages 1-8.
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Stephen Quirk. (2009) Triggered release of small molecules from proteinoid microspheres. Journal of Biomedical Materials Research Part A 91A:2, pages 391-399.
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Stephen Quirk. (2009) Triggered release from peptide-proteinoid microspheres. Journal of Biomedical Materials Research Part A 9999A, pages NA-NA.
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K. Sangeetha & T. Emilia Abraham. (2008) Investigation on the development of sturdy bioactive hydrogel beads. Journal of Applied Polymer Science 107:5, pages 2899-2908.
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Ibrahim A. Alsarra, Steven H. Neau & Matthew A. Howard. (2004) Effects of preparative parameters on the properties of chitosan hydrogel beads containing Candida rugosa lipase. Biomaterials 25:13, pages 2645-2655.
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Ruifeng Zhao, Mamoru Haratake & Raphael M. Ottenbrite. 1998. Science and Technology of Polymers and Advanced Materials. Science and Technology of Polymers and Advanced Materials 513 520 .
Mamoru Haratake, Ruifeng Zhao & Raphael M. Ottenbrite. (2016) Oligopeptides as an Oral Delivery System II. Effect of Amino Acid Sequences on Aggregation Behavior. Journal of Bioactive and Compatible Polymers 12:4, pages 282-293.
Crossref
Mamoru Haratake & Raphael M. Ottenbrite. (2016) Oligopeptides as an Oral Delivery System: I. Aggregation Characteristics and Drug Encapsulation. Journal of Bioactive and Compatible Polymers 12:2, pages 112-126.
Crossref
Raphael M. Ottenbrite, Ruifeng Zhao & Sam Milsteln. (2011) A new oral microsphere drug delivery system. Macromolecular Symposia 101:1, pages 379-387.
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