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Journal of Drug Targeting Volume 4, 1996 - Issue 2
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Research Article

Comparative pharmacokinetic, immunologic and hematologic studies on the anti-HIV-1/2 compounds aconitylated and succinylated HSA

P. Swart Groningen Institute for Drug Studies, University Centre for Pharmacy, Section Pharmacokinetics and Drug Delivery, A. Deusinglaan 2, 9713Correspondence[email protected]
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E. Beljaars Groningen Institute for Drug Studies, University Centre for Pharmacy, Section Pharmacokinetics and Drug Delivery, A. Deusinglaan 2, 9713
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C. Smit Groningen Institute for Drug Studies, University Centre for Pharmacy, Section Pharmacokinetics and Drug Delivery, A. Deusinglaan 2, 9713
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A. Pasma Groningen Institute for Drug Studies, University Centre for Pharmacy, Section Pharmacokinetics and Drug Delivery, A. Deusinglaan 2, 9713
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D. Meijer Groningen Institute for Drug Studies, University Centre for Pharmacy, Section Pharmacokinetics and Drug Delivery, A. Deusinglaan 2, 9713
&
H. SchuitemakerDepartment of Clinical Viro-Immunology Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology of the University of Amsterdam; Groningen Institute for Drug Studies, University Centre for Pharmacy, Section Pharmacokinetics and Drug Delivery, A. Deusinglaan 2, 9713
Pages 109-116 | Received 05 Jan 1996, Accepted 25 Mar 1996, Published online: 20 Oct 2008

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P. J. Swart, M. E. Kuipers, C. Smit, L. Beljaars, J. Ter Wiel & D. K. F. Meijer. (2001) The Metabolic Fate of the Anti-HIV Active Drug Carrier Succinylated Human Serum Albumin after Intravenous Administration in Rats. Journal of Drug Targeting 9:2, pages 95-109.
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M. E. Kuipers, P. J. Swart, M. Witvrouw, J. A. Esté, D. Reymen, E. De Clercq & D. K. F. Meijer. (1999) Anti-HIV-1 Activity of Combinations and Covalent Conjugates of Negatively Charged Human Serum Albumins (NCAs) and AZT. Journal of Drug Targeting 6:5, pages 323-335.
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Articles from other publishers (16)

Jesper Christensen, Karine Litherland, Thomas Faller, Esther van de Kerkhof, François Natt, Jürg Hunziker, Joel Krauser & Piet Swart. (2013) Metabolism Studies of Unformulated Internally [ 3 H]-Labeled Short Interfering RNAs in Mice . Drug Metabolism and Disposition 41:6, pages 1211-1219.
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Jesper Christensen, François Natt, Jürg Hunziker, Joel Krauser, Hendrik Andres & Piet Swart. (2012) Tritium labeling of full‐length small interfering RNAs. Journal of Labelled Compounds and Radiopharmaceuticals 55:6, pages 189-196.
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Huihui Chong, Xue Yao, Chao Zhang, Lifeng Cai, Sheng Cui, Youchun Wang & Yuxian He. (2012) Biophysical Property and Broad Anti-HIV Activity of Albuvirtide, a 3-Maleimimidopropionic Acid-Modified Peptide Fusion Inhibitor. PLoS ONE 7:3, pages e32599.
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Cheryl A. Stoddart, Geneviève Nault, Sofiya A. Galkina, Karen Thibaudeau, Peter Bakis, Nathalie Bousquet-Gagnon, Martin Robitaille, Maryanne Bellomo, Véronique Paradis, Patricia Liscourt, Alexandra Lobach, Marie-Ève Rivard, Roger G. Ptak, Marie K. Mankowski, Dominique Bridon & Omar Quraishi. (2008) Albumin-conjugated C34 Peptide HIV-1 Fusion Inhibitor. Journal of Biological Chemistry 283:49, pages 34045-34052.
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Yuriy V. Lisnyak, Arthur V. Martynov, Vyacheslav N. Baumer, Oleg V. Shishkin & Anna V. Gubskaya. (2007) Crystal and molecular structure of β-cyclodextrin inclusion complex with succinic acid. Journal of Inclusion Phenomena and Macrocyclic Chemistry 58:3-4, pages 367-375.
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Heni Rachmawati, Catharina Reker-Smit, Marjolijn N. Lub-de Hooge, Annemiek van Loenen-Weemaes, Klaas Poelstra & Leonie Beljaars. (2007) Chemical Modification of Interleukin-10 with Mannose 6-Phosphate Groups Yields a Liver-Selective Cytokine. Drug Metabolism and Disposition 35:5, pages 814-821.
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Joost N Vermeulen, Dirk KF Meijer, Jan OverJoep MA Lange, Johannes H Proost, Hester I Bakker, Leonie Beljaars, Ferdinand WNM Wit & Jan M Prins. (2007) A Phase I/IIa Study with Succinylated Human Serum Albumin (Suc-HSA), a candidate HIV-1 Fusion Inhibitor. Antiviral Therapy 12:2, pages 273-278.
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Johannes H. Proost, Leonie Beljaars, Peter Olinga, Pieter J. Swart, Mirjam E. Kuipers, Catharina Reker-Smit, Geny M.M. Groothuis & Dirk K.F. Meijer. (2006) Prediction of the pharmacokinetics of succinylated human serum albumin in man from in vivo disposition data in animals and in vitro liver slice incubations. European Journal of Pharmaceutical Sciences 27:2-3, pages 123-132.
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Yasuomi Yamasaki, Jin Hisazumi, Kiyoshi Yamaoka & Yoshinobu Takakura. (2003) Efficient scavenger receptor-mediated hepatic targeting of proteins by introduction of negative charges on the proteins by aconitylation: the influence of charge density and size of the proteins molecules. European Journal of Pharmaceutical Sciences 18:5, pages 305-312.
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Leonie Beljaars, René Floris, Ben Berkhout, Catharina Smit, Dirk K.F. Meijer & Grietje Molema. (2002) The influence of charge clustering on the anti-HIV-1 activity and in vivo distribution of negatively charged albumins. Biochemical Pharmacology 63:9, pages 1663-1673.
Crossref
Leonie Beljaars, Barbro Melgert, Dirk Meijer, Grietje Molema & Klaas Poelstra. 2001. Drug Targeting Technology. Drug Targeting Technology.
Peter D. Kwong, Richard Wyatt, Quentin J. Sattentau, Joseph Sodroski & Wayne A. Hendrickson. (2000) Oligomeric Modeling and Electrostatic Analysis of the gp120 Envelope Glycoprotein of Human Immunodeficiency Virus. Journal of Virology 74:4, pages 1961-1972.
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Pieter J Swart, Takashi Hirano, Mirjam E Kuipers, Yuko Ito, Catharina Smit, Mitsuru Hashida, Makiya Nishikawa, Leonie Beljaars, Dirk K.F Meijer & Klaas Poelstra. (1999) Targeting of superoxide dismutase to the liver results in anti-inflammatory effects in rats with fibrotic livers. Journal of Hepatology 31:6, pages 1034-1043.
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Pieter J Swart, Leonie Beljaars, Mirjam E Kuipers, Catharina Smit, Paul Nieuwenhuis & Dirk K.F Meijer. (1999) Homing of negatively charged albumins to the lymphatic system. Biochemical Pharmacology 58:9, pages 1425-1435.
Crossref
Leonie Beljaars, Klaas Poelstra, Grietje Molema & Dirk K.F. Meijer. (1998) Targeting of sugar- and charge-modified albumins to fibrotic rat livers: the accessibility of hepatic cells after chronic bile duct ligation. Journal of Hepatology 29:4, pages 579-588.
Crossref
P.J. SWART, C.S. SUN, M.E. KUIPERS, C. ASUNCION, S. JOSEPHS, C. SMIT & D.K.F. MEIJER. (1997) The in Vitro Anti-HIV Efficacy of Negatively Charged Human Serum Albumin Is Antagonized by Heparin . AIDS Research and Human Retroviruses 13:8, pages 677-683.
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