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Journal of Drug Targeting Volume 19, 2011 - Issue 10: Special Issue: In honour of Professor JindÅ™ich (Henry) KopeÄek, Recipient of the Journal of Drug Targeting’s Life-time Achievement Award for 2011
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Research Article

Peptide-directed HPMA copolymer-doxorubicin conjugates as targeted therapeutics for colorectal cancer

Eva KopanskyDepartment of Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
,
Yosi ShamayDepartment of Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
&
Ayelet DavidDepartment of Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, IsraelCorrespondence[email protected]
Pages 933-943 | Received 10 Jul 2011, Accepted 22 Sep 2011, Published online: 10 Nov 2011

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Longfa Kou, Qing Yao, Sathish Sivaprakasam, Qiuhua Luo, Yinghua Sun, Qiang Fu, Zhonggui He, Jin Sun & Vadivel Ganapathy. (2017) Dual targeting of l-carnitine-conjugated nanoparticles to OCTN2 and ATB0,+ to deliver chemotherapeutic agents for colon cancer therapy. Drug Delivery 24:1, pages 1338-1349.
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Mingliang Fan, Xiaofei Liang, Danbo Yang, Xiaorong Pan, Zonghai Li, Hongyang Wang & Bizhi Shi. (2016) Epidermal growth factor receptor-targeted peptide conjugated phospholipid micelles for doxorubicin delivery. Journal of Drug Targeting 24:2, pages 111-119.
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Bita Taghizadeh, Shahrouz Taranejoo, Seyed Ali Monemian, Zoha Salehi Moghaddam, Karim Daliri, Hossein Derakhshankhah & Zaynab Derakhshani. (2015) Classification of stimuli–responsive polymers as anticancer drug delivery systems. Drug Delivery 22:2, pages 145-155.
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Karina V. Mariño, Alejandro J. Cagnoni, Diego O. Croci & Gabriel A. Rabinovich. (2023) Targeting galectin-driven regulatory circuits in cancer and fibrosis. Nature Reviews Drug Discovery 22:4, pages 295-316.
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Tang Hailing, Pan Yonghong, Zhang Yufeng & Tang Haitao. (2022) Challenges for the application of EGFR-targeting peptide GE11 in tumor diagnosis and treatment. Journal of Controlled Release 349, pages 592-605.
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Li Yuan Gabriella Nadine Lee, Si Yuan Leow, Hongmei Wen, Jian Yi Soh, Wen Chin Chiang, Youjia Zhong, Elizabeth Huiwen Tham, Wenyin Loh, Dianne J. Delsing, Bee Wah Lee & Chiung-Hui Huang. (2022) An Evaluation of the Mechanisms of Galacto-Oligosaccharide (GOS)-Induced IgE Cross-Linking on Basophils in GOS Allergy. Frontiers in Allergy 3.
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Pinky Yadav, Jigna Jain & Atul P. Sherje. (2021) Recent advances in nanocarriers-based drug delivery for cancer therapeutics: A review. Reactive and Functional Polymers 165, pages 104970.
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Zeeshan Javed, Muhammad Javed Iqbal, Amna Rasheed, Haleema Sadia, Shahid Raza, Asma Irshad, Wojciech Koch, Wirginia Kukula-Koch, Anna Głowniak-Lipa, William C. Cho & Javad Sharifi-Rad. (2021) Regulation of Hedgehog Signaling by miRNAs and Nanoformulations: A Possible Therapeutic Solution for Colorectal Cancer. Frontiers in Oncology 10.
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Gonçalo A. Marcelo, David Montpeyo, Fernando Novio, Daniel Ruiz-Molina, Julia Lorenzo & Elisabete Oliveira. (2020) Luminescent silicon-based nanocarrier for drug delivery in colorectal cancer cells. Dyes and Pigments 181, pages 108393.
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Lilla Pethő, György Kasza, Eszter Lajkó, Orsolya Láng, László Kőhidai, Béla Iván & Gábor Mező. (2020) Amphiphilic drug–peptide–polymer conjugates based on poly(ethylene glycol) and hyperbranched polyglycerol for epidermal growth factor receptor targeting: the effect of conjugate aggregation on in vitro activity . Soft Matter 16:24, pages 5759-5769.
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M. R. Carvalho, R. L. Reis & J. M. Oliveira. (2020) Dendrimer nanoparticles for colorectal cancer applications. Journal of Materials Chemistry B 8:6, pages 1128-1138.
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Pramod Vishwanath Prasad, Kakali Purkayastha, Utkarsh Sharma & Mayadhar Barik. (2020) pH-Sensitive Nanomedicine for Treating Gynaecological Cancers. Journal of Woman's Reproductive Health 2:2, pages 35-50.
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Mariana R. Carvalho, Cristiana R. Carvalho, F. Raquel Maia, David Caballero, Subhas C. Kundu, Rui L. Reis & Joaquim M. Oliveira. (2019) Peptide‐Modified Dendrimer Nanoparticles for Targeted Therapy of Colorectal Cancer. Advanced Therapeutics 2:11, pages 1900132.
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Ayelet David. (2017) Peptide ligand-modified nanomedicines for targeting cells at the tumor microenvironment. Advanced Drug Delivery Reviews 119, pages 120-142.
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Bruno A Cisterna, Nazila Kamaly, Won Il Choi, Ali Tavakkoli, Omid C Farokhzad & Cristian Vilos. (2016) Targeted nanoparticles for colorectal cancer. Nanomedicine 11:18, pages 2443-2456.
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Fan Yang, Weilun Ai, Fagang Jiang, Xin Liu, Zebo Huang & Shibin Ai. (2016) Preclinical Evaluation of an Epidermal Growth Factor Receptor–Targeted Doxorubicin–Peptide Conjugate: Toxicity, Biodistribution, and Efficacy in Mice. Journal of Pharmaceutical Sciences 105:2, pages 639-649.
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Wei Sun, Lian Li, Qingqing Yang, Wei Shan, Zhirong Zhang & Yuan Huang. (2015) G3-C12 Peptide Reverses Galectin-3 from Foe to Friend for Active Targeting Cancer Treatment. Molecular Pharmaceutics 12:11, pages 4124-4136.
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Lijue Chen, Xiaodong She, Tao Wang, Li He, Sarah Shigdar, Wei Duan & Lingxue Kong. (2015) Overcoming acquired drug resistance in colorectal cancer cells by targeted delivery of 5-FU with EGF grafted hollow mesoporous silica nanoparticles. Nanoscale 7:33, pages 14080-14092.
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Sean Lowe, Neil M. O'Brien-Simpson & Luke A. Connal. (2015) Antibiofouling polymer interfaces: poly(ethylene glycol) and other promising candidates. Polymer Chemistry 6:2, pages 198-212.
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Yang Yang, Lian Li, Zhou Zhou, Qingqing Yang, Chong Liu & Yuan Huang. (2014) Targeting Prostate Carcinoma by G3-C12 Peptide Conjugated N -(2-Hydroxypropyl)methacrylamide Copolymers . Molecular Pharmaceutics 11:10, pages 3251-3260.
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Yosi Shamay, Lina Shpirt, Gonen Ashkenasy & Ayelet David. (2013) Complexation of Cell-Penetrating Peptide–Polymer Conjugates with Polyanions Controls Cells Uptake of HPMA Copolymers and Anti-tumor Activity. Pharmaceutical Research 31:3, pages 768-779.
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. (2013) Current World Literature. Current Opinion in Oncology 25:3, pages 325-337.
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J P Tiernan, S L Perry, E T Verghese, N P West, S Yeluri, D G Jayne & T A Hughes. (2013) Carcinoembryonic antigen is the preferred biomarker for in vivo colorectal cancer targeting. British Journal of Cancer 108:3, pages 662-667.
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Jindřich Kopeček. (2013) Polymer–drug conjugates: Origins, progress to date and future directions. Advanced Drug Delivery Reviews 65:1, pages 49-59.
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Yang Yang, Zhou Zhou, Shuang He, Tingting Fan, Yun Jin, Xi Zhu, Chunhui Chen, Zhi-rong Zhang & Yuan Huang. (2012) Treatment of prostate carcinoma with (Galectin-3)-targeted HPMA copolymer-(G3-C12)-5-Fluorouracil conjugates. Biomaterials 33:7, pages 2260-2271.
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Joana T. de Oliveira & Fátima Gärtner. 2012. Galectins and Disease Implications for Targeted Therapeutics. Galectins and Disease Implications for Targeted Therapeutics 181 194 .

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