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Review Article

PEG–lipid micelles as drug carriers: physiochemical attributes, formulation principles and biological implication

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Pages 222-231 | Received 07 Sep 2014, Accepted 08 Dec 2014, Published online: 30 Dec 2014

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Crossref
Snezana Agatonovic-Kustrin & David W. Morton. 2018. 61 91 .
Carla M. Lopes, Juliana Silva, Maria Elisabete C.D. Real Oliveira & Marlene Lúcio. 2018. Design of Nanostructures for Versatile Therapeutic Applications. Design of Nanostructures for Versatile Therapeutic Applications 565 622 .
Caroline Mari Ramos Oda, Renata Salgado Fernandes, Sávia Caldeira de Araújo Lopes, Mônica Cristina de Oliveira, Valbert Nascimento Cardoso, Daniel Moreira Santos, Adriano Monteiro de Castro Pimenta, Angelo Malachias, Rogério Paniago, Danyelle M. Townsend, Patrick M. Colletti, Domenico Rubello, Ricardo José Alves, André Luís Branco de Barros & Elaine Amaral Leite. (2017) Synthesis, characterization and radiolabeling of polymeric nano-micelles as a platform for tumor delivering. Biomedicine & Pharmacotherapy 89, pages 268-275.
Crossref
Christina M. Bailey, Ramanathan Nagarajan & Terri A. Camesano. 2017. Control of Amphiphile Self-Assembling at the Molecular Level: Supra-Molecular Assemblies with Tuned Physicochemical Properties for Delivery Applications. Control of Amphiphile Self-Assembling at the Molecular Level: Supra-Molecular Assemblies with Tuned Physicochemical Properties for Delivery Applications 35 70 .
Erica J. Carbone, Komal Rajpura, Brittany N. Allen, Emily Cheng, Bret D. Ulery & Kevin W.-H. Lo. (2017) Osteotropic nanoscale drug delivery systems based on small molecule bone-targeting moieties. Nanomedicine: Nanotechnology, Biology and Medicine 13:1, pages 37-47.
Crossref
Anna Brown, Siddharth Patel, Carl Ward, Anna Lorenz, Mauren Ortiz, Allison DuRoss, Fabian Wieghardt, Amanda Esch, Elsje G. Otten, Laura M. Heiser, Viktor I. Korolchuk, Conroy Sun, Sovan Sarkar & Gaurav Sahay. (2016) PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder. Scientific Reports 6:1.
Crossref
Matias I. Sancho, Sebastian Andujar, Rodolfo D. Porasso & Ricardo D. Enriz. (2016) Theoretical and Experimental Study of Inclusion Complexes of β-Cyclodextrins with Chalcone and 2′,4′-Dihydroxychalcone. The Journal of Physical Chemistry B 120:12, pages 3000-3011.
Crossref
Shizhu Chen, Keni Yang, Ruslan G. Tuguntaev, Anbu Mozhi, Jinchao Zhang, Paul C. Wang & Xing-Jie Liang. (2016) Targeting tumor microenvironment with PEG-based amphiphilic nanoparticles to overcome chemoresistance. Nanomedicine: Nanotechnology, Biology and Medicine 12:2, pages 269-286.
Crossref
Caiyan Zhao, Hongzhang Deng, Jing Xu, Shuyi Li, Lin Zhong, Leihou Shao, Yan Wu & Xing-jie Liang. (2016) “Sheddable” PEG-lipid to balance the contradiction of PEGylation between long circulation and poor uptake. Nanoscale 8:20, pages 10832-10842.
Crossref
Bing Han, Yanli Wang, Lan Wang, Zuhui Shang, Shuang Wang & Jin Pei. (2015) Preparation of GST Inhibitor Nanoparticle Drug Delivery System and Its Reversal Effect on the Multidrug Resistance in Oral Carcinoma. Nanomaterials 5:4, pages 1571-1587.
Crossref
Cynthia C. H. Paquette, Yashdeep Phanse, Jillian L. Perry, Irma Sanchez-Vargas, Paul M. Airs, Brendan M. Dunphy, Jing Xu, Jonathan O. Carlson, J. Christopher Luft, Joseph M. DeSimone, Lyric C. Bartholomay & Barry J. Beaty. (2015) Biodistribution and Trafficking of Hydrogel Nanoparticles in Adult Mosquitoes. PLOS Neglected Tropical Diseases 9:5, pages e0003745.
Crossref
Yongyong Li, Yuqin Chen, Haiqing Dong & Chunyan Dong. (2015) Supramolecular, prodrug-based micelles with enzyme-regulated release behavior for controlled drug delivery. MedChemComm 6:10, pages 1874-1881.
Crossref

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