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Journal of Drug Targeting Volume 24, 2016 - Issue 2
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Original Article

Valproic acid induces NET cell growth arrest and enhances tumor suppression of the receptor-targeted peptide–drug conjugate via activating somatostatin receptor type II

Lichun SunDepartment of Pharmacy, The Fifth People’s Hospital of Shanghai, Fudan University, Shanghai, China, ;Department of Medicine, Peptide Research Laboratories, Tulane Health Sciences Center, New Orleans, LA, USA, and Correspondence[email protected]
,
Qingqing QianDepartment of Pharmacy, The Fifth People’s Hospital of Shanghai, Fudan University, Shanghai, China,
,
Guangchun SunDepartment of Pharmacy, The Fifth People’s Hospital of Shanghai, Fudan University, Shanghai, China,
,
L. Vienna MackeyDepartment of Medicine, Peptide Research Laboratories, Tulane Health Sciences Center, New Orleans, LA, USA, and
,
Joseph A. FuselierDepartment of Medicine, Peptide Research Laboratories, Tulane Health Sciences Center, New Orleans, LA, USA, and
,
David H. CoyDepartment of Medicine, Peptide Research Laboratories, Tulane Health Sciences Center, New Orleans, LA, USA, and
&
Cui-Yun YuDepartment of Medicine, Peptide Research Laboratories, Tulane Health Sciences Center, New Orleans, LA, USA, and ;Department of Pharmacy, Institute of Pharmacy & Pharmacology, University of South China, Hengyang, ChinaCorrespondence[email protected]
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Pages 169-177 | Received 14 Mar 2015, Accepted 24 Jun 2015, Published online: 27 Jul 2015

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Sarvesh Loharkar & Sandip Basu. (2023) Peptide receptor radionuclide therapy in neuroendocrine neoplasms and related tumors: from fundamentals to personalization and the newer experimental approaches. Expert Review of Precision Medicine and Drug Development 8:1, pages 1-32.
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Eckhard Klieser, Bettina Neumayer, Pietro Di Fazio, Christian Mayr, Daniel Neureiter & Tobias Kiesslich. (2023) HDACs as an emerging target in endocrine tumors: a comprehensive review. Expert Review of Endocrinology & Metabolism 18:2, pages 143-154.
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M. Borghesani, L. Gervaso, C.A. Cella, L. Benini, D. Ciardiello, L. Algeri, A. Ferrero, C. Valenza, L. Guidi, MG. Zampino, F. Spada & N. Fazio. Promising targetable biomarkers in pancreatic neuroendocrine tumours. Expert Review of Endocrinology & Metabolism 0:0, pages 1-12.
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Rupali Sharma, Bhargav Earla, Kwamena E. Baidoo, Martha A. Zeiger, James P. Madigan, Freddy E. Escorcia & Samira M. Sadowski. (2023) Upregulation of Somatostatin Receptor Type 2 Improves 177Lu-DOTATATE Therapy in Receptor-Deficient Pancreatic Neuroendocrine Tumor Model. Molecular Cancer Therapeutics 22:9, pages 1052-1062.
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Liming Gong, Heming Zhao, Yanhong Liu, Hao Wu, Chao Liu, Shuangyan Chang, Liqing Chen, Mingji Jin, Qiming Wang, Zhonggao Gao & Wei Huang. (2023) Research advances in peptide‒drug conjugates. Acta Pharmaceutica Sinica B 13:9, pages 3659-3677.
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Janet H. PollardYusuf MendaK.D. ZambaMark MadsenM. Sue O'DorisioThomas O'DorisioDavid Bushnell. (2021) Potential for Increasing Uptake of Radiolabeled 68 Ga-DOTATOC and 123 I-MIBG in Patients with Midgut Neuroendocrine Tumors Using a Histone Deacetylase Inhibitor Vorinostat . Cancer Biotherapy and Radiopharmaceuticals 36:8, pages 632-641.
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M.J. Klomp, S.U. Dalm, M. de Jong, R.A. Feelders, J. Hofland & L.J. Hofland. (2020) Epigenetic regulation of somatostatin and somatostatin receptors in neuroendocrine tumors and other types of cancer. Reviews in Endocrine and Metabolic Disorders 22:3, pages 495-510.
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Samuel Adant, Girish M. Shah & Jean-Mathieu Beauregard. (2019) Combination treatments to enhance peptide receptor radionuclide therapy of neuroendocrine tumours. European Journal of Nuclear Medicine and Molecular Imaging 47:4, pages 907-921.
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Claudia von Arx, Monica Capozzi, Elena López-Jiménez, Alessandro Ottaiano, Fabiana Tatangelo, Annabella Di Mauro, Guglielmo Nasti, Maria Lina Tornesello & Salvatore Tafuto. (2019) Updates on the Role of Molecular Alterations and NOTCH Signalling in the Development of Neuroendocrine Neoplasms. Journal of Clinical Medicine 8:9, pages 1277.
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Tobias Hofving, Yvonne Arvidsson, Bilal Almobarak, Linda Inge, Roswitha Pfragner, Marta Persson, Göran Stenman, Erik Kristiansson, Viktor Johanson & Ola Nilsson. (2018) The neuroendocrine phenotype, genomic profile and therapeutic sensitivity of GEPNET cell lines. Endocrine-Related Cancer 25:3, pages 367-380.
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E T Aristizabal Prada & C J Auernhammer. (2018) Targeted therapy of gastroenteropancreatic neuroendocrine tumours: preclinical strategies and future targets. Endocrine Connections 7:1, pages R1-R25.
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Zhi-Ping Li, Ming-Chao Jiang, Bo Chen, Pei Gao, Sa Yang, Yu-Feng Liu, Peng-Ju Ye, Dong-Xiu He, Hong-Lin Huang & Cui-Yun Yu. (2018) Fabrication and characterization of a novel self-assembling micelle based on chitosan cross-linked pectin–doxorubicin conjugates macromolecular pro-drug for targeted cancer therapy. RSC Advances 8:22, pages 12004-12016.
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Bo Zhu, Lichun Sun, Wei Luo, Min Li, David H. Coy, Long Yu & Wenbo Yu. (2017) Activated Notch signaling augments cell growth in hepatocellular carcinoma via up-regulating the nuclear receptor NR4A2. Oncotarget 8:14, pages 23289-23302.
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Vincent F. Taelman, Piotr Radojewski, Nicolas Marincek, Anat Ben-Shlomo, Andrea Grotzky, Cristina I. Olariu, Aurel Perren, Christoph Stettler, Thomas Krause, Lorenz P. Meier, Renzo Cescato & Martin A. Walter. (2016) Upregulation of Key Molecules for Targeted Imaging and Therapy. Journal of Nuclear Medicine 57:11, pages 1805-1810.
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Mauro Cives, Valeria Simone, Francesca Maria Rizzo & Franco Silvestris. (2016) NETs: organ-related epigenetic derangements and potential clinical applications. Oncotarget 7:35, pages 57414-57429.
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