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Endothelium
Journal of Endothelial Cell Research
Volume 1, 1993 - Issue 3
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Original Article

Synthesis of NG, NG Dimethylarginine by Human Endothelial Cells

S. A. Fickling Department of Cellular and Molecular Sciences, St George's Hospital Medical School, London, SVJ17 ORE
,
A. M. Leone Department of Pharmacology & Clinical Pharmacology, St George's Hospital Medical School, London, SVJ17 ORE; Wellcome Research Laboratories, Langley Court, Beckenham, Kent, BR3 3BS
,
S. S. Nussey Department of Cellular and Molecular Sciences, St George's Hospital Medical School, London, SVJ17 ORE
,
P. Vallance Department of Pharmacology & Clinical Pharmacology, St George's Hospital Medical School, London, SVJ17 ORE
&
G. St J. Whitley Department of Cellular and Molecular Sciences, St George's Hospital Medical School, London, SVJ17 ORE
Pages 137-140 | Received 01 Jun 1993, Published online: 13 Jul 2009

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Ellen S. Kang, Taylor B. Cates, Dyette N. Harper, Thomas M. Chiang, Linda K. Myers, Sergio R. Acchiardo & Masumi Kimoto. (2001) An enzyme hydrolyzing methylated inhibitors of nitric oxide synthase is present in circulating human red blood cells. Free Radical Research 35:6, pages 693-707.
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CHULANANDA D. A. GOONASEKERA. (2000) Vascular Endothelial Cell Activation Associated with Increased Plasma Asymmetric Dimethyl Arginine in Children and Young Adults with Hypertension: A Basis for Atheroma?. Blood Pressure 9:1, pages 16-21.
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Anders Pettersson, Thomas Hedner & Ian Milsom. (1998) Increased circulating concentrations of asymmetric dimethyl arginine (ADMA), an endogenous inhibitor of nitric oxide synthesis, in preeclampsia. Acta Obstetricia et Gynecologica Scandinavica 77:8, pages 808-813.
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Giorgio Bertolini & Mario Aquino. (1994) Patent Update Cardiovascular & Renal: Nitric oxide synthase inhibitors: recent advances. Expert Opinion on Therapeutic Patents 4:11, pages 1339-1345.
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Articles from other publishers (58)

Shan Huang, Dajin Zou, Wenfang Peng, Xiaohong Jiang, Kan Shao, Lili Xia & Yubin Tang. (2016) The prediction roles of asymmetric dimethyl-arginine, adiponectin and apelin for macroangiopathy in patients with impaired glucose regulation. Annales d'Endocrinologie 77:6, pages 633-640.
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Edimar Cristiano Pereira, Marcelo Chiara Bertolami, André Arpad Faludi, Osmar Monte, Hermes Toros Xavier, Tiago Veiga Pereira & Dulcineia Saes Parra Abdalla. (2015) Predictive Potential of Twenty-Two Biochemical Biomarkers for Coronary Artery Disease in Type 2 Diabetes Mellitus. International Journal of Endocrinology 2015, pages 1-8.
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Sara Franceschelli, Alessio Ferrone, Mirko Pesce, Graziano Riccioni & Lorenza Speranza. (2013) Biological Functional Relevance of Asymmetric Dimethylarginine (ADMA) in Cardiovascular Disease. International Journal of Molecular Sciences 14:12, pages 24412-24421.
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Maike Anderssohn & Rainer Böger. 2013. Endothelium. Endothelium 198 228 .
Ruben Esse, Monica S. Rocha, Madalena Barroso, Cristina Florindo, Tom Teerlink, Robert M. Kok, Yvo M. Smulders, Isabel Rivera, Paula Leandro, Pieter Koolwijk, Rita Castro, Henk J. Blom & Isabel Tavares de Almeida. (2013) Protein Arginine Methylation Is More Prone to Inhibition by S-Adenosylhomocysteine than DNA Methylation in Vascular Endothelial Cells. PLoS ONE 8:2, pages e55483.
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Aleksandra Jaźwińska-Kozuba, Jens Martens-Lobenhoffer, Andrzej Surdacki, Olga Kruszelnicka, Jarosław Rycaj, Urszula Godula-Stuglik & Stefanie Bode-Böger. (2012) Associations between Endogenous Dimethylarginines and Renal Function in Healthy Children and Adolescents. International Journal of Molecular Sciences 13:12, pages 15464-15474.
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Makoto Tanaka, Tomohiro Osanai, Reiichi Murakami, Satoko Sasaki, Hirofumi Tomita, Naotaka Maeda, Kei Satoh, Koji Magota & Ken Okumura. (2006) Effect of vasoconstrictor coupling factor 6 on gene expression profile in human vascular endothelial cells: enhanced release of asymmetric dimethylarginine. Journal of Hypertension 24:3, pages 489-497.
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Duygu Çevik, Özlem Unay, Fatih Durmusoglu, Türkan Yurdun & A Serpil Bilsel. (2016) Plasma markers of NO synthase activity in women after ovarian hyperstimulation: influence of estradiol on ADMA. Vascular Medicine 11:1, pages 7-12.
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Katari A. Carello, Steven E. Whitesall, Mary C. Lloyd, Scott S. Billecke & Louis G. D'Alecy. (2006) Asymmetrical dimethylarginine plasma clearance persists after acute total nephrectomy in rats. American Journal of Physiology-Heart and Circulatory Physiology 290:1, pages H209-H216.
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M. Ata Seçilmiş, Yusuf Karataş, Özlem Yorulmaz, Kansu Büyükafşar, Ergin Şingirik, Figen Doran, Tamer C. Inal & Atilla Dikmen. (2005) Protective Effect of <i>L</i>-Arginine Intake on the Impaired Renal Vascular Responses in the Gentamicin-Treated Rats. Nephron Physiology 100:2, pages p13-p20.
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Yun-Feng Fu, Yan Xiong & Zheng Guo. (2005) A reduction of endogenous asymmetric dimethylarginine contributes to the effect of captopril on endothelial dysfunction induced by homocysteine in rats. European Journal of Pharmacology 508:1-3, pages 167-175.
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Rainer H. Böger. (2004) Asymmetric Dimethylarginine, an Endogenous Inhibitor of Nitric Oxide Synthase, Explains the “L-Arginine Paradox” and Acts as a Novel Cardiovascular Risk Factor. The Journal of Nutrition 134:10, pages 2842S-2847S.
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Jennifer Albsmeier, Edzard Schwedhelm, Friedrich Schulze, Mariola Kastner & Rainer H Böger. (2004) Determination of NG,NG-dimethyl-l-arginine, an endogenous NO synthase inhibitor, by gas chromatography–mass spectrometry. Journal of Chromatography B 809:1, pages 59-65.
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Patrick VallanceJames Leiper. (2004) Cardiovascular Biology of the Asymmetric Dimethylarginine:Dimethylarginine Dimethylaminohydrolase Pathway. Arteriosclerosis, Thrombosis, and Vascular Biology 24:6, pages 1023-1030.
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Tomohiro OsanaiMasayuki SaitohSatoko SasakiHirofumi TomitaToshiro MatsunagaKen Okumura. (2003) Effect of Shear Stress on Asymmetric Dimethylarginine Release From Vascular Endothelial Cells. Hypertension 42:5, pages 985-990.
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Rainer H Böger. (2016) Asymmetric dimethylarginine (ADMA) modulates endothelial function - therapeutic implications. Vascular Medicine 8:3, pages 149-151.
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Vinod AchanMichael BroadheadMohammed MalakiGuy WhitleyJames LeiperRaymond MacAllisterPatrick Vallance. (2003) Asymmetric Dimethylarginine Causes Hypertension and Cardiac Dysfunction in Humans and Is Actively Metabolized by Dimethylarginine Dimethylaminohydrolase. Arteriosclerosis, Thrombosis, and Vascular Biology 23:8, pages 1455-1459.
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Alexandra Martin, Michael R. Komada & David C. Sane. (2002) Abnormal angiogenesis in diabetes mellitus. Medicinal Research Reviews 23:2, pages 117-145.
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Rainer H. Böger. (2003) Association of Asymmetric Dimethylarginine and Endothelial Dysfunction. Clinical Chemistry and Laboratory Medicine 41:11.
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Takahiro Maeda, Toshihiro Yoshimura & Hitoshi Okamura. (2016) Asymmetric Dimethylarginine, an Endogenous Inhibitor of Nitric Oxide Synthase, in Maternal and Fetal Circulation. Journal of the Society for Gynecologic Investigation 10:1, pages 2-4.
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K. Y. Lin, A. Ito, T. Asagami, P. S. Tsao, S. Adimoolam, M. Kimoto, H. Tsuji, G. M. Reaven & J. P. Cooke. (2002) Impaired Nitric Oxide Synthase Pathway in Diabetes Mellitus: Role of Asymmetric Dimethylarginine and Dimethylarginine Dimethylaminohydrolase. Circulation 106:8, pages 987-992.
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HITOSHI MASUDA, TOSHIHIKO TSUJII, TETSUO OKUNO, KAZUNORI KIHARA, MORITAKA GOTO & HIROSHI AZUMA. (2002) Localization and Role of Nitric Oxide Synthase and Endogenous Nitric Oxide Synthase Inhibitors in the Rabbit Lower Urinary Tract. The Journal of Urology, pages 2235-2240.
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Akira Ito, Kensuke Egashira, Takahiro Narishige, Kouhei Muramatsu & Akira Takeshita. (2002) Angiotensin-Converting Enzyme Activity is Involved in the Mechanism of Increased Endogenous Nitric Oxide Synthase Inhibitor in Patients With Type 2 Diabetes Mellitus. Circulation Journal 66:9, pages 811-811.
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Markus Knipp, John M. Charnock, C. David Garner & Milan Vašák. (2001) Structural and Functional Characterization of the Zn(II) Site in Dimethylargininase-1 (DDAH-1) from Bovine Brain. Journal of Biological Chemistry 276:44, pages 40449-40456.
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Ellen S. Kang, Taylor B. Cates, Don E. Miles, Marjorie T. Tevlin & Sergio R. Acchiardo. (2001) Reversible Sequestration of Nitric Oxide by Hemoglobin During Hemodialysis in End-Stage Renal Disease. The American Journal of the Medical Sciences 321:2, pages 113-123.
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Akira Ito, Kensuke Egashira, Takahiro Narishige, Kouhei Muramatsu & Akira Takeshita. (2001) Renin-Angiotensin System is Involved in the Mechanism of Increased Serum Asymmetric Dimethylarginine in Essential Hypertension. Japanese Circulation Journal 65:9, pages 775-778.
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Rainer H Böger, Stefanie M Bode-Böger, Philip S Tsao, Patrick S Lin, Jason R Chan & John P Cooke. (2000) An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesiveness for monocytes. Journal of the American College of Cardiology 36:7, pages 2287-2295.
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Ian S. Young & Jayne V. Woodside. (2000) Folate and homocysteine. Current Opinion in Clinical Nutrition and Metabolic Care 3:6, pages 427-432.
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Ali FardCatherine H. TuckJoshua A. DonisRobert SciaccaMarco R. Di TullioHenry D. WuTodd A. BryantNiem-Tzu ChenMargarita Torres-TamayoRavichandran RamasamyLars BerglundHenry N. GinsbergShunichi HommaPaul J. Cannon. (2000) Acute Elevations of Plasma Asymmetric Dimethylarginine and Impaired Endothelial Function in Response to a High-Fat Meal in Patients With Type 2 Diabetes. Arteriosclerosis, Thrombosis, and Vascular Biology 20:9, pages 2039-2044.
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Rainer H. BögerKarsten SydowJürgen BorlakThomas ThumHenrike LenzenBibiana SchubertDimitrios TsikasStefanie M. Bode-Böger. (2000) LDL Cholesterol Upregulates Synthesis of Asymmetrical Dimethylarginine in Human Endothelial Cells. Circulation Research 87:2, pages 99-105.
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D. Gattullo, P. Pagliaro, N.A. Marsh & G. Losano. (1999) New insights into nitric oxide and coronary circulation. Life Sciences 65:21, pages 2167-2174.
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ELLEN S. KANG, MARJORIE T. TEVLIN, YU BO WANG, THOMAS M. CHIANG, RAUL CARDENAS, LINDA K. MYERS & SERGIO R. ACCHIARDO. (1999) Hemodialysis Hypotension: Interaction of Inhibitors, iNOS, and the Interdialytic Period. The American Journal of the Medical Sciences 317:1, pages 9-21.
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Rudi Busse & Ingrid Fleming. (1999) Nitric oxide, nitric oxide synthase, and hypertensive vascular disease. Current Hypertension Reports 1:1, pages 88-95.
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R. H. Boger, S. M. Bode-Boger, A. Szuba, P. S. Tsao, J. R. Chan, O. Tangphao, T. F. Blaschke & J. P. Cooke. (1998) Asymmetric Dimethylarginine (ADMA): A Novel Risk Factor for Endothelial Dysfunction : Its Role in Hypercholesterolemia. Circulation 98:18, pages 1842-1847.
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Stefanie M. Bode‐Böger, Rainer H. Böger, Andrea Galland, Dimitrios Tsikas & Jürgen C. Frölich. (2002) L‐arginine‐induced vasodilation in healthy humans:pharmacokinetic–pharmacodynamic relationship. British Journal of Clinical Pharmacology 46:5, pages 489-497.
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Jun Sato, Hiroshi Masuda, Satoru Tamaoki, Hidehisa Hamasaki, Kazuhiro Ishizaka, Osamu Matsubara & Hiroshi Azuma. (2009) Endogenous asymmetrical dimethylarginine and hypertension associated with puromycin nephrosis in the rat. British Journal of Pharmacology 125:3, pages 469-476.
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Desmond P. Holden, Sara A. Fickling, Guy St.J. Whitley & Stephen S. Nussey. (1998) Plasma concentrations of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and preeclampsia. American Journal of Obstetrics and Gynecology 178:3, pages 551-556.
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