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Hypertension in Pregnancy Volume 15, 1996 - Issue 2
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Review Article

Importance of Nitric Oxide in Control of Systemic and Renal Hemodynamics During Normal Pregnancy: Studies in the Rat and Implications for Preeclampsia

Chris Bay Lis Department of Physiology, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, West Virginia, 26506-9229
,
Tamas Suto Department of Physiology, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, West Virginia, 26506-9229
&
Kirk Conrad Magee Womens Research Institute West Virginia University, Morgantown, West Virginia, 26506-9229
Pages 147-169 | Published online: 07 Jul 2009

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Stefano R. Giannubilo, Marta Menegazzi, Elisa Tedeschi, Valeria Bezzeccheri, Hisanori Suzuki & Andrea L. Tranquilli. (2008) Doppler analysis and placental nitric oxide synthase expression during fetal growth restriction. The Journal of Maternal-Fetal & Neonatal Medicine 21:9, pages 617-622.
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K. P. Conrad, J. Novak, L. A. Danielson, L. J. Kerchner & A. Jeyabalan. (2005) Mechanisms of Renal Vasodilation and Hyperfiltration During Pregnancy: Current Perspectives and Potential Implications for Preeclampsia. Endothelium 12:1-2, pages 57-62.
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Stephen S. Ong, Ian P. Crocker, Averil Y. Warren & Philip N. Baker. (2002) FUNCTIONAL CHARACTERISTICS OF CHORIONIC PLATE PLACENTAL ARTERIES FROM NORMAL PREGNANT WOMEN AND WOMEN WITH PRE-ECLAMPSIA. Hypertension in Pregnancy 21:3, pages 175-183.
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Ernst Beinder, Markus G. Mohaupt, Dietmar Schlembach, Tina Fischer, R. Bernd Sterzel, Norbert Lang & Chris Baylis. (1999) Nitric Oxide Synthase Activity and Doppler Parameters in the Fetoplacental and Uteroplacental Circulation in Preeclampsia. Hypertension in Pregnancy 18:2, pages 115-127.
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Jeanne Francoual, FranÇOis Audibert, Catherine Claise, Jacqueline Chalas, Pascale Trioche, Rene Frydman & Albert Lindenbaum. (1999) Implication of Apolipoprotein E and the L-Arginine-Nitric Oxide System in Preeclampsia. Hypertension in Pregnancy 18:3, pages 229-237.
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Varpu H. Ranta, Arto K. Orpana, Tomi S. Mikkola, Lasse U. Viinikka & R. Olavi Ylikorkala. (1998) Preeclampsia and Expression of Inducible Nitric Oxide Synthase Messenger RNA in Umbilical Vein Endothelial Cells. Hypertension in Pregnancy 17:3, pages 307-314.
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Karolina-Rasa Kublickiene, Charlotta Grunewald, Bo Lindblom & Henry Nisell. (1998) Myogenic and Endothelial Properties of Myometrial Resistance Arteries from Women with Preeclampsia. Hypertension in Pregnancy 17:3, pages 271-281.
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Hung N. Winn, Herbert M. Todd, Erol Amon, Ahmed Al-Malt, Miklós Molnár & Frank Hertelendy. (1997) Effects of Serum from Preeclamptic Women on Prostacyclin Production by Human Endothelial Cells. Journal of Maternal-Fetal Medicine 6:5, pages 249-253.
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Articles from other publishers (30)

Kirk P. Conrad. (2011) Emerging Role of Relaxin in the Maternal Adaptations to Normal Pregnancy: Implications for Preeclampsia. Seminars in Nephrology 31:1, pages 15-32.
Crossref
D. L. Chandler, M. T. Llinas, J. F. Reckelhoff, B. LaMarca, J. Speed & J. P. Granger. (2009) Effects of Hyperhomocysteinemia on Arterial Pressure and Nitric Oxide Production in Pregnant Rats. American Journal of Hypertension 22:10, pages 1115-1119.
Crossref
Zekiye Sultan Altun, Sezer Uysal, Gul Guner, Osman Yilmaz & Cemal Posaci. (2008) Effects of oral L ‐arginine supplementation on blood pressure and asymmetric dimethylarginine in stress‐induced preeclamptic rats . Cell Biochemistry and Function 26:5, pages 648-653.
Crossref
Andrea L. Tranquilli, Stefano R. Giannubilo, Elisa Tedeschi, Valeria Bezzeccheri, Hisanori Suzuki & Marta Menegazzi. (2005) Placental expression of nitric oxide synthase during HELLP syndrome: the correlation with maternal–fetal Doppler velocimetry. Acta Obstetricia et Gynecologica Scandinavica 84:9, pages 849-853.
Crossref
KIRK P. CONRAD, ARUN JEYABALAN, LESLIE A. DANIELSON, LAURIE J. KERCHNER & JACQUELINE NOVAK. (2005) Role of Relaxin in Maternal Renal Vasodilation of Pregnancy. Annals of the New York Academy of Sciences 1041:1, pages 147-154.
Crossref
Lina Fern�ndez Celadilla, Maite Carbajo Rueda & Manuel Mu�oz Rodr�guez. (2004) Prolonged inhibition of nitric oxide synthesis in pregnant rats: effects on blood pressure, fetal growth and litter size. Archives of Gynecology and Obstetrics 271:3, pages 243-248.
Crossref
Kirk P. Conrad. (2016) Mechanisms of Renal Vasodilation and Hyperfiltration During Pregnancy. Journal of the Society for Gynecologic Investigation 11:7, pages 438-448.
Crossref
Víctor H. González-Quintero, Loren P. Smarkusky, Joaquín J. Jiménez, Lucía M. Mauro, Wenche Jy, Laurence L. Hortsman, Mary J. O'Sullivan & Yeon S. Ahn. (2004) Elevated plasma endothelial microparticles: Preeclampsia versus gestational hypertension. American Journal of Obstetrics and Gynecology 191:4, pages 1418-1424.
Crossref
Barbara T. AlexanderMaria T. LlinasWalter C. KruckebergJoey P. Granger. (2004) l -Arginine Attenuates Hypertension in Pregnant Rats With Reduced Uterine Perfusion Pressure . Hypertension 43:4, pages 832-836.
Crossref
Jason G. Murphy, Jason N. Herrington, Joey P. Granger & Raouf A. Khalil. (2003) Enhanced [Ca 2+ ] i in renal arterial smooth muscle cells of pregnant rats with reduced uterine perfusion pressure . American Journal of Physiology-Heart and Circulatory Physiology 284:1, pages H393-H403.
Crossref
Rosa A Bobadilla, Liliana Anguiano, Victor Pérez-Alvarez & Pedro López Sanchez. (2003) Pregnancy influence on the vascular interactions between nitric oxide and other endothelium-derived mediators in rat kidney. Canadian Journal of Physiology and Pharmacology 81:1, pages 1-8.
Crossref
Raouf A. Khalil & Joey P. Granger. (2002) Vascular mechanisms of increased arterial pressure in preeclampsia: lessons from animal models. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 283:1, pages R29-R45.
Crossref
Jena B. Giardina, Gachavis M. Green, Kathy L. Cockrell, Joey P. Granger & Raouf A. Khalil. (2002) TNF-α enhances contraction and inhibits endothelial NO-cGMP relaxation in systemic vessels of pregnant rats. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 283:1, pages R130-R143.
Crossref
Barbara T. AlexanderKathy CockrellFarrah D. ClineJoey P. Granger. (2002) Inducible Nitric Oxide Synthase Inhibition Attenuates Renal Hemodynamics During Pregnancy. Hypertension 39:2, pages 586-590.
Crossref
Justin R. Davis, Jena B. Giardina, Gachavis M. Green, Barbara T. Alexander, Joey P. Granger & Raouf A. Khalil. (2002) Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-α-induced hypertension in pregnant rats. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 282:2, pages R390-R399.
Crossref
Barbara T. Alexander, William A. Bennett, Raouf A. Khalil & Joey P. Granger. (2001) Preeclampsia: Linking Placental Ischemia with Cardiovascular-Renal Dysfunction. Physiology 16:6, pages 282-286.
Crossref
S. R. Abram, B. T. Alexander, W. A. Bennett & J. P. Granger. (2001) Role of neuronal nitric oxide synthase in mediating renal hemodynamic changes during pregnancy. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 281:5, pages R1390-R1393.
Crossref
Barbara T. AlexanderSalah E. KassabM. Todd MillerSean R. AbramJane F. ReckelhoffWilliam A. BennettJoey P. Granger. (2001) Reduced Uterine Perfusion Pressure During Pregnancy in the Rat Is Associated With Increases in Arterial Pressure and Changes in Renal Nitric Oxide. Hypertension 37:4, pages 1191-1195.
Crossref
Jason G. Murphy, John B. Fleming, Kathy L. Cockrell, Joey P. Granger & Raouf A. Khalil. (2001) [Ca 2+ ] i signaling in renal arterial smooth muscle cells of pregnant rat is enhanced during inhibition of NOS . American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 280:1, pages R87-R99.
Crossref
Lionel Carbillon, Michele Uzan & Serge Uzan. (2000) Pregnancy, Vascular Tone, and Maternal Hemodynamics: A Crucial Adaptation. Obstetrical & Gynecological Survey 55:9, pages 574-581.
Crossref
Celia A. Kanashiro, Kathy L. Cockrell, Barbara T. Alexander, Joey P. Granger & Raouf A. Khalil. (2000) Pregnancy-associated reduction in vascular protein kinase C activity rebounds during inhibition of NO synthesis. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 278:2, pages R295-R303.
Crossref
Janice K. CrewsJason N. HerringtonJoey P. GrangerRaouf A. Khalil. (2000) Decreased Endothelium-Dependent Vascular Relaxation During Reduction of Uterine Perfusion Pressure in Pregnant Rat. Hypertension 35:1, pages 367-372.
Crossref
Ikuko Makino, Kazuhiko Shibata, Yasuo Makino, Kenji Kangawa & Tatsuhiko Kawarabayashi. (1999) Potentiation of the hypotensive effect of adrenomedullin in pregnant rats. European Journal of Pharmacology 385:2-3, pages 129-136.
Crossref
Celia A. KanashiroBarbara T. AlexanderJoey P. GrangerRaouf A. Khalil. (1999) Ca 2+ -Insensitive Vascular Protein Kinase C During Pregnancy and NOS Inhibition . Hypertension 34:4, pages 924-930.
Crossref
Janice K. Crews, Jacqueline Novak, Joey P. Granger & Raouf A. Khalil. (1999) Stimulated mechanisms of Ca 2+ entry into vascular smooth muscle during NO synthesis inhibition in pregnant rats . American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 276:2, pages R530-R538.
Crossref
Barbara T. Alexander, M. Todd Miller, Salah Kassab, Jackie Novak, Jane F. Reckelhoff, Walter C. Kruckeberg & Joey P. Granger. (1999) Differential Expression of Renal Nitric Oxide Synthase Isoforms During Pregnancy in Rats. Hypertension 33:1, pages 435-439.
Crossref
J. Mahaney, C. FeltonD. Taylor, W. Fleming, J. Q. Kong & C. Baylis. (1998) Renal cortical Na + -K + -ATPase activity and abundance is decreased in normal pregnant rats . American Journal of Physiology-Renal Physiology 275:5, pages F812-F817.
Crossref
Bruno Cacciatore, Erja Halmesmäki, Risto Kaaja, Kari Teramo & Olavi Ylikorkala. (1998) Effects of transdermal nitroglycerin on impedance to flow in the uterine, umbilical, and fetal middle cerebral arteries in pregnancies complicated by preeclampsia and intrauterine growth retardation. American Journal of Obstetrics and Gynecology 179:1, pages 140-145.
Crossref
Raouf A. KhalilJanice K. CrewsJacqueline NovakSalah KassabJoey P. Granger. (1998) Enhanced Vascular Reactivity During Inhibition of Nitric Oxide Synthesis in Pregnant Rats. Hypertension 31:5, pages 1065-1069.
Crossref
Jacqueline NovakJane ReckelhoffLeslie BumgarnerKathy CockrellSalah KassabJoey P. Granger. (1997) Reduced Sensitivity of the Renal Circulation to Angiotensin II in Pregnant Rats. Hypertension 30:3, pages 580-584.
Crossref

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