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Clinical and Experimental Hypertension Volume 1, 1978 - Issue 2
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Original Article

Prazosin and Phentolamine: Comparative Cardiovascular and Autonomic Profiles

M. A. Commarato Warner-lambert/parke-davis Pharmaceutical Research Division, Department of Pharmacology, 2800 Plymouth Road, Ann Arbor, Michigan, 48105
,
A. E. Langley Warner-lambert/parke-davis Pharmaceutical Research Division, Department of Pharmacology, 2800 Plymouth Road, Ann Arbor, Michigan, 48105
,
D. H. Dugan Warner-lambert/parke-davis Pharmaceutical Research Division, Department of Pharmacology, 2800 Plymouth Road, Ann Arbor, Michigan, 48105
,
E. C. Lattime Warner-lambert/parke-davis Pharmaceutical Research Division, Department of Pharmacology, 2800 Plymouth Road, Ann Arbor, Michigan, 48105
,
R. D. Smith Warner-lambert/parke-davis Pharmaceutical Research Division, Department of Pharmacology, 2800 Plymouth Road, Ann Arbor, Michigan, 48105
,
D. K. Tessman Warner-lambert/parke-davis Pharmaceutical Research Division, Department of Pharmacology, 2800 Plymouth Road, Ann Arbor, Michigan, 48105
&
H. R. Kaplan Warner-lambert/parke-davis Pharmaceutical Research Division, Department of Pharmacology, 2800 Plymouth Road, Ann Arbor, Michigan, 48105
 show all
Pages 191-217 | Published online: 03 Jul 2009

Citations (26)

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M. Nakai, J. Yamamoto & Y. Matsui. (1986) Acute Systemic and Regional Hemodynamic Effects of Alpha1-Adrenoceptor Blockade in Conscious Spontaneously Hypertensive Rats. Clinical and Experimental Hypertension. Part A: Theory and Practice 8:6, pages 981-996.
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B. Persson, T. Yao & P. Thorén. (1981) Correlation Between Decreased Heart Rate and Central Inhibition of Sympathetic Discharge After Prazosin Administration in the Spontaneously Hypertensive Rat. Clinical and Experimental Hypertension 3:2, pages 245-255.
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T. Baum, C. Sabin & R. M. Moran. (1981) Comparison of Hypotensive, Orthostatic and Sympathetic Inhibitory Actions of Antihypertensive Drugs in Rats. Clinical and Experimental Hypertension 3:2, pages 219-243.
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Marlene L. Cohen, Kathryn S. Wiley & Ann Schwab Landry. (1980) In Vitro Comparison of the Pre- and Postsynaptic Alpha Adrenergic Receptor Blocking Properties of Prazosin and Tiodazosin (BL5111). Clinical and Experimental Hypertension 2:6, pages 1067-1082.
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J. P. Buyniski, A. W. Pircio, J. E. Schurig & J. A. Campbell. (1980) Effects of Tiodazosin, Prazosin, Trimazosin and Phentolamine on Blood Pressure, Heart Rate and on Pre- and Postsynaptic α-Adrenergic Receptors in the Rat. Clinical and Experimental Hypertension 2:6, pages 1039-1066.
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Articles from other publishers (21)

D R ALGATE, S RASHID & J F WATERFALL. (1981) Cardioregulatory properties of indoramin in the rat. Journal of Pharmacy and Pharmacology 33:1, pages 236-239.
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E. Sehic, Y. Ruan & K. U. Malik. (1997) Mechanism of Resistance to α-Adrenergic Receptor Antagonists of Renal Nerve Stimulation-Induced Vasoconstriction at Low Frequencies. Journal of Cardiovascular Pharmacology 29:1, pages 97-108.
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C. Bohmann, P. Schollmeyer & L.C. Rump. (2012) α 2 ‐Autoreceptor subclassification in rat isolated kidney by use of short trains of electrical stimulation . British Journal of Pharmacology 108:1, pages 262-268.
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Norbert Limberger, Leni Späth & Klaus Starke. (1991) Subclassification of the presynaptic α2-autoreceptors in rabbit brain cortex. British Journal of Pharmacology 103:1, pages 1251-1255.
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J. Vincent, C. A. Hamilton & J. L. Reid. (2007) THE CARDIOVASCULAR EFFECTS OF TRIMAZOSIN AND PRAZOSIN IN THE RABBIT. Clinical and Experimental Pharmacology and Physiology 13:8, pages 593-608.
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J. P. HIEBLE, SHARON H. NELSON & O. S. STEINSLAND. (2008) NEURONAL DOPAMINE RECEPTORS OF THE RABBIT EAR ARTERY: PHARMACOLOGICAL CHARACTERIZATION OF THE RECEPTOR. Journal of Autonomic Pharmacology 5:2, pages 115-124.
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Peter M. Paciorek & Nicholas B. Shepperson. (1985) The α2-adrenoceptor selectivities and haemodynamic effects of WY26392 and yohimbine in the anaesthetised dog. European Journal of Pharmacology 110:2, pages 191-201.
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Kazuo HONDA, Toichi TAKENAKA, Kumiko SHIONO, Akemi MIYATA-OSAWA & Chieko NAKAGAWA. (1985) Autonomic and Antihypertensive Activity of Oral Amosulalol (YM-09538), a Combined α- and β-Adrenoceptor Blocking Agent in Conscious Rats. Japanese Journal of Pharmacology 38:1, pages 31-41.
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Takushi WATANABE, Hirofumi SOKABE & Koichiro KAWASHIMA. (1985) An Analysis of Blood Pressure Effects of Nipradilol and Prizidilol in Normotensive and Spontaneously Hypertensive Rats. Japanese Journal of Pharmacology 38:3, pages 273-279.
Crossref
P. Zandberg. 1984. Pharmacology of Antihypertensive Drugs. Pharmacology of Antihypertensive Drugs 6 45 .
Donald T. Pals & John Orley. (1983) A nonhuman primate model for evaluating the potential of antihypertensive drugs to cause orthostatic hypotension. Journal of Pharmacological Methods 9:3, pages 183-192.
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Chi Ho Lee, Arthur M. Strosberg, Adolph P. Roszkowski & Lea Ann Warren. (1982) A model for evaluation of postural hypotension induced by drugs in conscious restrained normotensive rats. Journal of Pharmacological Methods 7:1, pages 15-24.
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P. E. HICKS. (2008) ANTAGONISM OF PRE AND POSTSYNAPTIC α‐ADRENORECEPTORS BY BE 2254 (HEAT) AND PRAZOSIN. Journal of Autonomic Pharmacology 1:5, pages 391-398.
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GJ Schapel & WH Betts. (2012) The effect of a single oral dose of prazosin on venous reflex response, blood pressure and pulse rate in normal volunteers.. British Journal of Clinical Pharmacology 12:6, pages 873-881.
Crossref
RICHARD A. GILLIS & JOHN A. QUEST. 1981. Cardiac Pharmacology. Cardiac Pharmacology 25 50 .
J. C. DOXEY & A. G. ROACH. (2008) PRESYNAPTIC α‐ADRENORECEPTORS; IN VITRO METHODS AND PREPARATIONS UTILISED IN THE EVALUATION OF AGONISTS AND ANTAGONISTS. Journal of Autonomic Pharmacology 1:1, pages 73-99.
Crossref
Icilio Cavero & Alan G. Roach. (1980) The pharmacology of prazosin, a novel antihypertensive agent. Life Sciences 27:17, pages 1525-1540.
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David Deitchman, John P. Braselton, Donald C. Hayes & Russell L. Stratman. (1980) The ganglion-blocked, angiotensin II-supported rat: A model for demonstrating antihypertensive vasodilator activity. Journal of Pharmacological Methods 3:4, pages 311-321.
Crossref
I. CAVERO, T. DENNIS, FRANÇOISE LEFÈVRE‐BORG, P. PERROT, A.G. ROACH & B. SCATTON. (2012) EFFECTS OF CLONIDINE, PRAZOSIN AND PHENTOLAMINE ON HEART RATE AND CORONARY SINUS CATECHOLAMINE CONCENTRATION DURING CARDIOACCELERATOR NERVE STIMULATION IN SPINAL DOGS. British Journal of Pharmacology 67:2, pages 283-292.
Crossref
Forrest C. Greenslade, Cynthia K. Scott, Mark Chasin, Sherrie M. Madison & Alfonso J. Tobia. (1979) Interaction of prazosin with alpha-adrenergic receptors—In vitro binding and in vivo antagonism. Biochemical Pharmacology 28:15, pages 2409-2411.
Crossref
W. Lesley Matier & William T. Comer. 1979. Annual Reports in Medicinal Chemistry Volume 14. Annual Reports in Medicinal Chemistry Volume 14 61 70 .

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