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Clinical and Experimental Hypertension Volume 3, 1981 - Issue 2
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Original Article

Correlation Between Decreased Heart Rate and Central Inhibition of Sympathetic Discharge After Prazosin Administration in the Spontaneously Hypertensive Rat

B. Persson Department of Pharmacology, University of Göteborg, Box 33031, S-400 33, Göteborg, Sweden; Department of Physiology, University of Göteborg, Box 33031, S-400 33, Göteborg, Sweden
,
T. Yao Department of Pharmacology, University of Göteborg, Box 33031, S-400 33, Göteborg, Sweden; Department of Physiology, University of Göteborg, Box 33031, S-400 33, Göteborg, Sweden
&
P. Thorén Department of Pharmacology, University of Göteborg, Box 33031, S-400 33, Göteborg, Sweden; Department of Physiology, University of Göteborg, Box 33031, S-400 33, Göteborg, Sweden
Pages 245-255 | Published online: 03 Jul 2009

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M. Kurnjek, N. Basso, L. Mikulic & A. C. Taquini. (1989) Effect of ketanserin and prazosin on blood pressure and cardiovascular reactivity to vasopressor agents during the development of two kidney - two clip renal hypertension in the conscious rat. Archives Internationales de Physiologie et de Biochimie 97:1, pages 59-64.
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Articles from other publishers (27)

Young-Beom Kim, Won Woo Jung, Seung Won Lee, Xiangyan Jin, Hyung Kyung Kang, Eun-Hwa Hong, Sun Seek Min, Yoon-Sik Kim, Hee Chul Han, Christopher S. Colwell & Yang In Kim. (2021) Excessive maternal salt intake gives rise to vasopressin-dependent salt sensitivity of blood pressure in male offspring. Journal of Molecular and Cellular Cardiology 150, pages 12-22.
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M H Yen, J R Sheu, I H Peng, Y M Lee & J W Chern. (1996) Pharmacological Activity of DC−015, a Novel Potent and Selective α1-Adrenoceptor Antagonist. Journal of Pharmacy and Pharmacology 48:1, pages 90-95.
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Philippe Guillaume, Stéphane Hervé, Sandra Picard & Pierre Lacroix. (2008) Orthostatic Hypotension Induced by Postural Change in the Rat (Tilt Test). Current Protocols in Pharmacology 40:1.
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I-Hsun Peng, Joen-Rong Sheu, Ji-Wang Chern, Yen-Mei Lee & Mao-Hsiung Yen. (1996) Antihypertensive and hypolipidemic effects of DC-015, a novel, potent and specific α1-adrenoceptor antagonist: Comparison with prazosin in spontaneously hypertensive rats. Journal of Biomedical Science 3:2, pages 108-116.
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Andrew G. Ramage & Michael G. Wyllie. (1995) A comparison of the effects of doxazosin and terazosin on the spontaneous sympathetic drive to the bladder and related organs in anaesthetized cats. European Journal of Pharmacology 294:2-3, pages 645-650.
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Sheu-Meei Yu, Shih-Yuan Hsu, Feng-Nien Ko, Chien-Chih Chen, Yu-Ling Huang, Tur-Fu Huang & Che-Ming Teng. (1992) Haemodynamic effects of dicentrine, a novel α1-adrenoceptor antagonist: comparison with prazosin in spontaneously hypertensive and normotensive Wistar-Kyoto rats. British Journal of Pharmacology 106:4, pages 797-801.
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Michael C. Koss. (1992) Comparison of peripheral and central nervous system sympatholytic actions of prazosin using the cat nictitating membrane. European Journal of Pharmacology 211:1, pages 61-67.
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Andrew G. Ramage. (2012) The mechanism of the sympathoinhibitory action of urapidil: role of 5‐HT 1A receptors . British Journal of Pharmacology 102:4, pages 998-1002.
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Michael C. Koss. (1991) Mechanism of ketanserin-induced sympatho-inhibition. European Journal of Pharmacology 194:2-3, pages 161-166.
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Gila Lavian, Gerald Di Bona & John P.M. Finberg. (1991) Inhibition of sympathetic nerve activity by acute administration of the tricyclic antidepressant desipramine. European Journal of Pharmacology 194:2-3, pages 153-159.
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Michael C. Koss, John A. Hey & Takashi Ito. (1990) Effect of prazosin on spontaneous sympathetic-cholinergic activity. European Journal of Pharmacology 182:2, pages 381-386.
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P. A. van Zwieten. 1990. Pharmacology of Antihypertensive Therapeutics. Pharmacology of Antihypertensive Therapeutics 105 129 .
P. Singh & R. C. Sharma. (1990) Quantitative Structure-Activity Relationship Studies on a New Class of Antihypertensive Agents: Derivatives of 3-Aryl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine. Quantitative Structure-Activity Relationships 9:1, pages 29-32.
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Kathryn Gradin, Anders Pettersson, Thomas Hedner & Bengt Persson. (2009) Central Sympathoinhibitory Effect of Ketanserin in the Spontaneously Hypertensive Rat. Pharmacology & Toxicology 64:4, pages 352-355.
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Takashi Ito, John A. Hey & Michael C. Koss. (1988) Studies on the mechanism of prazosin induced sympatho-inhibition. European Journal of Pharmacology 158:3, pages 225-231.
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Michel Laubie & Henri Schmitt. (1988) Prazosin produces a sustained and reflex-mediated increase in renal sympathetic nerve activity in anesthetized dogs. European Journal of Pharmacology 151:1, pages 75-82.
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Anne-Marie Huchet, François Huguet, Bruno Gautret, Catherine Gitton, Guy Narcisse & Henri Schmitt. (1986) Central α1-adrenergic and opiate systems in the control of the vagal tone in normotensive and spontaneously hypertensive rats. Journal of the Autonomic Nervous System 17:3, pages 175-183.
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Andrew G. Ramage. (1986) A comparison of the effects of doxazosin and alfuzosin with those of urapidil on preganglionic symphathetic nerve activity in anaesthetised cats. European Journal of Pharmacology 129:3, pages 307-314.
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F C Luft, R Veelken, H Becker, D Ganten, R E Lang & T Unger. (1986) Effect of urapidil, clonidine, and prazosin on sympathetic tone in conscious rats.. Hypertension 8:4, pages 303-311.
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Vanessa Pierce, N.B. Shepperson, M.H. Todd & J.F. Waterfall. (2012) Investigation into the cardioregulatory properties of the α 1 ‐adrenoceptor blocker indoramin . British Journal of Pharmacology 87:2, pages 433-441.
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Andrew G. Ramage. (1986) Evidence for a central sympathoinhibitory action of prazosin and indoramin. European Journal of Pharmacology 121:1, pages 83-89.
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Andrew G. Ramage. (1984) The effect of prazosin, indoramin and phentolamine on sympathetic nerve activity. European Journal of Pharmacology 106:3, pages 507-513.
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L. G. HOWES. (2008) CENTRAL CATECHOLAMINERGIC NEURONES AND SPONTANEOUSLY HYPERTENSIVE RATS. Journal of Autonomic Pharmacology 4:3, pages 207-217.
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P.B.M.W.M. Timmermans & P.A. van Zwieten. 1984. Pharmacology of Antihypertensive Drugs. Pharmacology of Antihypertensive Drugs 239 248 .
M L Kurnjek, E Mangiarua, N Basso & A C Taquini. (1983) Further studies on the development of two-kidney, two clip Goldblatt hypertension in 6-hydroxydopamine-treated rats.. Hypertension 5:6_pt_3.
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Anne-Marie Huchet, François Huguet, Gérard Ostermann, Françoise Bakri-Logeais, Henri Schmitt & Guy Narcisse. (1983) Central α1-adrenoceptors and cardiovascular control in normotensive and spontaneously hypertensive rats. European Journal of Pharmacology 95:3-4, pages 207-213.
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Anne-Marie Huchet, Marie-Françoise Doursout, Jacques Chelly & Henri Schmitt. (1982) Possible role of central α1-adrenoceptors in the control of the autonomic nervous system in normotensive and spontaneously hypertensive rats. European Journal of Pharmacology 85:2, pages 239-242.
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